ATE205542T1 - Vergleichende genomhybridisierung - Google Patents

Vergleichende genomhybridisierung

Info

Publication number
ATE205542T1
ATE205542T1 AT93907077T AT93907077T ATE205542T1 AT E205542 T1 ATE205542 T1 AT E205542T1 AT 93907077 T AT93907077 T AT 93907077T AT 93907077 T AT93907077 T AT 93907077T AT E205542 T1 ATE205542 T1 AT E205542T1
Authority
AT
Austria
Prior art keywords
subject
nucleic acid
sequences
genomes
copy numbers
Prior art date
Application number
AT93907077T
Other languages
English (en)
Inventor
Daniel Pinkel
Joe W Gray
Anne Kallioniemi
Olli Pekka Kallioniemi
Frederic Waldman
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of ATE205542T1 publication Critical patent/ATE205542T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6841—In situ hybridisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT93907077T 1992-03-04 1993-03-01 Vergleichende genomhybridisierung ATE205542T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84665992A 1992-03-04 1992-03-04
US96994892A 1992-10-30 1992-10-30
PCT/US1993/001775 WO1993018186A1 (en) 1992-03-04 1993-03-01 Comparative genomic hybridization (cgh)

Publications (1)

Publication Number Publication Date
ATE205542T1 true ATE205542T1 (de) 2001-09-15

Family

ID=27126656

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93907077T ATE205542T1 (de) 1992-03-04 1993-03-01 Vergleichende genomhybridisierung

Country Status (8)

Country Link
US (3) US5665549A (de)
EP (2) EP1134293A3 (de)
JP (1) JP3645903B2 (de)
AT (1) ATE205542T1 (de)
CA (1) CA2131543C (de)
DE (1) DE69330750T2 (de)
ES (1) ES2161715T3 (de)
WO (1) WO1993018186A1 (de)

Families Citing this family (269)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5721098A (en) * 1986-01-16 1998-02-24 The Regents Of The University Of California Comparative genomic hybridization
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
AU647741B2 (en) * 1989-12-01 1994-03-31 Regents Of The University Of California, The Methods and compositions for chromosome-specific staining
US6025126A (en) 1991-10-28 2000-02-15 Arch Development Corporation Methods and compositions for the detection of chromosomal aberrations
US7534567B2 (en) 1992-03-04 2009-05-19 The Regents Of The University Of California Detection of nucleic acid sequence differences by comparative genomic hybridization
US5976790A (en) * 1992-03-04 1999-11-02 The Regents Of The University Of California Comparative Genomic Hybridization (CGH)
ATE205542T1 (de) * 1992-03-04 2001-09-15 Univ California Vergleichende genomhybridisierung
US5472842A (en) * 1993-10-06 1995-12-05 The Regents Of The University Of California Detection of amplified or deleted chromosomal regions
DE4344726C2 (de) 1993-12-27 1997-09-25 Deutsches Krebsforsch Verfahren zum Nachweis von nicht balanciertem genetischen Material einer Spezies oder zum Nachweis der Genexpression in Zellen einer Spezies
US5962332A (en) * 1994-03-17 1999-10-05 University Of Massachusetts Detection of trinucleotide repeats by in situ hybridization
US6472585B1 (en) 1994-04-25 2002-10-29 Genentech, Inc. Cardiotrophin-1 defective mouse
US7258983B2 (en) 1994-04-25 2007-08-21 Genentech, Inc. Cardiotrophin-1 compositions and methods for the treatment of tumor
US7378236B1 (en) 1994-06-17 2008-05-27 The Board Of Trustees Of The Leland Stanford Junior University Method for analyzing gene expression patterns
US7323298B1 (en) 1994-06-17 2008-01-29 The Board Of Trustees Of The Leland Stanford Junior University Microarray for determining the relative abundances of polynuceotide sequences
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5795716A (en) 1994-10-21 1998-08-18 Chee; Mark S. Computer-aided visualization and analysis system for sequence evaluation
US5830645A (en) * 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
US5635351A (en) * 1995-03-14 1997-06-03 The Regents Of The University Of California Genetic gain and loss in gliomas
US5690894A (en) 1995-05-23 1997-11-25 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
DE69636118T2 (de) * 1995-07-28 2006-12-21 Rijksuniversiteit Groningen Verfahren und mittel für die bestimmung der relativen heufigkeit von mikroorganismen in gemischten populationen
US20040175718A1 (en) * 1995-10-16 2004-09-09 Affymetrix, Inc. Computer-aided visualization and analysis system for sequence evaluation
US5801021A (en) * 1995-10-20 1998-09-01 The Regents Of The University Of California Amplifications of chromosomal region 20q13 as a prognostic indicator in breast cancer
US7049424B2 (en) 1996-07-15 2006-05-23 The Regents Of The University Of California Genes from the 20Q13 amplicon and their uses
US7455964B1 (en) 1996-07-15 2008-11-25 The Hospital For Sick Children Genes from the 20q13 amplicon and their uses
EP0861331A1 (de) * 1995-11-13 1998-09-02 Institut Pasteur Hochauflösende, vergleichbare nukleinsäure hybridisierung auf angeordneten dns-fasern
DE69632252T2 (de) * 1995-12-22 2005-04-14 Exact Sciences Corp., Marlborough Verfahren zur erkennung von klonalen populationen von transformierten zellen in einer genomisch heterogenen zellulären probe
US5837196A (en) * 1996-01-26 1998-11-17 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
US5776683A (en) * 1996-07-11 1998-07-07 California Pacific Medical Center Methods for identifying genes amplified in cancer cells
US6146828A (en) * 1996-08-14 2000-11-14 Exact Laboratories, Inc. Methods for detecting differences in RNA expression levels and uses therefor
US6203993B1 (en) 1996-08-14 2001-03-20 Exact Science Corp. Methods for the detection of nucleic acids
US6020137A (en) * 1996-08-14 2000-02-01 Exact Laboratories, Inc. Methods for the detection of loss of heterozygosity
US6100029A (en) * 1996-08-14 2000-08-08 Exact Laboratories, Inc. Methods for the detection of chromosomal aberrations
US5928870A (en) * 1997-06-16 1999-07-27 Exact Laboratories, Inc. Methods for the detection of loss of heterozygosity
US6300077B1 (en) 1996-08-14 2001-10-09 Exact Sciences Corporation Methods for the detection of nucleic acids
FR2755147B1 (fr) * 1996-10-30 1999-01-15 Pasteur Institut Procede de diagnostic de maladies genetiques par peignage moleculaire et coffret de diagnostic
FR2755149B1 (fr) 1996-10-30 1999-01-15 Pasteur Institut Procede de diagnostic de maladies genetiques par peignage moleculaire et coffret de diagnostic
GB9704054D0 (en) 1997-02-27 1997-04-16 Univ Cambridge Tech Assay
EP1005653A4 (de) * 1997-03-24 2004-05-06 Smithkline Beecham Corp Verfahren zur herstellung einer subtraktions-bibliothek
EP0878552A1 (de) * 1997-05-13 1998-11-18 Erasmus Universiteit Rotterdam Molekularer Nachweis von chromosomalen Veränderungen
US6268136B1 (en) 1997-06-16 2001-07-31 Exact Science Corporation Methods for stool sample preparation
DE19743301A1 (de) * 1997-09-30 1999-04-01 Metasystems Hard & Software Gm Verfahren zum Vergleich der Kopienzahl von Nukleinsäuresequenzen
US20050084875A1 (en) * 1997-10-24 2005-04-21 University Of Rochester Molecular markers for the diagnosis of Alzheimer's disease
CA2307674C (en) * 1997-10-30 2013-02-05 Cold Spring Harbor Laboratory Probe arrays and methods of using probe arrays for distinguishing dna
WO1999028725A1 (en) 1997-12-02 1999-06-10 Ozo Diversified Automation, Inc. Automated system for chromosome microdissection and method of using same
JP2002510033A (ja) * 1998-01-12 2002-04-02 ザ・サルク・インスティチュート 二重微小ｄｎａを有する細胞を処理するための組成物およびその処理方法
US6289229B1 (en) 1998-01-20 2001-09-11 Scimed Life Systems, Inc. Readable probe array for in vivo use
US6673914B1 (en) 1998-01-22 2004-01-06 John Wayne Cancer Institute Human tumor-associated gene
DE59913678D1 (de) * 1998-02-16 2006-08-31 Metasystems Hard & Software Gm Verfahren zum Nachweis von Änderungen in Biopolymeren
EP1092783A4 (de) * 1998-02-25 2004-11-03 Sumitomo Electric Industries Verfahren zur krebsdiagnose auf basis des nachweises von chromosomenabnormalitäten
US6183957B1 (en) 1998-04-16 2001-02-06 Institut Pasteur Method for isolating a polynucleotide of interest from the genome of a mycobacterium using a BAC-based DNA library application to the detection of mycobacteria
JP2002513587A (ja) 1998-05-04 2002-05-14 ダコ エー エス 染色体異常を検出するための方法およびプローブ
US6979728B2 (en) * 1998-05-04 2005-12-27 Baylor College Of Medicine Articles of manufacture and methods for array based analysis of biological molecules
EP1078257A4 (de) 1998-05-09 2007-07-18 Iconisys Inc Verfahren und apparat für computergestützte diagnose seltener zellen, einschliesslich fetaler zellen
US7901887B2 (en) 1998-05-09 2011-03-08 Ikonisys, Inc. Automated cancer diagnostic methods using fish
US20020001800A1 (en) * 1998-08-14 2002-01-03 Stanley N. Lapidus Diagnostic methods using serial testing of polymorphic loci
JP5213202B2 (ja) * 1998-10-28 2013-06-19 バイシス・インコーポレーテツド 細胞アレイならびに遺伝障害マーカーの検出および使用方法
EP1127163A2 (de) * 1998-11-02 2001-08-29 The Brigham & Women's Hospital, Inc. Eine methode zur genomischen subtraktiven hybridisierung
WO2000031298A1 (en) * 1998-11-23 2000-06-02 Exact Laboratories, Inc. Methods for detecting lower-frequency molecules
US6503718B2 (en) 1999-01-10 2003-01-07 Exact Sciences Corporation Methods for detecting mutations using primer extension for detecting disease
US6280947B1 (en) 1999-08-11 2001-08-28 Exact Sciences Corporation Methods for detecting nucleotide insertion or deletion using primer extension
US6387618B1 (en) * 1999-03-03 2002-05-14 The United States Of America As Represented By The Secretary Of The Navy Micronucleus assay with genomic DNA hybridization probe and enzymatic color pigment detection
US6174681B1 (en) 1999-03-05 2001-01-16 Mayo Foundation For Medical Education And Research Method and probe set for detecting cancer
ATE331811T1 (de) 1999-04-09 2006-07-15 Exact Sciences Corp Verfahren zur detektion von nukleinsäuren, welche auf krebs hinweisen
US6465182B1 (en) 1999-04-29 2002-10-15 The Regents Of The University Of California Comparative fluorescence hybridization to oligonucleotide microarrays
AU6350800A (en) * 1999-07-19 2001-02-05 American Laboratory Technologies, Inc. Removing repetitive sequences from dna
US6440706B1 (en) 1999-08-02 2002-08-27 Johns Hopkins University Digital amplification
US6849403B1 (en) 1999-09-08 2005-02-01 Exact Sciences Corporation Apparatus and method for drug screening
US6524794B1 (en) 1999-10-29 2003-02-25 Decode Genetics Ehf. Identical-by-descent fragment enrichment
US6613516B1 (en) 1999-10-30 2003-09-02 Affymetrix, Inc. Preparation of nucleic acid samples
US7346200B1 (en) 1999-11-18 2008-03-18 Ikonisys, Inc. Method and apparatus for computer controlled cell based diagnosis
US6919174B1 (en) 1999-12-07 2005-07-19 Exact Sciences Corporation Methods for disease detection
CA2394921A1 (en) 1999-12-07 2001-06-14 Anthony P. Shuber Supracolonic aerodigestive neoplasm detection
DE60104392T2 (de) * 2000-01-12 2005-08-11 Ventana Medical Systems, Inc., Tucson Verfahren zum nachweis der effektivität einer krebstherapie
ES2323220T3 (es) 2000-01-13 2009-07-09 Genentech, Inc. Polipeptidos humanos stra6.
WO2001083813A1 (en) * 2000-05-02 2001-11-08 Centre National De La Recherche Scientifique Identification of genetic markers
WO2001094630A2 (en) * 2000-06-07 2001-12-13 Baylor College Of Medicine Compositions and methods for array-based nucleic acid hybridization
US7494817B2 (en) * 2000-09-06 2009-02-24 Transnet Yx, Inc. Methods for genotype screening using magnetic particles
US7011943B2 (en) * 2000-09-06 2006-03-14 Transnetyx, Inc. Method for detecting a designated genetic sequence in murine genomic DNA
US20030087286A1 (en) * 2000-09-06 2003-05-08 Hodge Timothy A. Isolation of eukaryotic genomic DNA using magnetically responsive solid functionalized particles
US20030082605A1 (en) * 2000-09-06 2003-05-01 Hodge Timothy A. Genomic DNA detection method and system thereof
US20050266494A1 (en) * 2000-09-06 2005-12-01 Hodge Timothy A System and method for computer network ordering of biological testing
US20050272085A1 (en) * 2000-09-06 2005-12-08 Hodge Timothy A Methods for forensic and congenic screening
US20050239125A1 (en) * 2000-09-06 2005-10-27 Hodge Timothy A Methods for genotype screening
WO2002044411A1 (en) * 2000-12-01 2002-06-06 Rosetta Inpharmatics, Inc. Use of profiling for detecting aneuploidy
US20020142305A1 (en) * 2001-03-27 2002-10-03 Koei Chin Methods for diagnosing and monitoring ovarian cancer by screening gene copy numbers
US20040161741A1 (en) * 2001-06-30 2004-08-19 Elazar Rabani Novel compositions and processes for analyte detection, quantification and amplification
US20060014186A1 (en) * 2001-09-04 2006-01-19 Hodge Timothy A Methods for genotype screening of a strain disposed on an adsorbent carrier
US7439346B2 (en) 2001-10-12 2008-10-21 Perkinelmer Las Inc. Nucleic acids arrays and methods of use therefor
US7335470B2 (en) * 2001-10-12 2008-02-26 Perkinelmer, Las, Inc. Compilations of nucleic acids and arrays and methods of using them
US20030082618A1 (en) * 2001-10-15 2003-05-01 Guangshan Li Methods for detecting genetic aberrations
CA2467629A1 (en) 2001-11-20 2003-05-30 Oncomedx, Inc. Methods for evaluating drug-resistance gene expression in the cancer patient
US20030124542A1 (en) * 2001-12-28 2003-07-03 Spectral Genomics, Inc. Methods for mapping the chromosomal loci of genes expressed by a cell
US6916621B2 (en) 2002-03-27 2005-07-12 Spectral Genomics, Inc. Methods for array-based comparitive binding assays
WO2003087774A2 (en) * 2002-04-12 2003-10-23 Curators Of The University Of Missouri Ecist microarrays for dual screening of dna hypermethylation and gene silencing
AU2003279697A1 (en) * 2002-05-17 2004-02-16 Nugen Technologies, Inc. Methods for fragmentation, labeling and immobilizaton of nucleic acids
EP1553912A4 (de) 2002-06-07 2007-08-08 Genentech Inc Zusammensetzungen und verfahren f r die tumordiagnose und behandlung
US9388459B2 (en) 2002-06-17 2016-07-12 Affymetrix, Inc. Methods for genotyping
NL1021160C2 (nl) * 2002-07-26 2004-01-27 Multigen Internat B V Werkwijze voor het bepalen van het kopieaantal van een nucleotidevolgorde.
US7011949B2 (en) * 2002-09-30 2006-03-14 Agilent Technologies, Inc. Methods and compositions for producing labeled probe nucleic acids for use in array based comparative genomic hybridization applications
JP2006519977A (ja) * 2002-11-11 2006-08-31 アフィメトリックス インコーポレイテッド Ｄｎａコピー数変化を同定するための方法
US7822555B2 (en) 2002-11-11 2010-10-26 Affymetrix, Inc. Methods for identifying DNA copy number changes
US10229244B2 (en) 2002-11-11 2019-03-12 Affymetrix, Inc. Methods for identifying DNA copy number changes using hidden markov model based estimations
JP2006511225A (ja) * 2002-12-23 2006-04-06 アジレント・テクノロジーズ・インク 固定化オリゴヌクレオチドフィーチャーを用いた比較ゲノムハイブリダイゼーションアッセイ及びその実施に用いるための組成物
US7750908B2 (en) 2003-04-04 2010-07-06 Agilent Technologies, Inc. Focus plus context viewing and manipulation of large collections of graphs
US20040219532A1 (en) * 2003-04-30 2004-11-04 Sampson Jeffrey R. Internal references measurements
CA2526810A1 (en) * 2003-05-23 2005-04-21 Cold Spring Harbor Laboratory Virtual representations of nucleotide sequences
US7211384B2 (en) * 2003-05-28 2007-05-01 Agilent Technologies, Inc. Comparative genomic hybridization assays using immobilized oligonucleotide targets with initially small sample sizes and compositions for practicing the same
JP2007521014A (ja) * 2003-08-01 2007-08-02 パーキンエルマー・エルエイエス・インコーポレイテッド 診断および毒物学用のシンテニーゲノムアレイの調製および使用のためのアレイ、方法およびキット
WO2005044086A2 (en) * 2003-10-30 2005-05-19 Tufts-New England Medical Center Prenatal diagnosis using cell-free fetal dna in amniotic fluid
AU2004311882A1 (en) 2003-12-29 2005-07-21 Nugen Technologies, Inc. Methods for analysis of nucleic acid methylation status and methods for fragmentation, labeling and immobilization of nucleic acids
US20060084067A1 (en) * 2004-02-03 2006-04-20 Zohar Yakhini Method and system for analysis of array-based, comparative-hybridization data
WO2005079474A2 (en) * 2004-02-17 2005-09-01 The Regents Of The University Of California Detection of nucleic acid sequence differences by comparative genomic hybridization
US8321138B2 (en) 2005-07-29 2012-11-27 Agilent Technologies, Inc. Method of characterizing quality of hybridized CGH arrays
US20070031883A1 (en) * 2004-03-04 2007-02-08 Kincaid Robert H Analyzing CGH data to identify aberrations
US20050233338A1 (en) * 2004-04-20 2005-10-20 Barrett Michael T Methods and compositions for assessing chromosome copy number
US20050233339A1 (en) * 2004-04-20 2005-10-20 Barrett Michael T Methods and compositions for determining the relationship between hybridization signal of aCGH probes and target genomic DNA copy number
US8911942B2 (en) 2004-05-20 2014-12-16 Quest Diagnostics Investments Incorporated Single label comparative hybridization
US20050282211A1 (en) * 2004-06-21 2005-12-22 Nuwaysir Emile F Probe optimization methods
JP4476050B2 (ja) * 2004-06-30 2010-06-09 株式会社ニデック 視野計
WO2006023769A2 (en) * 2004-08-18 2006-03-02 Abbott Molecular, Inc. Determining data quality and/or segmental aneusomy using a computer system
US20060080043A1 (en) * 2004-10-12 2006-04-13 Sampas Nicholas M Comparative genomic hybridization significance analysis using data smoothing with shaped response functions
US20070099227A1 (en) * 2004-10-12 2007-05-03 Curry Bo U Significance analysis using data smoothing with shaped response functions
US20060078899A1 (en) * 2004-10-12 2006-04-13 Scheffer Alicia F Methods and compositions for reducing label variation in array-based comparative genome hybridization assays
US20060078898A1 (en) * 2004-10-12 2006-04-13 Curry Bo U Methods and compositions for reducing label variation in array-based comparative genome hybridization assays II
WO2006047787A2 (en) 2004-10-27 2006-05-04 Exact Sciences Corporation Method for monitoring disease progression or recurrence
US20060110744A1 (en) * 2004-11-23 2006-05-25 Sampas Nicolas M Probe design methods and microarrays for comparative genomic hybridization and location analysis
ATE491941T1 (de) 2005-01-27 2011-01-15 Quest Diagnostics Invest Inc Schnelle komparative genomhybridisierung
US20060172314A1 (en) * 2005-01-31 2006-08-03 Song Min-Sun Quantification of amplified nucleic acids
US7541144B2 (en) * 2005-01-31 2009-06-02 Agilent Technologies, Inc. RNA labeling method
US20060173635A1 (en) * 2005-02-01 2006-08-03 Yakhini Zohar H Analyzing and visualizing enrichment in DNA sequence alterations
US20060192570A1 (en) * 2005-02-15 2006-08-31 Mann & Hummel Gmbh Apparatus for monitoring consumable parts
JP5744371B2 (ja) * 2005-02-22 2015-07-08 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ 脊髄小脳性運動失調５型に関する遺伝子の同定、及び使用方法。
WO2007044071A2 (en) 2005-04-21 2007-04-19 Exact Sciences Corporation Analysis of heterogeneous nucleic acid samples
US7544471B2 (en) * 2005-07-30 2009-06-09 Agilent Technologies, Inc. Preparing RNA from a wax-embedded tissue specimen
US20070048743A1 (en) * 2005-08-26 2007-03-01 Sampas Nicholas M Methods and compositions for assessing candidate aCGH probe nucleic acids
US20070087355A1 (en) * 2005-10-14 2007-04-19 Barrett Michael T Comparative genomic hybridization assays and compositions for practicing the same
US8076074B2 (en) 2005-11-29 2011-12-13 Quest Diagnostics Investments Incorporated Balanced translocation in comparative hybridization
US11306351B2 (en) 2005-12-21 2022-04-19 Affymetrix, Inc. Methods for genotyping
US20070231803A1 (en) * 2006-03-31 2007-10-04 Jensen Mark A Multiplex pcr mixtures and kits containing the same
US20070238106A1 (en) * 2006-04-07 2007-10-11 Agilent Technologies, Inc. Systems and methods of determining alleles and/or copy numbers
US8058055B2 (en) 2006-04-07 2011-11-15 Agilent Technologies, Inc. High resolution chromosomal mapping
US20070238104A1 (en) * 2006-04-07 2007-10-11 Agilent Technologies, Inc. Competitive oligonucleotides
US20070238108A1 (en) * 2006-04-07 2007-10-11 Agilent Technologies, Inc. Validation of comparative genomic hybridization
US20070259344A1 (en) * 2006-05-03 2007-11-08 Agilent Technologies, Inc. Compound probes and methods of increasing the effective probe densities of arrays
US20070259345A1 (en) * 2006-05-03 2007-11-08 Agilent Technologies, Inc. Target determination using compound probes
US20070259347A1 (en) * 2006-05-03 2007-11-08 Agilent Technologies, Inc. Methods of increasing the effective probe densities of arrays
US20070259346A1 (en) * 2006-05-03 2007-11-08 Agilent Technologies, Inc. Analysis of arrays
US7702468B2 (en) * 2006-05-03 2010-04-20 Population Diagnostics, Inc. Evaluating genetic disorders
US20080058218A1 (en) * 2006-05-03 2008-03-06 Gordon David B Arrays of compound probes and methods using the same
US10522240B2 (en) 2006-05-03 2019-12-31 Population Bio, Inc. Evaluating genetic disorders
US20100022403A1 (en) * 2006-06-30 2010-01-28 Nurith Kurn Methods for fragmentation and labeling of nucleic acids
US7437249B2 (en) 2006-06-30 2008-10-14 Agilent Technologies, Inc. Methods and systems for detrending signal intensity data from chemical arrays
US7943310B2 (en) 2006-08-30 2011-05-17 Centocor Ortho Biotech Inc. Methods for assessing response to therapy in subjects having ulcerative colitis
US8077951B2 (en) 2006-10-12 2011-12-13 Agilent Technologies, Inc. Method and system for dynamic, automated detection of outlying feature and feature background regions during processing of data scanned from a chemical array
US7881876B2 (en) 2006-10-12 2011-02-01 Agilent Technologies, Inc. Methods and systems for removing offset bias in chemical array data
US20080090236A1 (en) * 2006-10-13 2008-04-17 Yakhini Zohar H Methods and systems for identifying tumor progression in comparative genomic hybridization data
US20080102453A1 (en) * 2006-10-31 2008-05-01 Jayati Ghosh Methods and systems and analysis of CGH data
US8105770B2 (en) 2007-01-31 2012-01-31 Wako Pure Chemical Industries, Ltd. Method of detecting amplification or deletion in genomic DNA Fragment
US20080241829A1 (en) * 2007-04-02 2008-10-02 Milligan Stephen B Methods And Kits For Producing Labeled Target Nucleic Acid For Use In Array Based Hybridization Applications
US8200440B2 (en) * 2007-05-18 2012-06-12 Affymetrix, Inc. System, method, and computer software product for genotype determination using probe array data
US20080293589A1 (en) * 2007-05-24 2008-11-27 Affymetrix, Inc. Multiplex locus specific amplification
US7507539B2 (en) 2007-07-30 2009-03-24 Quest Diagnostics Investments Incorporated Substractive single label comparative hybridization
GB0715030D0 (en) * 2007-08-02 2007-09-12 Wilson Carol J Testing process
US20090075835A1 (en) * 2007-09-17 2009-03-19 Signature Genomics Laboratories, Llc Methods and systems for the detection of microdeletion and microduplication syndromes
US20090088330A1 (en) * 2007-09-28 2009-04-02 Leproust Emily M Methods And Kits For Producing Labeled Target Nucleic Acids For Use In Array Based Hybridization Applications
AU2008303080A1 (en) 2007-09-28 2009-04-02 Murdoch Childrens Research Institute Cell detection, monitoring and isolation method
US8093063B2 (en) 2007-11-29 2012-01-10 Quest Diagnostics Investments Incorporated Assay for detecting genetic abnormalities in genomic nucleic acids
US7964354B2 (en) 2007-12-20 2011-06-21 Celgene Corporation Use of micro-RNA as a biomarker of immunomodulatory drug activity
ES2581774T3 (es) 2008-08-29 2016-09-07 Janssen Biotech, Inc. Marcadores y métodos de evaluación y tratamiento de colitis ulcerosa y trastornos relacionados mediante un panel de 20 genes
US20100104513A1 (en) * 2008-10-28 2010-04-29 General Electric Company Method and system for dye assessment
US20100210471A1 (en) 2008-11-12 2010-08-19 University Of Utah Research Foundation Autism associated genetic markers
JP5645816B2 (ja) 2009-05-25 2014-12-24 国立大学法人東京工業大学 中枢神経細胞の増殖及び分化に係る中核因子を含む医薬組成物
WO2010138908A1 (en) 2009-05-29 2010-12-02 Ventana Medical Systems, Inc. Igfir gene copy number as a prognostic marker in a non-small cell lung cancer
US20120141472A1 (en) 2009-05-29 2012-06-07 Shalini Singh Methods of scoring gene copy number in a biological sample using in situ hybridization
EP2480684A1 (de) * 2009-09-25 2012-08-01 Signature Genomic Laboratories, Llc Mehrfach (+/-)-strängige arrays und tests für den nachweis von chromosomalen anomalien im zusammenhang mit krebs und anderen erkrankungen
WO2011048495A1 (en) 2009-10-19 2011-04-28 Stichting Het Nederlands Kanker Instituut Predicting benefit of anti-cancer therapy via array comparative genomic hybridization
EP2491141A2 (de) 2009-10-19 2012-08-29 Stichting Het Nederlands Kanker Instituut Differenzierung zwischen brca2-tumoren und sporadischen tumoren mittels array-basierter vergleichender genomhybridisierung
EP2491140A1 (de) 2009-10-19 2012-08-29 Stichting Het Nederlands Kanker Instituut Vorhersage des nutzens einer krebstherapie mit array-basierter vergleichender genomhybridisierung
EP3272884A3 (de) 2009-10-26 2018-02-14 Abbott Molecular Inc. Erkennung von chromosomenanomalien in verbindung mit der prognose von nicht kleinzelligem lungenkrebs
EP2519649A1 (de) 2009-12-29 2012-11-07 Cancer Genetics, Inc. Instrument für die diagnose und prognose von reifen b-zell-neoplasmen
US20110160076A1 (en) 2009-12-31 2011-06-30 Ventana Medical Systems, Inc. Methods for producing uniquely specific nucleic acid probes
US9587278B2 (en) 2010-01-08 2017-03-07 Oxford Gene Technology (Operations) Ltd. Combined CGH and allele specific hybridisation method
US8774488B2 (en) 2010-03-11 2014-07-08 Cellscape Corporation Method and device for identification of nucleated red blood cells from a maternal blood sample
CA2798190A1 (en) 2010-05-10 2011-11-17 Mayo Foundation For Medical Education And Research Detection of chromosomal abnormalities associated with endometrial cancer
US20110318741A1 (en) 2010-06-15 2011-12-29 Schafer Peter H Biomarkers for the treatment of psoriasis
US20120046877A1 (en) * 2010-07-06 2012-02-23 Life Technologies Corporation Systems and methods to detect copy number variation
EP2601609B1 (de) 2010-08-02 2017-05-17 Population Bio, Inc. Zusammensetzungen und verfahren zur erkennung der verursachenden mutationen in genetischen erkrankungen
EP2619326A2 (de) 2010-09-20 2013-07-31 Stichting Het Nederlands Kanker Instituut Verfahren zur vorhersage des ansprechens von krebspatienten auf eine anti-krebs-therapie
WO2012149299A2 (en) 2011-04-29 2012-11-01 Celgene Corporaiton Methods for the treatment of cancer and inflammatory diseases using cereblon as a predictor
EP2732049A1 (de) 2011-07-14 2014-05-21 Traslational Cancer Drugs Pharma, S.L. Verfahren zur ergebnisvorhersage von krebs bei einer person
EP3272882B1 (de) 2011-09-23 2019-02-20 Academisch Medisch Centrum Materialien und verfahren zur vorhersage der entwicklung von barrett-ösophagus
CA2851388C (en) 2011-10-10 2023-11-21 The Hospital For Sick Children Methods and compositions for screening and treating developmental disorders
US10378060B2 (en) 2011-10-14 2019-08-13 Dana-Farber Cancer Institute, Inc. ZNF365/ZFP365 biomarker predictive of anti-cancer response
SG11201401628WA (en) 2011-10-19 2014-05-29 Nugen Technologies Inc Compositions and methods for directional nucleic acid amplification and sequencing
US9121051B2 (en) 2011-10-31 2015-09-01 Arkray, Inc. Method of determining the abundance of a target nucleotide sequence of a gene of interest
WO2013067451A2 (en) 2011-11-04 2013-05-10 Population Diagnostics Inc. Methods and compositions for diagnosing, prognosing, and treating neurological conditions
TWI455461B (zh) * 2011-11-23 2014-10-01 Delta Electronics Inc 冷卻套
EP2788768A1 (de) 2011-12-10 2014-10-15 Abbott Molecular Inc. Materialien und verfahren zur diagnose bösartiger melanome und zur prognose von metastasen bösartiger melanome
BR112014015547A2 (pt) * 2011-12-22 2017-06-13 Centre Nat Rech Scient método de detecção e quantificação de dna por meio de hibridização e manipulação de moléculas isoladas
JP6284487B2 (ja) 2011-12-30 2018-02-28 アボツト・モレキユラー・インコーポレイテツド 膀胱癌の診断及びその再発のモニタリングのための材料及び方法
US9469877B2 (en) 2011-12-30 2016-10-18 Abbott Molecular Inc. Materials and methods for diagnosis, prognosis, monitoring of recurrence, and assessment of therapeutic/prophylactic treatment of pancreatobiliary cancer
ES2633183T3 (es) 2011-12-30 2017-09-19 Abbott Molecular Inc. Materiales y procedimientos para el diagnóstico, pronóstico y evaluación del tratamiento terapéutico/profiláctico del cáncer de próstata
GB2513793B (en) 2012-01-26 2016-11-02 Nugen Tech Inc Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generation
EP2812452B1 (de) 2012-02-09 2020-05-27 Population Bio, Inc. Verfahren und zusammensetzungen zum screening und zur behandlung von entwicklungsstörungen
WO2013124740A2 (en) 2012-02-23 2013-08-29 Stichting Vu-Vumc BRCA DEFICIENCY PROTEIN AND mRNA SIGNATURES USEFUL IN IDENTIFICATION OF PATIENTS WITH BRCA-DEFICIENT TUMORS AND PREDICTING BENEFIT OF ANTI-CANCER THERAPY IN CANCER PATIENTS
WO2013167387A1 (en) 2012-05-10 2013-11-14 Ventana Medical Systems, Inc. Uniquely specific probes for pten, pik3ca, met, top2a, and mdm2
ITMI20120846A1 (it) 2012-05-16 2013-11-17 Bongulielmi Reto Metodo e sistema per valutare molecole in campioni biologici tramite immagini derivate da microarray
GB2518078B (en) 2012-06-18 2015-04-29 Nugen Technologies Inc Compositions and methods for negative selection of non-desired nucleic acid sequences
ES2699810T3 (es) 2012-06-29 2019-02-12 Celgene Corp Métodos para determinar la eficacia de fármacos usando proteínas asociadas a cereblon
US20150011396A1 (en) 2012-07-09 2015-01-08 Benjamin G. Schroeder Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing
US9587281B2 (en) 2012-08-14 2017-03-07 Celgene Corporation Cereblon isoforms and their use as biomarkers for therapeutic treatment
EP2895621B1 (de) 2012-09-14 2020-10-21 Population Bio, Inc. Verfahren und zusammensetzungen zur diagnose, prognose und behandlung neurologischer erkrankungen
WO2014048942A1 (en) 2012-09-25 2014-04-03 Ventana Medical Systems, Inc. Probes for pten, pik3ca, met, and top2a, and method for using the probes
WO2014052855A1 (en) 2012-09-27 2014-04-03 Population Diagnostics, Inc. Methods and compositions for screening and treating developmental disorders
SMT201800561T1 (it) 2012-11-01 2018-11-09 Infinity Pharmaceuticals Inc Trattamento di cancri usando modulatori di isoforme di pi3 chinasi
EP2971091A1 (de) 2013-03-14 2016-01-20 Abbott Molecular Inc. Materialien und verfahren zur beurteilung von kolorektalen adenomen
EP2971130A4 (de) 2013-03-15 2016-10-05 Nugen Technologies Inc Sequentielle sequenzierung
CA2914284A1 (en) 2013-05-30 2014-12-04 Infinity Pharmaceuticals, Inc. Treatment of cancers using pi3 kinase isoform modulators
EP2813571A1 (de) 2013-06-13 2014-12-17 Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) Verfahren zur Behandlung von Lungenkrebs
US11104950B2 (en) 2013-09-11 2021-08-31 The Regents Of The University Of California Human blood molecular biodosimeter panel for distinguishing radiation exposure from inflammation stress
FI3511422T3 (fi) 2013-11-12 2023-01-31 Menetelmiä ja koostumuksia endometriooosin diagnosointia, ennustamista ja hoitoa varten
US9546399B2 (en) 2013-11-13 2017-01-17 Nugen Technologies, Inc. Compositions and methods for identification of a duplicate sequencing read
EA201691144A1 (ru) 2013-12-06 2016-11-30 Селджин Корпорейшн Способы определения эффективности лекарственного средства для лечения диффузной крупноклеточной b-клеточной лимфомы, множественной миеломы и злокачественных новообразований миелоидного ростка
US9745614B2 (en) 2014-02-28 2017-08-29 Nugen Technologies, Inc. Reduced representation bisulfite sequencing with diversity adaptors
WO2015164743A2 (en) 2014-04-24 2015-10-29 Dana-Farber Cancer Institute, Inc. Tumor suppressor and oncogene biomarkers predictive of anti-immune checkpoint inhibitor response
EP3827836A1 (de) 2014-06-27 2021-06-02 Celgene Corporation Zusammensetzungen und verfahren zur induktion von konformationsänderungen bei cereblon und anderen e3-ubiquitin-ligasen
US9994912B2 (en) 2014-07-03 2018-06-12 Abbott Molecular Inc. Materials and methods for assessing progression of prostate cancer
WO2016036403A1 (en) 2014-09-05 2016-03-10 Population Diagnostics Inc. Methods and compositions for inhibiting and treating neurological conditions
AU2015328411C1 (en) 2014-10-06 2022-03-03 Dana-Farber Cancer Institute, Inc. Angiopoietin-2 biomarkers predictive of anti-immune checkpoint response
WO2016057651A1 (en) 2014-10-09 2016-04-14 Dana-Farber Cancer Institute, Inc. Multiple-variable il-2 dose regimen for treating immune disorders
JP2017533733A (ja) 2014-11-11 2017-11-16 アボツト・モレキユラー・インコーポレイテツド ハイブリダイゼーションプローブおよび方法
HK1248812A1 (zh) 2015-03-06 2018-10-19 Dana-Farber Cancer Institute, Inc. 预测在食管胃癌中pd-1通路抑制剂响应的pd-l2生物标记
EP3109324B1 (de) * 2015-06-23 2018-09-19 ZytoVision GmbH Verfahren zur detektion von chromosomenaberrationen
HRP20211976T1 (hr) 2015-08-17 2022-03-18 Kura Oncology, Inc. Postupci liječenja bolesnika od raka inhibitorima farnezil transferaze
US10830762B2 (en) 2015-12-28 2020-11-10 Celgene Corporation Compositions and methods for inducing conformational changes in cereblon and other E3 ubiquitin ligases
KR20180095094A (ko) 2016-01-08 2018-08-24 셀진 코포레이션 암을 치료하기 위한 방법 및 치료요법에 대한 임상 감수성의 예측변수로서 바이오마커의 용도
US20190119758A1 (en) 2016-04-22 2019-04-25 Kura Oncology, Inc. Methods of selecting cancer patients for treatment with farnesyltransferase inhibitors
EP3515559B1 (de) 2016-09-20 2025-05-21 Dana-Farber Cancer Institute, Inc. Zusammensetzungen und verfahren zur identifizierung, beurteilung, prävention und behandlung von aml mit usp10-biomarkern und modulatoren
EP3838275A1 (de) 2016-11-03 2021-06-23 Kura Oncology, Inc. Farnesyltransferase-inhibitoren zur verwendung bei der behandlung von krebs
US10240205B2 (en) 2017-02-03 2019-03-26 Population Bio, Inc. Methods for assessing risk of developing a viral disease using a genetic test
WO2018144832A1 (en) 2017-02-03 2018-08-09 Celgene Corporation Methods for measuring small molecule affinity to cereblon
CA3053795A1 (en) 2017-02-21 2018-08-30 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
US10137121B2 (en) 2017-02-21 2018-11-27 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
US12492430B2 (en) 2017-04-11 2025-12-09 Tecan Genomics, Inc. Library quantitation and qualification
US11820822B2 (en) 2017-06-06 2023-11-21 Dana-Farber Cancer Institute, Inc. Methods for sensitizing cancer cells to T cell-mediated killing by modulating molecular pathways
US10806730B2 (en) 2017-08-07 2020-10-20 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
CA3071854A1 (en) 2017-08-07 2019-02-14 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
US11099202B2 (en) 2017-10-20 2021-08-24 Tecan Genomics, Inc. Reagent delivery system
WO2019125184A1 (en) 2017-12-19 2019-06-27 Auckland Uniservices Limited Use of biomarker in cancer therapy
AU2019227641B2 (en) 2018-02-28 2024-09-26 Dana-Farber Cancer Institute, Inc. Methods for treating cancer using combinations of anti-BTNL2 and immune checkpoint blockade agents
CA3091859A1 (en) 2018-04-06 2019-10-24 Dana-Farber Cancer Institute, Inc. Kir3dl3 as an hhla2 receptor, anti-hhla2 antibodies, and uses thereof
EP3796909B1 (de) 2018-05-23 2026-02-25 Celgene Corporation Behandlung von multiplem myelom und verwendung von biomarkern für 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)-piperazin-1-yl)-3-fluorbenzonitril
FI3625368T3 (fi) 2018-08-08 2023-01-13 Menetelmiä john cunningham -viruksen aiheuttaman progressiivin multifokaalin leukoenkefalopatian kehittymisen riskin arviointiin geneettisellä testauksella
EP3873469A2 (de) 2018-11-01 2021-09-08 Kura Oncology, Inc. Verfahren zur behandlung von krebs mit farnesyltransferase-inhibitoren
JP2022513082A (ja) 2018-11-19 2022-02-07 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 免疫応答を調節するためのＩＲＥ１α－ＸＢＰ１シグナル伝達経路バイオマーカーの使用
US20220142983A1 (en) 2019-03-01 2022-05-12 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
EP3946338B1 (de) 2019-03-29 2025-06-18 Kura Oncology, Inc. Verfahren zur behandlung von plattenepithelkarzinomen mit farnesyltransferase-inhibitoren
WO2020205387A1 (en) 2019-04-01 2020-10-08 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
WO2020223121A1 (en) 2019-04-30 2020-11-05 Dana-Farber Cancer Institute, Inc. Methods for treating cancer using combinations of anti-cx3cr1 and immune checkpoint blockade agents
US20220305001A1 (en) 2019-05-02 2022-09-29 Kura Oncology, Inc. Methods of treating acute myeloid leukemia with farnesyltransferase inhibitors
US20230075965A1 (en) 2020-01-24 2023-03-09 Constantine S. Mitsiades Uses of biomarkers for improving immunotherapy
CN113275053A (zh) 2020-02-03 2021-08-20 帝肯基因组学公司 试剂存储系统
WO2022120196A2 (en) * 2020-12-03 2022-06-09 Cytotest Inc. Nucleic acid probes
CN117425674A (zh) 2021-03-02 2024-01-19 丹娜法伯癌症研究院 治疗红细胞疾患的方法
WO2022261183A2 (en) 2021-06-08 2022-12-15 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating and/or identifying an agent for treating intestinal cancers
WO2023097119A2 (en) 2021-11-29 2023-06-01 Dana-Farber Cancer Institute, Inc. Methods and compositions to modulate riok2
CN119156456A (zh) 2022-04-15 2024-12-17 新基公司 预测淋巴瘤对药物的反应性的方法以及治疗淋巴瘤的方法
CN116453588A (zh) * 2023-04-12 2023-07-18 深圳华大基因股份有限公司 基于全基因组测序的strc基因拷贝数变异检测方法
WO2025034542A1 (en) 2023-08-04 2025-02-13 Cornell University Gene signature panel predicting cancer response to immune checkpoint blockade and radiation therapy

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2422956A1 (fr) * 1978-04-13 1979-11-09 Pasteur Institut Procede de detection et de caracterisation d'un acide nucleique ou d'une sequence de celui-ci, et reactif enzymatique pour la mise en oeuvre de ce procede
US4358535A (en) * 1980-12-08 1982-11-09 Board Of Regents Of The University Of Washington Specific DNA probes in diagnostic microbiology
US4711955A (en) * 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
US4681840A (en) * 1984-01-18 1987-07-21 The United States Of America As Represented By The Secretary Of Commerce Deoxyribonucleic acid molecules useful as probes for detecting oncogenes incorporated into chromosomal DNA
US4707440A (en) * 1984-01-30 1987-11-17 Enzo Biochem, Inc. Nucleic acid hybridization assay and detectable molecules useful in such assay
US4710465A (en) * 1984-04-19 1987-12-01 Yale University Junction-fragment DNA probes and probe clusters
US4647529A (en) * 1984-06-01 1987-03-03 Rodland Karin D Hybridization method of detecting nucleic acid sequences with probe containing thionucleotide
US4666828A (en) 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US4721669A (en) * 1985-01-18 1988-01-26 The Trustees Of Columbia University In The City Of New York Chemical probes for left-handed DNA and chiral metal complexes as Z-specific anti-tumor agents
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4772691A (en) * 1985-06-05 1988-09-20 The Medical College Of Wisconsin, Inc. Chemically cleavable nucleotides
US4725536A (en) * 1985-09-19 1988-02-16 Genetics Institute, Inc. Reagent polynucleotide complex with multiple target binding regions, and kit and methods
US4888278A (en) * 1985-10-22 1989-12-19 University Of Massachusetts Medical Center In-situ hybridization to detect nucleic acid sequences in morphologically intact cells
US4770992A (en) * 1985-11-27 1988-09-13 Den Engh Gerrit J Van Detection of specific DNA sequences by flow cytometry
US5447841A (en) * 1986-01-16 1995-09-05 The Regents Of The Univ. Of California Methods for chromosome-specific staining
US5721098A (en) 1986-01-16 1998-02-24 The Regents Of The University Of California Comparative genomic hybridization
JPS63503272A (ja) * 1986-02-21 1988-12-02 ホワイトヘッド　インスチチュ−ト　フォア−　バイオメディカル　リサ−チ Ｙ特異的ｄｎａハイブリダイゼ−シヨンプロ−ブおよびその使用
US5348855A (en) 1986-03-05 1994-09-20 Miles Inc. Assay for nucleic acid sequences in an unpurified sample
CA1284931C (en) 1986-03-13 1991-06-18 Henry A. Erlich Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
US4981783A (en) 1986-04-16 1991-01-01 Montefiore Medical Center Method for detecting pathological conditions
US5085983A (en) * 1988-08-19 1992-02-04 City Of Hope Detection of human tumor progression and drug resistance
US5194300A (en) 1987-07-15 1993-03-16 Cheung Sau W Methods of making fluorescent microspheres
JP2589729B2 (ja) * 1988-01-30 1997-03-12 極東製薬工業株式会社 染色体ｄｎａを用いた細菌の同定方法および該同定用キット
US5064948A (en) * 1988-02-12 1991-11-12 The United States Of America As Represented By The Department Of Energy Chromosome specific repetitive dna sequences
CN1046392A (zh) * 1988-11-15 1990-10-24 耶鲁大学 通过原位抑制杂交对人个体中期和间期细胞染色体定位
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
GB8920211D0 (en) 1989-09-07 1989-10-18 Ici Plc Diagnostic method
AU647741B2 (en) * 1989-12-01 1994-03-31 Regents Of The University Of California, The Methods and compositions for chromosome-specific staining
US5427932A (en) * 1991-04-09 1995-06-27 Reagents Of The University Of California Repeat sequence chromosome specific nucleic acid probes and methods of preparing and using
ATE205542T1 (de) 1992-03-04 2001-09-15 Univ California Vergleichende genomhybridisierung
US5976790A (en) * 1992-03-04 1999-11-02 The Regents Of The University Of California Comparative Genomic Hybridization (CGH)
US5840484A (en) 1992-07-17 1998-11-24 Incyte Pharmaceuticals, Inc. Comparative gene transcript analysis
US5472842A (en) * 1993-10-06 1995-12-05 The Regents Of The University Of California Detection of amplified or deleted chromosomal regions
US5830645A (en) 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays

Also Published As

Publication number Publication date
US20060292608A1 (en) 2006-12-28
JP3645903B2 (ja) 2005-05-11
DE69330750D1 (de) 2001-10-18
US7238484B2 (en) 2007-07-03
US20050118634A1 (en) 2005-06-02
US5665549A (en) 1997-09-09
EP1134293A2 (de) 2001-09-19
EP1134293A3 (de) 2004-01-07
DE69330750T2 (de) 2002-07-04
CA2131543C (en) 2002-09-17
JPH07505053A (ja) 1995-06-08
WO1993018186A1 (en) 1993-09-16
US7537895B2 (en) 2009-05-26
CA2131543A1 (en) 1993-09-16
ES2161715T3 (es) 2001-12-16
EP0631635B1 (de) 2001-09-12
EP0631635A1 (de) 1995-01-04

Similar Documents

Publication Publication Date Title
ATE205542T1 (de) Vergleichende genomhybridisierung
Zietkiewicz et al. Genome fingerprinting by simple sequence repeat (SSR)-anchored polymerase chain reaction amplification
Grunau et al. Large-scale methylation analysis of human genomic DNA reveals tissue-specific differences between the methylation profiles of genes and pseudogenes
Raine et al. SPlinted Ligation Adapter Tagging (SPLAT), a novel library preparation method for whole genome bisulphite sequencing
DK0800587T3 (da) Komparativ hybridisering af nukleinsyrerækker
WO2000040755A3 (en) Method for accelerating identification of single nucleotide polymorphisms and alignment of clones in genomic sequencing
ATE201451T1 (de) Multiple genomische dna-verstärkung zum nachweis einer deletion
ATE288474T1 (de) Ataxia-telangiectasia gen und dessen genomische organisation
Guldberg et al. Single‐step DGGE‐based mutation scanning of the p53 gene: application to genetic diagnosis of colorectal cancer
CA2163740A1 (en) Direct detection of expanded nucleotide repeats in the human genome
DE69518697D1 (de) Nachweis von Treponema Pallidum und Haemophilus Ducreyi
CA2366374C (en) Method for the detection and/or analysis, by means of primer extension techniques, of single nucleotide polymorphisms in restriction fragments, in particular in amplified restriction fragments generated using aflp
WO1999004034A1 (en) Primers for obtaining highly informative dna markers
AU1204600A (en) Systems and methods for sequencing by hybridization
US5032502A (en) Purification of polymorphic components of complex genomes
Huang et al. Fidelity and predominant mutations produced by deep vent wild-type and exonuclease-deficient DNA polymerases during in vitro DNA amplification
Carvalho et al. Optimization of a multiplex minisequencing protocol for population studies and medical genetics
Hutter et al. Use of polymorphisms in the noncoding region of the human mitochondrial genome to identify potential contamination of human leukemia-lymphoma cell lines
El‐Maarri et al. Intron 22‐specific long PCR for the Xba I polymorphism in the factor VIII gene
WO1989002440A3 (en) Y-specific dna hybridization probes and uses therefor
CA2392673A1 (en) Comparative genomic hybridization (cgh)
Fischel-Ghodsian et al. Rapid detection of the hemoglobin C mutation by allele-specific polymerase chain reaction
Wagner et al. Mismatch binding protein-based mutation detection systems
US20080044916A1 (en) Computational selection of probes for localizing chromosome breakpoints
Holoubek et al. A small chromatin‐associated RNA homologous to repetitive DNA sequences

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties