ATE458831T1 - Verfahren zum nachweis von lungenneoplasmen in fäkalen proben - Google Patents

Verfahren zum nachweis von lungenneoplasmen in fäkalen proben

Info

Publication number
ATE458831T1
ATE458831T1 AT00992876T AT00992876T ATE458831T1 AT E458831 T1 ATE458831 T1 AT E458831T1 AT 00992876 T AT00992876 T AT 00992876T AT 00992876 T AT00992876 T AT 00992876T AT E458831 T1 ATE458831 T1 AT E458831T1
Authority
AT
Austria
Prior art keywords
fecal samples
detecting lung
lung neoplasms
materials
detecting
Prior art date
Application number
AT00992876T
Other languages
English (en)
Inventor
Anthony Shuber
David Ahlquist
Original Assignee
Exact Sciences Corp
Mayo Clinic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exact Sciences Corp, Mayo Clinic filed Critical Exact Sciences Corp
Application granted granted Critical
Publication of ATE458831T1 publication Critical patent/ATE458831T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4746Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used p53
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82Translation products from oncogenes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT00992876T 1999-12-07 2000-12-07 Verfahren zum nachweis von lungenneoplasmen in fäkalen proben ATE458831T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16945799P 1999-12-07 1999-12-07
US19607400P 2000-04-10 2000-04-10
PCT/US2000/042683 WO2001042781A2 (en) 1999-12-07 2000-12-07 Supracolonic aerodigestive neoplasm detection

Publications (1)

Publication Number Publication Date
ATE458831T1 true ATE458831T1 (de) 2010-03-15

Family

ID=26865070

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00992876T ATE458831T1 (de) 1999-12-07 2000-12-07 Verfahren zum nachweis von lungenneoplasmen in fäkalen proben

Country Status (8)

Country Link
US (2) US7368233B2 (de)
EP (1) EP1238113B1 (de)
JP (1) JP2003516138A (de)
AT (1) ATE458831T1 (de)
AU (1) AU4714201A (de)
CA (1) CA2394921A1 (de)
DE (1) DE60043896D1 (de)
WO (1) WO2001042781A2 (de)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6818404B2 (en) 1997-10-23 2004-11-16 Exact Sciences Corporation Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples
EP1169479B1 (de) * 1999-04-09 2006-06-28 EXACT Sciences Corporation Verfahren zur detektion von nukleinsäuren, welche auf krebs hinweisen
US6586177B1 (en) * 1999-09-08 2003-07-01 Exact Sciences Corporation Methods for disease detection
US6849403B1 (en) 1999-09-08 2005-02-01 Exact Sciences Corporation Apparatus and method for drug screening
CA2394921A1 (en) 1999-12-07 2001-06-14 Anthony P. Shuber Supracolonic aerodigestive neoplasm detection
US6919174B1 (en) 1999-12-07 2005-07-19 Exact Sciences Corporation Methods for disease detection
US6911308B2 (en) 2001-01-05 2005-06-28 Exact Sciences Corporation Methods for detecting, grading or monitoring an H. pylori infection
US8980568B2 (en) 2001-10-11 2015-03-17 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US8986944B2 (en) 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
US7776524B2 (en) * 2002-02-15 2010-08-17 Genzyme Corporation Methods for analysis of molecular events
US7041481B2 (en) 2003-03-14 2006-05-09 The Regents Of The University Of California Chemical amplification based on fluid partitioning
US20040259101A1 (en) * 2003-06-20 2004-12-23 Shuber Anthony P. Methods for disease screening
US20050014165A1 (en) * 2003-07-18 2005-01-20 California Pacific Medical Center Biomarker panel for colorectal cancer
WO2005113769A1 (en) * 2004-05-14 2005-12-01 Exact Sciences Corporation Method for stabilizing biological samples for nucleic acid analysis
US9109256B2 (en) 2004-10-27 2015-08-18 Esoterix Genetic Laboratories, Llc Method for monitoring disease progression or recurrence
WO2006094149A2 (en) * 2005-03-01 2006-09-08 Exact Sciences Corporation Methods and compositions for detecting adenoma
US9777314B2 (en) 2005-04-21 2017-10-03 Esoterix Genetic Laboratories, Llc Analysis of heterogeneous nucleic acid samples
EP2041299A4 (de) * 2006-07-14 2010-01-13 Aviva Biosciences Corp Verfahren und zusammensetzungen für den nachweis seltener zellen aus einer biologischen probe
EP2167683A4 (de) 2007-05-31 2010-10-20 California Pacific Med Center Verfahren zur vorhersage oder diagnose einer magen-darm-störung oder -krankheit
US8883440B2 (en) * 2007-07-26 2014-11-11 Nancy M. Lee Method to predict or diagnose a gastrointestinal disorder or disease
EP2816122A1 (de) 2008-02-15 2014-12-24 Mayo Foundation For Medical Education And Research Neoplasmanachweis von einer Stuhlprobe
US8663920B2 (en) 2011-07-29 2014-03-04 Bio-Rad Laboratories, Inc. Library characterization by digital assay
WO2011120020A1 (en) 2010-03-25 2011-09-29 Quantalife, Inc. Droplet transport system for detection
EP4512526A3 (de) 2008-09-23 2025-06-04 Bio-Rad Laboratories, Inc. Tropfenbasiertes assaysystem
US9399215B2 (en) 2012-04-13 2016-07-26 Bio-Rad Laboratories, Inc. Sample holder with a well having a wicking promoter
US8951939B2 (en) 2011-07-12 2015-02-10 Bio-Rad Laboratories, Inc. Digital assays with multiplexed detection of two or more targets in the same optical channel
US10512910B2 (en) 2008-09-23 2019-12-24 Bio-Rad Laboratories, Inc. Droplet-based analysis method
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US12162008B2 (en) 2008-09-23 2024-12-10 Bio-Rad Laboratories, Inc. Partition-based method of analysis
US8633015B2 (en) 2008-09-23 2014-01-21 Bio-Rad Laboratories, Inc. Flow-based thermocycling system with thermoelectric cooler
US12090480B2 (en) 2008-09-23 2024-09-17 Bio-Rad Laboratories, Inc. Partition-based method of analysis
US9417190B2 (en) 2008-09-23 2016-08-16 Bio-Rad Laboratories, Inc. Calibrations and controls for droplet-based assays
US11130128B2 (en) 2008-09-23 2021-09-28 Bio-Rad Laboratories, Inc. Detection method for a target nucleic acid
US9764322B2 (en) 2008-09-23 2017-09-19 Bio-Rad Laboratories, Inc. System for generating droplets with pressure monitoring
US9492797B2 (en) 2008-09-23 2016-11-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US9132394B2 (en) 2008-09-23 2015-09-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US8709762B2 (en) 2010-03-02 2014-04-29 Bio-Rad Laboratories, Inc. System for hot-start amplification via a multiple emulsion
CA2767056C (en) 2009-09-02 2018-12-04 Bio-Rad Laboratories, Inc. System for mixing fluids by coalescence of multiple emulsions
US8399198B2 (en) 2010-03-02 2013-03-19 Bio-Rad Laboratories, Inc. Assays with droplets transformed into capsules
JP2013524169A (ja) 2010-03-25 2013-06-17 クァンタライフ・インコーポレーテッド 液滴によるアッセイ用の検出システム
CA2767182C (en) 2010-03-25 2020-03-24 Bio-Rad Laboratories, Inc. Droplet generation for droplet-based assays
EP2553463B1 (de) * 2010-03-26 2017-05-03 Hongzhi Zou Verfahren und materialien zur erkennung von kolorektalneoplasmen
EP3574990B1 (de) 2010-11-01 2022-04-06 Bio-Rad Laboratories, Inc. System zur formung von emulsionen
US12097495B2 (en) 2011-02-18 2024-09-24 Bio-Rad Laboratories, Inc. Methods and compositions for detecting genetic material
CN103534360A (zh) 2011-03-18 2014-01-22 伯乐生命医学产品有限公司 借助对信号的组合使用进行的多重数字分析
EP3395957B1 (de) 2011-04-25 2020-08-12 Bio-Rad Laboratories, Inc. Verfahren und zusammensetzungen zur nukleinsäureanalyse
WO2013039477A1 (en) * 2011-09-12 2013-03-21 University Of South Alabama Non-invasive methods of detecting target molecules
US8751261B2 (en) 2011-11-15 2014-06-10 Robert Bosch Gmbh Method and system for selection of patients to receive a medical device
CN104781421B (zh) 2012-09-04 2020-06-05 夸登特健康公司 检测稀有突变和拷贝数变异的系统和方法
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US11913065B2 (en) 2012-09-04 2024-02-27 Guardent Health, Inc. Systems and methods to detect rare mutations and copy number variation
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
CA2902916C (en) 2013-03-14 2018-08-28 Mayo Foundation For Medical Education And Research Detecting neoplasm
US10253358B2 (en) 2013-11-04 2019-04-09 Exact Sciences Development Company, Llc Multiple-control calibrators for DNA quantitation
US10138524B2 (en) 2013-12-19 2018-11-27 Exact Sciences Development Company, Llc Synthetic nucleic acid control molecules
ES2660989T3 (es) 2013-12-28 2018-03-27 Guardant Health, Inc. Métodos y sistemas para detectar variantes genéticas
CN120700143A (zh) 2014-03-31 2025-09-26 梅奥医学教育和研究基金会 检测结直肠赘生物
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
US10030272B2 (en) 2015-02-27 2018-07-24 Mayo Foundation For Medical Education And Research Detecting gastrointestinal neoplasms
US10435755B2 (en) 2015-03-27 2019-10-08 Exact Sciences Development Company, Llc Detecting esophageal disorders
CN114574585A (zh) 2015-08-31 2022-06-03 梅约医药教育及研究基金会 检测胃肿瘤
SG11201805119QA (en) 2015-12-17 2018-07-30 Guardant Health Inc Methods to determine tumor gene copy number by analysis of cell-free dna
JP7481804B2 (ja) 2016-04-14 2024-05-13 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ 高度膵異形成の検出
US10370726B2 (en) 2016-04-14 2019-08-06 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasia
EP3978624B1 (de) 2016-07-19 2025-03-26 Exact Sciences Corporation Methylierte kontroll-dna
WO2018017710A1 (en) 2016-07-19 2018-01-25 Exact Sciences Development Company, Llc Nucleic acid control molecules from non-human organisms
US9850523B1 (en) 2016-09-30 2017-12-26 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
EP3461274B1 (de) 2016-09-30 2020-11-04 Guardant Health, Inc. Verfahren zur mehrauflösungsanalyse von zellfreien nukleinsäuren
JP7122970B2 (ja) * 2016-10-21 2022-08-22 クラレノリタケデンタル株式会社 自己接着性歯科用コンポジットレジン
JP7356349B2 (ja) 2017-02-28 2023-10-04 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ 前立腺癌検出
JP7277460B2 (ja) 2017-11-30 2023-05-19 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ 乳癌の検出
WO2020160414A1 (en) 2019-01-31 2020-08-06 Guardant Health, Inc. Compositions and methods for isolating cell-free dna

Family Cites Families (169)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US433734A (en) * 1890-08-05 Device for carrying and affixing stamps
US485730A (en) * 1892-11-08 Peocess of treating oxidized or corroded lead
US3413464A (en) 1965-04-29 1968-11-26 Ibm Method for measuring the nucleic acid in biological cells after enhancement in an acidic solution
US4101279A (en) 1977-04-06 1978-07-18 Muhammed Javed Aslam Device for the collection and processing of stool specimens
US4333734A (en) 1980-01-18 1982-06-08 Sloan-Kettering Institute For Cancer Research Diagnostic device for fecal occult blood and method of use
US4535058A (en) 1982-10-01 1985-08-13 Massachusetts Institute Of Technology Characterization of oncogenes and assays based thereon
US4309782A (en) 1980-09-11 1982-01-12 Esteban Paulin Device for collecting fecal specimens
US4358535A (en) 1980-12-08 1982-11-09 Board Of Regents Of The University Of Washington Specific DNA probes in diagnostic microbiology
US5482834A (en) 1982-05-17 1996-01-09 Hahnemann University Evaluation of nucleic acids in a biological sample hybridization in a solution of chaotrophic salt solubilized cells
US4445235A (en) 1982-09-13 1984-05-01 Pearl Slover Stool specimen collector
US4578358A (en) 1983-05-03 1986-03-25 Warner-Lambert Company Collection of specimens and detection of occult blood therein
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4871838A (en) 1985-07-23 1989-10-03 The Board Of Rijks Universiteit Leiden Probes and methods for detecting activated ras oncogenes
US4705050A (en) 1985-10-02 1987-11-10 Markham Charles W Moisture-activated floatation device
US5348855A (en) 1986-03-05 1994-09-20 Miles Inc. Assay for nucleic acid sequences in an unpurified sample
CA1284931C (en) 1986-03-13 1991-06-18 Henry A. Erlich Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
US4981783A (en) 1986-04-16 1991-01-01 Montefiore Medical Center Method for detecting pathological conditions
CA1341576C (en) 1986-08-11 2008-07-08 Thaddeus P. Dryja Diagnosis of retinoblastoma
US4735905A (en) 1986-08-15 1988-04-05 V-Tech, Inc. Specimen-gathering apparatus and method
US4935342A (en) 1986-12-01 1990-06-19 Syngene, Inc. Method of isolating and purifying nucleic acids from biological samples
AU625169B2 (en) 1987-03-23 1992-07-02 Imperial Chemical Industries Plc Molecular markers
US4857300A (en) 1987-07-27 1989-08-15 Cytocorp, Inc. Cytological and histological fixative formulation and methods for using same
US5688657A (en) 1988-03-31 1997-11-18 International Bio-Immune Systems, Inc. Monoclonal antibodies against human colon carcinoma-associated antigens and uses therefor
IL89964A0 (en) 1988-04-15 1989-12-15 Montefiore Med Center Method for determining malignant progression,cdna,polypeptides encoded thereby and pharmaceutical compositions containing the same
FR2630000A1 (fr) 1988-04-18 1989-10-20 Sultan Bernard Flacon destine a recueillir un echantillon biologique urinaire pour examen cytobacteriologique
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
IE66572B1 (en) 1989-02-13 1996-01-24 Geneco Pty Ltd Detection of a nucleic acid sequence or a change therein
US5087617A (en) 1989-02-15 1992-02-11 Board Of Regents, The University Of Texas System Methods and compositions for treatment of cancer using oligonucleotides
US5248671A (en) 1989-02-15 1993-09-28 Board Of Regents, The University Of Texas System Methods and compositions for treatment of cancer using oligonucleotides
US5380645A (en) 1989-03-16 1995-01-10 The Johns Hopkins University Generalized method for assessment of colorectal carcinoma
US5362623A (en) 1991-06-14 1994-11-08 The John Hopkins University Sequence specific DNA binding by p53
EP0390323B2 (de) 1989-03-29 2012-08-08 Johns Hopkins University Nachweis des Ausfalls des Wildtyps des p53-Gens
US5527676A (en) * 1989-03-29 1996-06-18 The Johns Hopkins University Detection of loss of the wild-type P53 gene and kits therefor
US5196167A (en) 1989-04-04 1993-03-23 Helena Laboratories Corporation Fecal occult blood test product with positive and negative controls
US5192501A (en) 1989-04-04 1993-03-09 Helena Laboratories Corporation Method of formulating a test ink for a fecal occult blood test product
US5589335A (en) 1989-04-05 1996-12-31 Amoco Corporation Hybridization promotion reagents
DK0407789T3 (da) 1989-06-23 1993-11-01 Canon Kk Fremgangsmåde til detektering af nukleinsyrer
US5302509A (en) 1989-08-14 1994-04-12 Beckman Instruments, Inc. Method for sequencing polynucleotides
CA2029219A1 (en) 1989-11-08 1991-05-09 Mary K. Estes Methods and reagents to detect and characterize norwalk and related viruses
US5641628A (en) 1989-11-13 1997-06-24 Children's Medical Center Corporation Non-invasive method for isolation and detection of fetal DNA
US5137806A (en) 1989-12-11 1992-08-11 Board Of Regents, The University Of Texas System Methods and compositions for the detection of sequences in selected DNA molecules
ES2115611T3 (es) 1990-01-04 1998-07-01 Univ Johns Hopkins Gen suprimido en el cancer colorrectal humano.
US5126239A (en) 1990-03-14 1992-06-30 E. I. Du Pont De Nemours And Company Process for detecting polymorphisms on the basis of nucleotide differences
US5200314A (en) 1990-03-23 1993-04-06 Chiron Corporation Polynucleotide capture assay employing in vitro amplification
DK0489149T3 (da) 1990-06-27 2001-12-27 Univ Princeton Prober til påvisning af mutant P53
JPH06510363A (ja) 1990-10-29 1994-11-17 ディカルブ プラント ジェネティクス 磁気性粒子を使用する生物学的材料の単離
US5846710A (en) 1990-11-02 1998-12-08 St. Louis University Method for the detection of genetic diseases and gene sequence variations by single nucleotide primer extension
AU1366992A (en) 1991-01-16 1992-08-27 Cancer Institute, The Inherited and somatic mutations of apc gene in colorectal cancer of humans
US5352775A (en) 1991-01-16 1994-10-04 The Johns Hopkins Univ. APC gene and nucleic acid probes derived therefrom
WO1992013971A1 (en) 1991-02-05 1992-08-20 Lifecodes Corporation Molecular genetic identification using probes that recognize polymorphic loci
EP0571539A4 (en) 1991-02-05 1994-06-29 Kamal Bahar Simple test for detecting carcinoembryonic antigen
WO1992016657A1 (en) 1991-03-13 1992-10-01 E.I. Du Pont De Nemours And Company Method of identifying a nucleotide present at a defined position in a nucleic acid
US5330892A (en) 1991-03-13 1994-07-19 The Johns Hopkins University MCC gene (mutated in colorectal cancer) used for diagnosis of cancer in humans
US5378602A (en) 1991-05-29 1995-01-03 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Highly informative microsatellite repeat polymorphic DNA markers twenty-[seven]six
US5468610A (en) 1991-05-29 1995-11-21 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Three highly informative microsatellite repeat polymorphic DNA markers
US5149506A (en) 1991-08-09 1992-09-22 Sage Products, Inc. Stool collection and transport device
US5506105A (en) 1991-12-10 1996-04-09 Dade International Inc. In situ assay of amplified intracellular mRNA targets
EP1134293A3 (de) 1992-03-04 2004-01-07 The Regents of The University of California Vergleichende Genomhybridisierung
AU3919293A (en) 1992-03-27 1993-11-08 University Of Maryland At Baltimore Detection of gene mutations with mismatch repair enzymes
JP3633932B2 (ja) 1992-04-01 2005-03-30 ザ ジョーンズ ホプキンズ ユニバーシティー スクール オブ メディシン 糞便試料から単離した哺乳類の核酸を検出する方法、およびその検出用試薬
US5489508A (en) 1992-05-13 1996-02-06 University Of Texas System Board Of Regents Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
JP3399948B2 (ja) 1992-06-26 2003-04-28 ザ トラスティーズ オブ プリンストン ユニバーシティ P90抗体またはプローブを用いた前癌細胞または癌細胞の検出方法
US5710028A (en) 1992-07-02 1998-01-20 Eyal; Nurit Method of quick screening and identification of specific DNA sequences by single nucleotide primer extension and kits therefor
ATE231881T1 (de) 1992-07-02 2003-02-15 Savyon Diagnostics Ltd Verfahren zur einfachen nukleotid-primer- verlängerung zum nachweis spezifischer allele und dafür geeigneter kit
US5409586A (en) 1992-08-26 1995-04-25 Hitachi, Ltd. Method for analyzing nucleic acid or protein and apparatus therefor
US6214542B1 (en) 1992-10-20 2001-04-10 The United States Of America As Represented By The Department Of Health And Human Services Quantification of indicators of fibrosis
IL103600A0 (en) 1992-10-30 1993-03-15 Yeda Res & Dev Method and kit for cancer diagnosis
US5436142A (en) 1992-11-12 1995-07-25 Cold Spring Harbor Laboratory Methods for producing probes capable of distingushing variant genomic sequences
US5331973A (en) 1993-03-15 1994-07-26 Fiedler Paul N Method for obtaining stool samples for gastrointestinal cancer testing
CA2092115C (en) 1993-03-22 1998-12-15 Janet L. Taylor Testing for infestation of rapeseed and other cruciferae by the fungus leptosphaeria maculans (blackleg infestation)
US5492808A (en) 1993-05-05 1996-02-20 The Johns Hopkins University Means for detecting familial colon cancer (FCC)
SE501439C2 (sv) 1993-06-22 1995-02-13 Pharmacia Lkb Biotech Sätt och anordning för analys av polynukleotidsekvenser
US5466576A (en) 1993-07-02 1995-11-14 Fred Hutchinson Cancer Research Center Modulation of PIF-1-type helicases
DE69431510T2 (de) 1993-07-08 2003-02-27 Johnson & Johnson Clinical Diagnostics, Inc. Verfahren zur Koamplifikation zweier unterschiedlicher Nukleinsäure-Sequenzen unter Verwendung der Polymerase-Kettenreaktion
WO1995002068A1 (en) 1993-07-09 1995-01-19 Wakunaga Seiyaku Kabushiki Kaisha Method of discriminating nucleic acid and testing set for discriminating nucleic acid
FR2709761B1 (fr) 1993-09-10 1995-11-24 Pasteur Institut Procédé de détection de molécules contenant des mésappariements nucléotidiques et de localisation de ces mésappariements, et application à la détection de substitutions ou de délétions de bases .
US5472842A (en) 1993-10-06 1995-12-05 The Regents Of The University Of California Detection of amplified or deleted chromosomal regions
WO1995009928A1 (en) 1993-10-06 1995-04-13 The Regents Of The University Of California Methods for detecting cancer-associated chromosome deletions using in situ hybridization
GB9322795D0 (en) 1993-11-05 1993-12-22 Wellcome Found Novel compounds
US5561041A (en) 1993-11-12 1996-10-01 The Johns Hopkins University School Of Medicine Nucleic acid mutation detection by analysis of sputum
US5416025A (en) 1993-11-29 1995-05-16 Krepinsky; Jiri J. Screening test for early detection of colorectal cancer
WO1995015400A1 (en) 1993-12-03 1995-06-08 The Johns Hopkins University Genotyping by simultaneous analysis of multiple microsatellite loci
US5681697A (en) 1993-12-08 1997-10-28 Chiron Corporation Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor
US5709998A (en) 1993-12-15 1998-01-20 The Johns Hopkins University Molecular diagnosis of familial adenomatous polyposis
CH686982A5 (fr) 1993-12-16 1996-08-15 Maurice Stroun Méthode pour le diagnostic de cancers.
US5538851A (en) 1993-12-22 1996-07-23 Institut Pasteur And Cneva Primers for the amplification of genes coding for the enterotoxin and the lecithinase of Clostridium perfringens and their application to the determination of the presence and numeration of these bacteriae
WO1995018818A1 (en) 1994-01-03 1995-07-13 Children's Hospital Of Philadelphia Polymorphism at codon 36 of the p53 gene
US6025127A (en) 1994-01-14 2000-02-15 The Johns Hopkins University School Of Medicine Nucleic acid mutation detection in histologic tissue
CA2162150C (en) 1994-03-18 2010-03-30 Mark H. Skolnick Germline mutations in the mts gene and method for detecting predisposition to cancer at the mts gene
SE9500023L (sv) 1994-05-17 1995-11-18 Beki Ab Sätt att detektera cancer
US5496470A (en) 1994-05-27 1996-03-05 Barnes International, Inc. Magnetic separator
US6037465A (en) 1994-06-14 2000-03-14 Invitek Gmbh Universal process for isolating and purifying nucleic acids from extremely small amounts of highly contaminated various starting materials
US5667987A (en) 1994-07-12 1997-09-16 Bristol-Myers Squibb Company P53 response genes
MXPA00009654A (es) 1994-08-31 2005-09-08 Univ Johns Hopkins Med Deteccion de secuencias de acidos nucleicos hipermutables en tejidos.
JPH10507366A (ja) 1994-10-21 1998-07-21 ゼネカ・リミテッド Pcrによるテロメアdnaの可変性の特性決定法
US5629178A (en) 1994-10-28 1997-05-13 Genetics & Ivf Institute Method for enhancing amplification in the polymerase chain reaction employing peptide nucleic acid (PNA)
US5512441A (en) 1994-11-15 1996-04-30 American Health Foundation Quantative method for early detection of mutant alleles and diagnostic kits for carrying out the method
US5463782A (en) 1994-11-21 1995-11-07 Eric V. Carlson Foldable stool sample collection device
US5599662A (en) 1995-02-17 1997-02-04 Hoffmann-La Roche Inc. Oliconucleotide primers and probes for the detection of HIV-1
AU5296496A (en) 1995-03-24 1996-10-16 Mitokor Mutation detection by differential primer extension of mutant and wildtype target sequences
DE19530132C2 (de) 1995-08-16 1998-07-16 Max Planck Gesellschaft Verfahren zur Reinigung, Stabilisierung oder Isolierung von Nukleinsäuren aus biologischen Materialien
GB9517914D0 (en) 1995-09-02 1995-11-01 Tepnel Medical Ltd Identification of bases in nucleic acid sequences
GB9518156D0 (en) 1995-09-06 1995-11-08 Medical Res Council Method of isolating cells
NO954667D0 (no) * 1995-11-17 1995-11-17 Dagfinn Oegreid Fremgangsmåte til deteksjon av Ki-ras mutasjoner
US5670325A (en) 1996-08-14 1997-09-23 Exact Laboratories, Inc. Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample
ES2220997T3 (es) 1995-12-22 2004-12-16 Exact Sciences Corporation Metodos para la deteccion de poblaciones clonales de celulas transformadas en una muestra celular genomicamente heterogenea.
EP0784096A1 (de) 1996-01-10 1997-07-16 Boehringer Mannheim Gmbh Verfahren zum Nachweis von Polymorphismus und Heterozygotieverlust in einem Lungentumor-Suppressor-Gen
US5612473A (en) 1996-01-16 1997-03-18 Gull Laboratories Methods, kits and solutions for preparing sample material for nucleic acid amplification
AU720489B2 (en) 1996-01-30 2000-06-01 Exact Sciences Corporation Methods for detecting colon cancer from stool samples
US5741650A (en) 1996-01-30 1998-04-21 Exact Laboratories, Inc. Methods for detecting colon cancer from stool samples
US5897999A (en) 1996-03-22 1999-04-27 The Johns Hopkins University Cancer drug screen based on cell cycle uncoupling
US5645995A (en) 1996-04-12 1997-07-08 Baylor College Of Medicine Methods for diagnosing an increased risk for breast or ovarian cancer
US5976800A (en) 1996-06-28 1999-11-02 The Regents Of The University Of California Enhancement of cancer cell death
US6146828A (en) 1996-08-14 2000-11-14 Exact Laboratories, Inc. Methods for detecting differences in RNA expression levels and uses therefor
US6143529A (en) 1996-08-14 2000-11-07 Exact Laboratories, Inc. Methods for improving sensitivity and specificity of screening assays
US6300077B1 (en) 1996-08-14 2001-10-09 Exact Sciences Corporation Methods for the detection of nucleic acids
US5952178A (en) 1996-08-14 1999-09-14 Exact Laboratories Methods for disease diagnosis from stool samples
US6020137A (en) 1996-08-14 2000-02-01 Exact Laboratories, Inc. Methods for the detection of loss of heterozygosity
US5928870A (en) 1997-06-16 1999-07-27 Exact Laboratories, Inc. Methods for the detection of loss of heterozygosity
US6100029A (en) 1996-08-14 2000-08-08 Exact Laboratories, Inc. Methods for the detection of chromosomal aberrations
US6203993B1 (en) 1996-08-14 2001-03-20 Exact Science Corp. Methods for the detection of nucleic acids
EP0920535B1 (de) 1996-08-26 2007-11-14 Invitek Gesellschaft für Biotechnik & Biodesign mbH. Verfahren zum nachweis klinisch relevanter veränderungen der dns-sequenz des ki-ras-onkogens, seine verwendung und testkit zur früherkennung von tumoren
US5856104A (en) 1996-10-28 1999-01-05 Affymetrix, Inc. Polymorphisms in the glucose-6 phosphate dehydrogenase locus
US6235474B1 (en) * 1996-12-30 2001-05-22 The Johns Hopkins University Methods and kits for diagnosing and determination of the predisposition for diseases
EP0975797A1 (de) 1997-02-28 2000-02-02 Exact Laboratories, Inc. Verfahren zur analyse von nukleinsäuren
US5830665A (en) 1997-03-03 1998-11-03 Exact Laboratories, Inc. Contiguous genomic sequence scanning
DE19712332A1 (de) 1997-03-25 1998-10-01 Boehringer Mannheim Gmbh Verfahren zum Nachweis von Mikrosatelliten-Instabilität zur Tumordiagnostik
US5888778A (en) 1997-06-16 1999-03-30 Exact Laboratories, Inc. High-throughput screening method for identification of genetic mutations or disease-causing microorganisms using segmented primers
AU7816898A (en) 1997-06-16 1999-01-04 Exact Laboratories, Inc. Methods for stool sample preparation
US6566101B1 (en) 1997-06-16 2003-05-20 Anthony P. Shuber Primer extension methods for detecting nucleic acids
US6268136B1 (en) 1997-06-16 2001-07-31 Exact Science Corporation Methods for stool sample preparation
US6406857B1 (en) 1997-06-16 2002-06-18 Exact Sciences Corporation Methods for stool sample preparation
GB9715034D0 (en) * 1997-07-18 1997-09-24 Zeneca Ltd Assay
US6013442A (en) 1997-08-05 2000-01-11 Wisconsin Alumni Res Found Direct quantitation of low copy number RNA
AU8694598A (en) 1997-08-06 1999-03-01 Ludwig Institute For Cancer Research Methods for quantifying nucleic acid molecules
US5942396A (en) 1997-08-19 1999-08-24 The Rockefeller University Method for identifying individuals at risk for colorectal neoplasia by quantifying normal colonic mucosal epithelial cell apoptosis
DE19736691A1 (de) 1997-08-22 1999-02-25 Michael Prof Dr Med Giesing Verfahren zur Charakterisierung und Identifizierung disseminierter und metastasierter Krebszellen
US6818404B2 (en) 1997-10-23 2004-11-16 Exact Sciences Corporation Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples
JP2001520054A (ja) 1997-10-23 2001-10-30 エグザクト サイエンシーズ コーポレイション Pcrを用いる分子診断におけるコンタミネーションを検出するための方法
US6251660B1 (en) 1997-11-25 2001-06-26 Mosaic Technologies, Inc. Devices and methods for detecting target molecules in biological samples
EP1068518A2 (de) 1998-03-03 2001-01-17 Exact Sciences Corporation Reinigungs- und nachweisverfahren mittels reversibler affinitätselektrophorese
WO1999066077A2 (en) 1998-06-16 1999-12-23 Exact Laboratories, Inc. Methods for the detection of nucleic acids
WO1999066078A1 (en) 1998-06-18 1999-12-23 Mosaic Technologies Denaturing gradient affinity electrophoresis and methods of use thereof
CA2330732A1 (en) 1998-06-19 1999-12-23 Mosaic Technologies Detection of non-viral organisms with srp rna
WO2000011215A2 (en) 1998-08-14 2000-03-02 Exact Laboratories, Inc. Method for diagnostic screening
US20020001800A1 (en) 1998-08-14 2002-01-03 Stanley N. Lapidus Diagnostic methods using serial testing of polymorphic loci
WO2000020643A1 (en) 1998-10-05 2000-04-13 Mosaic Technologies Reverse displacement assay for detection of nucleic acid sequences
WO2000032820A1 (en) 1998-11-23 2000-06-08 Exact Laboratories, Inc. Method for detecting target sequences in small proportions in heterogeneous samples
CA2352456A1 (en) 1998-11-23 2000-06-02 Exact Sciences Corporation Primer extension methods utilizing donor and acceptor molecules for detecting nucleic acids
WO2000031298A1 (en) 1998-11-23 2000-06-02 Exact Laboratories, Inc. Methods for detecting lower-frequency molecules
US6503718B2 (en) 1999-01-10 2003-01-07 Exact Sciences Corporation Methods for detecting mutations using primer extension for detecting disease
US6280947B1 (en) 1999-08-11 2001-08-28 Exact Sciences Corporation Methods for detecting nucleotide insertion or deletion using primer extension
CA2372667A1 (en) 1999-01-10 2000-11-23 Steven Laken Methods of detecting colorectal disease by conduction an assay to detect a mutation in a bat-26 locus
AU752817B2 (en) 1999-02-25 2002-10-03 Exact Sciences Corporation Methods for preserving DNA integrity
ATE265040T1 (de) 1999-02-26 2004-05-15 Exact Sciences Corp Biochemische reinigungsgeräte mit immobilisierten fangsonden und ihre anwendungen
EP1235930A2 (de) 1999-04-02 2002-09-04 Mosaic Technologies Electrophoretische anlyse von zielmolekülen unter benutzung von adapter molekülen
EP1169479B1 (de) 1999-04-09 2006-06-28 EXACT Sciences Corporation Verfahren zur detektion von nukleinsäuren, welche auf krebs hinweisen
US20020004206A1 (en) 1999-04-09 2002-01-10 Berger Barry M. Methods of screening for disease
AU4669600A (en) 1999-05-03 2000-11-17 Exact Laboratories, Inc. Stool specimen collector
US6586177B1 (en) 1999-09-08 2003-07-01 Exact Sciences Corporation Methods for disease detection
CA2394921A1 (en) 1999-12-07 2001-06-14 Anthony P. Shuber Supracolonic aerodigestive neoplasm detection
WO2001042503A2 (en) 1999-12-07 2001-06-14 Exact Sciences Corporation Apparatus and methods for drug screening based on nucleic acid analysis
US6919174B1 (en) 1999-12-07 2005-07-19 Exact Sciences Corporation Methods for disease detection
WO2001064950A2 (en) 2000-02-28 2001-09-07 Exact Sciences Corporation Device and method for preparing a sample for analysis
US6911308B2 (en) 2001-01-05 2005-06-28 Exact Sciences Corporation Methods for detecting, grading or monitoring an H. pylori infection
JP2004521630A (ja) 2001-03-15 2004-07-22 エグザクト サイエンシーズ コーポレイション 変更検出のための方法
US6428964B1 (en) 2001-03-15 2002-08-06 Exact Sciences Corporation Method for alteration detection
US20030049659A1 (en) 2001-05-29 2003-03-13 Lapidus Stanley N. Devices and methods for isolating samples into subsamples for analysis

Also Published As

Publication number Publication date
US20040043467A1 (en) 2004-03-04
US7981612B2 (en) 2011-07-19
WO2001042781A2 (en) 2001-06-14
WO2001042781A3 (en) 2002-05-10
WO2001042781A9 (en) 2001-10-11
EP1238113A2 (de) 2002-09-11
EP1238113B1 (de) 2010-02-24
DE60043896D1 (de) 2010-04-08
JP2003516138A (ja) 2003-05-13
US7368233B2 (en) 2008-05-06
CA2394921A1 (en) 2001-06-14
US20080254547A1 (en) 2008-10-16
AU4714201A (en) 2001-06-18

Similar Documents

Publication Publication Date Title
ATE458831T1 (de) Verfahren zum nachweis von lungenneoplasmen in fäkalen proben
DE10084908T1 (de) Verfahren zum Chrakterisieren, Klassifizieren und Identifizieren von Unbekannten in Proben
DE60226271D1 (de) Verfahren zum nachweis von prostatakrebs
ATE232559T1 (de) Verfahren zur signalverstärkung
DK1137943T3 (da) Fremgangsmåde til påvisning af cancer og reagenser
DE69937835D1 (de) Antikörper für apoptosemarker und anwendungsverfahren
DK1734368T3 (da) Annexin-autoantistoffer anvendt som markörer for lungecancer
ATE540319T1 (de) Verfahren für die bestimmung von fk506
ATE516742T1 (de) Verfahren zur bestimmung der optischen eigenschaften eines mehrschichtigen gewebes
DE50113548D1 (de) Verfahren zum Nachweis von Influenza A/B-Viren in Speichel
DE60031939D1 (de) Als Quelle und Responder betreibbare ATM-Prüfvorrichtung zur Ausführung von mehreren Tests
DE60129151D1 (de) Verfahren zur erkennung von eierstockkrebs mittels menschlichem kallikrein (hk6)
DE602004019812D1 (de) Marker für neuromyelitis optica
ATE428808T1 (de) Verfahren und reagenzien zur erkennung von melanomen
DE60015726D1 (de) Verfahren und vorrichtung zum vorhersagen von haemostatischer funktionsstörung in patientenproben
DE60033551D1 (de) Sonde zum analysieren von protein-protein-wechselwirkungen und entsprechendes verfahren dafür
CY1105025T1 (el) Αναλυση λεπτινης βασιζομενη στην ανιχνευση εκφρασης ang-2
DE60027525D1 (de) Vorrichtungen und Verfahren zur Erfassung von asynchronen Breitbandigen CDMA-Signalen
DE60234465D1 (de) Zum nachweisen von erkrankungen der brust geeignete reagenzien und verfahren
DE69728665D1 (de) Verfahren und sets zur detektion von endotoxinen
ATE408832T1 (de) Verfahren zum nachweis von blutzell-antigenen und gegen diese gerichtete antikörper
DE60137189D1 (de) SONDE ZUM SICHTBARMACHEN VON cGMP UND VERFAHREN ZUM NACHWEIS UND ZUM QUANTIFIZIEREN VON cGMP
CY1106705T1 (el) Δοκιμασια για μετρηση ολο-τρανσκοβαλαμινης και φολικου
WO2002055555A3 (en) Antigenic ck-18 compounds for therapy and diagnosis and methods for using same
DE60327776D1 (de) Sonden zum nachweis von tumorzellen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties