ATE205847T1 - 5h,10h-imidazo(1,2-a)indeno(1,2-e)pyrazin-4-one derivate antagonisten der rezeptoren ampa und nmda, ihre herstellung und zwischenprodukte und sie enthaltende arzneimittel - Google Patents

5h,10h-imidazo(1,2-a)indeno(1,2-e)pyrazin-4-one derivate antagonisten der rezeptoren ampa und nmda, ihre herstellung und zwischenprodukte und sie enthaltende arzneimittel

Info

Publication number
ATE205847T1
ATE205847T1 AT97900236T AT97900236T ATE205847T1 AT E205847 T1 ATE205847 T1 AT E205847T1 AT 97900236 T AT97900236 T AT 97900236T AT 97900236 T AT97900236 T AT 97900236T AT E205847 T1 ATE205847 T1 AT E205847T1
Authority
AT
Austria
Prior art keywords
indeno
nmda
imidazo
pyrazine
production
Prior art date
Application number
AT97900236T
Other languages
English (en)
Inventor
Jean-Claude Aloup
Jean Bouquerel
Dominique Damour
Jean-Claude Hardy
Patrick Jimonet
Franco Manfre
Serge Mignani
Patrick Nemecek
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Application granted granted Critical
Publication of ATE205847T1 publication Critical patent/ATE205847T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT97900236T 1996-01-10 1997-01-06 5h,10h-imidazo(1,2-a)indeno(1,2-e)pyrazin-4-one derivate antagonisten der rezeptoren ampa und nmda, ihre herstellung und zwischenprodukte und sie enthaltende arzneimittel ATE205847T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9600192A FR2743366B1 (fr) 1996-01-10 1996-01-10 Derives de 5h,10h-imidazo(1,2-a)indeno(1,2-e)pyrazine-4-one, leur preparation, leurs intermediaires et les medicaments les contenant
PCT/FR1997/000019 WO1997025328A1 (fr) 1996-01-10 1997-01-06 DERIVES DE 5H,10H-IMIDAZO(1,2-a)INDENO(1,2-e)PYRAZINE-4-ONE, LEUR PREPARATION, LEURS INTERMEDIAIRES ET LES MEDICAMENTS LES CONTENANT______________________________________________________________

Publications (1)

Publication Number Publication Date
ATE205847T1 true ATE205847T1 (de) 2001-10-15

Family

ID=9487995

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97900236T ATE205847T1 (de) 1996-01-10 1997-01-06 5h,10h-imidazo(1,2-a)indeno(1,2-e)pyrazin-4-one derivate antagonisten der rezeptoren ampa und nmda, ihre herstellung und zwischenprodukte und sie enthaltende arzneimittel

Country Status (20)

Country Link
US (2) US5990108A (de)
EP (1) EP0880522B1 (de)
JP (1) JP2000505073A (de)
KR (1) KR19990077135A (de)
AR (1) AR005424A1 (de)
AT (1) ATE205847T1 (de)
AU (1) AU1383097A (de)
BG (1) BG102618A (de)
CA (1) CA2239254A1 (de)
CZ (1) CZ216698A3 (de)
DE (1) DE69706830T2 (de)
DK (1) DK0880522T3 (de)
ES (1) ES2164323T3 (de)
FR (1) FR2743366B1 (de)
MX (1) MX9805167A (de)
PL (1) PL327942A1 (de)
PT (1) PT880522E (de)
SK (1) SK93498A3 (de)
WO (1) WO1997025328A1 (de)
ZA (1) ZA9786B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6242493B1 (en) 1998-03-13 2001-06-05 Merck Frosst Canada & Co. Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment
EP1071648A2 (de) * 1998-03-13 2001-01-31 Merck Frosst Canada & Co. CARBONSÄUREN UND ACYLSULFONAMIDE, SOLCHE VERBINDUNGEN ENTHALTENDE Gemenge UND BEHANDLUNGSVERFAHREN
DE60226756D1 (de) * 2001-10-04 2008-07-03 Merck & Co Inc Heteroarylsubstituierte tetrazolmodulatoren des metabotropischen glutamatrezeptors-5
JPWO2003070722A1 (ja) * 2002-02-21 2005-06-09 アルフレッサファーマ株式会社 イミダゾール誘導体の改良製法およびその新規中間体
GB0415320D0 (en) * 2004-07-08 2004-08-11 Astrazeneca Ab Novel compounds
US7649098B2 (en) * 2006-02-24 2010-01-19 Lexicon Pharmaceuticals, Inc. Imidazole-based compounds, compositions comprising them and methods of their use
TW200920355A (en) * 2007-09-06 2009-05-16 Lexicon Pharmaceuticals Inc Compositions and methods for treating immunological and inflammatory diseases and disorders
US9737531B2 (en) 2012-07-12 2017-08-22 Glytech, Llc Composition and method for treatment of depression and psychosis in humans
CN110996948A (zh) 2017-06-12 2020-04-10 格莱泰施有限责任公司 用nmda拮抗剂和d2/5ht2a或选择性5ht2a拮抗剂治疗抑郁症

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2717812B1 (fr) * 1994-03-28 1996-05-10 Rhone Poulenc Rorer Sa Indeno[1,2-e]pyrazine-4-ones, leur préparation et les médicaments les contenant.
FR2732681B1 (fr) * 1995-04-05 1997-07-04 Rhone Poulenc Rorer Sa Derives de 10h-imidazo(1,2-a)indeno(1,2-e)pyrazin-4-one, leur preparation et les medicaments les contenant

Also Published As

Publication number Publication date
CZ216698A3 (cs) 1998-10-14
EP0880522B1 (de) 2001-09-19
SK93498A3 (en) 1998-12-02
PL327942A1 (en) 1999-01-04
FR2743366B1 (fr) 1998-02-06
WO1997025328A1 (fr) 1997-07-17
AR005424A1 (es) 1999-06-23
FR2743366A1 (fr) 1997-07-11
DK0880522T3 (da) 2002-01-21
PT880522E (pt) 2002-05-31
US6100264A (en) 2000-08-08
MX9805167A (es) 1998-10-31
BG102618A (en) 1999-09-30
AU1383097A (en) 1997-08-01
CA2239254A1 (fr) 1997-07-17
JP2000505073A (ja) 2000-04-25
DE69706830T2 (de) 2002-04-25
DE69706830D1 (de) 2001-10-25
ES2164323T3 (es) 2002-02-16
US5990108A (en) 1999-11-23
KR19990077135A (ko) 1999-10-25
EP0880522A1 (de) 1998-12-02
ZA9786B (en) 1997-07-17

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee