DK0880522T3 - 5H,10H-Imidazo[1,2-a]indeno[1,2-e]pyrazin-4-on-derivater AMPA- og NMDA-receptorantagonister, deres fremstilling, deres mellemprodukter og lægemidler med indhold deraf - Google Patents

5H,10H-Imidazo[1,2-a]indeno[1,2-e]pyrazin-4-on-derivater AMPA- og NMDA-receptorantagonister, deres fremstilling, deres mellemprodukter og lægemidler med indhold deraf

Info

Publication number
DK0880522T3
DK0880522T3 DK97900236T DK97900236T DK0880522T3 DK 0880522 T3 DK0880522 T3 DK 0880522T3 DK 97900236 T DK97900236 T DK 97900236T DK 97900236 T DK97900236 T DK 97900236T DK 0880522 T3 DK0880522 T3 DK 0880522T3
Authority
DK
Denmark
Prior art keywords
indeno
ampa
pyrazin
imidazo
intermediates
Prior art date
Application number
DK97900236T
Other languages
English (en)
Inventor
Jean-Claude Aloup
Jean Bouquerel
Dominique Damour
Jean-Claude Hardy
Patrick Jimonet
Franco Manfre
Serge Mignani
Patrick Nemecek
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Application granted granted Critical
Publication of DK0880522T3 publication Critical patent/DK0880522T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK97900236T 1996-01-10 1997-01-06 5H,10H-Imidazo[1,2-a]indeno[1,2-e]pyrazin-4-on-derivater AMPA- og NMDA-receptorantagonister, deres fremstilling, deres mellemprodukter og lægemidler med indhold deraf DK0880522T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9600192A FR2743366B1 (fr) 1996-01-10 1996-01-10 Derives de 5h,10h-imidazo(1,2-a)indeno(1,2-e)pyrazine-4-one, leur preparation, leurs intermediaires et les medicaments les contenant
PCT/FR1997/000019 WO1997025328A1 (fr) 1996-01-10 1997-01-06 DERIVES DE 5H,10H-IMIDAZO(1,2-a)INDENO(1,2-e)PYRAZINE-4-ONE, LEUR PREPARATION, LEURS INTERMEDIAIRES ET LES MEDICAMENTS LES CONTENANT______________________________________________________________

Publications (1)

Publication Number Publication Date
DK0880522T3 true DK0880522T3 (da) 2002-01-21

Family

ID=9487995

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97900236T DK0880522T3 (da) 1996-01-10 1997-01-06 5H,10H-Imidazo[1,2-a]indeno[1,2-e]pyrazin-4-on-derivater AMPA- og NMDA-receptorantagonister, deres fremstilling, deres mellemprodukter og lægemidler med indhold deraf

Country Status (20)

Country Link
US (2) US5990108A (da)
EP (1) EP0880522B1 (da)
JP (1) JP2000505073A (da)
KR (1) KR19990077135A (da)
AR (1) AR005424A1 (da)
AT (1) ATE205847T1 (da)
AU (1) AU1383097A (da)
BG (1) BG102618A (da)
CA (1) CA2239254A1 (da)
CZ (1) CZ216698A3 (da)
DE (1) DE69706830T2 (da)
DK (1) DK0880522T3 (da)
ES (1) ES2164323T3 (da)
FR (1) FR2743366B1 (da)
MX (1) MX9805167A (da)
PL (1) PL327942A1 (da)
PT (1) PT880522E (da)
SK (1) SK93498A3 (da)
WO (1) WO1997025328A1 (da)
ZA (1) ZA9786B (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1071648A2 (en) * 1998-03-13 2001-01-31 Merck Frosst Canada & Co. Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment
US6242493B1 (en) 1998-03-13 2001-06-05 Merck Frosst Canada & Co. Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment
DE60226756D1 (de) * 2001-10-04 2008-07-03 Merck & Co Inc Heteroarylsubstituierte tetrazolmodulatoren des metabotropischen glutamatrezeptors-5
JPWO2003070722A1 (ja) * 2002-02-21 2005-06-09 アルフレッサファーマ株式会社 イミダゾール誘導体の改良製法およびその新規中間体
GB0415320D0 (en) * 2004-07-08 2004-08-11 Astrazeneca Ab Novel compounds
US7649098B2 (en) * 2006-02-24 2010-01-19 Lexicon Pharmaceuticals, Inc. Imidazole-based compounds, compositions comprising them and methods of their use
TW200920355A (en) * 2007-09-06 2009-05-16 Lexicon Pharmaceuticals Inc Compositions and methods for treating immunological and inflammatory diseases and disorders
US9737531B2 (en) 2012-07-12 2017-08-22 Glytech, Llc Composition and method for treatment of depression and psychosis in humans
AU2018284335A1 (en) 2017-06-12 2020-01-30 Glytech Llc. Treatment of depression with NMDA antagonists and D2/5HT2A or selective 5HT2A antagonists

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2717812B1 (fr) * 1994-03-28 1996-05-10 Rhone Poulenc Rorer Sa Indeno[1,2-e]pyrazine-4-ones, leur préparation et les médicaments les contenant.
FR2732681B1 (fr) * 1995-04-05 1997-07-04 Rhone Poulenc Rorer Sa Derives de 10h-imidazo(1,2-a)indeno(1,2-e)pyrazin-4-one, leur preparation et les medicaments les contenant

Also Published As

Publication number Publication date
EP0880522B1 (fr) 2001-09-19
PT880522E (pt) 2002-05-31
ES2164323T3 (es) 2002-02-16
FR2743366A1 (fr) 1997-07-11
PL327942A1 (en) 1999-01-04
CZ216698A3 (cs) 1998-10-14
SK93498A3 (en) 1998-12-02
BG102618A (en) 1999-09-30
DE69706830T2 (de) 2002-04-25
AU1383097A (en) 1997-08-01
EP0880522A1 (fr) 1998-12-02
CA2239254A1 (fr) 1997-07-17
ZA9786B (en) 1997-07-17
AR005424A1 (es) 1999-06-23
US5990108A (en) 1999-11-23
DE69706830D1 (de) 2001-10-25
FR2743366B1 (fr) 1998-02-06
KR19990077135A (ko) 1999-10-25
JP2000505073A (ja) 2000-04-25
ATE205847T1 (de) 2001-10-15
MX9805167A (es) 1998-10-31
US6100264A (en) 2000-08-08
WO1997025328A1 (fr) 1997-07-17

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