ATE206117T1 - Verfahren zur herstellung von pyrimidin-derivaten - Google Patents
Verfahren zur herstellung von pyrimidin-derivatenInfo
- Publication number
- ATE206117T1 ATE206117T1 AT97920966T AT97920966T ATE206117T1 AT E206117 T1 ATE206117 T1 AT E206117T1 AT 97920966 T AT97920966 T AT 97920966T AT 97920966 T AT97920966 T AT 97920966T AT E206117 T1 ATE206117 T1 AT E206117T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- formula
- represented
- sec
- pyrimidine derivatives
- Prior art date
Links
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
- QPILYVQSKNWRDD-UHFFFAOYSA-N 1-methyl-1,2,3,4-tetrahydroisoquinoline Chemical compound C1=CC=C2C(C)NCCC2=C1 QPILYVQSKNWRDD-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000003230 pyrimidines Chemical class 0.000 abstract 1
- LECZXZOBEZITCL-UHFFFAOYSA-N revaprazan Chemical compound C1CC2=CC=CC=C2C(C)N1C(C(=C(C)N=1)C)=NC=1NC1=CC=C(F)C=C1 LECZXZOBEZITCL-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019960014538A KR0177294B1 (ko) | 1996-05-04 | 1996-05-04 | 피리미딘 유도체의 제조방법 |
| KR1019960014539A KR0177293B1 (ko) | 1996-05-04 | 1996-05-04 | 신규의 피리미딘 유도체 및 그의 제조방법 |
| KR1019960049381A KR100193080B1 (ko) | 1996-10-29 | 1996-10-29 | (r)-피리미딘 유도체의 제조방법 |
| KR1019960049380A KR0185292B1 (ko) | 1996-10-29 | 1996-10-29 | (s)-피리미딘 유도체의 제조방법 |
| KR1019960049382A KR100209587B1 (ko) | 1996-10-29 | 1996-10-29 | 피리미딘 유도체의 제조방법 |
| PCT/KR1997/000073 WO1997042186A1 (en) | 1996-05-04 | 1997-04-30 | Process for preparation of pyrimidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE206117T1 true ATE206117T1 (de) | 2001-10-15 |
Family
ID=27532197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97920966T ATE206117T1 (de) | 1996-05-04 | 1997-04-30 | Verfahren zur herstellung von pyrimidin-derivaten |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5990311A (de) |
| EP (1) | EP0900214B1 (de) |
| JP (2) | JP3160297B2 (de) |
| CN (2) | CN1190427C (de) |
| AT (1) | ATE206117T1 (de) |
| AU (1) | AU712970B2 (de) |
| CA (2) | CA2358479C (de) |
| DE (1) | DE69706981T2 (de) |
| DK (1) | DK0900214T3 (de) |
| ES (1) | ES2165052T3 (de) |
| PT (1) | PT900214E (de) |
| RU (1) | RU2174978C2 (de) |
| WO (1) | WO1997042186A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN188411B (de) | 1997-03-27 | 2002-09-21 | Yuhan Corp | |
| KR100272471B1 (ko) * | 1998-11-17 | 2000-11-15 | 김선진 | 신규의 피리미딘 유도체 및 그의 제조방법 |
| US6852739B1 (en) * | 1999-02-26 | 2005-02-08 | Nitromed Inc. | Methods using proton pump inhibitors and nitric oxide donors |
| GB0110338D0 (en) * | 2001-04-27 | 2001-06-20 | Sb Pharmco Inc | Novel processes |
| JP4634144B2 (ja) * | 2002-08-01 | 2011-02-16 | ニコックス エスエー | ニトロソ化プロトンポンプ阻害剤、組成物および使用方法 |
| US7776873B2 (en) | 2005-12-01 | 2010-08-17 | Yuhan Corporation | Method for treating damage to gastric mucosa |
| EP1965774A2 (de) * | 2005-12-30 | 2008-09-10 | Cogentus Pharmaceuticals, Inc. | Orale pharmazeutische formulierungen mit nichtsteroidalen entzündungshemmern und säurehemmern |
| CN101460154B (zh) | 2006-04-04 | 2015-07-01 | Kg艾克维泽生公司 | 包含抗血小板剂和抑酸剂的口服剂型 |
| CN102863423B (zh) * | 2011-07-04 | 2014-09-17 | 天津药物研究院 | 一种制备异喹啉基取代的嘧啶衍生物的方法 |
| CN105601611A (zh) * | 2014-11-19 | 2016-05-25 | 江苏天士力帝益药业有限公司 | 一种盐酸洛氟普啶多晶型物及其制备方法 |
| CN105669642B (zh) * | 2014-11-19 | 2020-06-09 | 江苏天士力帝益药业有限公司 | 一种盐酸洛氟普啶的制备方法 |
| CN105399727A (zh) * | 2015-12-02 | 2016-03-16 | 芷威（上海）化学科技有限公司 | 盐酸瑞伐拉赞新结晶形态 |
| CN106995432A (zh) * | 2016-01-25 | 2017-08-01 | 广东华南药业集团有限公司 | 一种瑞普拉生无水合物晶型及其制备方法和用途 |
| CN106995431A (zh) * | 2016-01-25 | 2017-08-01 | 广东华南药业集团有限公司 | 一种瑞普拉生水合物晶型及其制备方法和用途 |
| CN107759562B (zh) * | 2016-08-21 | 2020-10-23 | 常州四药制药有限公司 | 一种盐酸洛氟普啶的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4755218A (en) * | 1985-12-31 | 1988-07-05 | Monsanto Company | Haloacyl 1-substituted-1,2,3,4-tetrahydro-isoquinolines as herbicide antidotes |
| DE3881320D1 (de) * | 1987-09-28 | 1993-07-01 | Ciba Geigy Ag | Schaedlingsbekaempfungsmittel. |
| US4966622A (en) * | 1988-04-12 | 1990-10-30 | Ciba-Geigy Corporation | N-phenyl-N-pyrimidin-2-ylureas |
| GB9012592D0 (en) * | 1990-06-06 | 1990-07-25 | Smithkline Beecham Intercredit | Compounds |
| US5276186A (en) * | 1992-03-11 | 1994-01-04 | Ciba-Geigy Corporation | Process for the production of guanidine derivatives |
| KR0144833B1 (ko) * | 1992-12-28 | 1998-07-15 | 김태훈 | 신규의 퀴나졸린 유도체 및 그의 제조방법 |
| CN1102144C (zh) * | 1994-08-13 | 2003-02-26 | 株式会社柳韩洋行 | 新的嘧啶衍生物及其制备方法 |
-
1997
- 1997-04-30 WO PCT/KR1997/000073 patent/WO1997042186A1/en not_active Ceased
- 1997-04-30 AT AT97920966T patent/ATE206117T1/de active
- 1997-04-30 CA CA002358479A patent/CA2358479C/en not_active Expired - Fee Related
- 1997-04-30 RU RU98121687/04A patent/RU2174978C2/ru not_active IP Right Cessation
- 1997-04-30 DK DK97920966T patent/DK0900214T3/da active
- 1997-04-30 EP EP97920966A patent/EP0900214B1/de not_active Expired - Lifetime
- 1997-04-30 CN CNB021247854A patent/CN1190427C/zh not_active Expired - Lifetime
- 1997-04-30 AU AU27133/97A patent/AU712970B2/en not_active Ceased
- 1997-04-30 JP JP53975697A patent/JP3160297B2/ja not_active Expired - Fee Related
- 1997-04-30 ES ES97920966T patent/ES2165052T3/es not_active Expired - Lifetime
- 1997-04-30 CA CA002253906A patent/CA2253906C/en not_active Expired - Fee Related
- 1997-04-30 CN CN97194367A patent/CN1097591C/zh not_active Expired - Lifetime
- 1997-04-30 PT PT97920966T patent/PT900214E/pt unknown
- 1997-04-30 US US09/171,579 patent/US5990311A/en not_active Expired - Lifetime
- 1997-04-30 DE DE69706981T patent/DE69706981T2/de not_active Expired - Lifetime
-
2000
- 2000-06-30 JP JP2000198538A patent/JP2001055379A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN1217722A (zh) | 1999-05-26 |
| DK0900214T3 (da) | 2002-01-28 |
| US5990311A (en) | 1999-11-23 |
| DE69706981T2 (de) | 2002-06-06 |
| RU2174978C2 (ru) | 2001-10-20 |
| CN1425655A (zh) | 2003-06-25 |
| EP0900214B1 (de) | 2001-09-26 |
| WO1997042186A1 (en) | 1997-11-13 |
| CN1097591C (zh) | 2003-01-01 |
| JP2001055379A (ja) | 2001-02-27 |
| CN1190427C (zh) | 2005-02-23 |
| JPH11509237A (ja) | 1999-08-17 |
| AU2713397A (en) | 1997-11-26 |
| ES2165052T3 (es) | 2002-03-01 |
| CA2358479A1 (en) | 1997-11-13 |
| CA2358479C (en) | 2004-07-13 |
| HK1019336A1 (en) | 2000-02-03 |
| AU712970B2 (en) | 1999-11-18 |
| DE69706981D1 (de) | 2001-10-31 |
| CA2253906C (en) | 2002-04-02 |
| PT900214E (pt) | 2002-03-28 |
| EP0900214A1 (de) | 1999-03-10 |
| JP3160297B2 (ja) | 2001-04-25 |
| CA2253906A1 (en) | 1997-11-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |