ATE206133T1 - Substituierte propargylethoxyamido-nukleoside - Google Patents
Substituierte propargylethoxyamido-nukleosideInfo
- Publication number
- ATE206133T1 ATE206133T1 AT98914275T AT98914275T ATE206133T1 AT E206133 T1 ATE206133 T1 AT E206133T1 AT 98914275 T AT98914275 T AT 98914275T AT 98914275 T AT98914275 T AT 98914275T AT E206133 T1 ATE206133 T1 AT E206133T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- deazapurine
- purine
- pyrimidine
- attached
- Prior art date
Links
- 239000002777 nucleoside Substances 0.000 title abstract 5
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 6
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 abstract 4
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 125000003835 nucleoside group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- JAGBKMXGOMEWNO-UHFFFAOYSA-N 4-aminobut-2-ynoic acid Chemical compound NCC#CC(O)=O JAGBKMXGOMEWNO-UHFFFAOYSA-N 0.000 abstract 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N Benzoic acid Natural products OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 1
- 239000005711 Benzoic acid Substances 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- -1 alkylamino benzoic acid Chemical compound 0.000 abstract 1
- 150000001370 alpha-amino acid derivatives Chemical class 0.000 abstract 1
- 235000008206 alpha-amino acids Nutrition 0.000 abstract 1
- 235000010233 benzoic acid Nutrition 0.000 abstract 1
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 239000002212 purine nucleoside Substances 0.000 abstract 1
- 239000002718 pyrimidine nucleoside Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/833,855 US5770716A (en) | 1997-04-10 | 1997-04-10 | Substituted propargylethoxyamido nucleosides, oligonucleotides and methods for using same |
| PCT/US1998/005616 WO1998045310A1 (en) | 1997-04-10 | 1998-03-23 | Substituted propargylethoxyamido nucleosides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE206133T1 true ATE206133T1 (de) | 2001-10-15 |
Family
ID=25265453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98914275T ATE206133T1 (de) | 1997-04-10 | 1998-03-23 | Substituierte propargylethoxyamido-nukleoside |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5770716A (de) |
| EP (1) | EP0923597B1 (de) |
| JP (3) | JP2000513016A (de) |
| AT (1) | ATE206133T1 (de) |
| AU (1) | AU725288B2 (de) |
| CA (1) | CA2257227C (de) |
| DE (1) | DE69801802T2 (de) |
| WO (1) | WO1998045310A1 (de) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9096636B2 (en) | 1996-06-06 | 2015-08-04 | Isis Pharmaceuticals, Inc. | Chimeric oligomeric compounds and their use in gene modulation |
| US5898031A (en) | 1996-06-06 | 1999-04-27 | Isis Pharmaceuticals, Inc. | Oligoribonucleotides for cleaving RNA |
| US20080119427A1 (en) * | 1996-06-06 | 2008-05-22 | Isis Pharmaceuticals, Inc. | Double Strand Compositions Comprising Differentially Modified Strands for Use in Gene Modulation |
| US7812149B2 (en) | 1996-06-06 | 2010-10-12 | Isis Pharmaceuticals, Inc. | 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations |
| US6080852A (en) * | 1996-06-27 | 2000-06-27 | The Perkin-Elmer Corporation | 4,7-dichlororhodamine dyes |
| US7550570B2 (en) * | 2000-05-25 | 2009-06-23 | Applied Biosystems, Llc. | 4,7-dichlororhodamine dyes labeled polynucleotides |
| DE69841023D1 (de) | 1997-03-12 | 2009-09-10 | Applied Biosystems Llc | DNA Polymerasen mit verbesserten Fähigkeiten zum Einbau von markierten Nukleotiden |
| US6583168B1 (en) | 1997-11-25 | 2003-06-24 | Applera Corporation | Sulfonated diarylrhodamine dyes |
| US6080868A (en) | 1998-01-23 | 2000-06-27 | The Perkin-Elmer Corporation | Nitro-substituted non-fluorescent asymmetric cyanine dye compounds |
| US6096875A (en) | 1998-05-29 | 2000-08-01 | The Perlein-Elmer Corporation | Nucleotide compounds including a rigid linker |
| US5948648A (en) * | 1998-05-29 | 1999-09-07 | Khan; Shaheer H. | Nucleotide compounds including a rigid linker |
| US6653462B2 (en) | 1998-05-29 | 2003-11-25 | Applera Corporation | Nucleotide compounds including a rigid linker |
| US6403567B1 (en) | 1999-06-22 | 2002-06-11 | Cv Therapeutics, Inc. | N-pyrazole A2A adenosine receptor agonists |
| US6180615B1 (en) * | 1999-06-22 | 2001-01-30 | Cv Therapeutics, Inc. | Propargyl phenyl ether A2A receptor agonists |
| USRE47351E1 (en) | 1999-06-22 | 2019-04-16 | Gilead Sciences, Inc. | 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists |
| US6214807B1 (en) * | 1999-06-22 | 2001-04-10 | Cv Therapeutics, Inc. | C-pyrazole 2A A receptor agonists |
| US6221600B1 (en) | 1999-10-08 | 2001-04-24 | Board Of Regents, The University Of Texas System | Combinatorial oligonucleotide PCR: a method for rapid, global expression analysis |
| US6221604B1 (en) | 2000-02-07 | 2001-04-24 | Pe Corporation | Electron-deficient nitrogen heterocycle-substituted fluorescein dyes |
| CA2671940A1 (en) * | 2000-02-23 | 2001-08-30 | Cv Therapeutics, Inc. | Identification of partial agonists of the a2a adenosine receptor |
| US6465644B1 (en) * | 2000-05-02 | 2002-10-15 | Applera Corporation | Sulfonated [8,9] benzophenoxazine dyes and the use of their labelled conjugates |
| US6887664B2 (en) | 2000-06-06 | 2005-05-03 | Applera Corporation | Asynchronous primed PCR |
| EP1317464B1 (de) * | 2000-10-11 | 2009-05-13 | Applera Corporation | Fluoreszierende nukleobasekonjugate mit anionische linker |
| US20030082547A1 (en) * | 2001-08-27 | 2003-05-01 | Ewing Gregory J. | Non-fluorescent quencher compounds and biomolecular assays |
| US20050042629A1 (en) | 2002-09-13 | 2005-02-24 | Applera Corporation | Thermus scotoductus nucleic acid polymerases |
| US7052877B2 (en) | 2001-11-30 | 2006-05-30 | Applera Corporation | Thermus brockianus nucleic acid polymerases |
| US7115370B2 (en) | 2002-06-05 | 2006-10-03 | Capital Genomix, Inc. | Combinatorial oligonucleotide PCR |
| US20050020915A1 (en) * | 2002-07-29 | 2005-01-27 | Cv Therapeutics, Inc. | Myocardial perfusion imaging methods and compositions |
| NZ537975A (en) * | 2002-07-29 | 2007-08-31 | Cv Therapeutics Inc | Method of producing coronary vasodilation without peripheral vasodilation comprising administering at least 10 mcg of at least one A2A receptor agonist |
| US8470801B2 (en) | 2002-07-29 | 2013-06-25 | Gilead Sciences, Inc. | Myocardial perfusion imaging methods and compositions |
| AU2003291755A1 (en) | 2002-11-05 | 2004-06-07 | Isis Pharmaceuticals, Inc. | Oligomers comprising modified bases for binding cytosine and uracil or thymine and their use |
| US20040175704A1 (en) | 2003-03-06 | 2004-09-09 | Stratagene | Compositions and methods for polynucleotide sequence detection |
| US8569474B2 (en) | 2004-03-09 | 2013-10-29 | Isis Pharmaceuticals, Inc. | Double stranded constructs comprising one or more short strands hybridized to a longer strand |
| US8394947B2 (en) | 2004-06-03 | 2013-03-12 | Isis Pharmaceuticals, Inc. | Positionally modified siRNA constructs |
| US7884086B2 (en) | 2004-09-08 | 2011-02-08 | Isis Pharmaceuticals, Inc. | Conjugates for use in hepatocyte free uptake assays |
| KR20070083714A (ko) | 2004-10-20 | 2007-08-24 | 씨브이 쎄러퓨틱스, 인코포레이티드 | Ａ2ａ 아데노신 수용체 작용제의 용도 |
| US7732595B2 (en) | 2006-02-03 | 2010-06-08 | Gilead Palo Alto, Inc. | Process for preparing an A2A-adenosine receptor agonist and its polymorphs |
| CA2655310A1 (en) * | 2006-06-22 | 2008-05-29 | Cv Therapeutics, Inc. | Use of a2a adenosine receptor agonists in the treatment of ischemia |
| US20090081120A1 (en) * | 2006-09-01 | 2009-03-26 | Cv Therapeutics, Inc. | Methods and Compositions for Increasing Patient Tolerability During Myocardial Imaging Methods |
| US20080170990A1 (en) * | 2006-09-29 | 2008-07-17 | Cv Therapeutics, Inc. | Methods for Myocardial Imaging in Patients Having a History of Pulmonary Disease |
| JP2010515081A (ja) * | 2007-01-03 | 2010-05-06 | ギリアード・パロ・アルト・インコーポレイテッド | 心筋灌流画像化 |
| US20100280098A1 (en) * | 2007-10-05 | 2010-11-04 | Juliano Rudolph L | Receptor targeted oligonucleotides |
| AU2009296235A1 (en) * | 2008-09-29 | 2010-04-01 | Gilead Sciences, Inc. | Combinations of a rate control agent and an A-2-alpha receptor antagonist for use in multidetector computed tomography methods |
| WO2012044992A2 (en) | 2010-09-30 | 2012-04-05 | Agency For Science, Technology And Research (A*Star) | Methods and reagents for detection and treatment of esophageal metaplasia |
| CN104837996A (zh) | 2012-11-15 | 2015-08-12 | 罗氏创新中心哥本哈根有限公司 | 抗apob反义缀合物化合物 |
| WO2014118272A1 (en) | 2013-01-30 | 2014-08-07 | Santaris Pharma A/S | Antimir-122 oligonucleotide carbohydrate conjugates |
| AU2014211406B2 (en) | 2013-01-30 | 2019-07-18 | Roche Innovation Center Copenhagen A/S | LNA oligonucleotide carbohydrate conjugates |
| HUE048738T2 (hu) | 2013-06-27 | 2020-08-28 | Roche Innovation Ct Copenhagen As | Antiszensz oligomerek és konjugátumok, amelyek a PCK9-t célozzák meg |
| GB201408623D0 (en) | 2014-05-15 | 2014-07-02 | Santaris Pharma As | Oligomers and oligomer conjugates |
| EP3748002A1 (de) | 2015-01-12 | 2020-12-09 | Life Technologies Corporation | Verfahren, systeme und zusammensetzungen daraus zur kontrolle und quantifizierung der nukleinsäurebibliotheksqualität |
| RU2747822C2 (ru) | 2016-03-14 | 2021-05-14 | Ф. Хоффманн-Ля Рош Аг | Олигонуклеотиды для понижения экспрессии pd-l1 |
| EP3833715B1 (de) | 2018-08-10 | 2026-01-07 | Life Technologies Corporation | Siliziumsubstituierte rhodaminfarbstoffe und farbstoffkonjugate |
| CR20230308A (es) | 2020-12-11 | 2023-09-08 | Civi Biopharma Inc | Entrega oral de conjugados antisentido que tienen por blanco a pcsk9 |
| WO2022263489A1 (en) * | 2021-06-17 | 2022-12-22 | F. Hoffmann-La Roche Ag | Nucleoside-5 -oligophosphates having a cationically-modified nucleobase |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ214774A (en) * | 1986-01-08 | 1989-10-27 | Nz Scientific & Ind Res | Herbicidal and/or plant growth regulatory compositions based on 1,6-anhydro-beta-hexopyranose derivatives and certain of these derivatives |
| US5151507A (en) * | 1986-07-02 | 1992-09-29 | E. I. Du Pont De Nemours And Company | Alkynylamino-nucleotides |
| US5047519A (en) * | 1986-07-02 | 1991-09-10 | E. I. Du Pont De Nemours And Company | Alkynylamino-nucleotides |
| US5849482A (en) * | 1988-09-28 | 1998-12-15 | Epoch Pharmaceuticals, Inc. | Crosslinking oligonucleotides |
| US4879214A (en) * | 1988-11-15 | 1989-11-07 | E. I. Du Pont De Nemours And Company | Differentiation of nucleic acid segments on the basis of nucleotide differences |
| WO1993024511A1 (en) * | 1992-05-29 | 1993-12-09 | Howard Florey Institute Of Experimental Physiology And Medicine | Oligonucleotide-polyamide conjugates |
| WO1993003736A1 (en) * | 1991-08-21 | 1993-03-04 | Microprobe Corporation | Cross-linking oligonucleotides for enzyme-mediated triple strand formation |
| AU1436995A (en) * | 1993-12-30 | 1995-07-17 | Chemgenes Corporation | Synthesis of propargyl modified nucleosides and phosphoramidites and their incorporation into defined sequence oligonucleotides |
| US5821356A (en) * | 1996-08-12 | 1998-10-13 | The Perkin Elmer Corporation | Propargylethoxyamino nucleotides |
-
1997
- 1997-04-10 US US08/833,855 patent/US5770716A/en not_active Expired - Lifetime
-
1998
- 1998-03-23 AT AT98914275T patent/ATE206133T1/de not_active IP Right Cessation
- 1998-03-23 AU AU68672/98A patent/AU725288B2/en not_active Ceased
- 1998-03-23 DE DE69801802T patent/DE69801802T2/de not_active Expired - Lifetime
- 1998-03-23 JP JP10542803A patent/JP2000513016A/ja not_active Withdrawn
- 1998-03-23 CA CA002257227A patent/CA2257227C/en not_active Expired - Fee Related
- 1998-03-23 EP EP98914275A patent/EP0923597B1/de not_active Expired - Lifetime
- 1998-03-23 WO PCT/US1998/005616 patent/WO1998045310A1/en not_active Ceased
-
2009
- 2009-02-06 JP JP2009026772A patent/JP5280879B2/ja not_active Expired - Lifetime
-
2013
- 2013-04-12 JP JP2013083835A patent/JP2013166769A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2000513016A (ja) | 2000-10-03 |
| DE69801802D1 (de) | 2001-10-31 |
| AU6867298A (en) | 1998-10-30 |
| DE69801802T2 (de) | 2002-04-04 |
| JP5280879B2 (ja) | 2013-09-04 |
| JP2009143946A (ja) | 2009-07-02 |
| CA2257227C (en) | 2005-02-22 |
| EP0923597B1 (de) | 2001-09-26 |
| WO1998045310A1 (en) | 1998-10-15 |
| JP2013166769A (ja) | 2013-08-29 |
| EP0923597A1 (de) | 1999-06-23 |
| US5770716A (en) | 1998-06-23 |
| CA2257227A1 (en) | 1998-10-15 |
| AU725288B2 (en) | 2000-10-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |