ATE206133T1 - Substituierte propargylethoxyamido-nukleoside - Google Patents

Substituierte propargylethoxyamido-nukleoside

Info

Publication number: ATE206133T1
Authority: AT; Austria
Prior art keywords: group; deazapurine; purine; pyrimidine; attached
Prior art date: 1997-04-10

Application number

AT98914275T

Other languages

English (en)

Inventor

Shaheer H Khan

Steven M Menchen

Barnett B Rosenblum

Original Assignee

Pe Corp Ny

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-10

Filing date

1998-03-23

Publication date

2001-10-15

1998-03-23 Application filed by Pe Corp Ny filed Critical Pe Corp Ny

2001-10-15 Application granted granted Critical

2001-10-15 Publication of ATE206133T1 publication Critical patent/ATE206133T1/de

Links

239000002777 nucleoside Substances 0.000 title abstract 5
KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 6
125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 abstract 4
125000000714 pyrimidinyl group Chemical group 0.000 abstract 4
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 3
229910052799 carbon Inorganic materials 0.000 abstract 3
125000003835 nucleoside group Chemical group 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
JAGBKMXGOMEWNO-UHFFFAOYSA-N 4-aminobut-2-ynoic acid Chemical compound NCC#CC(O)=O JAGBKMXGOMEWNO-UHFFFAOYSA-N 0.000 abstract 1
WPYMKLBDIGXBTP-UHFFFAOYSA-N Benzoic acid Natural products OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 1
239000005711 Benzoic acid Substances 0.000 abstract 1
229910019142 PO4 Inorganic materials 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
-1 alkylamino benzoic acid Chemical compound 0.000 abstract 1
150000001370 alpha-amino acid derivatives Chemical class 0.000 abstract 1
235000008206 alpha-amino acids Nutrition 0.000 abstract 1
235000010233 benzoic acid Nutrition 0.000 abstract 1
150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
150000003013 phosphoric acid derivatives Chemical class 0.000 abstract 1
239000002157 polynucleotide Substances 0.000 abstract 1
102000040430 polynucleotide Human genes 0.000 abstract 1
108091033319 polynucleotide Proteins 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1
239000002212 purine nucleoside Substances 0.000 abstract 1
239000002718 pyrimidine nucleoside Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Physics & Mathematics (AREA)
Immunology (AREA)
Microbiology (AREA)
Biophysics (AREA)
Analytical Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Saccharide Compounds (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT98914275T 1997-04-10 1998-03-23 Substituierte propargylethoxyamido-nukleoside ATE206133T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/833,855 US5770716A (en)	1997-04-10	1997-04-10	Substituted propargylethoxyamido nucleosides, oligonucleotides and methods for using same
PCT/US1998/005616 WO1998045310A1 (en)	1997-04-10	1998-03-23	Substituted propargylethoxyamido nucleosides

Publications (1)

Publication Number	Publication Date
ATE206133T1 true ATE206133T1 (de)	2001-10-15

Family

ID=25265453

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98914275T ATE206133T1 (de)	1997-04-10	1998-03-23	Substituierte propargylethoxyamido-nukleoside

Country Status (8)

Country	Link
US (1)	US5770716A (de)
EP (1)	EP0923597B1 (de)
JP (3)	JP2000513016A (de)
AT (1)	ATE206133T1 (de)
AU (1)	AU725288B2 (de)
CA (1)	CA2257227C (de)
DE (1)	DE69801802T2 (de)
WO (1)	WO1998045310A1 (de)

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US20050020915A1 (en) *	2002-07-29	2005-01-27	Cv Therapeutics, Inc.	Myocardial perfusion imaging methods and compositions
US8470801B2 (en)	2002-07-29	2013-06-25	Gilead Sciences, Inc.	Myocardial perfusion imaging methods and compositions
AU2003295387A1 (en)	2002-11-05	2004-06-03	Isis Parmaceuticals, Inc.	Modified oligonucleotides for use in rna interference
US20040175704A1 (en)	2003-03-06	2004-09-09	Stratagene	Compositions and methods for polynucleotide sequence detection
US8569474B2 (en)	2004-03-09	2013-10-29	Isis Pharmaceuticals, Inc.	Double stranded constructs comprising one or more short strands hybridized to a longer strand
US8394947B2 (en)	2004-06-03	2013-03-12	Isis Pharmaceuticals, Inc.	Positionally modified siRNA constructs
CA2569419A1 (en) *	2004-06-03	2005-12-22	Isis Pharmaceuticals, Inc.	Double strand compositions comprising differentially modified strands for use in gene modulation
US7884086B2 (en)	2004-09-08	2011-02-08	Isis Pharmaceuticals, Inc.	Conjugates for use in hepatocyte free uptake assays
US7655636B2 (en) *	2004-10-20	2010-02-02	Gilead Palo Alto, Inc.	Use of A2A adenosine receptor agonists
US7732595B2 (en)	2006-02-03	2010-06-08	Gilead Palo Alto, Inc.	Process for preparing an A2A-adenosine receptor agonist and its polymorphs
US20070299089A1 (en) *	2006-06-22	2007-12-27	Cv Therapeutics, Inc.	Use of A2A Adenosine Receptor Agonists in the Treatment of Ischemia
US20090081120A1 (en) *	2006-09-01	2009-03-26	Cv Therapeutics, Inc.	Methods and Compositions for Increasing Patient Tolerability During Myocardial Imaging Methods
JP2011502101A (ja) *	2006-09-29	2011-01-20	ギリアード・パロ・アルト・インコーポレイテッド	肺疾患の病歴を有する患者における心筋画像化法
US20080267861A1 (en) *	2007-01-03	2008-10-30	Cv Therapeutics, Inc.	Myocardial Perfusion Imaging
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JP6452614B2 (ja)	2012-11-15	2019-01-16	ロシュイノベーションセンターコペンハーゲンエーエス	オリゴヌクレオチドコンジュゲート
WO2014118272A1 (en)	2013-01-30	2014-08-07	Santaris Pharma A/S	Antimir-122 oligonucleotide carbohydrate conjugates
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1997
- 1997-04-10 US US08/833,855 patent/US5770716A/en not_active Expired - Lifetime
1998
- 1998-03-23 AT AT98914275T patent/ATE206133T1/de not_active IP Right Cessation
- 1998-03-23 DE DE69801802T patent/DE69801802T2/de not_active Expired - Lifetime
- 1998-03-23 CA CA002257227A patent/CA2257227C/en not_active Expired - Fee Related
- 1998-03-23 AU AU68672/98A patent/AU725288B2/en not_active Ceased
- 1998-03-23 EP EP98914275A patent/EP0923597B1/de not_active Expired - Lifetime
- 1998-03-23 JP JP10542803A patent/JP2000513016A/ja not_active Withdrawn
- 1998-03-23 WO PCT/US1998/005616 patent/WO1998045310A1/en not_active Ceased
2009
- 2009-02-06 JP JP2009026772A patent/JP5280879B2/ja not_active Expired - Lifetime
2013
- 2013-04-12 JP JP2013083835A patent/JP2013166769A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
JP5280879B2 (ja)	2013-09-04
WO1998045310A1 (en)	1998-10-15
CA2257227A1 (en)	1998-10-15
DE69801802T2 (de)	2002-04-04
AU6867298A (en)	1998-10-30
JP2000513016A (ja)	2000-10-03
AU725288B2 (en)	2000-10-12
JP2013166769A (ja)	2013-08-29
JP2009143946A (ja)	2009-07-02
EP0923597A1 (de)	1999-06-23
CA2257227C (en)	2005-02-22
EP0923597B1 (de)	2001-09-26
US5770716A (en)	1998-06-23
DE69801802D1 (de)	2001-10-31

Legal Events

Date	Code	Title	Description
2002-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69801802D1 (de)	2001-10-31	Substituierte propargylethoxyamido-nukleoside
CA2230059A1 (en)	1998-02-19	Propargylethoxyamino nucleotides
CA2344643A1 (en)	2000-04-20	Nucleotide compounds including a rigid linker
PA8483101A1 (es)	2000-09-29	Compuestos quimicos
CA2227991A1 (en)	1997-02-13	1,2,4-triazolo¬1,5-c\|pyrimidine heterocyclic analogues having antagonistic activity on adenosine a2a receptor
ES2117134T3 (es)	1998-08-01	Analogos de 1,5-anhidrohexitol-nucleosidos y su uso farmaceutico.
WO1991015498A3 (en)	1992-06-11	Nucleoside derivatives
IL138697A0 (en)	2001-10-31	Novel crystalline forms of an antiviral benzimidazole compound
ES2083458T3 (es)	1996-04-16	Composicion antivirica.
GB9205071D0 (en)	1992-04-22	Therapeutic nucleosides
NO20084343L (no)	2001-03-28	Fremgangsmate for fremstilling av 6-(4-fenylbutoksy)heksylaminderivater
CA2298704A1 (en)	1999-02-25	Nucleosides analogues, such as antivirals including inhibitors of retroviral reverse transcriptase and the dna polymerase of hepatitis b virus (hbv)
AU2890497A (en)	1997-12-09	Nucleoside derivatives with photolabile protective groups
ES2083954T3 (es)	1996-05-01	Proceso para la preparacion de compuestos de piridina fundidos.
DE69406943D1 (de)	1998-01-02	Konformationell festgelegte nukleosidanaloge
DK1068209T3 (da)	2005-11-14	Fremgangsmåde til fremstilling af purinderivater og deres mellemprodukter
FR2701027B1 (fr)	1997-07-18	Procede de synthese ameliore du 9-(beta-d-arabinofuranosyl)adenine 5'-phosphate.
BR9508826A (pt)	1997-09-30	Análogos de nucleosídeo antivirais contendo uma base de benzimidazol substituída ligada a um anel carboxílico
MY127470A (en)	2006-12-29	Process for the synthesis of chloropurine intermediates
WO1999029702A3 (en)	1999-09-02	METHOD FOR SYNTHESIZING 9-(2,3-DIDEOXY-2-FLUORO-β-D-THREO-PENTOFURANOSYL)ADENINE (β-FddA)
WO1998034917A3 (en)	1999-01-14	Synthesis of acyclic nucleoside derivatives
MX9701111A (es)	1998-03-31	Oligomeros especificos de union de secuencia para acidos nucleicos y su uso en estrategias antisentido.
JPS6426594A (en)	1989-01-27	Nucleotides and antitumor agent
FR2733234B1 (fr)	1997-07-04	Derives de l'acyclovir comme agents antiviraux