ATE206308T1 - Arzneizusammensetzungen enthaltend ein bakterizides permeabilität erhöhendes protein und ein tensid - Google Patents
Arzneizusammensetzungen enthaltend ein bakterizides permeabilität erhöhendes protein und ein tensidInfo
- Publication number
- ATE206308T1 ATE206308T1 AT94907963T AT94907963T ATE206308T1 AT E206308 T1 ATE206308 T1 AT E206308T1 AT 94907963 T AT94907963 T AT 94907963T AT 94907963 T AT94907963 T AT 94907963T AT E206308 T1 ATE206308 T1 AT E206308T1
- Authority
- AT
- Austria
- Prior art keywords
- bpi
- surfactant
- compositions containing
- bactericidal
- medicinal compositions
- Prior art date
Links
- 230000000844 anti-bacterial effect Effects 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 239000004094 surface-active agent Substances 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 230000035699 permeability Effects 0.000 abstract 2
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 abstract 1
- 230000002776 aggregation Effects 0.000 abstract 1
- 238000004220 aggregation Methods 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229960000502 poloxamer Drugs 0.000 abstract 1
- 229920001983 poloxamer Polymers 0.000 abstract 1
- 229950008882 polysorbate Drugs 0.000 abstract 1
- 229920000136 polysorbate Polymers 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A61K38/1751—Bactericidal/permeability-increasing protein [BPI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Marine Sciences & Fisheries (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1236093A | 1993-02-02 | 1993-02-02 | |
| PCT/US1994/001239 WO1994017819A1 (en) | 1993-02-02 | 1994-02-02 | Pharmaceutical compositions containing bactericidal permeability increasing protein and a surfactant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE206308T1 true ATE206308T1 (de) | 2001-10-15 |
Family
ID=21754603
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94907963T ATE206308T1 (de) | 1993-02-02 | 1994-02-02 | Arzneizusammensetzungen enthaltend ein bakterizides permeabilität erhöhendes protein und ein tensid |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US5488034A (de) |
| EP (1) | EP0682524B1 (de) |
| JP (2) | JP3946246B2 (de) |
| CN (1) | CN1163264C (de) |
| AT (1) | ATE206308T1 (de) |
| AU (1) | AU695125B2 (de) |
| CA (1) | CA2155005C (de) |
| DE (1) | DE69428521T2 (de) |
| DK (1) | DK0682524T3 (de) |
| ES (1) | ES2164098T3 (de) |
| PT (1) | PT682524E (de) |
| WO (1) | WO1994017819A1 (de) |
Families Citing this family (77)
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|---|---|---|---|---|
| US6093391A (en) * | 1992-10-08 | 2000-07-25 | Supratek Pharma, Inc. | Peptide copolymer compositions |
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| US5420019A (en) * | 1993-02-02 | 1995-05-30 | Xoma Corporation | Stable bactericidal/permeability-increasing protein muteins |
| JP3946246B2 (ja) * | 1993-02-02 | 2007-07-18 | ゾーマ・コーポレイション | 殺菌性/浸透性増大タンパク質(Bactericidal/Permeability Increasing protein:BPI)及び界面活性剤を含有する医薬組成物 |
| US5858974A (en) * | 1995-07-20 | 1999-01-12 | Xoma Corporation | Anti-fungal peptides |
| US6214789B1 (en) | 1993-03-12 | 2001-04-10 | Xoma Corporation | Treatment of mycobacterial diseases by administration of bactericidal/permeability-increasing protein products |
| US5652332A (en) * | 1993-03-12 | 1997-07-29 | Xoma | Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof |
| WO1995000641A1 (en) | 1993-06-17 | 1995-01-05 | Xoma Corporation | Lipopolysaccharide binding protein derivatives |
| US5770561A (en) * | 1993-07-14 | 1998-06-23 | Xoma Corporation | Method for potentiating BPI protein product bactericidal activity by administration of LBP protein products |
| WO1995002414A1 (en) * | 1993-07-14 | 1995-01-26 | Xoma Corporation | Method for potentiating bpi protein product bactericidal activity by administration of lbp protein products |
| US6759203B1 (en) | 1993-09-22 | 2004-07-06 | Xoma Corporation | Method for quantifying BPI in body fluids |
| DE69430823T2 (de) * | 1993-09-22 | 2003-02-20 | Xoma Technology Ltd., Berkeley | Verfahren zur behandlung von gram-negativen bakterien infektion durch verabreichung von bakterientötendem/durchlässigkeiterhöhendem (bpi) proteinprodukt und antibiotikum |
| CN1133634A (zh) * | 1993-09-22 | 1996-10-16 | 爱克斯欧玛公司 | 定量体液中的bpi的方法 |
| DE69526216T2 (de) * | 1994-01-14 | 2002-11-14 | Xoma Technology Ltd., Berkeley | Antifungaleverfahren und mitteln |
| PT754050E (pt) * | 1994-01-14 | 2002-11-29 | Xoma Technology Ltd | Metodos e materiais contra bacterias gram-positivas |
| US5447913A (en) | 1994-03-11 | 1995-09-05 | Xoma Corporation | Therapeutic uses of bactericidal/permeability-increasing protein dimer products |
| US5830860A (en) * | 1994-03-24 | 1998-11-03 | Regents Of The University Of Minnesota | Peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use |
| US5786324A (en) * | 1994-03-24 | 1998-07-28 | Regents Of The University Of Minnesota | Synthetic peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use |
| US5932544A (en) * | 1994-05-31 | 1999-08-03 | Xoma Corporation | Bactericidal/permeability-increasing protein (BPI) compositions |
| US5646114A (en) * | 1994-07-11 | 1997-07-08 | Xoma Corporation | Anti-protozoan methods |
| US6271203B1 (en) | 1994-07-07 | 2001-08-07 | Xoma Corporation | Anti-protozoan methods and materials |
| US6221959B1 (en) | 1994-11-18 | 2001-04-24 | Supratek Pharma, Inc. | Polynucleotide compositions |
| US6353055B1 (en) | 1994-11-18 | 2002-03-05 | Supratek Pharma Inc. | Polynucleotide compositions |
| US5912228A (en) * | 1995-01-13 | 1999-06-15 | Xoma Corporation | Therapeutic compositions comprising bactericidal/permeability-increasing (BPI) protein products |
| US5494896A (en) * | 1995-03-31 | 1996-02-27 | Xoma Corporation | Method of treating conditions associated with burn injuries |
| US5686414A (en) * | 1995-11-14 | 1997-11-11 | Xoma Corporation | Methods of treating conditions associated with corneal transplantation |
| WO1997017990A1 (en) * | 1995-11-14 | 1997-05-22 | Xoma Corporation | Bactericidal permeability increasing protein (bpi) for treating conditions associated with corneal injury |
| US5741779A (en) | 1996-05-10 | 1998-04-21 | Xoma Corporation | Antithrombotic materials and methods |
| JP2000510845A (ja) * | 1996-05-10 | 2000-08-22 | ゾーマ コーポレイション | ヒト髄膜炎菌血症のためのbpiタンパク質産物の治療用途 |
| JP2000511190A (ja) * | 1996-05-23 | 2000-08-29 | ゾーマ コーポレイション | 外傷に起因する出血に見舞われたヒトにおけるbpiタンパク質産物の治療用途 |
| EP0939766A2 (de) | 1996-05-24 | 1999-09-08 | The Regents Of The University Of Minnesota | Synthese von löslichen beta-sheet bildenden peptiden |
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| EP1304118A3 (de) * | 1996-11-01 | 2004-01-14 | XOMA Technology Ltd. | Therapeutische Verwendung von BPI Proteineprodukten |
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| GB201116271D0 (en) * | 2011-09-21 | 2011-11-02 | Univ Cardiff | Dispersion anaesthetic device |
| EP3139965B1 (de) | 2014-05-07 | 2021-09-29 | Applied Molecular Transport Inc. | Von cholixtoxin abgeleitete fusionsmoleküle zur oralen verabreichung von biologisch aktiven stoffen |
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| KR20250174998A (ko) | 2018-03-08 | 2025-12-15 | 어플라이드 몰레큘라 트랜스포트 인크. | 경구 전달용 독소-유래 전달 구조체 |
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| US20230125871A1 (en) * | 2020-03-18 | 2023-04-27 | Gi Innovation, Inc. | Fusion protein preparation comprising il-2 and cd80 proteins |
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| US5348942A (en) * | 1993-03-12 | 1994-09-20 | Xoma Corporation | Therapeutic uses of bactericidal/permeability increasing protein products |
-
1994
- 1994-02-02 JP JP51821394A patent/JP3946246B2/ja not_active Expired - Fee Related
- 1994-02-02 DK DK94907963T patent/DK0682524T3/da active
- 1994-02-02 WO PCT/US1994/001239 patent/WO1994017819A1/en not_active Ceased
- 1994-02-02 PT PT94907963T patent/PT682524E/pt unknown
- 1994-02-02 DE DE69428521T patent/DE69428521T2/de not_active Expired - Fee Related
- 1994-02-02 AU AU61330/94A patent/AU695125B2/en not_active Ceased
- 1994-02-02 AT AT94907963T patent/ATE206308T1/de not_active IP Right Cessation
- 1994-02-02 CN CNB941913554A patent/CN1163264C/zh not_active Expired - Fee Related
- 1994-02-02 CA CA002155005A patent/CA2155005C/en not_active Expired - Fee Related
- 1994-02-02 ES ES94907963T patent/ES2164098T3/es not_active Expired - Lifetime
- 1994-02-02 US US08/190,869 patent/US5488034A/en not_active Expired - Lifetime
- 1994-02-02 EP EP94907963A patent/EP0682524B1/de not_active Expired - Lifetime
-
1995
- 1995-06-07 US US08/472,995 patent/US5696090A/en not_active Expired - Fee Related
-
1997
- 1997-12-08 US US08/986,413 patent/US5955427A/en not_active Expired - Fee Related
-
1999
- 1999-05-17 US US09/313,525 patent/US6066620A/en not_active Expired - Lifetime
-
2000
- 2000-02-11 US US09/502,356 patent/US6255284B1/en not_active Expired - Fee Related
-
2005
- 2005-02-25 JP JP2005052149A patent/JP2005145986A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| DE69428521T2 (de) | 2002-05-23 |
| EP0682524B1 (de) | 2001-10-04 |
| EP0682524A1 (de) | 1995-11-22 |
| AU695125B2 (en) | 1998-08-06 |
| US5955427A (en) | 1999-09-21 |
| PT682524E (pt) | 2002-03-28 |
| JPH10513433A (ja) | 1998-12-22 |
| DE69428521D1 (de) | 2001-11-08 |
| WO1994017819A1 (en) | 1994-08-18 |
| AU6133094A (en) | 1994-08-29 |
| US5488034A (en) | 1996-01-30 |
| CA2155005A1 (en) | 1994-08-18 |
| US6255284B1 (en) | 2001-07-03 |
| HK1014156A1 (en) | 1999-09-24 |
| JP2005145986A (ja) | 2005-06-09 |
| US5696090A (en) | 1997-12-09 |
| CN1163264C (zh) | 2004-08-25 |
| JP3946246B2 (ja) | 2007-07-18 |
| DK0682524T3 (da) | 2002-01-28 |
| CA2155005C (en) | 1999-04-06 |
| US6066620A (en) | 2000-05-23 |
| CN1127992A (zh) | 1996-07-31 |
| ES2164098T3 (es) | 2002-02-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |