ATE206401T1 - Zwischenprodukte für die herstellung von derivaten der 4-oxochinolin-3-carbonsäure - Google Patents

Zwischenprodukte für die herstellung von derivaten der 4-oxochinolin-3-carbonsäure

Info

Publication number
ATE206401T1
ATE206401T1 AT94103669T AT94103669T ATE206401T1 AT E206401 T1 ATE206401 T1 AT E206401T1 AT 94103669 T AT94103669 T AT 94103669T AT 94103669 T AT94103669 T AT 94103669T AT E206401 T1 ATE206401 T1 AT E206401T1
Authority
AT
Austria
Prior art keywords
oxocinoline
derivatives
production
carbonic acid
intermediate products
Prior art date
Application number
AT94103669T
Other languages
English (en)
Inventor
Masayuki Iwata
Tomio Kimura
Teruhiko Inoue
Yoshimi Fujihara
Tetsushi Katsube
Original Assignee
Ube Industries
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ube Industries, Sankyo Co filed Critical Ube Industries
Application granted granted Critical
Publication of ATE206401T1 publication Critical patent/ATE206401T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
AT94103669T 1988-07-20 1989-07-20 Zwischenprodukte für die herstellung von derivaten der 4-oxochinolin-3-carbonsäure ATE206401T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP18055788 1988-07-20
JP22422088 1988-09-07

Publications (1)

Publication Number Publication Date
ATE206401T1 true ATE206401T1 (de) 2001-10-15

Family

ID=26500036

Family Applications (2)

Application Number Title Priority Date Filing Date
AT89307423T ATE117295T1 (de) 1988-07-20 1989-07-20 4-oxochinolin-3-carbonsäure-derivate, ihre herstellung und ihre verwendung.
AT94103669T ATE206401T1 (de) 1988-07-20 1989-07-20 Zwischenprodukte für die herstellung von derivaten der 4-oxochinolin-3-carbonsäure

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT89307423T ATE117295T1 (de) 1988-07-20 1989-07-20 4-oxochinolin-3-carbonsäure-derivate, ihre herstellung und ihre verwendung.

Country Status (14)

Country Link
US (4) US5348961A (de)
EP (2) EP0610958B1 (de)
KR (2) KR950010325B1 (de)
CN (1) CN1028226C (de)
AT (2) ATE117295T1 (de)
AU (1) AU618823B2 (de)
CA (1) CA1335670C (de)
DE (2) DE68929330T2 (de)
DK (1) DK175617B1 (de)
ES (1) ES2070175T3 (de)
FI (1) FI95130C (de)
GR (1) GR3015818T3 (de)
IE (1) IE68941B1 (de)
NO (1) NO175256C (de)

Families Citing this family (34)

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IL90062A (en) * 1988-04-27 1994-10-07 Daiichi Seiyaku Co Pyridonecarboxylic acid derivatives, their preparation and pharmaceutical compositions containing them
DE3906365A1 (de) * 1988-07-15 1990-01-18 Bayer Ag 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe
DE4015299A1 (de) * 1990-05-12 1991-11-14 Bayer Ag Verfahren zur herstellung von 3-amino-2-(het)-aroyl-acrylsaeurederivaten
JP2613139B2 (ja) * 1990-07-19 1997-05-21 エスエス製薬 株式会社 キノロンカルボン酸誘導体
JP3165742B2 (ja) * 1991-07-16 2001-05-14 中外製薬株式会社 キノロンカルボン酸誘導体の製造方法
EP0545866A1 (de) * 1991-12-06 1993-06-09 Ciba-Geigy Ag Verfahren zur Herstellung von Trifluorbenzolderivaten
US5430028A (en) * 1992-05-26 1995-07-04 Ss Pharmaceutical Co., Ltd. 5-aminoquinolone carboxylic acid derivative and antibacterial agent containing the same as active ingredient
FR2692577B1 (fr) * 1992-05-26 1996-02-02 Bouchara Sa Nouvelles quinolones fluorees, leur procede de preparation et les compositions pharmaceutiques en renfermant.
DE4232505A1 (de) * 1992-09-29 1994-03-31 Degussa Verfahren zur Reduktion von Carbonsäuren oder Carbonsäurederivaten sowie neue Verbindungen
CA2152828A1 (en) * 1993-03-16 1994-07-07 Shin-Ichi Uesato 8-methoxy-quinolonecarboxylic acid derivatives
FR2706459B1 (fr) * 1993-06-17 1995-08-04 Bouchara Sa Nouveaux dérivés quinoloniques, leur procédé d'obtention et les compositions pharmaceutiques qui en contiennent.
US6964611B2 (en) * 1996-12-30 2005-11-15 Walker Digital, Llc System and method for automated play of lottery games
US6387928B1 (en) 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
SK286420B6 (sk) 1997-09-15 2008-09-05 The Procter & Gamble Company Zlúčenina so štruktúrou chinolónu, farmaceutický prostriedok s jej obsahom a jej použitie
ATE245140T1 (de) 1998-11-18 2003-08-15 Asahi Glass Co Ltd Derivate der aminoacryl-säure und ein verfahren zur herstellung derselben
US20010018446A1 (en) 1999-09-23 2001-08-30 G.D. Searle & Co. Substituted N-Aliphatic-N-Aromatictertiary-Heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
MXPA02007667A (es) 2000-02-09 2003-04-14 Daiichi Seiyaku Co Agentes antibacterianos antiacidos-resistentes que contienen acidos piridoncarboxilicos como el ingrediente activo.
US6878713B2 (en) 2001-04-25 2005-04-12 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US6964966B2 (en) * 2001-04-25 2005-11-15 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
JP5255183B2 (ja) 2003-09-04 2013-08-07 ウォックハート リミテッド ベンゾキノリジン−２−カルボン酸アルギニン塩四水和物
WO2005026145A2 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Quinolone antibacterial agents
ES2232309B1 (es) * 2003-11-13 2006-08-01 Quimica Sintetica, S.A. Procedimiento simplificado para la obtencion de gatifloxacino.
DE102004035203A1 (de) 2004-07-21 2006-02-16 Bayer Healthcare Ag Substituierte Chinolone
DE102006005861A1 (de) 2006-02-09 2007-08-23 Aicuris Gmbh & Co. Kg Substituierte Chinolone III
ES2284380B1 (es) * 2006-03-10 2008-11-01 Quimica Sintetica S.A. Procedimiento para la preparacion de moxifloxacino y moxifloxacino clorhidrato.
EP2001862B1 (de) * 2006-03-28 2011-04-27 Warner Chilcott Company, LLC Malatsalze und polymorphe von (3s,5s)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-chinolincarbonsäure
CA2647457C (en) * 2006-03-28 2011-05-24 The Procter & Gamble Company A hydride reduction process for preparing quinolone intermediates
MX2008012488A (es) * 2006-03-28 2008-10-10 Procter & Gamble Un proceso de acoplamiento para preparar intermedios de quinolona.
CN100415212C (zh) * 2006-07-21 2008-09-03 哈药集团制药总厂 一种含乳酸卡德沙星的口服制剂
US8500537B2 (en) 2007-05-17 2013-08-06 Walker Digital, Llc Group play of a lottery game
CN101775005B (zh) * 2009-01-13 2013-12-04 江苏恒瑞医药股份有限公司 盐酸卡屈沙星i型结晶及其制备方法
CN108129404B (zh) * 2018-01-30 2020-05-01 凯瑞斯德生化(苏州)有限公司 手性哌嗪酮衍生物的合成方法
CN108299317A (zh) * 2018-03-20 2018-07-20 爱斯特（成都）生物制药股份有限公司 1,4-二氮杂螺[5,5]十一烷盐酸盐的合成方法
CN108840814B (zh) * 2018-07-24 2021-09-24 南京药石科技股份有限公司 一种8-氧代-2,6,9-三氮杂螺[4.5]癸烷-2-羧酸叔丁酯制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3142854A1 (de) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4822801A (en) * 1984-07-20 1989-04-18 Warner-Lambert Company 4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial agents
US4977154A (en) * 1985-12-12 1990-12-11 Warner-Lambert Company 5-amino and 5-hydroxy-6-fluoroquinolones as antibacterial agents
JPH089597B2 (ja) * 1986-01-21 1996-01-31 杏林製薬株式会社 選択毒性に優れた８‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
JPS62205060A (ja) * 1986-03-04 1987-09-09 Kyorin Pharmaceut Co Ltd ８位置換キノロンカルボン酸誘導体
JPS62215572A (ja) * 1986-03-17 1987-09-22 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
EP0241206A3 (de) * 1986-03-31 1989-05-10 Sankyo Company Limited Chinolin-3-carbonsäurederivate, ihre Herstellung und Verwendung
US4803205A (en) * 1987-08-07 1989-02-07 Warner-Lambert Company Quinolones as antibacterial agents
US4780468A (en) * 1987-08-07 1988-10-25 Warner-Lambert Company 8-trifluoromethyl quinolones as antibacterial agents
US4851418A (en) * 1987-08-21 1989-07-25 Warner-Lambert Company Naphthyridine antibacterial agents containing an α-amino acid in the side chain of the 7-substituent

Also Published As

Publication number Publication date
DK359289D0 (da) 1989-07-19
FI893467L (fi) 1990-01-21
FI95130B (fi) 1995-09-15
AU618823B2 (en) 1992-01-09
CN1028226C (zh) 1995-04-19
IE68941B1 (en) 1996-07-24
EP0610958A2 (de) 1994-08-17
CA1335670C (en) 1995-05-23
DK175617B1 (da) 2004-12-27
ATE117295T1 (de) 1995-02-15
NO175256B (no) 1994-06-13
ES2070175T3 (es) 1995-06-01
AU3821889A (en) 1990-01-25
US5348961A (en) 1994-09-20
GR3015818T3 (en) 1995-07-31
FI95130C (fi) 1995-12-27
DE68920654D1 (de) 1995-03-02
DE68929330T2 (de) 2002-07-04
KR950010325B1 (ko) 1995-09-14
EP0352123A3 (en) 1990-09-05
US5436367A (en) 1995-07-25
EP0352123A2 (de) 1990-01-24
NO892952D0 (no) 1989-07-19
DE68920654T2 (de) 1995-08-31
EP0610958A3 (de) 1995-03-22
EP0352123B1 (de) 1995-01-18
US5496951A (en) 1996-03-05
IE892340L (en) 1990-01-20
FI893467A0 (fi) 1989-07-18
US5073556A (en) 1991-12-17
NO175256C (no) 1994-09-21
DE68929330D1 (de) 2001-11-08
KR900001686A (ko) 1990-02-27
EP0610958B1 (de) 2001-10-04
DK359289A (da) 1990-01-21
KR950011396B1 (ko) 1995-10-02
CN1040977A (zh) 1990-04-04
NO892952L (no) 1990-01-22

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee