NO175256C - Analogifremgangsmåte til fremstilling av terapeutisk aktive 4-oksokinolin-3-karboksylsyrederivater - Google Patents
Analogifremgangsmåte til fremstilling av terapeutisk aktive 4-oksokinolin-3-karboksylsyrederivaterInfo
- Publication number
- NO175256C NO175256C NO892952A NO892952A NO175256C NO 175256 C NO175256 C NO 175256C NO 892952 A NO892952 A NO 892952A NO 892952 A NO892952 A NO 892952A NO 175256 C NO175256 C NO 175256C
- Authority
- NO
- Norway
- Prior art keywords
- oxoquinoline
- carboxylic acid
- acid derivatives
- therapeutically active
- analogous process
- Prior art date
Links
- YCAZALSUJDPQPP-UHFFFAOYSA-N 4-oxo-3h-quinoline-3-carboxylic acid Chemical class C1=CC=C2C(=O)C(C(=O)O)C=NC2=C1 YCAZALSUJDPQPP-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18055788 | 1988-07-20 | ||
| JP22422088 | 1988-09-07 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO892952D0 NO892952D0 (no) | 1989-07-19 |
| NO892952L NO892952L (no) | 1990-01-22 |
| NO175256B NO175256B (no) | 1994-06-13 |
| NO175256C true NO175256C (no) | 1994-09-21 |
Family
ID=26500036
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO892952A NO175256C (no) | 1988-07-20 | 1989-07-19 | Analogifremgangsmåte til fremstilling av terapeutisk aktive 4-oksokinolin-3-karboksylsyrederivater |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US5348961A (de) |
| EP (2) | EP0610958B1 (de) |
| KR (2) | KR950010325B1 (de) |
| CN (1) | CN1028226C (de) |
| AT (2) | ATE206401T1 (de) |
| AU (1) | AU618823B2 (de) |
| CA (1) | CA1335670C (de) |
| DE (2) | DE68929330T2 (de) |
| DK (1) | DK175617B1 (de) |
| ES (1) | ES2070175T3 (de) |
| FI (1) | FI95130C (de) |
| GR (1) | GR3015818T3 (de) |
| IE (1) | IE68941B1 (de) |
| NO (1) | NO175256C (de) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL90062A (en) * | 1988-04-27 | 1994-10-07 | Daiichi Seiyaku Co | Pyridonecarboxylic acid derivatives, their preparation and pharmaceutical compositions containing them |
| DE3906365A1 (de) * | 1988-07-15 | 1990-01-18 | Bayer Ag | 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe |
| DE4015299A1 (de) * | 1990-05-12 | 1991-11-14 | Bayer Ag | Verfahren zur herstellung von 3-amino-2-(het)-aroyl-acrylsaeurederivaten |
| JP2613139B2 (ja) * | 1990-07-19 | 1997-05-21 | エスエス製薬 株式会社 | キノロンカルボン酸誘導体 |
| JP3165742B2 (ja) * | 1991-07-16 | 2001-05-14 | 中外製薬株式会社 | キノロンカルボン酸誘導体の製造方法 |
| EP0545866A1 (de) * | 1991-12-06 | 1993-06-09 | Ciba-Geigy Ag | Verfahren zur Herstellung von Trifluorbenzolderivaten |
| FR2692577B1 (fr) * | 1992-05-26 | 1996-02-02 | Bouchara Sa | Nouvelles quinolones fluorees, leur procede de preparation et les compositions pharmaceutiques en renfermant. |
| TW222272B (de) * | 1992-05-26 | 1994-04-11 | Ss Seiyaku Kk | |
| DE4232505A1 (de) * | 1992-09-29 | 1994-03-31 | Degussa | Verfahren zur Reduktion von Carbonsäuren oder Carbonsäurederivaten sowie neue Verbindungen |
| CA2152828A1 (en) * | 1993-03-16 | 1994-07-07 | Shin-Ichi Uesato | 8-methoxy-quinolonecarboxylic acid derivatives |
| FR2706459B1 (fr) * | 1993-06-17 | 1995-08-04 | Bouchara Sa | Nouveaux dérivés quinoloniques, leur procédé d'obtention et les compositions pharmaceutiques qui en contiennent. |
| US6964611B2 (en) * | 1996-12-30 | 2005-11-15 | Walker Digital, Llc | System and method for automated play of lottery games |
| US6387928B1 (en) | 1997-09-15 | 2002-05-14 | The Procter & Gamble Co. | Antimicrobial quinolones, their compositions and uses |
| CN1264837C (zh) * | 1997-09-15 | 2006-07-19 | 普罗克特和甘保尔公司 | 喹诺酮抗微生物剂、其组合物和应用 |
| DE69909646T2 (de) | 1998-11-18 | 2004-01-29 | Asahi Glass Co Ltd | Derivate der aminoacryl-säure und ein verfahren zur herstellung derselben |
| US20010018446A1 (en) | 1999-09-23 | 2001-08-30 | G.D. Searle & Co. | Substituted N-Aliphatic-N-Aromatictertiary-Heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity |
| AU3223801A (en) * | 2000-02-09 | 2001-08-20 | Daiichi Seiyaku Co | Anti-acid-fast bacterial agents containing pyridonecarboxylic acids as the active ingredient |
| US6964966B2 (en) * | 2001-04-25 | 2005-11-15 | Wockhardt Limited | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
| US6878713B2 (en) | 2001-04-25 | 2005-04-12 | Wockhardt Limited | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
| JP5255183B2 (ja) | 2003-09-04 | 2013-08-07 | ウォックハート リミテッド | ベンゾキノリジン−２−カルボン酸アルギニン塩四水和物 |
| WO2005026145A2 (en) * | 2003-09-12 | 2005-03-24 | Warner-Lambert Company Llc | Quinolone antibacterial agents |
| ES2232309B1 (es) * | 2003-11-13 | 2006-08-01 | Quimica Sintetica, S.A. | Procedimiento simplificado para la obtencion de gatifloxacino. |
| DE102004035203A1 (de) | 2004-07-21 | 2006-02-16 | Bayer Healthcare Ag | Substituierte Chinolone |
| DE102006005861A1 (de) | 2006-02-09 | 2007-08-23 | Aicuris Gmbh & Co. Kg | Substituierte Chinolone III |
| ES2284380B1 (es) * | 2006-03-10 | 2008-11-01 | Quimica Sintetica S.A. | Procedimiento para la preparacion de moxifloxacino y moxifloxacino clorhidrato. |
| ES2366150T3 (es) * | 2006-03-28 | 2011-10-17 | Warner Chilcott Company, Llc | Malatos de polimorfos de ácido (3s,5s)-7-[3-amino-5-metil-piperidinil]-1-ciclopropil-1,4-dihidro-8-metoxi-4-oxo-3-quinolinocarboxílico. |
| BRPI0709209A2 (pt) * | 2006-03-28 | 2011-06-28 | Procter & Gamble | processo de redução de hidreto para preparo de intermediários de quinolona |
| CA2647454A1 (en) * | 2006-03-28 | 2007-10-04 | The Procter & Gamble Company | A coupling process for preparing quinolone intermediates |
| CN100415212C (zh) * | 2006-07-21 | 2008-09-03 | 哈药集团制药总厂 | 一种含乳酸卡德沙星的口服制剂 |
| WO2008144536A1 (en) | 2007-05-17 | 2008-11-27 | Walker Digital, Llc | Group play of lottery game |
| CN101775005B (zh) * | 2009-01-13 | 2013-12-04 | 江苏恒瑞医药股份有限公司 | 盐酸卡屈沙星i型结晶及其制备方法 |
| CN108129404B (zh) * | 2018-01-30 | 2020-05-01 | 凯瑞斯德生化(苏州)有限公司 | 手性哌嗪酮衍生物的合成方法 |
| CN108299317A (zh) * | 2018-03-20 | 2018-07-20 | 爱斯特（成都）生物制药股份有限公司 | 1,4-二氮杂螺[5,5]十一烷盐酸盐的合成方法 |
| CN108840814B (zh) * | 2018-07-24 | 2021-09-24 | 南京药石科技股份有限公司 | 一种8-氧代-2,6,9-三氮杂螺[4.5]癸烷-2-羧酸叔丁酯制备方法 |
| MX2022010957A (es) | 2020-03-03 | 2023-01-24 | Twentyeight Seven Inc | Compuestos que se dirigen a las proteínas de unión al arn o a las proteínas modificadoras del arn. |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3142854A1 (de) * | 1981-10-29 | 1983-05-11 | Bayer Ag, 5090 Leverkusen | 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
| US4822801A (en) * | 1984-07-20 | 1989-04-18 | Warner-Lambert Company | 4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial agents |
| US4977154A (en) * | 1985-12-12 | 1990-12-11 | Warner-Lambert Company | 5-amino and 5-hydroxy-6-fluoroquinolones as antibacterial agents |
| JPH089597B2 (ja) * | 1986-01-21 | 1996-01-31 | 杏林製薬株式会社 | 選択毒性に優れた８‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法 |
| DE3705621C2 (de) * | 1986-02-25 | 1997-01-09 | Otsuka Pharma Co Ltd | Heterocyclisch substituierte Chinoloncarbonsäurederivate |
| JPS62205060A (ja) * | 1986-03-04 | 1987-09-09 | Kyorin Pharmaceut Co Ltd | ８位置換キノロンカルボン酸誘導体 |
| JPS62215572A (ja) * | 1986-03-17 | 1987-09-22 | Kyorin Pharmaceut Co Ltd | キノロンカルボン酸誘導体 |
| DK164287A (da) * | 1986-03-31 | 1987-10-01 | Sankyo Co | Quinolin-3-carboxylsyrederivater og fremgangsmaade til fremstilling deraf og deres anvendelse |
| US4780468A (en) * | 1987-08-07 | 1988-10-25 | Warner-Lambert Company | 8-trifluoromethyl quinolones as antibacterial agents |
| US4803205A (en) * | 1987-08-07 | 1989-02-07 | Warner-Lambert Company | Quinolones as antibacterial agents |
| US4851418A (en) * | 1987-08-21 | 1989-07-25 | Warner-Lambert Company | Naphthyridine antibacterial agents containing an α-amino acid in the side chain of the 7-substituent |
-
1989
- 1989-07-18 FI FI893467A patent/FI95130C/fi not_active IP Right Cessation
- 1989-07-18 AU AU38218/89A patent/AU618823B2/en not_active Ceased
- 1989-07-19 IE IE234089A patent/IE68941B1/en not_active IP Right Cessation
- 1989-07-19 NO NO892952A patent/NO175256C/no not_active IP Right Cessation
- 1989-07-19 CA CA000606157A patent/CA1335670C/en not_active Expired - Fee Related
- 1989-07-19 DK DK198903592A patent/DK175617B1/da not_active IP Right Cessation
- 1989-07-20 AT AT94103669T patent/ATE206401T1/de not_active IP Right Cessation
- 1989-07-20 EP EP94103669A patent/EP0610958B1/de not_active Expired - Lifetime
- 1989-07-20 EP EP89307423A patent/EP0352123B1/de not_active Expired - Lifetime
- 1989-07-20 KR KR1019890010312A patent/KR950010325B1/ko not_active Expired - Fee Related
- 1989-07-20 ES ES89307423T patent/ES2070175T3/es not_active Expired - Lifetime
- 1989-07-20 DE DE68929330T patent/DE68929330T2/de not_active Expired - Fee Related
- 1989-07-20 CN CN89107044A patent/CN1028226C/zh not_active Expired - Fee Related
- 1989-07-20 AT AT89307423T patent/ATE117295T1/de not_active IP Right Cessation
- 1989-07-20 DE DE68920654T patent/DE68920654T2/de not_active Expired - Fee Related
-
1990
- 1990-10-09 US US07/594,283 patent/US5348961A/en not_active Expired - Fee Related
-
1991
- 1991-02-22 US US07/659,829 patent/US5073556A/en not_active Expired - Lifetime
-
1994
- 1994-04-14 US US08/227,678 patent/US5436367A/en not_active Expired - Fee Related
-
1995
- 1995-01-27 US US08/379,975 patent/US5496951A/en not_active Expired - Fee Related
- 1995-04-17 GR GR950400948T patent/GR3015818T3/el unknown
- 1995-06-21 KR KR1019950016771A patent/KR950011396B1/ko not_active Expired - Fee Related
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |