ATE206760T1 - Transgenes, vernetztes hämoglobin - Google Patents

Transgenes, vernetztes hämoglobin

Info

Publication number: ATE206760T1
Authority: AT; Austria
Prior art keywords: transgenic; cross; human; hemoglobins; linked hemoglobin
Prior art date: 1990-12-20

Application number

AT92903512T

Other languages

English (en)

Inventor

Tim M Townes

Steven L Mccune

Original Assignee

Univ Alabama Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-12-20

Filing date

1991-12-20

Publication date

2001-10-15

1991-12-20 Application filed by Univ Alabama Res Found filed Critical Univ Alabama Res Found

2001-10-15 Application granted granted Critical

2001-10-15 Publication of ATE206760T1 publication Critical patent/ATE206760T1/de

Links

102000001554 Hemoglobins Human genes 0.000 title abstract 4
108010054147 Hemoglobins Proteins 0.000 title abstract 4
230000009261 transgenic effect Effects 0.000 title abstract 4
INGWEZCOABYORO-UHFFFAOYSA-N 2-(furan-2-yl)-7-methyl-1h-1,8-naphthyridin-4-one Chemical compound N=1C2=NC(C)=CC=C2C(O)=CC=1C1=CC=CO1 INGWEZCOABYORO-UHFFFAOYSA-N 0.000 abstract 3
241001465754 Metazoa Species 0.000 abstract 2
239000003633 blood substitute Substances 0.000 abstract 1
210000003743 erythrocyte Anatomy 0.000 abstract 1
230000000925 erythroid effect Effects 0.000 abstract 1
230000002163 immunogen Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Biotechnology (AREA)
Zoology (AREA)
General Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Environmental Sciences (AREA)
Wood Science & Technology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Biodiversity & Conservation Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Husbandry (AREA)
Plant Pathology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Physics & Mathematics (AREA)
Hematology (AREA)
Diabetes (AREA)
General Chemical & Material Sciences (AREA)
Microbiology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT92903512T 1990-12-20 1991-12-20 Transgenes, vernetztes hämoglobin ATE206760T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US63082590A	1990-12-20	1990-12-20
PCT/US1991/009624 WO1992011283A1 (en)	1990-12-20	1991-12-20	Transgenic, cross-linked hemoglobin

Publications (1)

Publication Number	Publication Date
ATE206760T1 true ATE206760T1 (de)	2001-10-15

Family

ID=24528700

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92903512T ATE206760T1 (de)	1990-12-20	1991-12-20	Transgenes, vernetztes hämoglobin

Country Status (7)

Country	Link
EP (1)	EP0668909B1 (de)
JP (1)	JPH06504056A (de)
AT (1)	ATE206760T1 (de)
AU (1)	AU668856B2 (de)
CA (1)	CA2098818A1 (de)
DE (1)	DE69132763D1 (de)
WO (1)	WO1992011283A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6022849A (en) *	1987-05-16	2000-02-08	Baxter Biotech Technology Saarl	Mutant recombinant hemoglobins containing heme pocket mutations
US6204009B1 (en)	1988-05-16	2001-03-20	BAXTER BIOTECH TECHNOLOGY SàRL	Nucleic acids encoding mutant recombinant hemoglobins containing heme pocket mutations
US5545727A (en) *	1989-05-10	1996-08-13	Somatogen, Inc.	DNA encoding fused di-alpha globins and production of pseudotetrameric hemoglobin
US6150506A (en) *	1989-05-10	2000-11-21	Baxter Biotech Technology Sarl	Modified hemoglobin-like compounds and methods of purifying same
US5844090A (en) *	1994-05-09	1998-12-01	Somatogen, Inc.	Modified hemoglobin-like compounds
US5939391A (en) *	1993-03-31	1999-08-17	Pro-Neuron, Inc.	Hemoglobin alpha chain peptide fragments useful for inhibiting stem cell proliferation
EP0691988B1 (de)	1993-03-31	2002-10-02	Pro-Neuron, Inc.	Inhibitor der stammzellproliferation und seine verwendung
US6610654B2 (en)	1993-03-31	2003-08-26	Wellstat Therapeutics Corporation	Inhibitor of stem cell proliferation and uses thereof
US5840851A (en) *	1993-07-23	1998-11-24	Plomer; J. Jeffrey	Purification of hemoglobin
US5578564A (en) *	1993-07-23	1996-11-26	Somatogen, Inc.	Nickel-free hemoglobin and methods for producing such hemoglobin
IS4198A (is) *	1993-08-13	1995-02-14	Somatogen, Inc	Meðferð vegna aukaverkana sem tengjast gjöf á utanfrumublóðrauða
US5665869A (en) *	1993-11-15	1997-09-09	Somatogen, Inc.	Method for the rapid removal of protoporphyrin from protoporphyrin IX-containing solutions of hemoglobin
US6242417B1 (en)	1994-03-08	2001-06-05	Somatogen, Inc.	Stabilized compositions containing hemoglobin
US5631219A (en) *	1994-03-08	1997-05-20	Somatogen, Inc.	Method of stimulating hematopoiesis with hemoglobin
US6812207B1 (en)	1995-10-23	2004-11-02	William Marsh Rice University	Hemoglobin mutants that reduce heme loss
CA2231245A1 (en) *	1995-10-23	1997-05-01	Mark S. Hargrove	Hemoglobin mutants that reduce heme loss
CA2236794A1 (en) *	1995-11-30	1997-06-05	Bruce A. Kerwin	Method for control of functionality during cross-linking of hemoglobins
EP0868521A2 (de)	1995-12-22	1998-10-07	Somatogen Inc.	Globinen mit bindenden domänen
US5861483A (en) *	1996-04-03	1999-01-19	Pro-Neuron, Inc.	Inhibitor of stem cell proliferation and uses thereof
US7494974B2 (en)	2006-10-24	2009-02-24	Ikor, Inc.	Carboxymethylated cross-linked tetrameric hemoglobin
US7504377B2 (en)	2006-10-23	2009-03-17	Ikor, Inc.	Nitric oxide-blocked cross-linked tetrameric hemoglobin

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0277289B8 (de) *	1986-11-10	2003-05-21	Biopure Corporation	Hochreines, halbsynthetisches Blutsurrogat
GB8711614D0 (en) *	1987-05-16	1987-06-24	Medical Res Council	Proteins
IE970086A1 (en) *	1989-05-10	2000-02-23	Somatogenetics Internat Inc	Production in bacteria and yeast of hemoglobin and analogues thereof

1991
- 1991-12-20 JP JP4503391A patent/JPH06504056A/ja active Pending
- 1991-12-20 CA CA002098818A patent/CA2098818A1/en not_active Abandoned
- 1991-12-20 WO PCT/US1991/009624 patent/WO1992011283A1/en not_active Ceased
- 1991-12-20 AT AT92903512T patent/ATE206760T1/de not_active IP Right Cessation
- 1991-12-20 AU AU91678/91A patent/AU668856B2/en not_active Ceased
- 1991-12-20 EP EP92903512A patent/EP0668909B1/de not_active Expired - Lifetime
- 1991-12-20 DE DE69132763T patent/DE69132763D1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0668909A4 (de)	1994-09-02
EP0668909B1 (de)	2001-10-10
DE69132763D1 (de)	2001-11-15
CA2098818A1 (en)	1992-06-21
EP0668909A1 (de)	1995-08-30
AU9167891A (en)	1992-07-22
AU668856B2 (en)	1996-05-23
JPH06504056A (ja)	1994-05-12
WO1992011283A1 (en)	1992-07-09

Legal Events

Date	Code	Title	Description
2002-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE206760T1 (de)	2001-10-15	Transgenes, vernetztes hämoglobin
IS3824A (is)	1992-09-26	Protein með bundið polyethylen og aðferð til framleiðslu þess
EP0842266A4 (de)	1999-07-21	Transgenes schwein und schweinezellen, die humane hla-gene aufweisen
ATE110276T1 (de)	1994-09-15	Blutersatz.
DK106588A (da)	1988-02-29	Peptidproduktion
DE3780293D1 (de)	1992-08-13	Herstellung von formgebend abgeschmolzenen austenitischen werkstoffbestandteilen.
DE3861987D1 (de)	1991-04-18	Thermoplastische silikonkautschukpfropfpolymerisate (ii).
ATE374525T1 (de)	2007-10-15	Transgenes fibrinogen
DE69100607D1 (de)	1993-12-16	Zusammensetzung zur Herstellung von künstlicher Milch für Kälber und daraus hergestellte künstliche Milch für Kälber.
NO885618L (no)	1989-06-19	Implantasjonsmateriale.
EP0655888A4 (de)	1997-06-11	Herstellung von humanen hämoglobin in transgenen schweinen.
DE3881533D1 (de)	1993-07-15	Tiermedizinische zusammensetzung zur verhinderung von diarrhoe bei tieren.
ATE42462T1 (de)	1989-05-15	Licht- und sonnenschutzmittel.
ATE313256T1 (de)	2006-01-15	Transgene schweine
ES2014245B3 (es)	1990-07-01	Pinza de colgar ropa en material plastico de una sola pieza.
DE68927083D1 (de)	1996-10-10	Das Protein Curuculin und Verwendung desselben
DE69210168D1 (de)	1996-05-30	Gelenkspielzeug, zum Beispiel als kleines Tier oder Puppe
DE68904336D1 (de)	1993-02-25	Anti-humankrebsproteinkomplexe, deren herstellung und verwendung.
NO870768D0 (no)	1987-02-25	Tilsetningsmiddel til dyrefor, fremgangsmaate for dets fremstilling og anvendelse i forblandinger.
NO892481D0 (no)	1989-06-15	Dyrefor og fremgangsmaate til pelletisering derav.
FI905247A0 (fi)	1990-10-24	Dietmaterial.
ATE100923T1 (de)	1994-02-15	Leuchtenraster.
DE3888045D1 (de)	1994-04-07	Chirurgisches thermoplastisches Nahtmaterial.
ATE327324T1 (de)	2006-06-15	Herstellung von protein c in transgenen tieren
ATE197528T1 (de)	2000-12-15	Einsperrgitter mit absperrungen