ATE206760T1 - Transgenes, vernetztes hämoglobin - Google Patents

Transgenes, vernetztes hämoglobin

Info

Publication number: ATE206760T1
Authority: AT; Austria
Prior art keywords: transgenic; cross; human; hemoglobins; linked hemoglobin
Prior art date: 1990-12-20

Application number

AT92903512T

Other languages

English (en)

Inventor

Tim M Townes

Steven L Mccune

Original Assignee

Univ Alabama Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-12-20

Filing date

1991-12-20

Publication date

2001-10-15

1991-12-20 Application filed by Univ Alabama Res Found filed Critical Univ Alabama Res Found

2001-10-15 Application granted granted Critical

2001-10-15 Publication of ATE206760T1 publication Critical patent/ATE206760T1/de

Links

102000001554 Hemoglobins Human genes 0.000 title abstract 4
108010054147 Hemoglobins Proteins 0.000 title abstract 4
230000009261 transgenic effect Effects 0.000 title abstract 4
INGWEZCOABYORO-UHFFFAOYSA-N 2-(furan-2-yl)-7-methyl-1h-1,8-naphthyridin-4-one Chemical compound N=1C2=NC(C)=CC=C2C(O)=CC=1C1=CC=CO1 INGWEZCOABYORO-UHFFFAOYSA-N 0.000 abstract 3
241001465754 Metazoa Species 0.000 abstract 2
239000003633 blood substitute Substances 0.000 abstract 1
210000003743 erythrocyte Anatomy 0.000 abstract 1
230000000925 erythroid effect Effects 0.000 abstract 1
230000002163 immunogen Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Biotechnology (AREA)
Zoology (AREA)
General Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Environmental Sciences (AREA)
Wood Science & Technology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Biodiversity & Conservation Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Husbandry (AREA)
Plant Pathology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Physics & Mathematics (AREA)
Hematology (AREA)
Diabetes (AREA)
General Chemical & Material Sciences (AREA)
Microbiology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT92903512T 1990-12-20 1991-12-20 Transgenes, vernetztes hämoglobin ATE206760T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US63082590A	1990-12-20	1990-12-20
PCT/US1991/009624 WO1992011283A1 (en)	1990-12-20	1991-12-20	Transgenic, cross-linked hemoglobin

Publications (1)

Publication Number	Publication Date
ATE206760T1 true ATE206760T1 (de)	2001-10-15

Family

ID=24528700

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92903512T ATE206760T1 (de)	1990-12-20	1991-12-20	Transgenes, vernetztes hämoglobin

Country Status (7)

Country	Link
EP (1)	EP0668909B1 (de)
JP (1)	JPH06504056A (de)
AT (1)	ATE206760T1 (de)
AU (1)	AU668856B2 (de)
CA (1)	CA2098818A1 (de)
DE (1)	DE69132763D1 (de)
WO (1)	WO1992011283A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6022849A (en) *	1987-05-16	2000-02-08	Baxter Biotech Technology Saarl	Mutant recombinant hemoglobins containing heme pocket mutations
US6204009B1 (en)	1988-05-16	2001-03-20	BAXTER BIOTECH TECHNOLOGY SàRL	Nucleic acids encoding mutant recombinant hemoglobins containing heme pocket mutations
US5844090A (en) *	1994-05-09	1998-12-01	Somatogen, Inc.	Modified hemoglobin-like compounds
US5545727A (en) *	1989-05-10	1996-08-13	Somatogen, Inc.	DNA encoding fused di-alpha globins and production of pseudotetrameric hemoglobin
US6150506A (en) *	1989-05-10	2000-11-21	Baxter Biotech Technology Sarl	Modified hemoglobin-like compounds and methods of purifying same
ATE225370T1 (de)	1993-03-31	2002-10-15	Pro Neuron Inc	Inhibitor der stammzellproliferation und seine verwendung
US5939391A (en) *	1993-03-31	1999-08-17	Pro-Neuron, Inc.	Hemoglobin alpha chain peptide fragments useful for inhibiting stem cell proliferation
US6610654B2 (en)	1993-03-31	2003-08-26	Wellstat Therapeutics Corporation	Inhibitor of stem cell proliferation and uses thereof
US5840851A (en) *	1993-07-23	1998-11-24	Plomer; J. Jeffrey	Purification of hemoglobin
US5578564A (en) *	1993-07-23	1996-11-26	Somatogen, Inc.	Nickel-free hemoglobin and methods for producing such hemoglobin
IS4198A (is) *	1993-08-13	1995-02-14	Somatogen, Inc	Meðferð vegna aukaverkana sem tengjast gjöf á utanfrumublóðrauða
US5665869A (en) *	1993-11-15	1997-09-09	Somatogen, Inc.	Method for the rapid removal of protoporphyrin from protoporphyrin IX-containing solutions of hemoglobin
US5631219A (en) *	1994-03-08	1997-05-20	Somatogen, Inc.	Method of stimulating hematopoiesis with hemoglobin
US6242417B1 (en)	1994-03-08	2001-06-05	Somatogen, Inc.	Stabilized compositions containing hemoglobin
JPH11514237A (ja) *	1995-10-23	1999-12-07	ライスユニバーシティ	ヘム損失を減少させるヘモグロビン変異体
US6812207B1 (en)	1995-10-23	2004-11-02	William Marsh Rice University	Hemoglobin mutants that reduce heme loss
JP2000502058A (ja) *	1995-11-30	2000-02-22	ソマトジェン，インコーポレイテッド	ヘモグロビン架橋の際の機能性制御のための方法
US6218513B1 (en)	1995-12-22	2001-04-17	Baxter Biotech Technology Sarl	Globins containing binding domains
US5861483A (en)	1996-04-03	1999-01-19	Pro-Neuron, Inc.	Inhibitor of stem cell proliferation and uses thereof
US7504377B2 (en)	2006-10-23	2009-03-17	Ikor, Inc.	Nitric oxide-blocked cross-linked tetrameric hemoglobin
US7494974B2 (en)	2006-10-24	2009-02-24	Ikor, Inc.	Carboxymethylated cross-linked tetrameric hemoglobin

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2962731B2 (ja) *	1986-11-10	1999-10-12	バイオピュアー、コーポレーション	超純枠半合成代用血液
GB8711614D0 (en) *	1987-05-16	1987-06-24	Medical Res Council	Proteins
CA2050601C (en) *	1989-05-10	2000-09-19	Stephen J. Hoffman	Production in bacteria and yeast of hemoglobin and analogues thereof

1991
- 1991-12-20 JP JP4503391A patent/JPH06504056A/ja active Pending
- 1991-12-20 AU AU91678/91A patent/AU668856B2/en not_active Ceased
- 1991-12-20 DE DE69132763T patent/DE69132763D1/de not_active Expired - Lifetime
- 1991-12-20 AT AT92903512T patent/ATE206760T1/de not_active IP Right Cessation
- 1991-12-20 EP EP92903512A patent/EP0668909B1/de not_active Expired - Lifetime
- 1991-12-20 CA CA002098818A patent/CA2098818A1/en not_active Abandoned
- 1991-12-20 WO PCT/US1991/009624 patent/WO1992011283A1/en not_active Ceased

Also Published As

Publication number	Publication date
EP0668909A1 (de)	1995-08-30
EP0668909B1 (de)	2001-10-10
AU9167891A (en)	1992-07-22
WO1992011283A1 (en)	1992-07-09
DE69132763D1 (de)	2001-11-15
EP0668909A4 (de)	1994-09-02
CA2098818A1 (en)	1992-06-21
AU668856B2 (en)	1996-05-23
JPH06504056A (ja)	1994-05-12

Legal Events

Date	Code	Title	Description
2002-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE206760T1 (de)	2001-10-15	Transgenes, vernetztes hämoglobin
EP0842266A4 (de)	1999-07-21	Transgenes schwein und schweinezellen, die humane hla-gene aufweisen
DK0510356T3 (da)	1999-09-13	Polyethylenglycolproteinkonjugater
DE3780293D1 (de)	1992-08-13	Herstellung von formgebend abgeschmolzenen austenitischen werkstoffbestandteilen.
DK0744891T3 (da)	2008-02-04	Transgene fibrinogener
DE69100607D1 (de)	1993-12-16	Zusammensetzung zur Herstellung von künstlicher Milch für Kälber und daraus hergestellte künstliche Milch für Kälber.
EP0655888A4 (de)	1997-06-11	Herstellung von humanen hämoglobin in transgenen schweinen.
DE3860646D1 (de)	1990-10-25	Thermoplastische siliconkautschukpfropfpolymerisate (i).
DE3881533D1 (de)	1993-07-15	Tiermedizinische zusammensetzung zur verhinderung von diarrhoe bei tieren.
ATE313256T1 (de)	2006-01-15	Transgene schweine
ES2014245B3 (es)	1990-07-01	Pinza de colgar ropa en material plastico de una sola pieza.
ATE142228T1 (de)	1996-09-15	Das protein curuculin und verwendung desselben
DE69210168D1 (de)	1996-05-30	Gelenkspielzeug, zum Beispiel als kleines Tier oder Puppe
DE68904336D1 (de)	1993-02-25	Anti-humankrebsproteinkomplexe, deren herstellung und verwendung.
SE9302169D0 (sv)	1993-06-23	Stoedanordning foer haest
NO870768D0 (no)	1987-02-25	Tilsetningsmiddel til dyrefor, fremgangsmaate for dets fremstilling og anvendelse i forblandinger.
NO892481D0 (no)	1989-06-15	Dyrefor og fremgangsmaate til pelletisering derav.
FI964917A7 (fi)	1996-12-09	Sellaisen hemoglobiinin tuottaminen, jossa on alfa:n kaltainen globiin i
FI905247A0 (fi)	1990-10-24	Dietmaterial.
ATE100923T1 (de)	1994-02-15	Leuchtenraster.
DE3888045D1 (de)	1994-04-07	Chirurgisches thermoplastisches Nahtmaterial.
DE69636172D1 (de)	2006-06-29	Herstellung von protein c in transgenen tieren
ATE197528T1 (de)	2000-12-15	Einsperrgitter mit absperrungen
Yoon et al.	1999	Major Hemolymph Proteins and Vitellogenin in Mulberry Longicorn Beetle, Apriona germari Hope
RU93037923A (ru)	1995-01-20	Способ отбора овец романовской породы, устойчивых к аденоматозу