ATE207064T1 - Benzodiazepinderivate - Google Patents

Benzodiazepinderivate

Info

Publication number: ATE207064T1
Authority: AT; Austria
Prior art keywords: 6alkyl; optionally substituted; pct; azacyclic; azabicyclic
Prior art date: 1992-07-29

Application number

AT93917939T

Other languages

English (en)

Inventor

Pineiro Jose Luis Castro

William Robert Carling

Mark Stuart Chambers

Stephen Robert Fletcher

Sarah Christine Hobbs

Victor Giulio Matassa

Kevin William Moore

Graham Andrew Showell

Michael Geoffrey Russel

Original Assignee

Merck Sharp & Dohme

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-07-29

Filing date

1993-07-28

Publication date

2001-11-15

1992-07-29 Priority claimed from GB929216123A external-priority patent/GB9216123D0/en

1992-07-30 Priority claimed from GB929216231A external-priority patent/GB9216231D0/en

1992-07-30 Priority claimed from GB929216238A external-priority patent/GB9216238D0/en

1992-10-06 Priority claimed from GB929220957A external-priority patent/GB9220957D0/en

1992-10-30 Priority claimed from GB929222821A external-priority patent/GB9222821D0/en

1992-11-02 Priority claimed from GB929222934A external-priority patent/GB9222934D0/en

1992-11-11 Priority claimed from GB929223583A external-priority patent/GB9223583D0/en

1992-12-16 Priority claimed from GB929226242A external-priority patent/GB9226242D0/en

1992-12-17 Priority claimed from GB929226360A external-priority patent/GB9226360D0/en

1993-01-22 Priority claimed from GB939301277A external-priority patent/GB9301277D0/en

1993-04-07 Priority claimed from GB939307318A external-priority patent/GB9307318D0/en

1993-07-28 Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme

2001-11-15 Publication of ATE207064T1 publication Critical patent/ATE207064T1/de

2001-11-15 Application granted granted Critical

Links

229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 title 1
150000001557 benzodiazepines Chemical class 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
125000001475 halogen functional group Chemical group 0.000 abstract 2
125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
101100240518 Caenorhabditis elegans nhr-12 gene Proteins 0.000 abstract 1
102100021022 Gastrin Human genes 0.000 abstract 1
108010052343 Gastrins Proteins 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/24—Camphidines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Toxicology (AREA)
Psychology (AREA)
Addiction (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Absorbent Articles And Supports Therefor (AREA)

AT93917939T 1992-07-29 1993-07-28 Benzodiazepinderivate ATE207064T1 (de)

Applications Claiming Priority (12)

Application Number	Priority Date	Filing Date	Title
GB929216123A GB9216123D0 (en)	1992-07-29	1992-07-29	Therapeutic agents
GB929216238A GB9216238D0 (en)	1992-07-30	1992-07-30	Therapeutic agents
GB929216231A GB9216231D0 (en)	1992-07-30	1992-07-30	Therapeutic agents
GB929220957A GB9220957D0 (en)	1992-10-06	1992-10-06	Therapeutic agents
GB929222821A GB9222821D0 (en)	1992-10-30	1992-10-30	Therapeutic agents
GB929222934A GB9222934D0 (en)	1992-11-02	1992-11-02	Therapeutic compounds
GB929223583A GB9223583D0 (en)	1992-11-11	1992-11-11	Therapeutic agents
GB929226242A GB9226242D0 (en)	1992-12-16	1992-12-16	Therapeutic agents
GB929226360A GB9226360D0 (en)	1992-12-17	1992-12-17	Therapeutic agents
GB939301277A GB9301277D0 (en)	1993-01-22	1993-01-22	Therapeutic agents
GB939307318A GB9307318D0 (en)	1993-04-07	1993-04-07	Therapeutic agents
PCT/GB1993/001599 WO1994003437A1 (en)	1992-07-29	1993-07-28	Benzodiazepine derivatives

Publications (1)

Publication Number	Publication Date
ATE207064T1 true ATE207064T1 (de)	2001-11-15

Family

ID=27581673

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93917939T ATE207064T1 (de)	1992-07-29	1993-07-28	Benzodiazepinderivate

Country Status (13)

Country	Link
US (1)	US5618812A (de)
EP (1)	EP0652871B1 (de)
JP (1)	JP3457312B2 (de)
AT (1)	ATE207064T1 (de)
AU (1)	AU671477B2 (de)
CA (1)	CA2140009A1 (de)
DE (1)	DE69330959T2 (de)
DK (1)	DK0652871T3 (de)
ES (1)	ES2163410T3 (de)
GR (1)	GR3036924T3 (de)
LV (1)	LV12956B (de)
PT (1)	PT652871E (de)
WO (1)	WO1994003437A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH08505120A (ja) *	1992-07-29	1996-06-04	メルクシヤープエンドドームリミテツド	ベンゾジアゼピン誘導体
US5739129A (en) *	1994-04-14	1998-04-14	Glaxo Wellcome Inc.	CCK or gastrin modulating 5-heterocyclic-1, 5 benzodiazepines
US5750353A (en) *	1995-12-11	1998-05-12	New England Medical Center Hospitals, Inc.	Assay for non-peptide agonists to peptide hormone receptors
JP4442930B2 (ja)	1995-12-11	2010-03-31	タフツメディカルセンターインコーポレイテッド	ペプチドホルモンレセプターリガンドに関するアッセイ法およびその使用
US5852010A (en) *	1996-04-03	1998-12-22	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
US5929071A (en) *	1996-07-02	1999-07-27	Merck & Co., Inc.	Method for the treatment of preterm labor
AU3591697A (en) *	1996-07-02	1998-01-21	Merck & Co., Inc.	Method for the treatment of preterm labor
US6100254A (en) *	1997-10-10	2000-08-08	Board Of Regents, The University Of Texas System	Inhibitors of protein tyrosine kinases
US6569851B1 (en) *	1998-06-22	2003-05-27	Elan Pharmaceutials, Inc.	Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
NZ509241A (en)	1998-08-07	2003-08-29	Du Pont Pharm Co	Succinoylamino lactams as inhibitors of alpha-beta protein production
HRP990246A2 (en)	1998-08-07	2000-06-30	Du Pont Pharm Co	Succinoylamino benzodiazepines as inhibitors of a beta protein production
JP4615727B2 (ja)	1998-12-24	2011-01-19	ブリストル−マイヤーズスクイブファーマカンパニー	Ａβタンパク質生成の阻害剤としてのスクシノイルアミノベンゾジアゼピン
US6503902B2 (en)	1999-09-13	2003-01-07	Bristol-Myers Squibb Pharma Company	Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production
US6960576B2 (en) *	1999-09-13	2005-11-01	Bristol-Myers Squibb Pharma Company	Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production
EP1222176A1 (de)	1999-10-08	2002-07-17	Bristol-Myers Squibb Pharma Company	Amino-laktam-sulfonamide als inhibitoren der bildung von a-beta-protein
ATE261945T1 (de)	1999-10-15	2004-04-15	Hoffmann La Roche	Benzodiazepinderivate und deren verwendung als metabotrope glutamatrezeptor antagonisten
US6525044B2 (en)	2000-02-17	2003-02-25	Bristol-Myers Squibb Company	Succinoylamino carbocycles and heterocycles as inhibitors of a-β protein production
MXPA02009729A (es)	2000-04-03	2003-03-27	Bristol Myers Squibb Pharma Co	Lactamas ciclicas como inhibidores de la produccion de la proteina a-beta.
AU2001253090A1 (en)	2000-04-03	2001-10-15	Bristol-Myers Squibb Pharma Company	Cyclic lactams as inhibitors of abeta protein production
US20100009966A1 (en) *	2001-04-11	2010-01-14	Bristol-Myers Squibb Pharma Company	Substituted lactams as inhibitors of abeta protein production
US6632812B2 (en) *	2000-04-11	2003-10-14	Dupont Pharmaceuticals Company	Substituted lactams as inhibitors of Aβ protein production
AU2001261728A1 (en) *	2000-05-17	2001-11-26	Bristol-Myers Squibb Pharma Company	Use of small molecule radioligands for diagnostic imaging
CA2379445C (en)	2000-06-01	2007-08-21	Bristol-Myers Squibb Pharma Company	Lactams substituted by cyclic succinates as inhibitors of a.beta. protein production
WO2002016407A2 (en) *	2000-08-22	2002-02-28	The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services	Sh2 domain binding inhibitors
US20090062256A1 (en) *	2001-06-01	2009-03-05	Bristol-Myers Squibb Pharma Company	LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Abeta PROTEIN PRODUCTION
US6974869B2 (en) *	2001-09-18	2005-12-13	Bristol-Myers Squibb Pharma Company	Piperizinones as modulators of chemokine receptor activity
DE10163595A1 (de) *	2001-12-21	2003-08-07	Gruenenthal Gmbh	In 3-Position heterocyclisch substituierte Piperidin-2,6-dione
US7845356B2 (en) *	2002-09-06	2010-12-07	Koninklijke Philips Electronics N.V.	Implantable devices, systems, and methods for maintaining desired orientations in targeted tissue regions
US20050192265A1 (en) *	2003-03-20	2005-09-01	Thompson Richard C.	Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
KR101155335B1 (ko) *	2005-01-07	2012-06-11	엘지전자 주식회사	이동통신 단말기의 멀티미디어 메시지 동작방법
US7642302B2 (en) *	2005-12-29	2010-01-05	Firestone Polymers, Llc	Modified asphalt binders and asphalt paving compositions
US7781503B2 (en) *	2005-12-29	2010-08-24	Firestone Polymers, Llc	Modified asphalt binders and asphalt paving compositions
BRPI0810655A2 (pt)	2007-04-19	2014-11-04	Hoffmann La Roche	Derivados de di-hidro-benzo[b][1,4] diazepin-2-ona sulfonamida
KR20100017766A (ko) *	2007-05-10	2010-02-16	에이엠알 테크놀로지, 인크.	아릴- 및 헤테로아릴-치환된 테트라히드로벤조-1,4-디아제핀 및 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 이의 용도

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2032226A1 (en) *	1989-12-18	1991-06-19	Mark G. Bock	Benzodiazepine analogs
IL96613A0 (en) *	1989-12-18	1991-09-16	Merck & Co Inc	Pharmaceutical compositions containing benzodiazepine analogs
JPH07500589A (ja) *	1991-10-24	1995-01-19	メルク　シヤープ　エンド　ドーム　リミテツド	ベンゾジアゼピン誘導体、並びにコレシストキニン及び／又はガストリンレセプターのアンタゴニストとしての該誘導体の使用
CA2083891A1 (en) *	1991-12-03	1993-06-04	Angus Murray Macleod	Heterocyclic compounds, compositions containing them and their use in therapy
JPH07507993A (ja) *	1991-12-20	1995-09-07	メルク　シヤープ　エンド　ドーム　リミテツド	医薬活性を有する中枢神経系コレシストキニンアンタゴニスト
GB9209518D0 (en) *	1992-05-01	1992-06-17	Merck Sharp & Dohme	Therapeutic agents
US5360802A (en) *	1992-05-11	1994-11-01	Merck Sharpe & Dohme Ltd.	Benzodiazepine derivatives, compositions containing them and their use in therapy
JPH08505120A (ja) *	1992-07-29	1996-06-04	メルクシヤープエンドドームリミテツド	ベンゾジアゼピン誘導体

1993
- 1993-07-28 AU AU47178/93A patent/AU671477B2/en not_active Ceased
- 1993-07-28 DE DE69330959T patent/DE69330959T2/de not_active Expired - Fee Related
- 1993-07-28 PT PT93917939T patent/PT652871E/pt unknown
- 1993-07-28 DK DK93917939T patent/DK0652871T3/da active
- 1993-07-28 AT AT93917939T patent/ATE207064T1/de not_active IP Right Cessation
- 1993-07-28 WO PCT/GB1993/001599 patent/WO1994003437A1/en not_active Ceased
- 1993-07-28 US US08/374,748 patent/US5618812A/en not_active Expired - Fee Related
- 1993-07-28 JP JP50508994A patent/JP3457312B2/ja not_active Expired - Fee Related
- 1993-07-28 ES ES93917939T patent/ES2163410T3/es not_active Expired - Lifetime
- 1993-07-28 CA CA002140009A patent/CA2140009A1/en not_active Abandoned
- 1993-07-28 EP EP93917939A patent/EP0652871B1/de not_active Expired - Lifetime
2001
- 2001-10-18 GR GR20010401745T patent/GR3036924T3/el not_active IP Right Cessation
2002
- 2002-10-16 LV LVP-02-185A patent/LV12956B/en unknown

Also Published As

Publication number	Publication date
WO1994003437A1 (en)	1994-02-17
EP0652871A1 (de)	1995-05-17
LV12956B (en)	2003-06-20
JP3457312B2 (ja)	2003-10-14
US5618812A (en)	1997-04-08
AU671477B2 (en)	1996-08-29
DK0652871T3 (da)	2001-12-03
EP0652871B1 (de)	2001-10-17
DE69330959T2 (de)	2002-04-11
AU4717893A (en)	1994-03-03
DE69330959D1 (de)	2001-11-22
JPH07509482A (ja)	1995-10-19
PT652871E (pt)	2002-03-28
CA2140009A1 (en)	1994-02-17
GR3036924T3 (en)	2002-01-31
ES2163410T3 (es)	2002-02-01

Legal Events

Date	Code	Title	Description
2002-02-15	UEP	Publication of translation of european patent specification
2006-04-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE207064T1 (de)	2001-11-15	Benzodiazepinderivate
ATE204269T1 (de)	2001-09-15	Substituierte biphenyl- oder phenylpyridinderivate, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen
DE69327541D1 (en)	2000-02-10	4-arylmethyloxymethyl piperidine als tachykinin antagonisten
ATE235470T1 (de)	2003-04-15	Gastrin- und cck-antagonisten
NO940927D0 (no)	1994-03-15	Kondenserte tricykliske nitrogenholdige heterocykler som substans-P-reseptor-antagonister
FR2619111B1 (fr)	1991-01-11	Derives de (piperidinyl-4)methyl-2 tetrahydro-1,2,3,4 9h-pyrido (3,4-b) indole, leur preparation et leur application en therapeutique
TW342385B (en)	1998-10-11	Bicyclic benzazepin, the process for their preparation and the pharmaceutical composition containing them
ES2123756T3 (es)	1999-01-16	Derivados de piperazina.
GB9426090D0 (en)	1995-02-22	Pharmaceutical compounds
ES2063381T3 (es)	1995-01-01	Antagonistas de los receptores muscarinicos.
PT813411E (pt)	2002-07-31	Utilizacao de derivados de vinpocetina para inibicao da producao ou da secrecao de proteina amiloide beta
AU6531296A (en)	1997-02-26	Benzocycloalkene compounds with melatonine receptor binding affinity, their production and use
IL112588A0 (en)	1995-05-26	Imidazo [1,2-a] quinoxalinone derivatives, their preparation and pharmaceutical compositions containing them
DK32287A (da)	1987-07-23	3-acylaminomethyl-imidazo(1,2-a)pyridinderivater, fremgangsmaade til fremstilling deraf samt laegemiddel indeholdende saadanne derivater
DK0625982T3 (da)	2002-09-30	4-Oxo- og 4H-imidazo(5,1-c)(1,4)benzoxaziner anvendelige som benzodiazepinreceptor-bindemidler
DE69403896D1 (de)	1997-07-24	4-amino-2-(hetero)aryl-butanamide verwenbar als 5-ht1a-antagonisten
DK0877612T3 (da)	2000-10-09	Anvendelse af piperazinderivater til behandling af cognitive forstyrrelser
DK0599732T3 (da)	1997-09-22	1-phenylbicyklo 2.2.2 octanderivater, fremgangsmåde til fremstilling heraf og farmaceutiske midler, som indeholder dem.
FR2695643B1 (fr)	1994-11-25	Dérivés d'uréido-acétamide, leur préparation et les médicaments les contenant.
ATE89551T1 (de)	1993-06-15	Verfahren zur herstellung von optisch aktiven acyloxyazetidinonen.
SE8106573L (sv)	1983-03-25	Fenylsubstituerade pyrido(1,4)bensodiazepiner samt mellanprodukter vid framstellning av dessa