ATE207064T1 - Benzodiazepinderivate - Google Patents

Benzodiazepinderivate

Info

Publication number: ATE207064T1
Authority: AT; Austria
Prior art keywords: 6alkyl; optionally substituted; pct; azacyclic; azabicyclic
Prior art date: 1992-07-29

Application number

AT93917939T

Other languages

English (en)

Inventor

Pineiro Jose Luis Castro

William Robert Carling

Mark Stuart Chambers

Stephen Robert Fletcher

Sarah Christine Hobbs

Victor Giulio Matassa

Kevin William Moore

Graham Andrew Showell

Michael Geoffrey Russel

Original Assignee

Merck Sharp & Dohme

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-07-29

Filing date

1993-07-28

Publication date

2001-11-15

1992-07-29 Priority claimed from GB929216123A external-priority patent/GB9216123D0/en

1992-07-30 Priority claimed from GB929216231A external-priority patent/GB9216231D0/en

1992-07-30 Priority claimed from GB929216238A external-priority patent/GB9216238D0/en

1992-10-06 Priority claimed from GB929220957A external-priority patent/GB9220957D0/en

1992-10-30 Priority claimed from GB929222821A external-priority patent/GB9222821D0/en

1992-11-02 Priority claimed from GB929222934A external-priority patent/GB9222934D0/en

1992-11-11 Priority claimed from GB929223583A external-priority patent/GB9223583D0/en

1992-12-16 Priority claimed from GB929226242A external-priority patent/GB9226242D0/en

1992-12-17 Priority claimed from GB929226360A external-priority patent/GB9226360D0/en

1993-01-22 Priority claimed from GB939301277A external-priority patent/GB9301277D0/en

1993-04-07 Priority claimed from GB939307318A external-priority patent/GB9307318D0/en

1993-07-28 Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme

2001-11-15 Publication of ATE207064T1 publication Critical patent/ATE207064T1/de

2001-11-15 Application granted granted Critical

Links

229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 title 1
150000001557 benzodiazepines Chemical class 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
125000001475 halogen functional group Chemical group 0.000 abstract 2
125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
101100240518 Caenorhabditis elegans nhr-12 gene Proteins 0.000 abstract 1
102100021022 Gastrin Human genes 0.000 abstract 1
108010052343 Gastrins Proteins 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/24—Camphidines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Ophthalmology & Optometry (AREA)
Toxicology (AREA)
Addiction (AREA)
Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Absorbent Articles And Supports Therefor (AREA)

AT93917939T 1992-07-29 1993-07-28 Benzodiazepinderivate ATE207064T1 (de)

Applications Claiming Priority (12)

Application Number	Priority Date	Filing Date	Title
GB929216123A GB9216123D0 (en)	1992-07-29	1992-07-29	Therapeutic agents
GB929216238A GB9216238D0 (en)	1992-07-30	1992-07-30	Therapeutic agents
GB929216231A GB9216231D0 (en)	1992-07-30	1992-07-30	Therapeutic agents
GB929220957A GB9220957D0 (en)	1992-10-06	1992-10-06	Therapeutic agents
GB929222821A GB9222821D0 (en)	1992-10-30	1992-10-30	Therapeutic agents
GB929222934A GB9222934D0 (en)	1992-11-02	1992-11-02	Therapeutic compounds
GB929223583A GB9223583D0 (en)	1992-11-11	1992-11-11	Therapeutic agents
GB929226242A GB9226242D0 (en)	1992-12-16	1992-12-16	Therapeutic agents
GB929226360A GB9226360D0 (en)	1992-12-17	1992-12-17	Therapeutic agents
GB939301277A GB9301277D0 (en)	1993-01-22	1993-01-22	Therapeutic agents
GB939307318A GB9307318D0 (en)	1993-04-07	1993-04-07	Therapeutic agents
PCT/GB1993/001599 WO1994003437A1 (en)	1992-07-29	1993-07-28	Benzodiazepine derivatives

Publications (1)

Publication Number	Publication Date
ATE207064T1 true ATE207064T1 (de)	2001-11-15

Family

ID=27581673

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93917939T ATE207064T1 (de)	1992-07-29	1993-07-28	Benzodiazepinderivate

Country Status (13)

Country	Link
US (1)	US5618812A (de)
EP (1)	EP0652871B1 (de)
JP (1)	JP3457312B2 (de)
AT (1)	ATE207064T1 (de)
AU (1)	AU671477B2 (de)
CA (1)	CA2140009A1 (de)
DE (1)	DE69330959T2 (de)
DK (1)	DK0652871T3 (de)
ES (1)	ES2163410T3 (de)
GR (1)	GR3036924T3 (de)
LV (1)	LV12956B (de)
PT (1)	PT652871E (de)
WO (1)	WO1994003437A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
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JPH08505120A (ja) *	1992-07-29	1996-06-04	メルクシヤープエンドドームリミテツド	ベンゾジアゼピン誘導体
US5739129A (en) *	1994-04-14	1998-04-14	Glaxo Wellcome Inc.	CCK or gastrin modulating 5-heterocyclic-1, 5 benzodiazepines
JP4442930B2 (ja)	1995-12-11	2010-03-31	タフツメディカルセンターインコーポレイテッド	ペプチドホルモンレセプターリガンドに関するアッセイ法およびその使用
US5750353A (en) *	1995-12-11	1998-05-12	New England Medical Center Hospitals, Inc.	Assay for non-peptide agonists to peptide hormone receptors
US5852010A (en) *	1996-04-03	1998-12-22	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
US5929071A (en) *	1996-07-02	1999-07-27	Merck & Co., Inc.	Method for the treatment of preterm labor
WO1998000406A1 (en) *	1996-07-02	1998-01-08	Merck & Co., Inc.	Method for the treatment of preterm labor
US6100254A (en) *	1997-10-10	2000-08-08	Board Of Regents, The University Of Texas System	Inhibitors of protein tyrosine kinases
US6569851B1 (en) *	1998-06-22	2003-05-27	Elan Pharmaceutials, Inc.	Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
NZ525513A (en)	1998-08-07	2004-09-24	Pont Pharmaceuticals Du	Succinoylamino lactams as inhibitors of Abeta protein production
HRP990246A2 (en)	1998-08-07	2000-06-30	Du Pont Pharm Co	Succinoylamino benzodiazepines as inhibitors of a beta protein production
WO2000038618A2 (en) *	1998-12-24	2000-07-06	Du Pont Pharmaceuticals Company	SUCCINOYLAMINO BENZODIAZEPINES AS INHIBITORS OF Aβ PROTEIN PRODUCTION
US6503902B2 (en)	1999-09-13	2003-01-07	Bristol-Myers Squibb Pharma Company	Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production
US6960576B2 (en) *	1999-09-13	2005-11-01	Bristol-Myers Squibb Pharma Company	Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production
EP1222176A1 (de)	1999-10-08	2002-07-17	Bristol-Myers Squibb Pharma Company	Amino-laktam-sulfonamide als inhibitoren der bildung von a-beta-protein
ATE261945T1 (de)	1999-10-15	2004-04-15	Hoffmann La Roche	Benzodiazepinderivate und deren verwendung als metabotrope glutamatrezeptor antagonisten
CA2395862A1 (en)	2000-02-17	2001-08-23	Hong Liu	Succinoylamino carbocycles and heterocycles as inhibitors of a.beta. protein production
EP1268434A1 (de)	2000-04-03	2003-01-02	Bristol-Myers Squibb Pharma Company	Zyklische lactame als a-beta proteinproduktionsinhibitoren
CN1436175A (zh)	2000-04-03	2003-08-13	布里斯托尔-迈尔斯斯奎布药品公司	作为Aβ－蛋白生产抑制剂的环状内酰胺
WO2001077086A1 (en) *	2000-04-11	2001-10-18	Dupont Pharmaceuticals Company	SUBSTITUTED LACTAMS AS INHIBITORS OF Aβ PROTEIN PRODUCTION
US20100009966A1 (en) *	2001-04-11	2010-01-14	Bristol-Myers Squibb Pharma Company	Substituted lactams as inhibitors of abeta protein production
US6878363B2 (en) *	2000-05-17	2005-04-12	Bristol-Myers Squibb Pharma Company	Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging
CN1386118A (zh)	2000-06-01	2002-12-18	布里斯托尔-迈尔斯斯奎布药品公司	作为Aβ蛋白产生抑制剂的被环状琥珀酸酯取代的内酰胺类化合物
US6977241B2 (en) *	2000-08-22	2005-12-20	The United States Of America As Represented By The Department Of Health & Human Services	SH2 domain binding inhibitors
US20090062256A1 (en) *	2001-06-01	2009-03-05	Bristol-Myers Squibb Pharma Company	LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Abeta PROTEIN PRODUCTION
WO2003024401A2 (en) *	2001-09-18	2003-03-27	Bristol-Myers Squibb Company	Piperizinones as modulators of chemokine receptor activity
DE10163595A1 (de) *	2001-12-21	2003-08-07	Gruenenthal Gmbh	In 3-Position heterocyclisch substituierte Piperidin-2,6-dione
US7845356B2 (en) *	2002-09-06	2010-12-07	Koninklijke Philips Electronics N.V.	Implantable devices, systems, and methods for maintaining desired orientations in targeted tissue regions
US20050192265A1 (en) *	2003-03-20	2005-09-01	Thompson Richard C.	Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
KR101155335B1 (ko) *	2005-01-07	2012-06-11	엘지전자 주식회사	이동통신 단말기의 멀티미디어 메시지 동작방법
US7781503B2 (en) *	2005-12-29	2010-08-24	Firestone Polymers, Llc	Modified asphalt binders and asphalt paving compositions
US7642302B2 (en) *	2005-12-29	2010-01-05	Firestone Polymers, Llc	Modified asphalt binders and asphalt paving compositions
ES2369866T3 (es)	2007-04-19	2011-12-07	F. Hoffmann-La Roche Ag	Derivados de dihidro-benzo[b][1,4]diazepin-2-ona-sulfonamida.
JP2010526825A (ja) *	2007-05-10	2010-08-05	エーエムアールテクノロジーインコーポレイテッド	アリール置換およびヘテロアリール置換テトラヒドロベンゾ−１，４−ジアゼピンならびにノルエピネフリン、ドーパミンおよびセロトニンの再取り込みを遮断するためのその使用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2032226A1 (en) *	1989-12-18	1991-06-19	Mark G. Bock	Benzodiazepine analogs
IL96613A0 (en) *	1989-12-18	1991-09-16	Merck & Co Inc	Pharmaceutical compositions containing benzodiazepine analogs
EP0609306A1 (de) *	1991-10-24	1994-08-10	MERCK SHARP & DOHME LTD.	Benzodiazepinderivate und ihre verwendung als antagonisten von cholecystokinin und/oder gastrin rezeptoren
CA2083891A1 (en) *	1991-12-03	1993-06-04	Angus Murray Macleod	Heterocyclic compounds, compositions containing them and their use in therapy
WO1993012791A1 (en) *	1991-12-20	1993-07-08	Merck Sharp & Dohme Limited	Central cholecystokinin antagonists having pharmaceutical activity
GB9209518D0 (en) *	1992-05-01	1992-06-17	Merck Sharp & Dohme	Therapeutic agents
US5360802A (en) *	1992-05-11	1994-11-01	Merck Sharpe & Dohme Ltd.	Benzodiazepine derivatives, compositions containing them and their use in therapy
JPH08505120A (ja) *	1992-07-29	1996-06-04	メルクシヤープエンドドームリミテツド	ベンゾジアゼピン誘導体

1993
- 1993-07-28 EP EP93917939A patent/EP0652871B1/de not_active Expired - Lifetime
- 1993-07-28 AT AT93917939T patent/ATE207064T1/de not_active IP Right Cessation
- 1993-07-28 DK DK93917939T patent/DK0652871T3/da active
- 1993-07-28 ES ES93917939T patent/ES2163410T3/es not_active Expired - Lifetime
- 1993-07-28 WO PCT/GB1993/001599 patent/WO1994003437A1/en not_active Ceased
- 1993-07-28 JP JP50508994A patent/JP3457312B2/ja not_active Expired - Fee Related
- 1993-07-28 PT PT93917939T patent/PT652871E/pt unknown
- 1993-07-28 CA CA002140009A patent/CA2140009A1/en not_active Abandoned
- 1993-07-28 AU AU47178/93A patent/AU671477B2/en not_active Ceased
- 1993-07-28 US US08/374,748 patent/US5618812A/en not_active Expired - Fee Related
- 1993-07-28 DE DE69330959T patent/DE69330959T2/de not_active Expired - Fee Related
2001
- 2001-10-18 GR GR20010401745T patent/GR3036924T3/el not_active IP Right Cessation
2002
- 2002-10-16 LV LVP-02-185A patent/LV12956B/en unknown

Also Published As

Publication number	Publication date
CA2140009A1 (en)	1994-02-17
ES2163410T3 (es)	2002-02-01
US5618812A (en)	1997-04-08
JP3457312B2 (ja)	2003-10-14
AU671477B2 (en)	1996-08-29
WO1994003437A1 (en)	1994-02-17
DK0652871T3 (da)	2001-12-03
EP0652871B1 (de)	2001-10-17
GR3036924T3 (en)	2002-01-31
JPH07509482A (ja)	1995-10-19
DE69330959D1 (de)	2001-11-22
LV12956B (en)	2003-06-20
EP0652871A1 (de)	1995-05-17
AU4717893A (en)	1994-03-03
PT652871E (pt)	2002-03-28
DE69330959T2 (de)	2002-04-11

Legal Events

Date	Code	Title	Description
2002-02-15	UEP	Publication of translation of european patent specification
2006-04-15	REN	Ceased due to non-payment of the annual fee

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DK0877612T3 (da)	2000-10-09	Anvendelse af piperazinderivater til behandling af cognitive forstyrrelser
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FR2695643B1 (fr)	1994-11-25	Dérivés d'uréido-acétamide, leur préparation et les médicaments les contenant.
ATE89551T1 (de)	1993-06-15	Verfahren zur herstellung von optisch aktiven acyloxyazetidinonen.
SE8600688L (sv)	1986-02-17	Fenylsubstituerade pyrido/1,4/bensodiazepiner samt mellanprodukter vid framstellningen av dessa