ATE207922T1 - Carbapenem-derivate - Google Patents
Carbapenem-derivateInfo
- Publication number
- ATE207922T1 ATE207922T1 AT95909978T AT95909978T ATE207922T1 AT E207922 T1 ATE207922 T1 AT E207922T1 AT 95909978 T AT95909978 T AT 95909978T AT 95909978 T AT95909978 T AT 95909978T AT E207922 T1 ATE207922 T1 AT E207922T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- substituted
- lower alkyl
- alkyl group
- single bond
- Prior art date
Links
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical class C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000005153 alkyl sulfamoyl group Chemical group 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- -1 pyridinio group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000001422 pyrrolinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5268694 | 1994-02-25 | ||
| JP6460694 | 1994-03-08 | ||
| JP10756894 | 1994-04-22 | ||
| JP11028994 | 1994-04-26 | ||
| JP11428894 | 1994-04-28 | ||
| PCT/JP1995/000280 WO1995023150A1 (en) | 1994-02-25 | 1995-02-24 | Carbapenem derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE207922T1 true ATE207922T1 (de) | 2001-11-15 |
Family
ID=27523026
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95909978T ATE207922T1 (de) | 1994-02-25 | 1995-02-24 | Carbapenem-derivate |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5707987A (de) |
| EP (1) | EP0747381B1 (de) |
| JP (1) | JP4182545B2 (de) |
| AT (1) | ATE207922T1 (de) |
| AU (1) | AU680736B2 (de) |
| CA (1) | CA2184101C (de) |
| DE (1) | DE69523574T2 (de) |
| WO (1) | WO1995023150A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1682599A (en) * | 1997-12-16 | 1999-07-05 | Banyu Pharmaceutical Co., Ltd. | Carbapenem derivatives |
| BR0112655A (pt) | 2000-07-19 | 2003-06-24 | Hoffmann La Roche | Derivados de pirrolidino como inibidores de metaloproteases |
| ATE486842T1 (de) * | 2002-03-12 | 2010-11-15 | Merck Sharp & Dohme | Substituierte amide |
| MY133587A (en) | 2002-05-29 | 2007-11-30 | Glaxo Group Ltd | Aromatic sulfones and their medical use |
| AU2003291227A1 (en) | 2002-11-05 | 2004-06-07 | Smithkline Beecham Corporation | Antibacterial agents |
| EP1698621A4 (de) * | 2003-12-26 | 2008-11-19 | Daiichi Seiyaku Co | Verfahren zur herstellung eines pyrrolidinderivats |
| DK2666481T3 (en) | 2003-12-26 | 2019-02-25 | Masatoshi Hagiwara | A method for regulating the phosphorylation of SR protein and antiviral agents comprising an SR protein activity regulator as the active ingredient |
| KR100599876B1 (ko) * | 2004-08-31 | 2006-07-13 | 한국화학연구원 | 2-아릴메틸아제티딘 카바페넴 유도체 및 그의 제조방법 |
| CA2584485C (en) * | 2004-10-20 | 2013-12-31 | Resverlogix Corp. | Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases |
| JP5368792B2 (ja) | 2005-07-29 | 2013-12-18 | レスバーロジックス コーポレイション | 複合疾患の予防および処置のための薬学的組成物および挿入可能な医療用デバイスによるその送達 |
| US20100055071A1 (en) * | 2006-11-21 | 2010-03-04 | Martin Robert Leivers | Anti-Viral Compounds |
| DK2118074T3 (en) * | 2007-02-01 | 2014-03-10 | Resverlogix Corp | Compounds for the prevention and treatment of cardiovascular diseases |
| CN101343272B (zh) * | 2007-07-13 | 2011-02-09 | 山东轩竹医药科技有限公司 | 含有环己烷的碳青霉烯化合物 |
| CN101412720B (zh) * | 2007-08-27 | 2011-05-18 | 山东轩竹医药科技有限公司 | 含有巯基氮杂环乙烯基的碳青霉烯化合物 |
| KR101629356B1 (ko) | 2008-06-26 | 2016-06-13 | 리스버로직스 코퍼레이션 | 퀴나졸리논 유도체의 제조방법 |
| NZ594332A (en) | 2009-01-08 | 2013-09-27 | Resverlogix Corp | Compounds for the prevention and treatment of cardiovascular disease |
| KR101709492B1 (ko) | 2009-03-18 | 2017-02-23 | 리스버로직스 코퍼레이션 | 신규한 소염제 |
| US9757368B2 (en) | 2009-04-22 | 2017-09-12 | Resverlogix Corp. | Anti-inflammatory agents |
| RU2640115C2 (ru) | 2011-11-01 | 2017-12-26 | Ресверлоджикс Корп. | Фармацевтические композиции замещенных хиназолинонов |
| US9073878B2 (en) | 2012-11-21 | 2015-07-07 | Zenith Epigenetics Corp. | Cyclic amines as bromodomain inhibitors |
| WO2014080291A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Biaryl derivatives as bromodomain inhibitors |
| US9271978B2 (en) | 2012-12-21 | 2016-03-01 | Zenith Epigenetics Corp. | Heterocyclic compounds as bromodomain inhibitors |
| US10111885B2 (en) | 2015-03-13 | 2018-10-30 | Resverlogix Corp. | Compositions and therapeutic methods for the treatment of complement-associated diseases |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62155279A (ja) * | 1984-11-08 | 1987-07-10 | Sumitomo Pharmaceut Co Ltd | 新規なβ−ラクタム化合物 |
| JPH0780883B2 (ja) * | 1986-03-27 | 1995-08-30 | 住友製薬株式会社 | 新規なβ−ラクタム化合物 |
| EP0272455B1 (de) * | 1986-11-24 | 1993-02-10 | Fujisawa Pharmaceutical Co., Ltd. | 3-Pyrrolidinylthio-1-azabicyclo[3.2.0]hept-2-en-2-carbonsäure-Derivate |
| US4925838A (en) * | 1988-03-18 | 1990-05-15 | Fujisawa Pharmaceutical Company, Ltd. | 3-pyrrolidinylthio-1-azabicyclo[3.2.0]-hept-2-ene-2-carboxylic acid compounds |
| US4963544A (en) * | 1988-05-23 | 1990-10-16 | Fujisawa Pharmaceutical Company, Ltd. | 3-pyrrolidinylthio-1-azabicyclo[3.2.0]-hept-2-ene-2-carboxylic acid compounds |
| DE68916908T2 (de) * | 1988-11-08 | 1994-12-01 | Daiichi Seiyaku Co | Carbapenemderivate. |
| CA2091309A1 (en) * | 1992-03-26 | 1993-09-27 | Frederic H. Jung | Antibiotic compounds |
-
1995
- 1995-02-24 JP JP52226095A patent/JP4182545B2/ja not_active Expired - Fee Related
- 1995-02-24 DE DE69523574T patent/DE69523574T2/de not_active Expired - Lifetime
- 1995-02-24 AU AU18240/95A patent/AU680736B2/en not_active Ceased
- 1995-02-24 CA CA002184101A patent/CA2184101C/en not_active Expired - Fee Related
- 1995-02-24 AT AT95909978T patent/ATE207922T1/de not_active IP Right Cessation
- 1995-02-24 WO PCT/JP1995/000280 patent/WO1995023150A1/ja not_active Ceased
- 1995-02-24 US US08/696,910 patent/US5707987A/en not_active Expired - Lifetime
- 1995-02-24 EP EP95909978A patent/EP0747381B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69523574T2 (de) | 2002-05-29 |
| CA2184101C (en) | 2005-11-22 |
| US5707987A (en) | 1998-01-13 |
| DE69523574D1 (de) | 2001-12-06 |
| EP0747381A1 (de) | 1996-12-11 |
| AU680736B2 (en) | 1997-08-07 |
| EP0747381B1 (de) | 2001-10-31 |
| JP4182545B2 (ja) | 2008-11-19 |
| AU1824095A (en) | 1995-09-11 |
| CA2184101A1 (en) | 1995-08-31 |
| WO1995023150A1 (en) | 1995-08-31 |
| EP0747381A4 (de) | 1997-04-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |