ATE207934T1 - Neues verfahren für die produktion von biologisch aktivem protein (tgf) - Google Patents

Neues verfahren für die produktion von biologisch aktivem protein (tgf)

Info

Publication number
ATE207934T1
ATE207934T1 AT95926858T AT95926858T ATE207934T1 AT E207934 T1 ATE207934 T1 AT E207934T1 AT 95926858 T AT95926858 T AT 95926858T AT 95926858 T AT95926858 T AT 95926858T AT E207934 T1 ATE207934 T1 AT E207934T1
Authority
AT
Austria
Prior art keywords
tgf
biologically active
production
new process
active protein
Prior art date
Application number
AT95926858T
Other languages
English (en)
Inventor
Nico Cerletti
Original Assignee
Novartis Erfind Verwalt Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Erfind Verwalt Gmbh filed Critical Novartis Erfind Verwalt Gmbh
Application granted granted Critical
Publication of ATE207934T1 publication Critical patent/ATE207934T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT95926858T 1994-07-25 1995-07-12 Neues verfahren für die produktion von biologisch aktivem protein (tgf) ATE207934T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94810439 1994-07-25
PCT/EP1995/002719 WO1996003433A1 (en) 1994-07-25 1995-07-12 New process for the production of biologically active protein

Publications (1)

Publication Number Publication Date
ATE207934T1 true ATE207934T1 (de) 2001-11-15

Family

ID=8218293

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95926858T ATE207934T1 (de) 1994-07-25 1995-07-12 Neues verfahren für die produktion von biologisch aktivem protein (tgf)

Country Status (19)

Country Link
US (1) US7057016B2 (de)
EP (1) EP0779896B1 (de)
JP (2) JPH11505404A (de)
KR (1) KR100394532B1 (de)
AT (1) ATE207934T1 (de)
AU (1) AU699879B2 (de)
CA (1) CA2194578A1 (de)
DE (1) DE69523611T2 (de)
DK (1) DK0779896T3 (de)
ES (1) ES2166402T3 (de)
FI (1) FI118385B (de)
HU (1) HU222829B1 (de)
IL (1) IL114702A (de)
NO (1) NO317730B1 (de)
NZ (1) NZ290374A (de)
PT (1) PT779896E (de)
TW (1) TW517059B (de)
WO (1) WO1996003433A1 (de)
ZA (1) ZA956139B (de)

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JP4019432B2 (ja) * 1995-12-21 2007-12-12 味の素株式会社 ヒトアクチビンａのリフォールディング方法
DE10026713A1 (de) * 2000-05-30 2001-12-06 Walter Sebald Mutein einer Kette eines Proteins aus der Superfamilie des Wachstumsfaktors TGF-beta
US20030134292A1 (en) * 2001-10-30 2003-07-17 Farchaus Joseph W. Thermostable DNA polymerases and methods of making same
FR2871061B1 (fr) * 2004-06-04 2007-08-10 Coletica Sa Principe actif capable d'induire la transformation du tgbf- latent inactif en tgfb actif
US7572474B2 (en) * 2005-06-01 2009-08-11 Mead Johnson Nutrition Company Method for simulating the functional attributes of human milk oligosaccharides in formula-fed infants
US8075934B2 (en) * 2008-10-24 2011-12-13 Mead Johnson Nutrition Company Nutritional composition with improved digestibility
US8435224B2 (en) 2005-09-12 2013-05-07 Abela Pharmaceuticals, Inc. Materials for facilitating administration of dimethyl sulfoxide (DMSO) and related compounds
EP2324838A1 (de) 2005-09-12 2011-05-25 Abela Pharmaceuticals, Inc. Zusammensetzungen mit Dimethyl-Sulfoxid
US8480797B2 (en) 2005-09-12 2013-07-09 Abela Pharmaceuticals, Inc. Activated carbon systems for facilitating use of dimethyl sulfoxide (DMSO) by removal of same, related compounds, or associated odors
JP5399072B2 (ja) 2005-09-12 2014-01-29 アベラ ファーマスーティカルズ インコーポレイテッド ジメチルスルホキシド（ｄｍｓｏ）若しくは関連化合物、又はそれに関連する臭気を除去するシステム
GB0604966D0 (en) * 2006-03-11 2006-04-19 Renovo Ltd Medicaments and proteins
US8986769B2 (en) * 2008-10-24 2015-03-24 Mead Johnson Nutrition Company Methods for preserving endogenous TGF-β
BRPI0921494A2 (pt) 2008-11-03 2018-10-30 Prad Reasearch And Development Ltd método de planejamento de uma operação de amostragem para uma formação subterrãnea, método de contolar uma operação de amostragem de formação subterrânea, método de controlar uma operação de perfuração para uma formação subterrãnea, e método de realizar uma amostragem durante a operação de perfuração.
AU2010313253B2 (en) 2009-10-30 2015-02-19 Abela Pharmaceuticals, Inc. Dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) formulations to treat osteoarthritis
US10647777B2 (en) * 2014-05-28 2020-05-12 Genzyme Corporation Methods of controlling the formation of disulfide bonds in protein solutions
JP2016183118A (ja) * 2015-03-25 2016-10-20 東ソー株式会社 増殖因子前駆体のリフォールディング方法
WO2018122794A1 (en) 2016-12-30 2018-07-05 Biogend Therapeutics Co., Ltd. Recombinant polypeptides and nucleic acid molecules, compositions, and methods of making and uses thereof
KR20240082356A (ko) * 2021-10-11 2024-06-10 유니버시티 오브 피츠버그 - 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 조작된 tgf-베타 단량체 및 사용 방법
GB2616476A (en) * 2022-03-11 2023-09-13 Multus Biotechnology Ltd Recombinant transforming growth factor beta 3 in yeast

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US4620948A (en) 1982-12-22 1986-11-04 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
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EP0154434B1 (de) 1984-02-17 1993-01-27 Genentech, Inc. Menschlicher Transformationswachstumsfaktor und Vorläufer oder Fragment hiervon, Zellen, DNA, Vektoren und Verfahren zu ihrer Herstellung, Zusammensetzungen und Produkte, die diese enthalten, sowie davon abgeleitete Antikörper und Diagnostizierverfahren
US4572798A (en) 1984-12-06 1986-02-25 Cetus Corporation Method for promoting disulfide bond formation in recombinant proteins
US4731440A (en) 1985-02-22 1988-03-15 Monsanto Company Method of somatotropin solubilization using dimethylsulfone and naturation
IL78197A (en) 1985-03-22 1991-07-18 Genentech Inc Nucleic acid encoding tgf-beta and its uses
GB8508340D0 (en) 1985-03-29 1985-05-09 Creighton T E Production of protein
EP0208539A3 (de) 1985-07-11 1988-08-03 Repligen Corporation In Falten gelegte Proteine, durch Disulfid gebunden
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JPH0759598B2 (ja) * 1986-02-14 1995-06-28 藤沢薬品工業株式会社 ヒトインスリン様成長因子▲ｉ▼の製造法
NZ222168A (en) 1986-10-20 1991-05-28 Oncogene Science Inc Tumour growth inhibiting protein related to tgf-#b#1 and tgf-#b#2, preparation by genetic engineering methods, antibodies and pharmaceutical compositions
EP0268561A3 (de) 1986-11-17 1988-10-26 Sandoz Ag Herstellung und Verwendung eines T-Zellen-Suppressorfaktors
FI100106B (fi) 1986-12-05 1997-09-30 Novartis Ag Menetelmä plasminogeenin yksisäikeisen yhdistelmäaktivaattorin valmist amiseksi
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US5144006A (en) * 1991-06-13 1992-09-01 The Rockefeller University Oxidative folding of peptide and protein substrates using hydrocarbon sulfoxides
AU2738392A (en) * 1991-11-11 1993-05-13 Ciba-Geigy Ag Novel hybrid transforming growth factors
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TW440566B (en) * 1994-07-25 2001-06-16 Novartis Ag Novel process for the production of biologically active dimeric protein

Also Published As

Publication number Publication date
IL114702A (en) 2005-03-20
NO970326D0 (no) 1997-01-24
DK0779896T3 (da) 2002-02-18
JP2007082554A (ja) 2007-04-05
NZ290374A (en) 1998-07-28
TW517059B (en) 2003-01-11
DE69523611T2 (de) 2002-06-20
FI118385B (fi) 2007-10-31
FI970258A0 (fi) 1997-01-22
HU222829B1 (hu) 2003-11-28
JPH11505404A (ja) 1999-05-21
EP0779896A1 (de) 1997-06-25
NO317730B1 (no) 2004-12-13
AU3109695A (en) 1996-02-22
KR100394532B1 (ko) 2003-10-22
CA2194578A1 (en) 1996-02-08
WO1996003433A1 (en) 1996-02-08
ES2166402T3 (es) 2002-04-16
JP4354980B2 (ja) 2009-10-28
EP0779896B1 (de) 2001-10-31
PT779896E (pt) 2002-03-28
US20020115834A1 (en) 2002-08-22
NO970326L (no) 1997-01-24
IL114702A0 (en) 1995-11-27
FI970258L (fi) 1997-01-22
AU699879B2 (en) 1998-12-17
DE69523611D1 (de) 2001-12-06
ZA956139B (en) 1996-03-07
HUT76667A (en) 1997-10-28
US7057016B2 (en) 2006-06-06

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee