ATE208632T1 - Verabreichungssystem für phospholipide - Google Patents

Verabreichungssystem für phospholipide

Info

Publication number
ATE208632T1
ATE208632T1 AT90911837T AT90911837T ATE208632T1 AT E208632 T1 ATE208632 T1 AT E208632T1 AT 90911837 T AT90911837 T AT 90911837T AT 90911837 T AT90911837 T AT 90911837T AT E208632 T1 ATE208632 T1 AT E208632T1
Authority
AT
Austria
Prior art keywords
phospholipide
administration system
therapeutically active
delivery
chloro
Prior art date
Application number
AT90911837T
Other languages
English (en)
Inventor
Alan Joseph Mautone
Joel Klayman
Original Assignee
Scient Dev & Res Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scient Dev & Res Inc filed Critical Scient Dev & Res Inc
Application granted granted Critical
Publication of ATE208632T1 publication Critical patent/ATE208632T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases or cochleates; Sponge phases

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT90911837T 1989-07-27 1990-07-09 Verabreichungssystem für phospholipide ATE208632T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/385,907 US5174988A (en) 1989-07-27 1989-07-27 Phospholipid delivery system
PCT/US1990/003836 WO1991001765A1 (en) 1989-07-27 1990-07-09 A phospholipid delivery system

Publications (1)

Publication Number Publication Date
ATE208632T1 true ATE208632T1 (de) 2001-11-15

Family

ID=23523374

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90911837T ATE208632T1 (de) 1989-07-27 1990-07-09 Verabreichungssystem für phospholipide

Country Status (7)

Country Link
US (2) US5174988A (de)
EP (1) EP0607118B1 (de)
AT (1) ATE208632T1 (de)
DE (1) DE69033856T2 (de)
DK (1) DK0607118T3 (de)
ES (1) ES2167308T3 (de)
WO (1) WO1991001765A1 (de)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05503527A (ja) * 1990-02-22 1993-06-10 マクノート・ピーティーワイ・リミテッド 人工涙液
US5665770A (en) * 1993-11-05 1997-09-09 Gakko Hojin Kinki Daigaku Method for treatment of cataract with radical scavenger
TW274516B (de) * 1993-11-12 1996-04-21 Ciba Geigy Ag
WO1995014488A1 (en) * 1993-11-24 1995-06-01 Ocutech, Inc. Compositions and methods for the treatment of dry eyes and other ocular disorders
WO1995024430A2 (en) 1994-03-04 1995-09-14 University Of Washington Block and graft copolymers and methods relating thereto
US5531219A (en) * 1994-11-04 1996-07-02 Alliance Pharmaceutical Corp. Use of liquid fluorocarbons to facilitate pulmonary drug delivery
EE9700138A (et) 1994-12-22 1997-12-15 Astra Aktiebolag Aerosoolravimvormid
US6524557B1 (en) 1994-12-22 2003-02-25 Astrazeneca Ab Aerosol formulations of peptides and proteins
WO1997029738A1 (en) * 1996-02-16 1997-08-21 The Administrators Of The Tulane Educational Fund Methods and compositions for treating eustachian tube dysfunction by inhalation
CA2225398C (en) * 1996-04-19 2008-07-15 R-Tech Ueno, Ltd. Pharmaceutical composition comprising albumin as an active ingredient
US20020052310A1 (en) * 1997-09-15 2002-05-02 Massachusetts Institute Of Technology The Penn State Research Foundation Particles for inhalation having sustained release properties
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US6254854B1 (en) * 1996-05-24 2001-07-03 The Penn Research Foundation Porous particles for deep lung delivery
US6652837B1 (en) 1996-05-24 2003-11-25 Massachusetts Institute Of Technology Preparation of novel particles for inhalation
CA2277801C (en) * 1997-01-16 2002-10-15 Massachusetts Institute Of Technology Preparation of particles for inhalation
EP1498115A1 (de) * 1997-01-16 2005-01-19 Massachusetts Institute Of Technology Zubereitung von partikelhaltigen Arzneimitteln zur Inhalation
US20040228910A1 (en) * 1997-02-11 2004-11-18 Mse Pharmazeutika Gmbh Transdermal, oral and intravenous formulations of 2, 3-dimethoxy-5-methyl-6-decaprenyl-1, 4-benzoquinone
GB9716376D0 (en) * 1997-08-01 1997-10-08 Isis Innovation Artificial tear formulation
US7052678B2 (en) 1997-09-15 2006-05-30 Massachusetts Institute Of Technology Particles for inhalation having sustained release properties
US20020017295A1 (en) * 2000-07-07 2002-02-14 Weers Jeffry G. Phospholipid-based powders for inhalation
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US6482391B1 (en) * 1997-12-03 2002-11-19 Britannia Pharmaceuticals Limited Medicaments for asthma treatment
EP1273290A1 (de) * 1998-06-24 2003-01-08 Advanced Inhalation Research, Inc. Grosse poröse Partikel ausgestossen von einem Inhalator
WO1999066903A2 (en) * 1998-06-24 1999-12-29 Advanced Inhalation Research, Inc. Large porous particles emitted from an inhaler
US6956021B1 (en) * 1998-08-25 2005-10-18 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
US6290987B1 (en) * 1998-09-27 2001-09-18 Generex Pharmaceuticals, Inc. Mixed liposome pharmaceutical formulation with amphiphiles and phospholipids
GB9912639D0 (en) * 1999-05-28 1999-07-28 Britannia Pharmaceuticals Ltd Improvements in and relating to treatment of respiratory conditions
US6294153B1 (en) * 1998-12-21 2001-09-25 Generex Pharmaceuticals, Inc. Aerosol pharmaceutical formulation for pulmonary and nasal delivery
US6849263B2 (en) * 1998-12-21 2005-02-01 Generex Pharmaceutical Incorporated Pharmaceutical compositions for buccal delivery of pain relief medications
US7087215B2 (en) * 1998-12-21 2006-08-08 Generex Pharmaceuticals Incorporated Methods of administering and enhancing absorption of pharmaceutical agents
US6312665B1 (en) * 1998-12-21 2001-11-06 Generex Pharmaceuticals Incorporated Aerosol formulations for buccal and pulmonary application
US6350432B1 (en) * 1999-03-19 2002-02-26 Generex Pharmaceuticals Incorporated Pressurized container having an aerosolized pharmaceutical composition
US6858199B1 (en) * 2000-06-09 2005-02-22 Advanced Inhalation Research, Inc. High efficient delivery of a large therapeutic mass aerosol
EP1210067A2 (de) * 1999-08-25 2002-06-05 Advanced Inhalation Research, Inc. Modulation der freigabe aus trockenpulverformulierungen
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
US6749835B1 (en) 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
US20010036481A1 (en) * 1999-08-25 2001-11-01 Advanced Inhalation Research, Inc. Modulation of release from dry powder formulations
PT1228030E (pt) 1999-11-09 2005-08-31 Alcon Inc Derivados benzenoidicos do acido 15-hidroxieicosatetraenoico e metodos para a sua utilizacao no tratamento das perturbacoes do olho seco
CA2386632A1 (en) 1999-11-09 2001-05-17 Alcon, Inc. Omega chain modified 15-hydroxyeicosatetraenoic acid derivatives and methods of their use for the treatment of dry eye
PT1228032E (pt) 1999-11-09 2004-10-29 Alcon Inc Composicoes contendo derivados do acido hidroxieicosatetraenoico e metodos de utilizacao para o tratamento de desordens do olho seco
HK1045985B (en) 1999-11-09 2004-04-23 Alcon, Inc. 15-hydroxyeicosatetraenoic acid-related compounds and methods of use
DE60019322T2 (de) 1999-11-09 2005-09-08 Alcon Inc. Heteroatomunterbrochene analoge von15-hydroxyeicosatetraensäure und verfahren zu deren verwendung
AU1226001A (en) 1999-11-09 2001-06-06 Alcon Universal Limited Phospholipids of hydroxyeicosatetraenoic acid-like derivatives
WO2001034550A2 (en) 1999-11-09 2001-05-17 Alcon Universal Ltd. 15-hydroxyeicosatetraenoic acid analogs with enhanced metabolic stability and methods of their use in treating dry eye disorders
US6458854B2 (en) 1999-11-09 2002-10-01 Alcon Universal Ltd. Phospholipids of hydroxyeicosatetraenoic acid-like derivatives and methods of use
WO2001034553A2 (en) 1999-11-09 2001-05-17 Alcon Universal Ltd. 2,2-difluoro 15-hydroxyeicosatetraenoic acid analogs and methods of use
US6552084B2 (en) 1999-11-09 2003-04-22 Alcon Universal Ltd. Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders
ATE258791T1 (de) 1999-11-09 2004-02-15 Alcon Inc Lipoxin-a4 und deren analoge zur behandlung von trockenen augen
US6803385B2 (en) 1999-11-09 2004-10-12 Alcon, Inc. Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders
DK1228027T3 (da) 1999-11-09 2004-07-19 Alcon Inc 3-heteroatomsubstituerede og to carbonhomologe af 15-HETE og fremgangsmåder til anvendelse
PT1228028E (pt) 1999-11-09 2005-10-31 Alcon Inc Sais de hidroxieicosatetraeniato, composicoes e metodos para utilizacao no tratamento de perturbacoes da secura ocular
US7064132B2 (en) * 1999-11-28 2006-06-20 Scientific Development And Research, Inc. Composition and method for treatment of otitis external
US6645467B2 (en) * 1999-11-28 2003-11-11 Scientific Development And Research, Inc. Composition and method for decreasing upper respiratory airway resistance
US6676930B2 (en) 1999-11-28 2004-01-13 Scientific Development And Research, Inc. Composition and method for treatment of otitis media
US6156294A (en) * 1999-11-28 2000-12-05 Scientific Development And Research, Inc. Composition and method for treatment of otitis media
US6565861B1 (en) * 2000-02-11 2003-05-20 Isis Innovation Limited Artificial tear formulation
DE10012151A1 (de) * 2000-03-13 2001-09-27 Gsf Forschungszentrum Umwelt Mittel zur Behandlung von Erkrankungen des Tracheo-Brochialtraktes, insbesondere der COPD
PT1280520E (pt) * 2000-05-10 2014-12-16 Novartis Ag Pós à base de fosfolípidos para administração de fármacos
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
JP2005504715A (ja) * 2000-12-29 2005-02-17 アドバンスト インハレーション リサーチ，インコーポレイテッド 持続放出特性を有する吸入用粒子
US20020141946A1 (en) * 2000-12-29 2002-10-03 Advanced Inhalation Research, Inc. Particles for inhalation having rapid release properties
US7112588B2 (en) * 2001-05-21 2006-09-26 Alcon, Inc. Use of proteasome inhibitors to treat dry eye disorders
EP1392322A1 (de) * 2001-05-21 2004-03-03 Alcon, Inc. Methode zur behandlung des trockenen auges
BR0209883A (pt) 2001-05-21 2004-06-08 Alcon Inc Uso de inibidores da proteasoma para o tratamento de distúrbios do olho seco
JP2004527578A (ja) 2001-05-21 2004-09-09 アルコン，インコーポレイテッド ドライアイ障害を処置するためのＮＦ−κＢインヒビターの使用
US6872382B1 (en) 2001-05-21 2005-03-29 Alcon, Inc. Use of selective PDE IV inhibitors to treat dry eye disorders
US6645994B1 (en) 2001-06-01 2003-11-11 Alcon, Inc. Method of treating dry eye disorders
US6750250B1 (en) 2001-07-12 2004-06-15 Alcon, Inc. 11,12-oxidoarachidonic acid derivatives and methods of their use in treating dry eye disorders
PL369960A1 (en) * 2001-10-11 2005-05-02 Alcon, Inc. Methods for treating dry eye by a combination of an antiinflammatory steroid and a muc-1 secretagogue
WO2003030894A1 (en) * 2001-10-11 2003-04-17 Alcon, Inc. Methods for treating dry eye
AU2002352836B2 (en) 2001-11-20 2005-09-29 Alkermes, Inc. Improved particulate compositions for pulmonary delivery
US20030129250A1 (en) * 2001-11-20 2003-07-10 Advanced Inhalation Research Inc. Particulate compositions for improving solubility of poorly soluble agents
PT1458360E (pt) * 2001-12-19 2011-07-13 Novartis Ag Derivados de indole como agonistas do recetor s1p1
AU2003215334A1 (en) * 2002-02-22 2003-09-09 Advanced Inhalation Research, Inc. Inhalable formulations for sustained release
US7754242B2 (en) * 2002-03-20 2010-07-13 Alkermes, Inc. Inhalable sustained therapeutic formulations
WO2003079885A2 (en) * 2002-03-20 2003-10-02 Advanced Inhalation Research, Inc. Inhalable sustained therapeutic formulations
AU2006220411B2 (en) * 2002-03-20 2008-06-26 Alkermes, Inc. Inhalable Sustained Therapeutic Formulations
DE10214983A1 (de) * 2002-04-04 2004-04-08 TransMIT Gesellschaft für Technologietransfer mbH Vernebelbare Liposomen und ihre Verwendung zur pulmonalen Applikation von Wirkstoffen
EP1542768A1 (de) * 2002-09-20 2005-06-22 Alcon, Inc. Verwendung von zytokin-synthesehemmern zur behandlung von erkrankungen mit trockenem auge
US20040248794A1 (en) * 2002-12-20 2004-12-09 Yanni John M. Treatment of dry eye by restoring 15-lipoxygenase activity to ocular surface cells
WO2004093878A1 (en) * 2003-04-16 2004-11-04 Alcon, Inc. Use of fused pyridazine derivatives for treating dry eye disorders
US7923471B2 (en) * 2004-05-14 2011-04-12 Alcon, Inc. Method of treating dry eye disorders and uveitis
DE602005017762D1 (de) * 2004-05-14 2009-12-31 Alcon Inc Methode zur behandlung trockener augen und uveitis
MXPA06014425A (es) * 2004-06-08 2007-05-23 Ocularis Pharma Inc Composiciones oftalmicas hidrofobas y metodo de uso.
AU2005262392A1 (en) * 2004-07-01 2006-01-19 Johnson & Johnson Vision Care, Inc. Compositions and methods for treating eye disorders and conditions
US20070265341A1 (en) * 2004-07-01 2007-11-15 The Schepens Eye Research Institute Inc. Compositions and methods for treating eye disorders and conditions
US7223737B1 (en) 2004-08-13 2007-05-29 Alcon, Inc. Method of treating dry eye disorders using glycosides
US20060128803A1 (en) * 2004-12-14 2006-06-15 Alcon, Inc. Method of treating dry eye disorders using 13(S)-HODE and its analogs
US20070031342A1 (en) * 2005-06-22 2007-02-08 Nektar Therapeutics Sustained release microparticles for pulmonary delivery
US7745461B1 (en) 2006-02-27 2010-06-29 Alcon Research, Ltd. Method of treating dry eye disorders
WO2010017365A1 (en) * 2008-08-06 2010-02-11 University Of Louisville Research Foundation Wax-based emulsion for the treatment of dry eye conditions
DE102009031274A1 (de) 2009-06-30 2011-01-13 Justus-Liebig-Universität Giessen Liposomen zur pulmonalen Applikation
WO2020142420A1 (en) * 2018-12-31 2020-07-09 Novus Therapeutics, Inc. Novel surfactant-lipid alloy drug substance, methods of making the same, and pharmaceutical compositions comprising the same

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1575343A (en) * 1977-05-10 1980-09-17 Ici Ltd Method for preparing liposome compositions containing biologically active compounds
SE442705B (sv) * 1979-05-08 1986-01-27 Viktor Kare Larsson Medel for bildande av ett skyddsskikt pa ett underlag i form av hud eller slemhinna samt forfarande for att bilda ett skyddsskikt pa huden i icke-terapeutiskt syfte med hjelp av detta medel
US4394372A (en) * 1980-12-22 1983-07-19 The Procter & Gamble Company Process for making lipid membrane structures
IL64397A0 (en) * 1981-01-07 1982-02-28 Weder Hans G Process for the preparation of liposomal medicaments
US4394722A (en) * 1981-08-31 1983-07-19 Rca Corporation Television receiver high voltage generator
FR2521565B1 (fr) * 1982-02-17 1985-07-05 Dior Sa Parfums Christian Melange pulverulent de constituants lipidiques et de constituants hydrophobes, procede pour le preparer, phases lamellaires lipidiques hydratees et procede de fabrication, compositions pharmaceutiques ou cosmetiques comportant des phases lamellaires lipidiques hydratees
JPS59164724A (ja) * 1983-03-10 1984-09-17 Tokyo Tanabe Co Ltd サ−フアクタント及びそれを含有する呼吸窮迫症候群治療剤
GB8501015D0 (en) * 1985-01-16 1985-02-20 Riker Laboratories Inc Drug
US4870011A (en) * 1985-01-22 1989-09-26 Director General Of Agency Of Industrial Science And Technology Method for obtaining lipids from fungus bodies
JPS63500175A (ja) * 1985-05-22 1988-01-21 リポソ−ム　テクノロジ−，インコ−ポレイテツド リポソ−ム吸入法および吸入システム
SE462894B (sv) * 1985-10-28 1990-09-17 Biogram Ab Mikrokapslar, foerfarande foer framstaellning daerav samt anvaendning
US4883658A (en) * 1986-04-28 1989-11-28 Holly Frank J Ophthalmic solution for treatment of dry-eye syndrome
US4839175A (en) * 1986-07-28 1989-06-13 Liposome Technology, Inc. Liposomes with enhanced retention on mucosal tissue
US4818537A (en) * 1986-10-21 1989-04-04 Liposome Technology, Inc. Liposome composition for treating dry eye
CA1338736C (fr) * 1986-12-05 1996-11-26 Roger Baurain Microcristaux comportant une substance active presentant une affinite pour les phospholipides, et au moins un phospholipide, procede de preparation
US4923700A (en) * 1988-06-03 1990-05-08 Kaufman Herbert E Artificial tear suspension

Also Published As

Publication number Publication date
DE69033856T2 (de) 2002-07-04
WO1991001765A1 (en) 1991-02-21
US5174988A (en) 1992-12-29
US5306483A (en) 1994-04-26
ES2167308T3 (es) 2002-05-16
EP0607118B1 (de) 2001-11-14
DK0607118T3 (da) 2002-02-18
EP0607118A1 (de) 1994-07-27
EP0607118A4 (de) 1993-03-17
DE69033856D1 (de) 2001-12-20

Similar Documents

Publication Publication Date Title
ATE208632T1 (de) Verabreichungssystem für phospholipide
DK344586A (da) Tidskontrolleret laegemiddelafgivelse
MY105121A (en) Pharmaceutical composition for systemic transdermal administration.
AU525135B2 (en) Lipid membrane system for drug delivery
ES8800037A1 (es) Procedimiento para solubilizar drogas en propulsores de aerosol a base de clorofluorcarburos
DE3065315D1 (en) A preparation containing nitroglycerine and optionally other medicaments and preparation thereof
DE3783356D1 (de) Benzimidazolderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische praeparate.
ATE300936T1 (de) Anwendung von boral-polyol-komplexen für ophthalmische arzneizusammensetzungen
IT8719064A0 (it) Compressa per uso farmaceutico atta al rilascio in tempi successivi di sostanze attive.
ES2191682T3 (es) Nueva formulacion farmaceutica.
ES2094539T3 (es) Preparacion farmaceutica y procedimiento para su preparacion.
IE44562L (en) Pharmaceutical compositions of addicting agents having¹reduced addiction liability
DE2964438D1 (en) Method of making solid medicaments with active agents applied in form of drops
SE8800731L (sv) Fenylkarbamat
ES2063013T3 (es) Procedimiento para eliminar pirogenos.
MY114388A (en) Multiple unit pharmaceutical preparation
ES2074124T5 (es) Composicion en forma de una espuma que contiene acido 5-aminosalicilico para administracion intra-rectal.
PT768867E (pt) Forma de dosagem para a administracao de droga em formulacao liquida
ES534598A0 (es) Un procedimiento para preparar una solucion acuosa que contiene una sustancia farmaceutica soluble en lipidos
FI970788A0 (fi) Kasveilla käytettäviksi tarkoitettuja suihkutettavissa olevia, kalvon muodostavia järjestelmiä vaikuttavien aineiden antamiseksi
IS3787A7 (is) Aðferð til framleiðslu nýrra lyfjaforma, sem innihalda jónanleg, lyfjafræðilega virk efni
EP0160501A3 (de) Intranasale Zusammenstellung mit verzögerter Freigabe und Gebrauchsanweisung
ATE40292T1 (de) Verfahren zur herstellung von unilamellaren liposomen von grobem diameter, ihre pharmazeutische anwendung fuer die verkapselung von aktivem prinzip fuer die verzoegerte wirkstoffabgabe und vorrichtung hierfuer.
FI911207A0 (fi) Menetelmä uuden terapeuttisesti käyttökelpoisen retinoidin valmistamiseksi
ATE110570T1 (de) Nephroprotektive infusionslösung.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0607118

Country of ref document: EP

REN Ceased due to non-payment of the annual fee