ATE209034T1 - Taxolderivate - Google Patents

Taxolderivate

Info

Publication number: ATE209034T1
Authority: AT; Austria
Prior art keywords: taxol derivatives; formula; taxol; ch2opo3; ch2oso3
Prior art date: 1993-07-15

Application number

AT94921511T

Other languages

English (en)

Inventor

Larry L Klein

Clarence J Maring

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-15

Filing date

1994-07-15

Publication date

2001-12-15

1994-07-15 Application filed by Abbott Lab filed Critical Abbott Lab

2001-12-15 Application granted granted Critical

2001-12-15 Publication of ATE209034T1 publication Critical patent/ATE209034T1/de

Links

150000004579 taxol derivatives Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 1
229930012538 Paclitaxel Natural products 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
229960001592 paclitaxel Drugs 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
150000003254 radicals Chemical class 0.000 abstract 1
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Epoxy Compounds (AREA)
Medicinal Preparation (AREA)
Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Materials For Medical Uses (AREA)

AT94921511T 1993-07-15 1994-07-15 Taxolderivate ATE209034T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/092,124 US5468769A (en)	1993-07-15	1993-07-15	Paclitaxel derivatives
PCT/US1994/007973 WO1995002400A1 (en)	1993-07-15	1994-07-15	Taxol derivatives

Publications (1)

Publication Number	Publication Date
ATE209034T1 true ATE209034T1 (de)	2001-12-15

Family

ID=22231738

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94921511T ATE209034T1 (de)	1993-07-15	1994-07-15	Taxolderivate

Country Status (8)

Country	Link
US (1)	US5468769A (de)
EP (1)	EP0708642B1 (de)
JP (1)	JPH09500138A (de)
AT (1)	ATE209034T1 (de)
CA (1)	CA2165079A1 (de)
DE (1)	DE69429173T2 (de)
ES (1)	ES2168304T3 (de)
WO (1)	WO1995002400A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5990325A (en)	1993-03-05	1999-11-23	Florida State University	Process for the preparation of 9-desoxotaxol, 9-desoxobaccatin III and analogs thereof
US5973160A (en)	1992-12-23	1999-10-26	Poss; Michael A.	Methods for the preparation of novel sidechain-bearing taxanes
EP1155689B1 (de)	1993-07-19	2006-09-20	Angiotech Pharmaceuticals, Inc.	Anti-angiogener Stent und Verfahren zu dessen Herstellung
US5965566A (en) *	1993-10-20	1999-10-12	Enzon, Inc.	High molecular weight polymer-based prodrugs
US6441025B2 (en) *	1996-03-12	2002-08-27	Pg-Txl Company, L.P.	Water soluble paclitaxel derivatives
DE69735057T2 (de)	1996-03-12	2006-08-31	PG-TXL Co., L.P., Houston	Wasserlösliche paclitaxel-prodrogen
US5635531A (en) *	1996-07-08	1997-06-03	Bristol-Myers Squibb Company	3'-aminocarbonyloxy paclitaxels
AU4768797A (en)	1996-10-24	1998-05-15	Institute Armand-Frappier	A family of canadensol taxanes, the semi-synthetic preparation and therapeutic use thereof
US6458373B1 (en) *	1997-01-07	2002-10-01	Sonus Pharmaceuticals, Inc.	Emulsion vehicle for poorly soluble drugs
US20020077290A1 (en) *	2000-03-17	2002-06-20	Rama Bhatt	Polyglutamic acid-camptothecin conjugates and methods of preparation
HUP0302599A3 (en)	2000-09-22	2005-05-30	Bristol Myers Squibb Co	Method for reducing toxicity of combined chemotherapic compositions
CA2426762A1 (en)	2000-11-02	2002-05-10	Sloan-Kettering Institute For Cancer Research	Methods for enhancing the efficacy of cytotoxic agents through the use of hsp90 inhibitors
JP2006513152A (ja) *	2002-10-09	2006-04-20	ファイトジェンライフサイエンシズインコーポレイテッド	新規タキサンならびにその使用および調製に関する方法
US8088737B2 (en)	2003-04-04	2012-01-03	Incyte Corporation	Compositions, methods and kits relating to Her-2 cleavage
US7202370B2 (en) *	2003-10-27	2007-04-10	Conor Medsystems, Inc.	Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
USH2260H1 (en)	2005-02-17	2011-07-05	Angiotech International Ag	Stents combined with paclitaxel derivatives
CN101611007A (zh)	2006-12-20	2009-12-23	先灵公司	新颖的jnk抑制剂
JP2013506669A (ja)	2009-09-30	2013-02-28	メルク・シャープ・アンド・ドーム・コーポレーション	Ｅｒｋ阻害剤である新規化合物
CA2811990C (en)	2010-08-23	2023-03-21	Dean Y. Maeda	Aminopyridine- and aminopyrimidinecarboxamides as cxcr2 modulators
US8969365B2 (en)	2013-08-02	2015-03-03	Syntrix Biosystems, Inc.	Thiopyrimidinecarboxamides as CXCR1/2 modulators
EP3027627B1 (de)	2013-08-02	2018-01-31	Syntrix Biosystems Inc.	2-[5-[n-(4-fluorophenyl)carbamoyl]pyrimidin-2-ylsulfanylmethyl]-4-(trifluoromethoxy)phenyl]bor saure
US10561676B2 (en)	2013-08-02	2020-02-18	Syntrix Biosystems Inc.	Method for treating cancer using dual antagonists of CXCR1 and CXCR2
US10046002B2 (en)	2013-08-02	2018-08-14	Syntrix Biosystems Inc.	Method for treating cancer using chemokine antagonists
BR112022004851A2 (pt)	2019-09-19	2022-08-23	Leap Therapeutics Inc	Uso de inibidores de dkk-1 para tratar câncer
EP4061419A1 (de)	2019-11-22	2022-09-28	Leap Therapeutics, Inc.	Methoden zum behandeln von krebs mit dkk-1-hemmern

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4942184A (en) *	1988-03-07	1990-07-17	The United States Of America As Represented By The Department Of Health And Human Services	Water soluble, antineoplastic derivatives of taxol
JPH07505887A (ja) *	1992-04-17	1995-06-29	アボツト・ラボラトリーズ	タキソール誘導体

1993
- 1993-07-15 US US08/092,124 patent/US5468769A/en not_active Expired - Fee Related
1994
- 1994-07-15 ES ES94921511T patent/ES2168304T3/es not_active Expired - Lifetime
- 1994-07-15 JP JP7504746A patent/JPH09500138A/ja not_active Withdrawn
- 1994-07-15 AT AT94921511T patent/ATE209034T1/de not_active IP Right Cessation
- 1994-07-15 DE DE69429173T patent/DE69429173T2/de not_active Expired - Fee Related
- 1994-07-15 WO PCT/US1994/007973 patent/WO1995002400A1/en not_active Ceased
- 1994-07-15 EP EP94921511A patent/EP0708642B1/de not_active Expired - Lifetime
- 1994-07-15 CA CA002165079A patent/CA2165079A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP0708642A1 (de)	1996-05-01
DE69429173T2 (de)	2002-07-04
EP0708642A4 (de)	1996-03-12
CA2165079A1 (en)	1995-01-26
EP0708642B1 (de)	2001-11-21
JPH09500138A (ja)	1997-01-07
DE69429173D1 (en)	2002-01-03
ES2168304T3 (es)	2002-06-16
US5468769A (en)	1995-11-21
WO1995002400A1 (en)	1995-01-26

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Legal Events

Date	Code	Title	Description
2002-05-15	UEP	Publication of translation of european patent specification
2004-04-15	REN	Ceased due to non-payment of the annual fee