ATE209035T1 - Inhibitor von der atherosklerotischen intimalerdickung - Google Patents

Inhibitor von der atherosklerotischen intimalerdickung

Info

Publication number: ATE209035T1
Authority: AT; Austria
Prior art keywords: alkyl; hydrogen; butoxy; chem; tert
Prior art date: 1991-10-04

Application number

AT92116417T

Other languages

English (en)

Inventor

Yasushi Saito

Masaki Seibutsukagaku Kitahara

Shiraoka-Machi Shiraoka

Mitsuaki Seibutsukag Sakashita

Kyomi Seibutsukagaku Ke Toyoda

Shiraoka-Machi

Toshie Seibutsukagak Shibazaki

Original Assignee

Nissan Chemical Ind Ltd

Kowa Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-10-04

Filing date

1992-09-24

Publication date

2001-12-15

1992-09-24 Application filed by Nissan Chemical Ind Ltd, Kowa Co filed Critical Nissan Chemical Ind Ltd

2001-12-15 Application granted granted Critical

2001-12-15 Publication of ATE209035T1 publication Critical patent/ATE209035T1/de

Links

206010072810 Vascular wall hypertrophy Diseases 0.000 title abstract 2
230000003143 atherosclerotic effect Effects 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 12
229910052739 hydrogen Inorganic materials 0.000 abstract 8
239000001257 hydrogen Substances 0.000 abstract 8
-1 n-butoxy, i-butoxy, sec-butoxy, tert-butoxy Chemical group 0.000 abstract 6
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
150000002431 hydrogen Chemical class 0.000 abstract 4
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000005907 alkyl ester group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
239000011575 calcium Substances 0.000 abstract 1
229910052791 calcium Inorganic materials 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
239000011591 potassium Substances 0.000 abstract 1
229910052700 potassium Inorganic materials 0.000 abstract 1
239000011734 sodium Substances 0.000 abstract 1
229910052708 sodium Inorganic materials 0.000 abstract 1
125000003866 trichloromethyl group Chemical group ClC(Cl)(Cl)* 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Quinoline Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT92116417T 1991-10-04 1992-09-24 Inhibitor von der atherosklerotischen intimalerdickung ATE209035T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP03257870A JP3130342B2 (ja)	1991-10-04	1991-10-04	動脈硬化性血管内膜肥厚抑制薬

Publications (1)

Publication Number	Publication Date
ATE209035T1 true ATE209035T1 (de)	2001-12-15

Family

ID=17312323

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92116417T ATE209035T1 (de)	1991-10-04	1992-09-24	Inhibitor von der atherosklerotischen intimalerdickung

Country Status (18)

Country	Link
US (1)	US6162798A (de)
EP (1)	EP0535548B1 (de)
JP (1)	JP3130342B2 (de)
KR (1)	KR100264543B1 (de)
AT (1)	ATE209035T1 (de)
AU (1)	AU652669B2 (de)
CA (1)	CA2079706C (de)
CZ (1)	CZ281786B6 (de)
DE (1)	DE69232217T2 (de)
DK (1)	DK0535548T3 (de)
HU (1)	HU214624B (de)
MX (1)	MX9205659A (de)
NO (1)	NO302452B1 (de)
NZ (1)	NZ244555A (de)
RU (1)	RU2114620C1 (de)
SK (1)	SK279277B6 (de)
TW (1)	TW238300B (de)
UA (1)	UA39095C2 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1995011898A1 (en) *	1992-05-12	1995-05-04	Nissan Chemical Industries Ltd.	Condensed pyridine type mevalonolactone intermediate and process for its production
WO1997025986A1 (en) *	1996-01-17	1997-07-24	Taiho Pharmaceutical Co., Ltd.	Intimal thickening inhibitors
JP4281248B2 (ja) *	1998-07-23	2009-06-17	日産化学工業株式会社	キノリン誘導体の製造法及び中間体
KR100655671B1 (ko) *	1999-01-14	2006-12-08	닛산 가가쿠 고교 가부시키 가이샤	퀴놀린카르브알데히드의 제조 방법
JP4496586B2 (ja) *	2000-01-24	2010-07-07	日産化学工業株式会社	キノリルアクリロニトリルの製造法及びその中間体
ATE366239T1 (de) *	2000-01-24	2007-07-15	Nissan Chemical Ind Ltd	Verfahren zur herstellung von quinolylpropenal
JP4496584B2 (ja) *	2000-01-24	2010-07-07	日産化学工業株式会社	キノリルプロペナールの製造法
JP4496585B2 (ja) *	2000-01-24	2010-07-07	日産化学工業株式会社	キノリルプロペナールの製造方法
WO2001060800A1 (en)	2000-02-21	2001-08-23	Kuraray Co., Ltd.	Processes for preparing quinoline derivatives and intermediates thereof
JP4867071B2 (ja) *	2000-02-21	2012-02-01	日産化学工業株式会社	キノリン誘導体の製造方法
WO2001098301A1 (en) *	2000-06-20	2001-12-27	Japan Tobacco Inc.	Pyrazolopyridine compounds and use thereof as drugs
TWI309644B (de) *	2001-02-14	2009-05-11	Nissan Chemical Ind Ltd
MXPA03009095A (es) *	2001-04-05	2004-02-12	Nissan Chemical Ind Ltd	Metodo para preparar 7-quinolinil-3,5-dihidroxihept-6-enoato.
US6835838B2 (en) *	2002-01-28	2004-12-28	Novartis Ag	Process for the manufacture of organic compounds
CA2478317A1 (en) *	2002-03-04	2003-09-18	Medimmune, Inc.	Methods of preventing or treating disorders by administering an integrin .alpha.v.beta.3 antagonist in combination with an hmg-coa reductase inhibitor or a bisphosphonate
CN100378077C (zh) *	2002-11-06	2008-04-02	日产化学工业株式会社	喹啉甲醛类的制造方法
EP1568693A4 (de) *	2002-11-06	2007-09-05	Nissan Chemical Ind Ltd	Verfahren zur herstellung von chinolincarbaldehyd
US7420059B2 (en)	2003-11-20	2008-09-02	Bristol-Myers Squibb Company	HMG-CoA reductase inhibitors and method
AU2004298486A1 (en)	2003-12-12	2005-06-30	Wyeth	Quinolines useful in treating cardiovascular disease
DE602005011286D1 (en) *	2004-07-05	2009-01-08	Astellas Pharma Inc	Pyrazolopyridinderivate
CN100445267C (zh) *	2005-10-21	2008-12-24	上海医药工业研究院	4-(4-氟-苯基)-3-羟甲基-2-环丙基-喹啉的制备方法
EP2867236B1 (de)	2012-06-29	2017-06-14	Pfizer Inc	Neue 4-(substituierte amino)-7h-pyrrolo[2,3-d]pyrimidine als lrrk2 hemmer
CN103204807B (zh) *	2013-04-08	2015-12-23	黄河三角洲京博化工研究院有限公司	一种2-环丙基-4-（4-氟-苯基）-3-喹啉甲醛的合成方法
ES2671377T3 (es) *	2013-12-13	2018-06-06	Daiichi Sankyo Company, Limited	Derivados de 5-hidroxi-4-(trifluorometil)pirazolopiridina
EP3083618B1 (de)	2013-12-17	2018-02-21	Pfizer Inc	Neuartige 3,4-disubstituierte-1h-pyrrolo[2,3-b]pyridine und 4,5-disubstituierte 7h-pyrrolo[2,3-c]pyridazine als lrrk2-hemmer
CN104031034B (zh) *	2014-07-01	2017-01-04	上海信谊百路达药业有限公司	一种匹伐他汀钙原料药中间体的制备方法
RU2722149C1 (ru)	2015-09-14	2020-05-27	Пфайзер Инк.	Новые производные имидазо[4,5-c] хинолинов и имидазо[4,5-c][1,5] нафтиридинов в качестве ингибиторов LRRK2

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2569746B2 (ja) *	1987-08-20	1997-01-08	日産化学工業株式会社	キノリン系メバロノラクトン類
CA1336714C (en) *	1987-08-20	1995-08-15	Yoshihiro Fujikawa	Quinoline type mevalonolactone inhibitors of cholesterol biosynthesis
US4761419A (en) *	1987-12-07	1988-08-02	Warner-Lambert Company	6-(((substituted)quinolinyl)ethyl)-and ethenyl)tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
US4822799A (en) *	1988-01-27	1989-04-18	Sandoz Pharm. Corp.	Pyrazolopyridine analogs of mevalonolactone and derivatives thereof useful for inhibiting cholesterol biosynthesis in mammals
JP2890448B2 (ja) *	1988-04-26	1999-05-17	日産化学工業株式会社	ピラゾロピリジン系メバロノラクトン類
US5024999A (en) *	1988-04-26	1991-06-18	Nissan Chemical Industries Ltd.	Pyrazolopyridine type mevalonolactones useful as pharmaeuticals
US5026698A (en) *	1988-11-02	1991-06-25	Nissan Chemical Industries, Ltd.	Thienopyridine type mevalonolactones

1991
- 1991-10-04 JP JP03257870A patent/JP3130342B2/ja not_active Expired - Fee Related
1992
- 1992-09-24 AT AT92116417T patent/ATE209035T1/de not_active IP Right Cessation
- 1992-09-24 DE DE69232217T patent/DE69232217T2/de not_active Expired - Lifetime
- 1992-09-24 DK DK92116417T patent/DK0535548T3/da active
- 1992-09-24 EP EP92116417A patent/EP0535548B1/de not_active Expired - Lifetime
- 1992-09-28 AU AU26012/92A patent/AU652669B2/en not_active Ceased
- 1992-09-30 NZ NZ244555A patent/NZ244555A/en not_active IP Right Cessation
- 1992-09-30 US US07/953,716 patent/US6162798A/en not_active Expired - Fee Related
- 1992-10-01 TW TW081107817A patent/TW238300B/zh not_active IP Right Cessation
- 1992-10-02 SK SK3027-92A patent/SK279277B6/sk not_active IP Right Cessation
- 1992-10-02 KR KR1019920018157A patent/KR100264543B1/ko not_active Expired - Fee Related
- 1992-10-02 RU SU5052949A patent/RU2114620C1/ru active
- 1992-10-02 NO NO923858A patent/NO302452B1/no not_active IP Right Cessation
- 1992-10-02 MX MX9205659A patent/MX9205659A/es unknown
- 1992-10-02 CA CA002079706A patent/CA2079706C/en not_active Expired - Fee Related
- 1992-10-02 CZ CS923027A patent/CZ281786B6/cs not_active IP Right Cessation
- 1992-10-02 HU HU9203138A patent/HU214624B/hu not_active IP Right Cessation
1993
- 1993-04-22 UA UA93002706A patent/UA39095C2/uk unknown

Also Published As

Publication number	Publication date
HUT62794A (en)	1993-06-28
HU214624B (hu)	1998-04-28
CZ302792A3 (en)	1993-10-13
AU652669B2 (en)	1994-09-01
NO923858D0 (no)	1992-10-02
JP3130342B2 (ja)	2001-01-31
EP0535548A1 (de)	1993-04-07
NO923858L (no)	1993-04-05
EP0535548B1 (de)	2001-11-21
CZ281786B6 (cs)	1997-01-15
TW238300B (de)	1995-01-11
CA2079706C (en)	2004-03-30
UA39095C2 (uk)	2001-06-15
SK279277B6 (sk)	1998-09-09
NO302452B1 (no)	1998-03-09
US6162798A (en)	2000-12-19
AU2601292A (en)	1993-04-08
DE69232217D1 (de)	2002-01-03
JPH06329540A (ja)	1994-11-29
SK302792A3 (en)	1995-11-08
CA2079706A1 (en)	1993-04-15
KR930007449A (ko)	1993-05-20
RU2114620C1 (ru)	1998-07-10
DE69232217T2 (de)	2002-05-23
NZ244555A (en)	2000-06-23
DK0535548T3 (da)	2002-05-13
MX9205659A (es)	1993-04-01
KR100264543B1 (ko)	2001-10-24

Legal Events

Date	Code	Title	Description
2002-03-15	UEP	Publication of translation of european patent specification
2011-06-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE209035T1 (de)	2001-12-15	Inhibitor von der atherosklerotischen intimalerdickung
ATE114645T1 (de)	1994-12-15	Mevalonolaktone vom chinolin-typ.
MY110447A (en)	1998-05-30	New herbicides
DK0613618T3 (da)	1997-05-26	Fremgangsmåde til beskyttelse af nytteplanter mod herbicider med substituerede benzopyran- og tetrahydronaphthalenforbindelser
MY131297A (en)	2007-08-30	Herbicides
IL104614A (en)	1997-04-15	4-benzoylisoxazole derivatives and herbicidal compositions comprising them
BR8305546A (pt)	1984-05-15	Processo para a preparacao de derivados substituidos de 1-hidroxietil-triazolilo, composicoes de protecao as plantas e fungicidas e processos para o combate a fungos, para a protecao de plantas e para a preparacao de composicoes
FI951731A0 (fi)	1995-04-11	Heterosykliset yhdisteet, joilla on sokeritautia vastustava vaikutus, niiden valmistus ja käyttö
NZ331123A (en)	2000-03-27	2-(benzo-1,4-oxathiin)- or (benzo-1,4-dithiin)-cyclohexane-1,3-diones and herbicidal compositions
MX9710375A (es)	1998-07-31	Cetales y espirociclicos herbicidas.
EA200100310A1 (ru)	2001-10-22	Кислородсодержащие гетероциклические соединения
DK0540356T3 (da)	1999-10-11	Fremgangsmåde til fremstilling af visse substituerede biphenyltetrazolderivater
ES8304579A1 (es)	1983-03-01	Un procedimiento para la preparacion de orto (sulfonil) oxibenceno-sulfonamidas.
WO2000024717A3 (en)	2000-09-14	Isoquinoline derivatives
DE69018335D1 (de)	1995-05-11	Imidazochinolonderivate.
DK0479175T3 (da)	1994-06-13	Pradimicinderivater
DE69124017D1 (de)	1997-02-20	Heterocyclische Derivate
GR3031960T3 (en)	2000-03-31	Novel compounds.
FI853907L (fi)	1986-04-10	Mellanprodukter foer framstaellning av 16-fenoxi- och 16-substituerade fenoxi-prostatriensyraderivat.
DE3778088D1 (de)	1992-05-14	Substituierte pyrimidochinoxaline.
IL74633A (en)	1988-11-15	Synergistic herbicidal compositions comprising trimethylsulphonium salt of n-phosphonomethyl-glycine and 1-m-trifluoromethyl-phenyl-3-chloro-4-chloromethyl-2-pyrrolidone
JPS57142915A (en)	1982-09-03	Antiphlogistic agent
BR8704391A (pt)	1988-04-19	Composto,processo para sua preparacao,composicao herbicida e processo para combater o crescimento de planta indesejada
TW349949B (en)	1999-01-11	New imidazole derivatives, preparation process, intermediates obtained, use as medicaments, pharmaceutical compositions and new use
ES2038672T3 (es)	1993-08-01	Antagonistas h1 purinicos de la histamina, su preparacion y composiciones farmaceuticas que los contienen.