ATE209650T1 - Wellenlängenspezifisches, cytotoxisches mittel - Google Patents

Wellenlängenspezifisches, cytotoxisches mittel

Info

Publication number: ATE209650T1
Authority: AT; Austria
Prior art keywords: tissues; cells; specific; wavelength; cytotoxic agent
Prior art date: 1988-07-19

Application number

AT94115192T

Other languages

English (en)

Inventor

Julia G Levy

David Dolphin

Jack K Chow

Ethan Sternberg

Original Assignee

Univ British Columbia

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-07-19

Filing date

1989-07-19

Publication date

2001-12-15

1989-07-19 Application filed by Univ British Columbia filed Critical Univ British Columbia

2001-12-15 Application granted granted Critical

2001-12-15 Publication of ATE209650T1 publication Critical patent/ATE209650T1/de

Links

229940127089 cytotoxic agent Drugs 0.000 title 1
239000002254 cytotoxic agent Substances 0.000 title 1
231100000599 cytotoxic agent Toxicity 0.000 title 1
UJKPHYRXOLRVJJ-MLSVHJFASA-N CC(O)C1=C(C)/C2=C/C3=N/C(=C\C4=C(CCC(O)=O)C(C)=C(N4)/C=C4\N=C(\C=C\1/N\2)C(C)=C4C(C)O)/C(CCC(O)=O)=C3C Chemical class CC(O)C1=C(C)/C2=C/C3=N/C(=C\C4=C(CCC(O)=O)C(C)=C(N4)/C=C4\N=C(\C=C\1/N\2)C(C)=C4C(C)O)/C(CCC(O)=O)=C3C UJKPHYRXOLRVJJ-MLSVHJFASA-N 0.000 abstract 1
241000700605 Viruses Species 0.000 abstract 1
238000010521 absorption reaction Methods 0.000 abstract 1
239000008280 blood Substances 0.000 abstract 1
210000004369 blood Anatomy 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000012634 fragment Substances 0.000 abstract 1
239000003446 ligand Substances 0.000 abstract 1
239000000463 material Substances 0.000 abstract 1
150000004032 porphyrins Chemical class 0.000 abstract 1
230000005855 radiation Effects 0.000 abstract 1
238000007086 side reaction Methods 0.000 abstract 1
229940043517 specific immunoglobulins Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0485—Porphyrins, texaphyrins wherein the nitrogen atoms forming the central ring system complex the radioactive metal
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0036—Porphyrins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0058—Antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmacology & Pharmacy (AREA)
Optics & Photonics (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Physics & Mathematics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Steroid Compounds (AREA)

AT94115192T 1988-07-19 1989-07-19 Wellenlängenspezifisches, cytotoxisches mittel ATE209650T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/221,161 US4920143A (en)	1987-04-23	1988-07-19	Hydro-monobenzoporphyrin wavelength-specific cytotoxic agents

Publications (1)

Publication Number	Publication Date
ATE209650T1 true ATE209650T1 (de)	2001-12-15

Family

ID=22826617

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT89307281T ATE127696T1 (de)	1988-07-19	1989-07-19	Wellenlängenspeziphisches, cytotoxisches mittel.
AT94115192T ATE209650T1 (de)	1988-07-19	1989-07-19	Wellenlängenspezifisches, cytotoxisches mittel

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT89307281T ATE127696T1 (de)	1988-07-19	1989-07-19	Wellenlängenspeziphisches, cytotoxisches mittel.

Country Status (10)

Country	Link
US (1)	US4920143A (de)
EP (2)	EP0641796B1 (de)
AT (2)	ATE127696T1 (de)
AU (1)	AU638675B2 (de)
CA (1)	CA1339927C (de)
DE (3)	DE68929351T2 (de)
ES (2)	ES2169060T3 (de)
GR (1)	GR3017426T3 (de)
LU (1)	LU90718I2 (de)
NL (1)	NL300037I2 (de)

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WO1999013943A1 (en)	1996-03-05	1999-03-25	Ekos Corporation	Ultrasound assembly for use with light activated drugs
US5693789A (en) *	1996-04-10	1997-12-02	Abbott Laboratories	Process for the preparation of a protoporphyrin
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US6043237A (en)	1996-12-10	2000-03-28	Qlt Phototherapeutics, Inc.	Use of photodynamic therapy for prevention of secondary cataracts
ES2210740T3 (es) *	1997-05-07	2004-07-01	University Of British Columbia	Nueva clase de compuestos fotoactivos derivados de la benzoporfirina.
US6756396B1 (en)	1997-05-07	2004-06-29	Qlt Inc.	Ethylene glycol esters as photoactive agents
US5880145A (en) *	1997-05-07	1999-03-09	The University Of British Columbia	Class of benzoporphyrin derivative photoactive compounds
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US6316215B1 (en)	1999-12-27	2001-11-13	Edwin L. Adair	Methods of cancer screening utilizing fluorescence detection techniques and selectable imager charge integration periods
CN1203900C (zh)	1998-01-06	2005-06-01	塞鲁斯公司	用于淬灭生物材料中病原体灭活剂的方法
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WO2000061584A1 (en)	1999-04-14	2000-10-19	The University Of British Columbia	IMPROVED β,β,-DIHYDROXY MESO-SUBSTITUTED CHLORINS, ISOBACTERIOCHLORINS, AND BACTERIOCHLORINS
US20020022032A1 (en) *	1999-04-23	2002-02-21	Curry Patrick Mark	Immuno-adjuvant PDT treatment of metastatic tumors
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US6750037B2 (en) *	1999-12-27	2004-06-15	Edwin L. Adair	Method of cancer screening primarily utilizing non-invasive cell collection, fluorescence detection techniques, and radio tracing detection techniques
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US7282215B2 (en)	2000-05-08	2007-10-16	The University Of British Columbia	Supports for photosensitizer formulations
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WO2004034889A2 (en) *	2002-10-18	2004-04-29	The Regents Of The University Of California	Photodynamic therapy for ocular neovascularization
US20040220167A1 (en) *	2003-05-02	2004-11-04	Nasrollah Samiy	Methods of treating neuralgic pain
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CA2720824C (en)	2008-04-09	2021-09-14	Cerus Corporation	Improved quenching methods for red blood cell pathogen inactivation
US8829020B2 (en)	2009-07-16	2014-09-09	Mallinckrodt Llc	Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
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CN104379602B (zh)	2012-03-08	2017-05-03	哈洛齐梅公司	具有条件活性的抗表皮生长因子受体抗体及其使用方法
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SG11201601770YA (en)	2013-09-12	2016-04-28	Halozyme Inc	Modified anti-epidermal growth factor receptor antibodies and methods of use thereof
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1988
- 1988-07-19 US US07/221,161 patent/US4920143A/en not_active Expired - Lifetime
1989
- 1989-07-17 CA CA000605858A patent/CA1339927C/en not_active Expired - Lifetime
- 1989-07-19 EP EP94115192A patent/EP0641796B1/de not_active Expired - Lifetime
- 1989-07-19 EP EP89307281A patent/EP0352076B1/de not_active Expired - Lifetime
- 1989-07-19 DE DE68929351T patent/DE68929351T2/de not_active Expired - Lifetime
- 1989-07-19 DE DE68924215T patent/DE68924215T2/de not_active Expired - Lifetime
- 1989-07-19 AT AT89307281T patent/ATE127696T1/de active
- 1989-07-19 AT AT94115192T patent/ATE209650T1/de not_active IP Right Cessation
- 1989-07-19 AU AU38258/89A patent/AU638675B2/en not_active Expired
- 1989-07-19 ES ES94115192T patent/ES2169060T3/es not_active Expired - Lifetime
- 1989-07-19 ES ES89307281T patent/ES2080745T3/es not_active Expired - Lifetime
- 1989-07-19 DE DE2001199008 patent/DE10199008I2/de active Active
1995
- 1995-09-18 GR GR950402549T patent/GR3017426T3/el unknown
2000
- 2000-01-17 LU LU90718C patent/LU90718I2/fr unknown
2001
- 2001-01-15 NL NL300037C patent/NL300037I2/nl unknown

Also Published As

Publication number	Publication date
DE68929351D1 (de)	2002-01-10
GR3017426T3 (en)	1995-12-31
CA1339927C (en)	1998-06-23
ES2080745T3 (es)	1996-02-16
DE68929351T2 (de)	2002-05-08
AU3825889A (en)	1990-02-08
DE10199008I1 (de)	2003-06-12
EP0352076A3 (de)	1991-07-17
EP0352076B1 (de)	1995-09-13
DE68924215T2 (de)	1996-02-15
EP0641796A1 (de)	1995-03-08
ES2169060T3 (es)	2002-07-01
AU638675B2 (en)	1993-07-08
DE68924215D1 (de)	1995-10-19
DE10199008I2 (de)	2004-10-14
NL300037I2 (nl)	2001-08-01
ATE127696T1 (de)	1995-09-15
NL300037I1 (nl)	2001-03-01
LU90718I2 (fr)	2001-03-01
EP0352076A2 (de)	1990-01-24
US4920143A (en)	1990-04-24
EP0641796B1 (de)	2001-11-28

Legal Events

Date	Code	Title	Description
2002-03-15	UEP	Publication of translation of european patent specification
2009-10-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
ATE127696T1 (de)	1995-09-15	Wellenlängenspeziphisches, cytotoxisches mittel.
EP0947222B1 (de)	2006-04-12	Verfahren zur Aktivierung von photoempfindlichen Mitteln
BR9712599A (pt)	1999-12-21	Processos para o tratamento de um volume particular, de câncer e de um volume de tecido canceroso em tecido e para produzir pelo menos um agente molecular foto-ativo num volume particular de material e aparelhos para o tratamento de um volume particular de tecido de planta ou de animal e para a administração de um tratamento médico foto-dinâmico
HU220251B (hu)	2001-11-28	Fényérzékenyítő anyagok in vivo transzkután aktiválása a vérben
Wachter et al.	1998	Simultaneous two-photon excitation of photodynamic therapy agents
EP1120119A4 (de)	2003-10-01	Heilmittel für die photochemotherapie
RU2006110554A (ru)	2006-08-10	Соединение для антимикробной фотодинамической терапии и способ применения
Biolo et al.	1994	Photodynamic therapy of B16 pigmented melanoma with liposome‐delivered Si (IV)‐naphthalocyanine
Ash et al.	1989	Photodynamic therapy--achievements and prospects
Petrozzi et al.	1977	Topical methoxsalen and blacklight in the treatment of psoriasis
WO1992000106A3 (en)	1992-02-20	Method of treatment and compositions therefore
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