ATE209911T1 - Gepresste nitroglycerintablette und verfahren zu ihrer herstellung - Google Patents

Gepresste nitroglycerintablette und verfahren zu ihrer herstellung

Info

Publication number: ATE209911T1
Authority: AT; Austria
Prior art keywords: nitroglycerin; tablets; tablet; stable; direct compression
Prior art date: 1997-10-03

Application number

AT98948293T

Other languages

English (en)

Inventor

Roberto L Capella

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-03

Filing date

1998-09-16

Publication date

2001-12-15

1998-09-16 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

2001-12-15 Application granted granted Critical

2001-12-15 Publication of ATE209911T1 publication Critical patent/ATE209911T1/de

Links

238000000034 method Methods 0.000 title abstract 2
SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 abstract 4
239000000006 Nitroglycerin Substances 0.000 abstract 4
229960003711 glyceryl trinitrate Drugs 0.000 abstract 4
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 2
230000003247 decreasing effect Effects 0.000 abstract 2
238000007907 direct compression Methods 0.000 abstract 2
239000008101 lactose Substances 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
239000003826 tablet Substances 0.000 abstract 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
229920002472 Starch Polymers 0.000 abstract 1
238000010521 absorption reaction Methods 0.000 abstract 1
CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 abstract 1
235000013539 calcium stearate Nutrition 0.000 abstract 1
239000008116 calcium stearate Substances 0.000 abstract 1
239000007891 compressed tablet Substances 0.000 abstract 1
238000010790 dilution Methods 0.000 abstract 1
239000012895 dilution Substances 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
229910021485 fumed silica Inorganic materials 0.000 abstract 1
230000005012 migration Effects 0.000 abstract 1
238000013508 migration Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000008107 starch Substances 0.000 abstract 1
235000019698 starch Nutrition 0.000 abstract 1
239000006190 sub-lingual tablet Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Emergency Medicine (AREA)
Zoology (AREA)
Nutrition Science (AREA)
Physiology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT98948293T 1997-10-03 1998-09-16 Gepresste nitroglycerintablette und verfahren zu ihrer herstellung ATE209911T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US6110597P	1997-10-03	1997-10-03
PCT/US1998/019356 WO1999017766A1 (en)	1997-10-03	1998-09-16	Compressed nitroglycerin tablet and its method of manufacture

Publications (1)

Publication Number	Publication Date
ATE209911T1 true ATE209911T1 (de)	2001-12-15

Family

ID=22033623

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98948293T ATE209911T1 (de)	1997-10-03	1998-09-16	Gepresste nitroglycerintablette und verfahren zu ihrer herstellung

Country Status (16)

Country	Link
US (1)	US6500456B1 (de)
EP (1)	EP1019039B1 (de)
JP (1)	JP2001518500A (de)
KR (1)	KR100569763B1 (de)
AT (1)	ATE209911T1 (de)
AU (1)	AU759018B2 (de)
BR (1)	BR9812605B1 (de)
CA (1)	CA2299231C (de)
DE (1)	DE69802832T2 (de)
DK (1)	DK1019039T3 (de)
ES (1)	ES2169558T3 (de)
IL (1)	IL134395A (de)
NZ (1)	NZ502878A (de)
PT (1)	PT1019039E (de)
TW (1)	TWI228989B (de)
WO (1)	WO1999017766A1 (de)

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US7815937B2 (en) *	1998-10-27	2010-10-19	Biovail Laboratories International Srl	Quick dissolve compositions and tablets based thereon
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US7815936B2 (en)	2001-10-30	2010-10-19	Evonik Degussa Gmbh	Use of granular materials based on pyrogenically produced silicon dioxide in pharmaceutical compositions
US20040109889A1 (en)	2002-12-04	2004-06-10	Bunick Frank J.	Surface treatment composition for soft substrates
US10172810B2 (en)	2003-02-24	2019-01-08	Pharmaceutical Productions, Inc.	Transmucosal ketamine delivery composition
EP2343045A3 (de) *	2003-02-24	2011-09-21	Pharmaceutical Productions Inc.	System zur transmukosalen Verabreichung von Arzneimitteln
US9254294B2 (en)	2003-02-24	2016-02-09	Pharmaceutical Productions Inc.	Transmucosal hormone delivery system
US9498454B2 (en)	2003-02-24	2016-11-22	Pharmaceutical Productions Inc.	Transmucosal drug delivery system
US9358296B2 (en)	2003-02-24	2016-06-07	Pharmaceutical Productions Inc.	Transmucosal drug delivery system
US20070059346A1 (en) *	2003-07-01	2007-03-15	Todd Maibach	Film comprising therapeutic agents
US7999003B2 (en) *	2003-08-26	2011-08-16	Mannatech, Incorporated	Antioxidant compositions and methods thereto
US20060134202A1 (en) *	2004-12-22	2006-06-22	Hack Jacob C	Homeopathic sublingual dosage forms and methods thereof
US8252328B2 (en) *	2006-01-06	2012-08-28	Acelrx Pharmaceuticals, Inc.	Bioadhesive drug formulations for oral transmucosal delivery
US8535714B2 (en)	2006-01-06	2013-09-17	Acelrx Pharmaceuticals, Inc.	Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US8865743B2 (en)	2006-01-06	2014-10-21	Acelrx Pharmaceuticals, Inc.	Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US9066847B2 (en)	2007-01-05	2015-06-30	Aceirx Pharmaceuticals, Inc.	Storage and dispensing devices for administration of oral transmucosal dosage forms
US8357114B2 (en)	2006-01-06	2013-01-22	Acelrx Pharmaceuticals, Inc.	Drug dispensing device with flexible push rod
US8202535B2 (en)	2006-01-06	2012-06-19	Acelrx Pharmaceuticals, Inc.	Small-volume oral transmucosal dosage forms
US8753308B2 (en)	2006-01-06	2014-06-17	Acelrx Pharmaceuticals, Inc.	Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US9289583B2 (en)	2006-01-06	2016-03-22	Acelrx Pharmaceuticals, Inc.	Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US8252329B2 (en)	2007-01-05	2012-08-28	Acelrx Pharmaceuticals, Inc.	Bioadhesive drug formulations for oral transmucosal delivery
US20100215774A1 (en) *	2007-02-09	2010-08-26	Todd Maibach	Film comprising nitroglycerin
US20090004254A1 (en) *	2007-06-19	2009-01-01	Todd Maibach	Film comprising active drugs
EP2604257B1 (de) *	2007-08-07	2017-06-28	Acelrx Pharmaceuticals, Inc.	Orale transmukosale Dosierungsformen mit Sufentanil und Triazolam
US8945592B2 (en) *	2008-11-21	2015-02-03	Acelrx Pharmaceuticals, Inc.	Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same
US20110091544A1 (en) *	2009-10-16	2011-04-21	Acelrx Pharmaceuticals, Inc.	Compositions and Methods for Mild Sedation, Anxiolysis and Analgesia in the Procedural Setting
ES2582309T3 (es)	2010-08-03	2016-09-12	G. Pohl-Boskamp Gmbh & Co. Kg	Uso de trinitrato de glicerilo para el tratamiento de edema traumático
WO2012113564A1 (en)	2011-02-25	2012-08-30	G. Pohl-Boskamp Gmbh & Co. Kg	Stabilized granules containing glyceryl trinitrate
US9248099B2 (en)	2012-05-31	2016-02-02	Desmoid Aktiengesellschaft	Use of stabilized granules containing glyceryl trinitrate for arteriogenesis
PL2668947T3 (pl)	2012-05-31	2017-06-30	G. Pohl-Boskamp Gmbh & Co. Kg	Indukcja arteriogenezy donorem NO, takim jak nitrogliceryna
EP2668948A1 (de) *	2012-05-31	2013-12-04	G. Pohl-Boskamp GmbH & Co. KG	Verwendung von stabilisierten Körnchen mit Glyceryltrinitrat für Arteriogenese
CA2883270A1 (en) *	2012-08-31	2014-03-06	Astellas Pharma Inc.	Orally administered medical composition
CN113842362A (zh)	2012-11-14	2021-12-28	格雷斯公司	含有生物活性材料与无序无机氧化物的组合物
US20140303227A1 (en) *	2013-03-14	2014-10-09	Pharmaceutical Productions Inc.	Transmucosal hormone delivery system
EP2878310B1 (de)	2013-11-29	2017-01-11	G. Pohl-Boskamp GmbH & Co. KG	Sprühbare wässrige Zusammensetzung mit Nitroglycerin
WO2015119641A1 (en) *	2014-02-07	2015-08-13	Scilabs Pharmaceuticals	All natural, non-toxic sublingual drug delivery systems
WO2021226416A1 (en)	2020-05-08	2021-11-11	Psilera Inc.	Novel compositions of matter and pharmaceutical compositions
CN113679682A (zh) *	2020-05-19	2021-11-23	珠海润都制药股份有限公司	一种硝酸甘油舌下片及其制备方法
CA3218110A1 (en)	2021-05-25	2022-12-01	Majed Fawaz	New n,n-dimethyltryptamine salts and crystalline salt forms
WO2023129956A2 (en)	2021-12-30	2023-07-06	ATAI Life Sciences AG	Dimethyltryptamine analogues as nitric oxide delivery drugs
CN114469881A (zh) *	2022-03-14	2022-05-13	河北坤安药业有限公司	一种硝酸甘油片及其制备方法
CN115154431B (zh) *	2022-07-21	2024-03-12	南京卓康医药科技有限公司	一种硝酸甘油片剂及其制备方法
WO2025024637A1 (en) *	2023-07-25	2025-01-30	Atai Therapeutics, Inc.	Compositions for limiting sympathomimetic effects of psychedelic therapeutics
CN117653610B (zh) *	2023-09-28	2024-07-05	海南卓科制药有限公司	一种硝酸甘油片及其制备方法

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DE2357503A1 (de) *	1973-11-17	1975-05-28	Cassella Farbwerke Mainkur Ag	Verfahren zur herstellung von festen carbocromen-hydrochlorid enthaltenden praeparaten
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WO1996036330A2 (en) *	1995-05-17	1996-11-21	Cedars-Sinai Medical Center	Compositions containing fatty acids for improving digestion and absorption in the small intestine
US5874418A (en) *	1997-05-05	1999-02-23	Cydex, Inc.	Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use

1998
- 1998-09-16 US US09/508,705 patent/US6500456B1/en not_active Expired - Lifetime
- 1998-09-16 KR KR1020007003497A patent/KR100569763B1/ko not_active Expired - Fee Related
- 1998-09-16 NZ NZ502878A patent/NZ502878A/en unknown
- 1998-09-16 PT PT98948293T patent/PT1019039E/pt unknown
- 1998-09-16 IL IL13439598A patent/IL134395A/xx not_active IP Right Cessation
- 1998-09-16 ES ES98948293T patent/ES2169558T3/es not_active Expired - Lifetime
- 1998-09-16 WO PCT/US1998/019356 patent/WO1999017766A1/en not_active Ceased
- 1998-09-16 AU AU94893/98A patent/AU759018B2/en not_active Ceased
- 1998-09-16 EP EP98948293A patent/EP1019039B1/de not_active Expired - Lifetime
- 1998-09-16 BR BRPI9812605-9A patent/BR9812605B1/pt not_active IP Right Cessation
- 1998-09-16 CA CA002299231A patent/CA2299231C/en not_active Expired - Fee Related
- 1998-09-16 DK DK98948293T patent/DK1019039T3/da active
- 1998-09-16 DE DE69802832T patent/DE69802832T2/de not_active Expired - Fee Related
- 1998-09-16 JP JP2000514637A patent/JP2001518500A/ja active Pending
- 1998-09-16 AT AT98948293T patent/ATE209911T1/de not_active IP Right Cessation
- 1998-09-29 TW TW087116123A patent/TWI228989B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69802832D1 (de)	2002-01-17
TWI228989B (en)	2005-03-11
CA2299231A1 (en)	1999-04-15
IL134395A0 (en)	2001-04-30
DK1019039T3 (da)	2002-03-25
WO1999017766A1 (en)	1999-04-15
NZ502878A (en)	2002-03-01
CA2299231C (en)	2003-03-18
DE69802832T2 (de)	2002-06-20
ES2169558T3 (es)	2002-07-01
AU9489398A (en)	1999-04-27
IL134395A (en)	2005-08-31
AU759018B2 (en)	2003-04-03
BR9812605B1 (pt)	2009-01-13
KR20010030839A (ko)	2001-04-16
KR100569763B1 (ko)	2006-04-11
EP1019039B1 (de)	2001-12-05
PT1019039E (pt)	2002-04-29
JP2001518500A (ja)	2001-10-16
US6500456B1 (en)	2002-12-31
EP1019039A1 (de)	2000-07-19
BR9812605A (pt)	2000-08-01

Legal Events

Date	Code	Title	Description
2002-05-15	UEP	Publication of translation of european patent specification
2010-06-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE209911T1 (de)	2001-12-15	Gepresste nitroglycerintablette und verfahren zu ihrer herstellung
KR900012606A (ko)	1990-09-01	이중 정제
NZ336789A (en)	2000-11-24	Use of methacrylic acid copolymer type C in the manufacture of tablets
EA199700110A1 (ru)	1997-12-30	Композиция с высоким содержанием ацетаминофена для прямого прессования
ATE100708T1 (de)	1994-02-15	Unbeschichtete pharmazeutische reaktionstablette.
IL115309A0 (en)	1995-12-31	Pharmaceutical preparation containing metformin and processes for the production thereof
NO975320L (no)	1998-01-27	Kontinuerlige, fluorkjemiske mikrodispersjoner for avlevering av farmasöytiske midler
BG101901A (bg)	1998-10-30	2-метил-тиено-бензодиазепинова формулировка за приемане през устата и метод за нейното получаване
ATE68346T1 (de)	1991-11-15	Feuchtigkeitsstabile feste valproinsaeurezubereitung und verfahren zu ihrer herstellung.
ATE186462T1 (de)	1999-11-15	Gepirone enthaltende zusammensetzungen
RU2002123182A (ru)	2004-03-20	Содержащая ибупрофен композиция
MY120570A (en)	2005-11-30	Pharmaceutical preparation containing levothyroxine sodium
MXPA04003346A (es)	2004-09-28	Formulacion de dosis oral de disolucion instantanea.
ATE441410T1 (de)	2009-09-15	Fenofibrattabletten
KR900004326A (ko)	1990-04-12	디히드로에르고톡신 및 그의 산 부가염의 분산성 정제
WO2003033808A3 (en)	2003-09-18	Composition and method for treating diabetes
EP0235363A3 (en)	1987-11-19	Sustained release tablets of theophylline
AU2003255355A1 (en)	2004-02-25	Progesterone receptor modulators having an increased antigonadotropic activity for use in female fertility testing and hormone replacement therapy
CA2185242C (en)	2004-11-23	Sustained release tablet containing diclofenac-na
GB9914936D0 (en)	1999-08-25	Directly compressible starch as enhancer of properties of excipients when used as binder and disintegrant for compression tablets
DE60203997D1 (de)	2005-06-09	Nasses granulationsverfahren zur herstellung von pharmazeutischen tabletten mit paroxetinhydrochlorid anhydrat
WO2001002340A3 (en)	2001-06-14	Novel aminoindanes
HU9602470D0 (en)	1996-10-28	Tablets containing captopril and process for producing them
ATE72118T1 (de)	1992-02-15	Pharmazeutische zusammensetzung und verfahren zu ihrer herstellung.
CA2343949A1 (en)	2002-10-12	Benazepril hydrochloride tablet formulations