DK1019039T3 - Komprimeret nitroglycerintablet og fremgangsmåde til dens fremstilling - Google Patents

Komprimeret nitroglycerintablet og fremgangsmåde til dens fremstilling

Info

Publication number: DK1019039T3
Authority: DK; Denmark
Prior art keywords: nitroglycerin; tablets; stable; direct compression; compression technology
Prior art date: 1997-10-03

Application number

DK98948293T

Other languages

Danish (da)

English (en)

Inventor

Roberto L Capella

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-03

Filing date

1998-09-16

Publication date

2002-03-25

1998-09-16 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

2002-03-25 Application granted granted Critical

2002-03-25 Publication of DK1019039T3 publication Critical patent/DK1019039T3/da

Links

SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 title abstract 5
239000000006 Nitroglycerin Substances 0.000 title abstract 5
229960003711 glyceryl trinitrate Drugs 0.000 title abstract 5
238000000034 method Methods 0.000 title abstract 2
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 2
230000003247 decreasing effect Effects 0.000 abstract 2
238000007907 direct compression Methods 0.000 abstract 2
239000008101 lactose Substances 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
239000003826 tablet Substances 0.000 abstract 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
229920002472 Starch Polymers 0.000 abstract 1
238000010521 absorption reaction Methods 0.000 abstract 1
CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 abstract 1
235000013539 calcium stearate Nutrition 0.000 abstract 1
239000008116 calcium stearate Substances 0.000 abstract 1
239000007891 compressed tablet Substances 0.000 abstract 1
238000010790 dilution Methods 0.000 abstract 1
239000012895 dilution Substances 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
229910021485 fumed silica Inorganic materials 0.000 abstract 1
230000005012 migration Effects 0.000 abstract 1
238000013508 migration Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000008107 starch Substances 0.000 abstract 1
235000019698 starch Nutrition 0.000 abstract 1
239000006190 sub-lingual tablet Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Nutrition Science (AREA)
Physiology (AREA)
Zoology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK98948293T 1997-10-03 1998-09-16 Komprimeret nitroglycerintablet og fremgangsmåde til dens fremstilling DK1019039T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US6110597P	1997-10-03	1997-10-03
PCT/US1998/019356 WO1999017766A1 (en)	1997-10-03	1998-09-16	Compressed nitroglycerin tablet and its method of manufacture

Publications (1)

Publication Number	Publication Date
DK1019039T3 true DK1019039T3 (da)	2002-03-25

Family

ID=22033623

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98948293T DK1019039T3 (da)	1997-10-03	1998-09-16	Komprimeret nitroglycerintablet og fremgangsmåde til dens fremstilling

Country Status (16)

Country	Link
US (1)	US6500456B1 (de)
EP (1)	EP1019039B1 (de)
JP (1)	JP2001518500A (de)
KR (1)	KR100569763B1 (de)
AT (1)	ATE209911T1 (de)
AU (1)	AU759018B2 (de)
BR (1)	BR9812605B1 (de)
CA (1)	CA2299231C (de)
DE (1)	DE69802832T2 (de)
DK (1)	DK1019039T3 (de)
ES (1)	ES2169558T3 (de)
IL (1)	IL134395A (de)
NZ (1)	NZ502878A (de)
PT (1)	PT1019039E (de)
TW (1)	TWI228989B (de)
WO (1)	WO1999017766A1 (de)

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US9254294B2 (en)	2003-02-24	2016-02-09	Pharmaceutical Productions Inc.	Transmucosal hormone delivery system
US10172810B2 (en)	2003-02-24	2019-01-08	Pharmaceutical Productions, Inc.	Transmucosal ketamine delivery composition
KR101170844B1 (ko) *	2003-02-24	2012-08-02	파마슈티칼 프로덕션스, 인크.	경점막 약물 전달 시스템
US9498454B2 (en)	2003-02-24	2016-11-22	Pharmaceutical Productions Inc.	Transmucosal drug delivery system
US9358296B2 (en)	2003-02-24	2016-06-07	Pharmaceutical Productions Inc.	Transmucosal drug delivery system
EP1648362A4 (de) *	2003-07-01	2012-01-11	Todd Maibach	Therapeutische mittel mit film
US7999003B2 (en) *	2003-08-26	2011-08-16	Mannatech, Incorporated	Antioxidant compositions and methods thereto
US20060134202A1 (en) *	2004-12-22	2006-06-22	Hack Jacob C	Homeopathic sublingual dosage forms and methods thereof
US8865743B2 (en)	2006-01-06	2014-10-21	Acelrx Pharmaceuticals, Inc.	Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US8252329B2 (en)	2007-01-05	2012-08-28	Acelrx Pharmaceuticals, Inc.	Bioadhesive drug formulations for oral transmucosal delivery
US9066847B2 (en)	2007-01-05	2015-06-30	Aceirx Pharmaceuticals, Inc.	Storage and dispensing devices for administration of oral transmucosal dosage forms
US9289583B2 (en)	2006-01-06	2016-03-22	Acelrx Pharmaceuticals, Inc.	Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US8535714B2 (en)	2006-01-06	2013-09-17	Acelrx Pharmaceuticals, Inc.	Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US8202535B2 (en)	2006-01-06	2012-06-19	Acelrx Pharmaceuticals, Inc.	Small-volume oral transmucosal dosage forms
US8357114B2 (en)	2006-01-06	2013-01-22	Acelrx Pharmaceuticals, Inc.	Drug dispensing device with flexible push rod
US8252328B2 (en) *	2006-01-06	2012-08-28	Acelrx Pharmaceuticals, Inc.	Bioadhesive drug formulations for oral transmucosal delivery
US8753308B2 (en)	2006-01-06	2014-06-17	Acelrx Pharmaceuticals, Inc.	Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US20100215774A1 (en) *	2007-02-09	2010-08-26	Todd Maibach	Film comprising nitroglycerin
US20090004254A1 (en) *	2007-06-19	2009-01-01	Todd Maibach	Film comprising active drugs
CA2704929C (en) *	2007-08-07	2018-05-15	Pamela Palmer	Compositions and methods for procedural sedation and analgesia using oral transmucosal dosage forms
US8945592B2 (en) *	2008-11-21	2015-02-03	Acelrx Pharmaceuticals, Inc.	Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same
US20110091544A1 (en) *	2009-10-16	2011-04-21	Acelrx Pharmaceuticals, Inc.	Compositions and Methods for Mild Sedation, Anxiolysis and Analgesia in the Procedural Setting
WO2012016691A1 (en)	2010-08-03	2012-02-09	G. Pohl-Boskamp Gmbh & Co. Kg	Use of glyceryl trinitrate for treating traumatic edema
ES2565632T3 (es)	2011-02-25	2016-04-06	G. Pohl-Boskamp Gmbh & Co. Kg	Envase de preparaciones farmacéuticas sólidas que contienen la substancia activa trinitrato de glicerilo
EP2668948A1 (de) *	2012-05-31	2013-12-04	G. Pohl-Boskamp GmbH & Co. KG	Verwendung von stabilisierten Körnchen mit Glyceryltrinitrat für Arteriogenese
ES2617494T3 (es)	2012-05-31	2017-06-19	G. Pohl-Boskamp Gmbh & Co. Kg	Inducción de arteriogénesis con un donador de óxido nítrico tal como nitroglicerina
US9248099B2 (en)	2012-05-31	2016-02-02	Desmoid Aktiengesellschaft	Use of stabilized granules containing glyceryl trinitrate for arteriogenesis
EP2891493A4 (de) *	2012-08-31	2016-05-18	Astellas Pharma Inc	Oral verabreichte medizinische zusammensetzung
CN105050708A (zh)	2012-11-14	2015-11-11	格雷斯公司	含有生物活性材料与无序无机氧化物的组合物
US20140303227A1 (en) *	2013-03-14	2014-10-09	Pharmaceutical Productions Inc.	Transmucosal hormone delivery system
EP2878310B1 (de)	2013-11-29	2017-01-11	G. Pohl-Boskamp GmbH & Co. KG	Sprühbare wässrige Zusammensetzung mit Nitroglycerin
CN115671064A (zh) *	2014-02-07	2023-02-03	讯唐制药公司	全天然无毒舌下药物递送系统
EP4146198A4 (de)	2020-05-08	2024-05-15	Psilera Inc.	Neue stoffzusammensetzungen und pharmazeutische zusammensetzungen
CN113679682A (zh) *	2020-05-19	2021-11-23	珠海润都制药股份有限公司	一种硝酸甘油舌下片及其制备方法
CA3218110A1 (en)	2021-05-25	2022-12-01	Majed Fawaz	New n,n-dimethyltryptamine salts and crystalline salt forms
EP4457214A4 (de)	2021-12-30	2025-12-03	Atai Therapeutics Inc	Dimethyltryptamin-analoga als stickoxid-abgabemittel
CN114469881A (zh) *	2022-03-14	2022-05-13	河北坤安药业有限公司	一种硝酸甘油片及其制备方法
CN115154431B (zh) *	2022-07-21	2024-03-12	南京卓康医药科技有限公司	一种硝酸甘油片剂及其制备方法
WO2025024637A1 (en) *	2023-07-25	2025-01-30	Atai Therapeutics, Inc.	Compositions for limiting sympathomimetic effects of psychedelic therapeutics
CN117653610B (zh) *	2023-09-28	2024-07-05	海南卓科制药有限公司	一种硝酸甘油片及其制备方法

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DE2357503A1 (de) *	1973-11-17	1975-05-28	Cassella Farbwerke Mainkur Ag	Verfahren zur herstellung von festen carbocromen-hydrochlorid enthaltenden praeparaten
US4389393A (en) *	1982-03-26	1983-06-21	Forest Laboratories, Inc.	Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
WO1996036330A2 (en) *	1995-05-17	1996-11-21	Cedars-Sinai Medical Center	Compositions containing fatty acids for improving digestion and absorption in the small intestine
US5874418A (en) *	1997-05-05	1999-02-23	Cydex, Inc.	Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use

1998
- 1998-09-16 DK DK98948293T patent/DK1019039T3/da active
- 1998-09-16 PT PT98948293T patent/PT1019039E/pt unknown
- 1998-09-16 NZ NZ502878A patent/NZ502878A/en unknown
- 1998-09-16 KR KR1020007003497A patent/KR100569763B1/ko not_active Expired - Fee Related
- 1998-09-16 AT AT98948293T patent/ATE209911T1/de not_active IP Right Cessation
- 1998-09-16 US US09/508,705 patent/US6500456B1/en not_active Expired - Lifetime
- 1998-09-16 WO PCT/US1998/019356 patent/WO1999017766A1/en not_active Ceased
- 1998-09-16 DE DE69802832T patent/DE69802832T2/de not_active Expired - Fee Related
- 1998-09-16 CA CA002299231A patent/CA2299231C/en not_active Expired - Fee Related
- 1998-09-16 IL IL13439598A patent/IL134395A/xx not_active IP Right Cessation
- 1998-09-16 AU AU94893/98A patent/AU759018B2/en not_active Ceased
- 1998-09-16 BR BRPI9812605-9A patent/BR9812605B1/pt not_active IP Right Cessation
- 1998-09-16 ES ES98948293T patent/ES2169558T3/es not_active Expired - Lifetime
- 1998-09-16 EP EP98948293A patent/EP1019039B1/de not_active Expired - Lifetime
- 1998-09-16 JP JP2000514637A patent/JP2001518500A/ja active Pending
- 1998-09-29 TW TW087116123A patent/TWI228989B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
TWI228989B (en)	2005-03-11
CA2299231A1 (en)	1999-04-15
AU759018B2 (en)	2003-04-03
EP1019039B1 (de)	2001-12-05
WO1999017766A1 (en)	1999-04-15
BR9812605A (pt)	2000-08-01
ES2169558T3 (es)	2002-07-01
EP1019039A1 (de)	2000-07-19
JP2001518500A (ja)	2001-10-16
AU9489398A (en)	1999-04-27
IL134395A0 (en)	2001-04-30
DE69802832D1 (de)	2002-01-17
KR100569763B1 (ko)	2006-04-11
KR20010030839A (ko)	2001-04-16
US6500456B1 (en)	2002-12-31
PT1019039E (pt)	2002-04-29
NZ502878A (en)	2002-03-01
BR9812605B1 (pt)	2009-01-13
IL134395A (en)	2005-08-31
ATE209911T1 (de)	2001-12-15
DE69802832T2 (de)	2002-06-20
CA2299231C (en)	2003-03-18

Publication	Publication Date	Title
BR9812605A (pt)	2000-08-01	Tablete comprimido de nitroglicerina e o método de fabricação do mesmo
KR900012606A (ko)	1990-09-01	이중 정제
ATE100708T1 (de)	1994-02-15	Unbeschichtete pharmazeutische reaktionstablette.
RU2000123156A (ru)	2003-01-20	Быстро расщепляющаяся фармацевтическая лекарственная форма
EP0151344A3 (de)	1987-04-15	Kaugummizusammensetzung, Herstellungsverfahren von Kaugummi und Kaugummi
IS7208A (is)	2004-04-06	Snöggbráðnandi lyfjagjafarform til inntöku um munn
ATE186462T1 (de)	1999-11-15	Gepirone enthaltende zusammensetzungen
ATE441410T1 (de)	2009-09-15	Fenofibrattabletten
KR900004326A (ko)	1990-04-12	디히드로에르고톡신 및 그의 산 부가염의 분산성 정제
CN108904455B (zh)	2021-04-02	一种含有高剂量油酯成分的片剂的制备方法
CA2502582A1 (en)	2004-04-29	Pharmaceutical formulation of olanzapine
KR100690311B1 (ko)	2007-03-09	새로운 제약 조성물 및 그것의 제조방법
AU3850599A (en)	2000-12-12	Immediate release medicinal compositions for oral use
ATE294580T1 (de)	2005-05-15	Nasses granulationsverfahren zur herstellung von pharmazeutischen tabletten mit paroxetinhydrochlorid anhydrat
NO20054897L (no)	2005-10-24	Farmasoytisk preparat inneholdende platinakompleks som aktiv substans og fremgangsmate for fremstilling derav
KR100676617B1 (ko)	2007-01-30	아목시실린 및/또는 클라불란산 또는 이의 염을 함유하는경구용 현탁정제 조성물
HU9602470D0 (en)	1996-10-28	Tablets containing captopril and process for producing them
US20020183308A1 (en)	2002-12-05	Benazepril Hydrochloride tablet formulations
JPH06340530A (ja)	1994-12-13	経口投与用固体組成物
UY24437A1 (es)	1997-06-06	Procedimiento para preparar productos farmaceuticos
DK0381182T3 (da)	1995-10-30	Erosionskontrolleret frigivelsessystem for aktive midler og fremgangsmåde til fremstilling deraf
RU2314812C2 (ru)	2008-01-20	Твердая лекарственная форма диосмина
KR910009287A (ko)	1991-06-28	활성 화합물의 방출이 지연되지 않는 압착물, 이의 제조방법 및 이러한 압착물 제조용 폴리하이드록시부티르산의 용도
JP2004250398A (ja)	2004-09-09	安定化したマレイン酸エナラプリルを含有する医薬用組成物
YU28404A (sh)	2006-08-17	Brzo topljiva formulacija za oralno doziranje