ZA957568B - Imidazolidines substituted by a heterocycle their preparation process and intermediates their use as medicaments and the pharmaceutical compositions containing them - Google Patents

Imidazolidines substituted by a heterocycle their preparation process and intermediates their use as medicaments and the pharmaceutical compositions containing them

Info

Publication number
ZA957568B
ZA957568B ZA957568A ZA957568A ZA957568B ZA 957568 B ZA957568 B ZA 957568B ZA 957568 A ZA957568 A ZA 957568A ZA 957568 A ZA957568 A ZA 957568A ZA 957568 B ZA957568 B ZA 957568B
Authority
ZA
South Africa
Prior art keywords
opt
substd
heterocycle
medicaments
intermediates
Prior art date
Application number
ZA957568A
Other languages
English (en)
Inventor
Andrew Claussner
Francois Goubet
Jean-Georges Teutsch
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of ZA957568B publication Critical patent/ZA957568B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ZA957568A 1994-09-29 1995-09-08 Imidazolidines substituted by a heterocycle their preparation process and intermediates their use as medicaments and the pharmaceutical compositions containing them ZA957568B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9411649A FR2725206B1 (fr) 1994-09-29 1994-09-29 Nouvelles imidazolidines substituees par un heterocycle, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant

Publications (1)

Publication Number Publication Date
ZA957568B true ZA957568B (en) 1996-09-09

Family

ID=9467411

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA957568A ZA957568B (en) 1994-09-29 1995-09-08 Imidazolidines substituted by a heterocycle their preparation process and intermediates their use as medicaments and the pharmaceutical compositions containing them

Country Status (19)

Country Link
US (3) US5646172A (de)
EP (1) EP0704448B1 (de)
JP (1) JPH0899977A (de)
CN (1) CN1055471C (de)
AT (1) ATE210134T1 (de)
AU (1) AU707569B2 (de)
BR (1) BR9504205A (de)
CA (1) CA2159425A1 (de)
DE (1) DE69524344T2 (de)
DK (1) DK0704448T3 (de)
ES (1) ES2169112T3 (de)
FI (1) FI111259B (de)
FR (1) FR2725206B1 (de)
HU (1) HU222564B1 (de)
IL (1) IL114939A (de)
PT (1) PT704448E (de)
RU (1) RU2170231C2 (de)
UA (1) UA48937C2 (de)
ZA (1) ZA957568B (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2741342B1 (fr) * 1995-11-22 1998-02-06 Roussel Uclaf Nouvelles phenylimidazolidines fluorees ou hydroxylees, procede, intermediaires de preparation, application comme medicaments, nouvelle utilisation et compositions pharmaceutiques
FR2742749B1 (fr) * 1995-12-22 1998-02-06 Roussel Uclaf Nouvelles phenylimidazolidines comportant notamment un radical nitrooxy ou carbonyloxy, procede et intermediaires de preparation, application comme medicaments, nouvelles utilisations et compositions pharmaceutiques
DE19632126A1 (de) * 1996-08-09 1998-02-12 Bayer Ag Phenylsubstituierte cyclische Ketoenole
US20020142993A1 (en) * 2000-10-12 2002-10-03 Dr. Reddy's Laboratories Ltd. Pharmaceutically acceptable salts of bicyclic compounds
DK1385515T3 (da) * 2001-04-18 2008-10-27 Euro Celtique Sa Spiropyrazole forbindelser
RU2243227C1 (ru) * 2003-07-25 2004-12-27 Институт проблем химической физики РАН (dl)-1-гидрокси-3,7,7,9,9-пентаметил-1,4,8-триазаспиро [4,5] декан-2-он и способ его получения
EP1786816A4 (de) * 2003-09-10 2009-11-04 Virochem Pharma Inc Spirohydantoinverbindungen und -verfahren zur modulation von chemokin-rezeptoraktivität
EP1709193B1 (de) * 2003-12-19 2011-03-16 The Regents of The University of California Verfahren und materialien zur beurteilung von prostatakrebstherapien
WO2005099693A2 (en) * 2004-02-24 2005-10-27 The Regents Of The University Of California Methods and materials for assessing prostate cancer therapies and compounds
US7709517B2 (en) 2005-05-13 2010-05-04 The Regents Of The University Of California Diarylhydantoin compounds
CA2608436C (en) 2005-05-13 2015-03-24 The Regents Of The University Of California Diarylhydantoin compounds and their use in the treatment of hyperproliferative disorders
US8211904B2 (en) * 2005-07-18 2012-07-03 Merck, Sharp & Dohme Corp. Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease
ES2689292T3 (es) 2006-03-27 2018-11-13 The Regents Of The University Of California Modulador del receptor de andrógenos para el tratamiento del cáncer de próstata y enfermedades asociadas con el receptor de andrógenos
NZ572374A (en) 2006-03-29 2011-12-22 Univ California Diarylthiohydantoin compounds
US8168667B2 (en) 2006-05-31 2012-05-01 Galapagos Nv Imidazolidine derivatives, uses therefor, preparation thereof and compositions comprising such
GB0610765D0 (en) * 2006-05-31 2006-07-12 Proskelia Sas Imidazolidine derivatives, uses therefor, preparation thereof and compositions comprising such
AU2007293416A1 (en) * 2006-09-07 2008-03-13 Merck & Co., Inc. Spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease
EP2220050A2 (de) 2007-10-26 2010-08-25 The Regents Of The University Of California Diarylhydantoinverbindungen als androgenrezeptormodulatoren
CA2773038A1 (en) 2009-09-04 2011-03-10 P. Jeffrey Conn Mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
KR101456994B1 (ko) 2009-09-10 2014-11-04 통유지 안드로겐 수용체 길항제 및 그의 용도
SG10201907588XA (en) 2010-02-16 2019-09-27 Aragon Pharmaceuticals Inc Androgen Receptor Modulators And Uses Thereof
RU2434851C1 (ru) * 2010-07-22 2011-11-27 Александр Васильевич Иващенко Циклические n, n'-диарилтиомочевины или n, n'-диарилмочевины - антагонисты андрогенных рецепторов, противораковое средство, способ получения и применения
CN103608333B (zh) * 2011-03-10 2016-01-06 苏州开拓药业有限公司 雄激素受体拮抗剂及其用途
CN115737643A (zh) 2012-09-26 2023-03-07 阿拉贡药品公司 用于治疗非转移性去势抵抗性前列腺癌的抗雄激素
DK2945628T3 (da) 2013-01-15 2020-05-04 Aragon Pharmaceuticals Inc Androgen receptormodulator i kombination med abirateronacetat og prednison til behandling af prostatacancer
EP3327144B1 (de) 2013-02-25 2020-03-25 Novartis AG Neuartige androgenrezeptormutation
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
EP3500310A1 (de) 2016-08-20 2019-06-26 FTF Pharma Private Limited Pharmazeutische zusammensetzung mit einem androgenrezeptorinhibitor
MX2020003845A (es) 2017-10-16 2020-11-06 Aragon Pharmaceuticals Inc Antiandrógenos para el tratamiento de cáncer de próstata no metastásico resistente a la castración.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS421179Y1 (de) * 1964-03-13 1967-01-24
JPS4623738Y1 (de) * 1968-05-29 1971-08-16
DE2126532A1 (de) * 1971-05-28 1972-12-07 Merck Patent Gmbh, 6100 Darmstadt Neue Derivate der 6-Aminopenicillansäure und Verfahren zu ihrer Herstellung
FR2329276A1 (fr) * 1975-10-29 1977-05-27 Roussel Uclaf Nouvelles imidazolidines substituees, procede de preparation, application comme medicament et compositions les renfermant
US4200642A (en) * 1978-08-21 1980-04-29 Pfizer Inc. Spiro-oxazolidindiones
US4320135A (en) * 1980-05-19 1982-03-16 Sandoz, Inc. Inhibiting growth hormone secretion with 5,5-substituted hydantoin derivatives
DE3382406D1 (de) * 1982-04-08 1991-10-17 Shell Int Research Neue hydantoine, ihre herstellung und verwendung.
US5221675A (en) * 1989-12-15 1993-06-22 Abbott Laboratories Aza-spirocyclic compounds that enhance cholinergic neurotransmission
US5534520A (en) * 1990-04-10 1996-07-09 Fisher; Abraham Spiro compounds containing five-membered rings
FR2694290B1 (fr) * 1992-07-08 1994-09-02 Roussel Uclaf Nouvelles phénylimidazolidines éventuellement substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.

Also Published As

Publication number Publication date
DE69524344T2 (de) 2002-08-22
ATE210134T1 (de) 2001-12-15
FI954612A0 (fi) 1995-09-28
CN1127753A (zh) 1996-07-31
DK0704448T3 (da) 2002-03-25
CN1055471C (zh) 2000-08-16
JPH0899977A (ja) 1996-04-16
FI111259B (fi) 2003-06-30
US5705654A (en) 1998-01-06
AU3292195A (en) 1996-04-18
FR2725206A1 (fr) 1996-04-05
HU222564B1 (hu) 2003-08-28
DE69524344D1 (de) 2002-01-17
BR9504205A (pt) 1996-08-06
FI954612L (fi) 1996-03-30
ES2169112T3 (es) 2002-07-01
EP0704448A1 (de) 1996-04-03
FR2725206B1 (fr) 1996-12-06
IL114939A0 (en) 1995-12-08
AU707569B2 (en) 1999-07-15
RU2170231C2 (ru) 2001-07-10
US5646172A (en) 1997-07-08
US5958936A (en) 1999-09-28
IL114939A (en) 2005-11-20
UA48937C2 (uk) 2002-09-16
HU9502841D0 (en) 1995-11-28
CA2159425A1 (fr) 1996-03-30
EP0704448B1 (de) 2001-12-05
PT704448E (pt) 2002-05-31
HUT72748A (en) 1996-05-28

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