ATE210427T1 - Verfahren zur herstellung von arzneimittelenthaltenden gefriergetrockneten formulierungen - Google Patents

Verfahren zur herstellung von arzneimittelenthaltenden gefriergetrockneten formulierungen

Info

Publication number: ATE210427T1
Authority: AT; Austria
Prior art keywords: freeze; frozen; liquid; dried formulations; producing medicinal
Prior art date: 1989-04-18

Application number

AT90304230T

Other languages

English (en)

Inventor

Seigo Ueda

Kunio Hashi

Takashi Shiokari

Akira Kusai

Original Assignee

Sankyo Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-04-18

Filing date

1990-04-18

Publication date

2001-12-15

1990-04-18 Application filed by Sankyo Co filed Critical Sankyo Co

2001-12-15 Application granted granted Critical

2001-12-15 Publication of ATE210427T1 publication Critical patent/ATE210427T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
239000000203 mixture Substances 0.000 title 1
239000007788 liquid Substances 0.000 abstract 7
150000001875 compounds Chemical class 0.000 abstract 2
238000002360 preparation method Methods 0.000 abstract 2
238000004108 freeze drying Methods 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
- F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
- A23B2/00—Preservation of foods or foodstuffs, in general
- A23B2/90—Preservation of foods or foodstuffs, in general by drying or kilning; Subsequent reconstitution
- A23B2/92—Freeze drying
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Mechanical Engineering (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Polymers & Plastics (AREA)
Molecular Biology (AREA)
Food Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Saccharide Compounds (AREA)
Electrophonic Musical Instruments (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines Containing Plant Substances (AREA)

AT90304230T 1989-04-18 1990-04-18 Verfahren zur herstellung von arzneimittelenthaltenden gefriergetrockneten formulierungen ATE210427T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP9856189		1989-04-18

Publications (1)

Publication Number	Publication Date
ATE210427T1 true ATE210427T1 (de)	2001-12-15

Family

ID=14223093

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90304230T ATE210427T1 (de)	1989-04-18	1990-04-18	Verfahren zur herstellung von arzneimittelenthaltenden gefriergetrockneten formulierungen

Country Status (16)

Country	Link
US (1)	US5044091B1 (de)
EP (1)	EP0394050B1 (de)
JP (1)	JPH07116022B2 (de)
KR (1)	KR950007908B1 (de)
AT (1)	ATE210427T1 (de)
AU (1)	AU624494B2 (de)
CA (1)	CA2014714C (de)
DE (1)	DE69033874T2 (de)
DK (1)	DK0394050T3 (de)
ES (1)	ES2165839T3 (de)
FI (1)	FI104360B (de)
HU (1)	HU204993B (de)
NO (1)	NO180801C (de)
NZ (1)	NZ233344A (de)
PH (1)	PH27522A (de)
ZA (1)	ZA902909B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5215756A (en) *	1989-12-22	1993-06-01	Gole Dilip J	Preparation of pharmaceutical and other matrix systems by solid-state dissolution
US5169834A (en) *	1990-11-30	1992-12-08	American Cyanamid Company	Compositions and method for reducing vial breakage during lyophilization
GR910100193A (el) *	1991-05-03	1993-03-31	Mediventures Inc	Παρασκευη φαρμακευτικων και αλλων περιβληματων με διαλυση σε στερεα κατασταση.
US5362442A (en) *	1993-07-22	1994-11-08	2920913 Canada Inc.	Method for sterilizing products with gamma radiation
US20040067157A1 (en) *	1993-07-22	2004-04-08	Clearant, Inc.	Methods for sterilizing biological materials
DE19547973C2 (de) *	1995-12-21	1999-08-12	Plantamed Arzneimittel Gmbh	Verfahren zur schonenden Keimreduzierung von pharmazeutischen Zubereitungen
IL120202A (en) *	1996-03-07	2001-03-19	Akzo Nobel Nv	Container with freeze-dried vaccine components
WO1999037288A1 (en) *	1998-01-21	1999-07-29	Takeda Chemical Industries, Ltd.	Lyophilization method for sustained-release preparations
US20040086420A1 (en) *	2000-03-23	2004-05-06	Macphee Martin J.	Methods for sterilizing serum or plasma
US6682695B2 (en) *	2001-03-23	2004-01-27	Clearant, Inc.	Methods for sterilizing biological materials by multiple rates
US6696060B2 (en) *	2001-06-14	2004-02-24	Clearant, Inc.	Methods for sterilizing preparations of monoclonal immunoglobulins
EG24184A (en) *	2001-06-15	2008-10-08	Otsuka Pharma Co Ltd	Dry powder inhalation system for transpulmonary
US6946098B2 (en)	2001-08-10	2005-09-20	Clearant, Inc.	Methods for sterilizing biological materials
US7252799B2 (en) *	2001-08-31	2007-08-07	Clearant, Inc.	Methods for sterilizing preparations containing albumin
US6749851B2 (en)	2001-08-31	2004-06-15	Clearant, Inc.	Methods for sterilizing preparations of digestive enzymes
US20110091353A1 (en) *	2001-09-24	2011-04-21	Wilson Burgess	Methods for Sterilizing Tissue
US20030095890A1 (en) *	2001-09-24	2003-05-22	Shirley Miekka	Methods for sterilizing biological materials containing non-aqueous solvents
US20030185702A1 (en) *	2002-02-01	2003-10-02	Wilson Burgess	Methods for sterilizing tissue
US6783968B2 (en)	2001-09-24	2004-08-31	Clearant, Inc.	Methods for sterilizing preparations of glycosidases
US20030124023A1 (en) *	2001-12-21	2003-07-03	Wilson Burgess	Method of sterilizing heart valves
US7387796B2 (en) *	2002-01-30	2008-06-17	Hebert Rolland F	Stable compositions of S-adenosyl-l-methionine with dextran
US20030180181A1 (en) *	2002-02-01	2003-09-25	Teri Greib	Methods for sterilizing tissue
US20040013562A1 (en) *	2002-07-18	2004-01-22	Wilson Burgess	Methods for sterilizing milk.
US6908591B2 (en) *	2002-07-18	2005-06-21	Clearant, Inc.	Methods for sterilizing biological materials by irradiation over a temperature gradient
JP2006111532A (ja) *	2004-10-12	2006-04-27	Yoshindo:Kk	パニペネム含有ダブルバッグ型製剤
EP1870649A1 (de)	2006-06-20	2007-12-26	Octapharma AG	Gefriertocknung zum Erzielen einer bestimmte Restfeuchte durch beschränkte Desorptionsenergiepegeln.
TWI343262B (en) *	2006-09-26	2011-06-11	Schering Corp	Rapidly disintegrating lyophilized oral formulations of a thrombin receptor antagonist
US10548839B2 (en) *	2010-03-16	2020-02-04	Wei Tian	Process of manufacturing a lyophilized fast dissolving, multi-phasic dosage form
PL2864724T3 (pl)	2012-06-26	2019-06-28	Bioneer A/S	Strzykawka z wydrążonym tłokiem do produktów liofilizowanych
US11517533B2 (en)	2016-10-25	2022-12-06	Catalent U.K. Swindon Zydis Limited	Compositions of different densities for fast disintegrating multi-layer tablet
JP7575776B2 (ja) *	2020-12-09	2024-10-30	アスザックフーズ株式会社	乾燥食品製造方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB797774A (en) *	1955-03-02	1958-07-09	Armour & Co	Improvements in and relating to the production and packaging of stratiform products
US3616543A (en) *	1969-10-31	1971-11-02	Merck & Co Inc	Method of producing a multicomponent lyophilized product
FR2109201A6 (de) *	1970-10-07	1972-05-26	Air Liquide
EP0069176A1 (de) *	1981-07-03	1983-01-12	American Home Products Corporation	Verfahren zur Herstellung eines gefriergetrockneten Produktes
US4433558A (en) *	1981-08-25	1984-02-28	Cheng Chen Yen	Parallel contact distillative freezing process for separating volatile mixtures and apparatuses for use therein
DE3264450D1 (en) *	1981-12-11	1985-08-01	Wyeth John & Brother Ltd	Process and apparatus for freezing a liquid medium
US4430807A (en) *	1982-05-17	1984-02-14	The Dow Chemical Company	Process for drying water-wet membranes
JPS6168412A (ja) *	1984-09-10	1986-04-08	Fujisawa Pharmaceut Co Ltd	医薬品の凍結乾燥方法
IL78930A0 (en) *	1985-07-29	1986-09-30	Abbott Lab	Lyophilized emulsion compositions for parenteral administration
FR2601702A1 (fr) *	1986-07-21	1988-01-22	Atochem	Composition a base de chlorure de methylene - son utilisation pour le degraissage des metaux

1990
- 1990-04-16 US US07509967 patent/US5044091B1/en not_active Expired - Lifetime
- 1990-04-16 JP JP2100132A patent/JPH07116022B2/ja not_active Expired - Lifetime
- 1990-04-17 AU AU53289/90A patent/AU624494B2/en not_active Ceased
- 1990-04-17 CA CA002014714A patent/CA2014714C/en not_active Expired - Fee Related
- 1990-04-17 NO NO901691A patent/NO180801C/no not_active IP Right Cessation
- 1990-04-18 HU HU902472A patent/HU204993B/hu not_active IP Right Cessation
- 1990-04-18 DK DK90304230T patent/DK0394050T3/da active
- 1990-04-18 DE DE69033874T patent/DE69033874T2/de not_active Expired - Fee Related
- 1990-04-18 ES ES90304230T patent/ES2165839T3/es not_active Expired - Lifetime
- 1990-04-18 FI FI901947A patent/FI104360B/fi not_active IP Right Cessation
- 1990-04-18 AT AT90304230T patent/ATE210427T1/de not_active IP Right Cessation
- 1990-04-18 PH PH40390A patent/PH27522A/en unknown
- 1990-04-18 KR KR1019900005437A patent/KR950007908B1/ko not_active Expired - Lifetime
- 1990-04-18 EP EP90304230A patent/EP0394050B1/de not_active Expired - Lifetime
- 1990-04-18 NZ NZ233344A patent/NZ233344A/xx unknown
- 1990-04-18 ZA ZA902909A patent/ZA902909B/xx unknown

Also Published As

Publication number	Publication date
AU5328990A (en)	1990-10-25
EP0394050A2 (de)	1990-10-24
HK1010685A1 (en)	1999-06-25
NO901691D0 (no)	1990-04-17
EP0394050B1 (de)	2001-12-12
FI901947A0 (fi)	1990-04-18
AU624494B2 (en)	1992-06-11
JPH0347115A (ja)	1991-02-28
NO180801B (no)	1997-03-24
CA2014714A1 (en)	1990-10-18
NO901691L (no)	1990-10-19
DK0394050T3 (da)	2002-02-11
FI104360B (fi)	2000-01-14
KR900015715A (ko)	1990-11-10
KR950007908B1 (ko)	1995-07-21
US5044091B1 (en)	1997-12-30
HU204993B (en)	1992-03-30
JPH07116022B2 (ja)	1995-12-13
DE69033874D1 (de)	2002-01-24
NZ233344A (en)	1991-05-28
US5044091A (en)	1991-09-03
EP0394050A3 (de)	1992-06-10
ZA902909B (en)	1991-12-24
ES2165839T3 (es)	2002-04-01
HUT54885A (en)	1991-04-29
CA2014714C (en)	2000-07-18
DE69033874T2 (de)	2002-08-29
HU902472D0 (en)	1990-08-28
PH27522A (en)	1993-08-18
NO180801C (no)	1997-07-02

Legal Events

Date	Code	Title	Description
2002-04-15	UEP	Publication of translation of european patent specification
2006-01-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE210427T1 (de)	2001-12-15	Verfahren zur herstellung von arzneimittelenthaltenden gefriergetrockneten formulierungen
DE68928956D1 (de)	1999-04-22	Verfahren zur Herstellung von optisch aktivem 1,3-Butanediol
DE3789435D1 (de)	1994-04-28	Verfahren zur Herstellung von Eicosapentaensäure.
DE58906574D1 (de)	1994-02-10	Verfahren zur Herstellung von cyclischen Kohlensäureestern.
DE69009237D1 (de)	1994-07-07	Verfahren zur Herstellung von optisch aktiven Estern der 6-t-Butoxy-3,5-dihydroxyhexansäure.
ATE100095T1 (de)	1994-01-15	2,2-dimethylchromenderivate, verfahren zur herstellung und diese enthaltende pharmazeutische zusammenstellungen.
DE59004490D1 (de)	1994-03-17	Verfahren zur Herstellung von alpha-Fluoracrylsäurederivaten.
DE3685275D1 (de)	1992-06-17	Herstellung von 5-fluor-2'-deoxyuridin estern zur intravenoesen verabreichung.
DE3789412D1 (de)	1994-04-28	Verfahren zur Herstellung von 3-Alkoxymethylcephalosporinen.
FI873701L (fi)	1988-02-29	Menetelmä kylmäkuivattujen farmaseuttisten fenyylikinoliinikarboksyylihappokoostumusten valmistamiseksi
PT85874A (de)	1987-11-01	Verfahren zur herstellung von oligopeptid-antibiotika
DE3750669D1 (de)	1994-11-24	Verfahren zur Herstellung von alpha-L-Aspartyl-L-phenylalaninmethylester mit verbesserter Löslichkeit.
DE3751193D1 (de)	1995-05-04	Verfahren zur Herstellung von trockenem alpha-L-Aspartyl-L-phenylalaninmethylester.
DE58909208D1 (de)	1995-06-08	Verfahren zur Herstellung von Imidazol-2-carbonsäuren.
DE3773716D1 (de)	1991-11-21	Verfahren zur herstellung von monosodiumsalz und dessen monohydrat von 1-beta-d-arabinofuranosylcytosin-5'stearylphosphat und diese enthaltende pharmazeutische zusammensetzung.
DE69006558D1 (de)	1994-03-24	Verfahren zur Herstellung von Sulfophenylkohlensäureestern.
DE58909337D1 (de)	1995-08-17	Verfahren zur Herstellung von reinen 3-Butenyltriorganyloxysilanen.
DE68916768D1 (de)	1994-08-18	Verfahren zur Herstellung von para-Hydroxybenzoesäure.
ATE57912T1 (de)	1990-11-15	Verfahren zur herstellung von anilinofumarat und 2,3-chinolindicarbonsaeure.
DE59002773D1 (de)	1993-10-28	Verfahren zur Herstellung von Anthrachinonderivaten.
DE68912856D1 (de)	1994-03-17	Verfahren zur Herstellung von Carbamidsäureestern.
DE68928788D1 (de)	1998-09-24	Verfahren zur Herstellung von optisch aktiven 3,4-Dihydroxybuttersäurederivaten
DE68915904D1 (de)	1994-07-14	Verfahren zur Herstellung von Para-bromphenoxyacetaldehyd-dialkylacetal-Derivaten.
DE58907865D1 (de)	1994-07-21	Verfahren zur Herstellung von alpha-Ketocarbonsäureestern.
DE69020372D1 (de)	1995-08-03	Verfahren zur Herstellung von Aminothiazolylessigsäure-Derivate.