ATE210640T1 - Modifizierte mehrfach ungesättigte fettsäuren - Google Patents

Modifizierte mehrfach ungesättigte fettsäuren

Info

Publication number
ATE210640T1
ATE210640T1 AT95933988T AT95933988T ATE210640T1 AT E210640 T1 ATE210640 T1 AT E210640T1 AT 95933988 T AT95933988 T AT 95933988T AT 95933988 T AT95933988 T AT 95933988T AT E210640 T1 ATE210640 T1 AT E210640T1
Authority
AT
Austria
Prior art keywords
fatty acid
polyunsaturated fatty
oxa
provides
fatty acids
Prior art date
Application number
AT95933988T
Other languages
English (en)
Inventor
Antonio Ferrante
Alfred Poulos
Christopher John Easton
Michael Joseph Pitt
Thomas Alistair Robertson
Deborah Ann Rathjen
Original Assignee
Peptide Technology Ltd
Womens & Childrens Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AUPM8781A external-priority patent/AUPM878194A0/en
Priority claimed from AUPM9066A external-priority patent/AUPM906694A0/en
Application filed by Peptide Technology Ltd, Womens & Childrens Hospital filed Critical Peptide Technology Ltd
Application granted granted Critical
Publication of ATE210640T1 publication Critical patent/ATE210640T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C409/00—Peroxy compounds
    • C07C409/02—Peroxy compounds the —O—O— group being bound between a carbon atom, not further substituted by oxygen atoms, and hydrogen, i.e. hydroperoxides
    • C07C409/04—Peroxy compounds the —O—O— group being bound between a carbon atom, not further substituted by oxygen atoms, and hydrogen, i.e. hydroperoxides the carbon atom being acyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C409/00—Peroxy compounds
    • C07C409/16—Peroxy compounds the —O—O— group being bound between two carbon atoms not further substituted by oxygen atoms, i.e. peroxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C409/00—Peroxy compounds
    • C07C409/40—Peroxy compounds containing nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C409/00—Peroxy compounds
    • C07C409/42—Peroxy compounds containing sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/60—Unsaturated compounds containing ether groups, groups, groups, or groups the non-carboxylic part of the ether being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708—Ethers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fats And Perfumes (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT95933988T 1994-10-13 1995-10-13 Modifizierte mehrfach ungesättigte fettsäuren ATE210640T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPM8781A AUPM878194A0 (en) 1994-10-13 1994-10-13 Modified fatty acids in the treatment of inflammation
AUPM9066A AUPM906694A0 (en) 1994-10-26 1994-10-26 Novel compounds for treating malaria and other diseases
PCT/AU1995/000677 WO1996011908A1 (en) 1994-10-13 1995-10-13 Modified polyunsaturated fatty acids

Publications (1)

Publication Number Publication Date
ATE210640T1 true ATE210640T1 (de) 2001-12-15

Family

ID=25644792

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95933988T ATE210640T1 (de) 1994-10-13 1995-10-13 Modifizierte mehrfach ungesättigte fettsäuren

Country Status (9)

Country Link
US (1) US6376688B1 (de)
EP (1) EP0869941B1 (de)
JP (1) JPH10507179A (de)
KR (1) KR100463709B1 (de)
CN (1) CN1088058C (de)
AT (1) ATE210640T1 (de)
CA (1) CA2202503C (de)
DE (1) DE69524639T2 (de)
WO (1) WO1996011908A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
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EP0904072A4 (de) * 1996-04-12 2003-07-30 Peptide Technology Pty Ltd Verfahren zur behandlung von immuno-pathologien unter verwendung mehrfach ungesättigter fetzäuren
DE19649869A1 (de) * 1996-12-02 1998-06-04 Biotechnolog Forschung Gmbh Ungesättigte aliphatische Carbonsäuren (Maracenine), Herstellungsverfahren und Mittel
AUPQ291499A0 (en) * 1999-09-17 1999-10-07 Women's And Children's Hospital Adelaide Novel nitro and sulphur containing compounds
AU784116B2 (en) * 1999-09-17 2006-02-09 Peplin Biolipids Pty Ltd Anti-cancer nitro- and thia-fatty acids
NO328803B1 (no) 2000-03-03 2010-05-18 Thia Medica Nye fettsyreanaloger
NO20006008L (no) * 2000-11-28 2002-05-29 Thia Medica As Fettsyreanaloger for behandling av inflammatoriske og autoimmune sykdommer
AU2002352726A1 (en) 2001-11-15 2003-06-10 Galileo Laboratories, Inc. Formulations and methods for treatment or amelioration of inflammatory conditions
WO2003105824A1 (en) * 2002-06-14 2003-12-24 Alcon, Inc. Topical use of hydroxyeicosatetraenoic acid compounds to treat psoriasis
US6825232B2 (en) * 2002-06-14 2004-11-30 Alcon, Inc. Use of hydroxyeicosatetraenoic acid compounds to treat ophthalmic inflammatory disorders
CN100351259C (zh) 2002-06-20 2007-11-28 Icvec有限公司 含硫的磷脂衍生物
WO2005073164A1 (en) * 2004-01-30 2005-08-11 Peplin Biolipids Pty Ltd Therapeutic and carrier molecules
AU2007251591B2 (en) * 2006-05-12 2010-09-09 Allnex Netherlands B.V. Aqueous dispersion of an auto-oxidatively drying polyurethane
RU2507193C2 (ru) * 2006-11-01 2014-02-20 Пронова Биофарма Норге А/С Альфа-замещенные омега-3 липиды, которые являются активаторами или модуляторами рецептора, активируемого пролифераторами пероксисом (ppar)
WO2009006668A1 (en) * 2007-02-05 2009-01-15 Children, Youth And Women's Health Service Modulators of antigen-dependent t cell proliferation
US8324277B2 (en) 2007-08-01 2012-12-04 University of Pittsburgh—of the Commonwealth System of Higher Education Nitrated-fatty acids modulation of type II diabetes
WO2009134383A2 (en) 2008-05-01 2009-11-05 Complexa Inc. Vinyl substituted fatty acids
GB2460056A (en) * 2008-05-14 2009-11-18 Arab Science & Technology Foun Compositions comprising omega-6 fatty acids for use in treating schistosomiasis
US20140024713A1 (en) 2008-06-19 2014-01-23 University Of Utah Research Foundation Use of nitrated lipids for treatment of side effects of toxic medical therapies
EP2299997A4 (de) 2008-06-19 2012-01-11 Univ Utah Res Found Verwendung von nitrierten lipiden zur behandlung von nebenwirkungen von toxischen medizinischen therapien
EP2147910A1 (de) * 2008-07-15 2010-01-27 Pronova BioPharma Norge AS Neue Lipid-Verbindungen
EP2208720A1 (de) 2009-01-13 2010-07-21 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Neuartige Eicosanoidderivate
JP5843755B2 (ja) 2009-05-08 2016-01-13 プロノヴァ・バイオファーマ・ノルゲ・アーエスPronova BioPharma Norge AS 心血管性、代謝性および炎症性疾患領域に関する疾患の処置のための多価不飽和脂肪酸
EP3045167A1 (de) 2009-07-31 2016-07-20 University of Pittsburgh - Of the Commonwealth System of Higher Education Ketofettsäuren als entzündungshemmende wirkstoffe
CA2781276A1 (en) * 2009-10-02 2011-04-07 Complexa, Inc. Heteroatom containing substituted fatty acids
NZ610705A (en) 2010-11-05 2014-10-31 Pronova Biopharma Norge As Methods of treatment using lipid compounds
EP2744491B1 (de) 2011-08-19 2020-07-29 The University of Utah Research Foundation Kombinationstherapie mit nitrierten lipiden und inhibitoren des renin-angiotensin-aldosteron-systems
AU2014222389B2 (en) 2013-02-28 2018-11-29 Pronova Biopharma Norge As A composition comprising a lipid compound, a triglyceride, and a surfactant, and methods of using the same
US9670126B2 (en) * 2013-10-29 2017-06-06 Dignity Sciences Limited Methods of making 15-hydroxy fatty acid derivatives
US20180104201A1 (en) 2015-04-28 2018-04-19 Pronova Biopharma Norge As Use of structurally enhanced fatty acids containing sulphur for preventing and or treating non alcoholic steatohepatitis
BR112018000254A2 (pt) 2015-07-07 2018-09-04 H Lundbeck As inibidores de pde9 com cadeia principal de imidazotriazinona e cadeia principal de imidazopirazinona para o tratamento de doenças periféricas
IL258476B2 (en) 2015-10-02 2023-04-01 Complexa Inc Prevention, treatment and reversal of disease using therapeutically effective amounts of activated fatty acids
GB201521085D0 (en) * 2015-11-30 2016-01-13 Biozep As Use
WO2017223447A1 (en) * 2016-06-23 2017-12-28 The Regents Of The University Of Michigan 12(s)-hydroxyeicosatrienoic acid compounds and their use as therapeutic agents
PT3720431T (pt) 2017-12-06 2024-12-05 Basf As Derivados de ácidos gordos para o tratamento da esteato-hepatite não alcoólica
EP3801526B1 (de) 2018-05-25 2023-12-27 Imara Inc. Monohydrat und kristalline formen von 6-[(3s,4s)-4-methyl-1- (pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-tetrahydropyran-4-yl- 7h-imid azo [1,5- a] pyrazin-8-on
CN112996512B (zh) 2018-08-31 2025-01-03 卡都瑞恩医药公司 用于治疗镰状细胞病的pde9抑制剂

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6372648A (ja) * 1986-09-16 1988-04-02 Sumitomo Pharmaceut Co Ltd 新規不飽和脂肪酸誘導体
GB8813012D0 (en) * 1988-06-02 1988-07-06 Norsk Hydro As Non-b-oxidizable fatty acid analogues to reduce concentration of cholesterol & triglycerides in blood of mammals
CA2112399C (en) * 1991-06-24 2004-06-29 Antonio Ferrante Methods and compositions for treating malaria and other diseases
WO1994022848A1 (en) 1993-03-29 1994-10-13 Pace Asciak Cecil R Hepoxilin analogs useful as anti-inflammatory agents
WO1995009622A1 (en) * 1993-10-06 1995-04-13 Peptide Technology Limited Polyunsaturated fatty acids and uses thereof

Also Published As

Publication number Publication date
EP0869941B1 (de) 2001-12-12
CA2202503A1 (en) 1996-04-25
EP0869941A4 (de) 1998-10-14
US6376688B1 (en) 2002-04-23
WO1996011908A1 (en) 1996-04-25
KR100463709B1 (ko) 2005-08-04
CA2202503C (en) 2008-07-15
EP0869941A1 (de) 1998-10-14
JPH10507179A (ja) 1998-07-14
CN1088058C (zh) 2002-07-24
KR970707088A (ko) 1997-12-01
DE69524639D1 (de) 2002-01-24
CN1163609A (zh) 1997-10-29
DE69524639T2 (de) 2002-08-08

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Legal Events

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