ATE210650T1 - Sulfonamid substituierte benzopyrane als kaliumkanalaktivatoren - Google Patents
Sulfonamid substituierte benzopyrane als kaliumkanalaktivatorenInfo
- Publication number
- ATE210650T1 ATE210650T1 AT96109023T AT96109023T ATE210650T1 AT E210650 T1 ATE210650 T1 AT E210650T1 AT 96109023 T AT96109023 T AT 96109023T AT 96109023 T AT96109023 T AT 96109023T AT E210650 T1 ATE210650 T1 AT E210650T1
- Authority
- AT
- Austria
- Prior art keywords
- potassium channel
- benzopyranes
- channel activators
- sulfonamide substituted
- compounds
- Prior art date
Links
- 150000001562 benzopyrans Chemical class 0.000 title 1
- 239000004036 potassium channel stimulating agent Substances 0.000 title 1
- 229940124530 sulfonamide Drugs 0.000 title 1
- 150000003456 sulfonamides Chemical group 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000003213 activating effect Effects 0.000 abstract 1
- 229940125692 cardiovascular agent Drugs 0.000 abstract 1
- 239000002327 cardiovascular agent Substances 0.000 abstract 1
- 108010083133 potassium channel protein I(sk) Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Saccharide Compounds (AREA)
- Seasonings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/481,007 US5869478A (en) | 1995-06-07 | 1995-06-07 | Sulfonamido substituted benzopyran derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE210650T1 true ATE210650T1 (de) | 2001-12-15 |
Family
ID=23910215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96109023T ATE210650T1 (de) | 1995-06-07 | 1996-06-05 | Sulfonamid substituierte benzopyrane als kaliumkanalaktivatoren |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5869478A (de) |
| EP (1) | EP0747374B1 (de) |
| JP (1) | JP3926868B2 (de) |
| AT (1) | ATE210650T1 (de) |
| AU (1) | AU714432B2 (de) |
| CA (1) | CA2178353A1 (de) |
| DE (1) | DE69617803T2 (de) |
| DK (1) | DK0747374T3 (de) |
| ES (1) | ES2169174T3 (de) |
| PT (1) | PT747374E (de) |
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| RU2388748C2 (ru) * | 2004-12-21 | 2010-05-10 | Ф. Хоффманн-Ля Рош Аг | Производные тетралина и индана и их применения в качестве антагонистов 5-нт |
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| CN1854135B (zh) * | 2005-04-18 | 2013-06-12 | 李伟章 | 由氰基胍连接组成的杂环化合物及其医药应用 |
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| KR20080064972A (ko) | 2005-10-07 | 2008-07-10 | 그렌마크 파머수티칼스 에스. 아. | 치환된 벤조융합 유도체 및 이의 바닐로이드 수용체리간드로서의 용도 |
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| BRPI0713502A2 (pt) * | 2006-06-20 | 2012-03-13 | F. Hoffmann-La Roche Ag | derivados de tetralina de arilsulfonamidil e empregos destes |
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| EP2063905B1 (de) | 2006-09-18 | 2014-07-30 | Raptor Pharmaceutical Inc | Behandlungen von lebererkrankungen durch verabreichung von konjugaten aus rezeptor-assoziierten proteinen |
| DK2398500T3 (da) | 2009-02-20 | 2019-05-13 | 2 Bbb Medicines B V | Glutathion-baseret lægemiddelafgivelsessystem |
| SG175896A1 (en) | 2009-05-06 | 2011-12-29 | Lab Skin Care Inc | Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same |
| TW201216963A (en) | 2010-09-03 | 2012-05-01 | Forma Therapeutics Inc | Novel compounds and compositions for the inhibition of NAMPT |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
| KR102484846B1 (ko) * | 2015-11-27 | 2023-01-05 | 한림제약(주) | 벤조피란 유도체의 정제방법, 이의 결정형 및 상기 결정형의 제조방법 |
| JP2020536045A (ja) | 2017-01-17 | 2020-12-10 | デイヴィッド フォレスト マイケル | Ａｔｐ合成酵素のリバースモードの治療的阻害剤 |
| CA3099077A1 (en) | 2017-07-13 | 2019-01-17 | Michael David FORREST | Therapeutic modulators of the reverse mode of atp synthase |
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| US5393771A (en) * | 1993-05-12 | 1995-02-28 | Brisol-Myers Squibb Company | 4-substituted benzopyran and related compounds |
| GB9316111D0 (en) * | 1993-08-04 | 1993-09-22 | Pfizer Ltd | Benzopyrans |
| US5837702A (en) * | 1993-10-07 | 1998-11-17 | Bristol-Myers Squibb Co. | 4-arylamino-benzopyran and related compounds |
-
1995
- 1995-06-07 US US08/481,007 patent/US5869478A/en not_active Expired - Fee Related
-
1996
- 1996-06-05 DK DK96109023T patent/DK0747374T3/da active
- 1996-06-05 DE DE69617803T patent/DE69617803T2/de not_active Expired - Fee Related
- 1996-06-05 EP EP96109023A patent/EP0747374B1/de not_active Expired - Lifetime
- 1996-06-05 ES ES96109023T patent/ES2169174T3/es not_active Expired - Lifetime
- 1996-06-05 AT AT96109023T patent/ATE210650T1/de not_active IP Right Cessation
- 1996-06-05 PT PT96109023T patent/PT747374E/pt unknown
- 1996-06-06 AU AU54762/96A patent/AU714432B2/en not_active Ceased
- 1996-06-06 CA CA002178353A patent/CA2178353A1/en not_active Abandoned
- 1996-06-07 JP JP14628896A patent/JP3926868B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69617803T2 (de) | 2002-08-01 |
| DK0747374T3 (da) | 2002-04-08 |
| CA2178353A1 (en) | 1996-12-08 |
| EP0747374A1 (de) | 1996-12-11 |
| DE69617803D1 (de) | 2002-01-24 |
| US5869478A (en) | 1999-02-09 |
| ES2169174T3 (es) | 2002-07-01 |
| JP3926868B2 (ja) | 2007-06-06 |
| JPH093035A (ja) | 1997-01-07 |
| AU5476296A (en) | 1996-12-19 |
| PT747374E (pt) | 2002-05-31 |
| EP0747374B1 (de) | 2001-12-12 |
| AU714432B2 (en) | 2000-01-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |