DK0747374T3 - Sulfonamidsubstituerede benzopyraner som kaliumkanalaktivatorer - Google Patents
Sulfonamidsubstituerede benzopyraner som kaliumkanalaktivatorerInfo
- Publication number
- DK0747374T3 DK0747374T3 DK96109023T DK96109023T DK0747374T3 DK 0747374 T3 DK0747374 T3 DK 0747374T3 DK 96109023 T DK96109023 T DK 96109023T DK 96109023 T DK96109023 T DK 96109023T DK 0747374 T3 DK0747374 T3 DK 0747374T3
- Authority
- DK
- Denmark
- Prior art keywords
- potassium channel
- sulfonamide
- channel activators
- substituted benzopyrans
- benzopyrans
- Prior art date
Links
- 150000001562 benzopyrans Chemical class 0.000 title 1
- 239000004036 potassium channel stimulating agent Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000003213 activating effect Effects 0.000 abstract 1
- 229940125692 cardiovascular agent Drugs 0.000 abstract 1
- 239000002327 cardiovascular agent Substances 0.000 abstract 1
- 108010083133 potassium channel protein I(sk) Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyrane Compounds (AREA)
- Saccharide Compounds (AREA)
- Seasonings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/481,007 US5869478A (en) | 1995-06-07 | 1995-06-07 | Sulfonamido substituted benzopyran derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0747374T3 true DK0747374T3 (da) | 2002-04-08 |
Family
ID=23910215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK96109023T DK0747374T3 (da) | 1995-06-07 | 1996-06-05 | Sulfonamidsubstituerede benzopyraner som kaliumkanalaktivatorer |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5869478A (de) |
| EP (1) | EP0747374B1 (de) |
| JP (1) | JP3926868B2 (de) |
| AT (1) | ATE210650T1 (de) |
| AU (1) | AU714432B2 (de) |
| CA (1) | CA2178353A1 (de) |
| DE (1) | DE69617803T2 (de) |
| DK (1) | DK0747374T3 (de) |
| ES (1) | ES2169174T3 (de) |
| PT (1) | PT747374E (de) |
Families Citing this family (34)
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| US6077850A (en) | 1997-04-21 | 2000-06-20 | G.D. Searle & Co. | Substituted benzopyran analogs for the treatment of inflammation |
| US6034256A (en) * | 1997-04-21 | 2000-03-07 | G.D. Searle & Co. | Substituted benzopyran derivatives for the treatment of inflammation |
| GB9822024D0 (en) * | 1998-10-09 | 1998-12-02 | Novartis Ag | Organic compounds |
| GB9909792D0 (en) * | 1998-12-04 | 1999-06-23 | Cambridge Bioclinical Limited | Potassium channel activators and their use |
| FR2807045B1 (fr) | 2000-03-31 | 2004-02-27 | Atofina | Copolymeres acryliques hydrosolubles et leur utilisation comme fluidifiants ou dispersants |
| JP4202250B2 (ja) | 2001-07-25 | 2008-12-24 | バイオマリン ファーマシューティカル インコーポレイテッド | 血液脳関門輸送を調節するための組成物および方法 |
| KR100492252B1 (ko) * | 2002-08-09 | 2005-05-30 | 한국화학연구원 | 이미다졸을 포함하는 이차아민으로 치환된 벤조피란유도체 및 그의 제조방법 |
| EP1589015A1 (de) * | 2004-02-03 | 2005-10-26 | Université de Liège | Benzopyranderivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
| KR100823805B1 (ko) * | 2004-05-05 | 2008-04-21 | 에프. 호프만-라 로슈 아게 | 5-ｈｔ6 수용체, 5-ｈｔ2ａ 수용체 또는 둘다를 조절하기에유용한 아릴설포닐 벤조다이옥산 |
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| US20070026079A1 (en) * | 2005-02-14 | 2007-02-01 | Louis Herlands | Intranasal administration of modulators of hypothalamic ATP-sensitive potassium channels |
| CN1854135B (zh) * | 2005-04-18 | 2013-06-12 | 李伟章 | 由氰基胍连接组成的杂环化合物及其医药应用 |
| EP2671507A3 (de) | 2005-04-28 | 2014-02-19 | Proteus Digital Health, Inc. | Pharma-Informatiksystem |
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| BRPI0618206A2 (pt) * | 2005-11-03 | 2011-08-23 | Hoffmann La Roche | arilsulfonil cromanos como inibidores de 5-ht6, bem como composição farmacêutica, uso e processo para produção dos mesmos |
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| CA2752373C (en) | 2009-02-20 | 2017-10-10 | To-Bbb Holding B.V. | Glutathione-based drug delivery system |
| IL255113B (en) | 2009-05-06 | 2022-09-01 | Laboratory Skin Care Inc | Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same |
| CN106243023A (zh) | 2010-09-03 | 2016-12-21 | 福马Tm有限责任公司 | 用于抑制nampt的胍化合物和组合物 |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
| KR102484846B1 (ko) * | 2015-11-27 | 2023-01-05 | 한림제약(주) | 벤조피란 유도체의 정제방법, 이의 결정형 및 상기 결정형의 제조방법 |
| WO2018134265A1 (en) | 2017-01-17 | 2018-07-26 | Forrest Michael David | Therapeutic inhibitors of the reverse mode of atp synthase |
| WO2019012149A1 (en) | 2017-07-13 | 2019-01-17 | Forrest Michael David | THERAPEUTIC MODULATORS OF THE INVERSE MODE OF ATP SYNTHASE |
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| US5393771A (en) * | 1993-05-12 | 1995-02-28 | Brisol-Myers Squibb Company | 4-substituted benzopyran and related compounds |
| GB9316111D0 (en) * | 1993-08-04 | 1993-09-22 | Pfizer Ltd | Benzopyrans |
| US5837702A (en) * | 1993-10-07 | 1998-11-17 | Bristol-Myers Squibb Co. | 4-arylamino-benzopyran and related compounds |
-
1995
- 1995-06-07 US US08/481,007 patent/US5869478A/en not_active Expired - Fee Related
-
1996
- 1996-06-05 AT AT96109023T patent/ATE210650T1/de not_active IP Right Cessation
- 1996-06-05 DE DE69617803T patent/DE69617803T2/de not_active Expired - Fee Related
- 1996-06-05 PT PT96109023T patent/PT747374E/pt unknown
- 1996-06-05 DK DK96109023T patent/DK0747374T3/da active
- 1996-06-05 EP EP96109023A patent/EP0747374B1/de not_active Expired - Lifetime
- 1996-06-05 ES ES96109023T patent/ES2169174T3/es not_active Expired - Lifetime
- 1996-06-06 CA CA002178353A patent/CA2178353A1/en not_active Abandoned
- 1996-06-06 AU AU54762/96A patent/AU714432B2/en not_active Ceased
- 1996-06-07 JP JP14628896A patent/JP3926868B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69617803D1 (de) | 2002-01-24 |
| EP0747374A1 (de) | 1996-12-11 |
| ES2169174T3 (es) | 2002-07-01 |
| AU714432B2 (en) | 2000-01-06 |
| CA2178353A1 (en) | 1996-12-08 |
| JPH093035A (ja) | 1997-01-07 |
| PT747374E (pt) | 2002-05-31 |
| AU5476296A (en) | 1996-12-19 |
| EP0747374B1 (de) | 2001-12-12 |
| US5869478A (en) | 1999-02-09 |
| JP3926868B2 (ja) | 2007-06-06 |
| DE69617803T2 (de) | 2002-08-01 |
| ATE210650T1 (de) | 2001-12-15 |
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