ATE287959T1 - Verfahren zur herstellung von trans-4-hydroxy-l- prolin - Google Patents

Verfahren zur herstellung von trans-4-hydroxy-l- prolin

Info

Publication number: ATE287959T1
Authority: AT; Austria
Prior art keywords: proline; hydroxy; trans; producing; hydroxylase
Prior art date: 1996-09-03

Application number

AT97115289T

Other languages

English (en)

Inventor

Akio Ozaki

Takeshi Shibasaki

Hideo Mori

Akihiko Maruyama

Hiroaki Motoyama

Original Assignee

Kyowa Hakko Kogyo Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-09-03

Filing date

1997-09-03

Publication date

2005-02-15

1997-09-03 Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk

2005-02-15 Application granted granted Critical

2005-02-15 Publication of ATE287959T1 publication Critical patent/ATE287959T1/de

Links

PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 title abstract 5
PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 title abstract 5
PMMYEEVYMWASQN-IMJSIDKUSA-N trans-4-Hydroxy-L-proline Natural products O[C@@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-IMJSIDKUSA-N 0.000 title abstract 5
238000004519 manufacturing process Methods 0.000 title 1
ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 4
229960002429 proline Drugs 0.000 abstract 4
229930182821 L-proline Natural products 0.000 abstract 3
238000000034 method Methods 0.000 abstract 3
KPGXRSRHYNQIFN-UHFFFAOYSA-N 2-oxoglutaric acid Chemical compound OC(=O)CCC(=O)C(O)=O KPGXRSRHYNQIFN-UHFFFAOYSA-N 0.000 abstract 2
239000012736 aqueous medium Substances 0.000 abstract 2
230000015572 biosynthetic process Effects 0.000 abstract 2
230000000694 effects Effects 0.000 abstract 2
108090000623 proteins and genes Proteins 0.000 abstract 2
241000187643 Amycolatopsis Species 0.000 abstract 1
241001495437 Dactylosporangium Species 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
102000004190 Enzymes Human genes 0.000 abstract 1
ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 1
241000187747 Streptomyces Species 0.000 abstract 1
239000000654 additive Substances 0.000 abstract 1
230000000996 additive effect Effects 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
235000013305 food Nutrition 0.000 abstract 1
230000033444 hydroxylation Effects 0.000 abstract 1
238000005805 hydroxylation reaction Methods 0.000 abstract 1
XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 1
229910052742 iron Inorganic materials 0.000 abstract 1
-1 iron ion Chemical class 0.000 abstract 1
244000005700 microbiome Species 0.000 abstract 1
239000002994 raw material Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/24—Proline; Hydroxyproline; Histidine
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli

Landscapes

Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Pyrrole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT97115289T 1996-09-03 1997-09-03 Verfahren zur herstellung von trans-4-hydroxy-l- prolin ATE287959T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP23272496A JP3739143B2 (ja)	1996-09-03	1996-09-03	トランス−４−ヒドロキシ−ｌ−プロリンの製造法

Publications (1)

Publication Number	Publication Date
ATE287959T1 true ATE287959T1 (de)	2005-02-15

Family

ID=16943800

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97115289T ATE287959T1 (de)	1996-09-03	1997-09-03	Verfahren zur herstellung von trans-4-hydroxy-l- prolin

Country Status (9)

Country	Link
EP (1)	EP0826773B1 (de)
JP (1)	JP3739143B2 (de)
KR (2)	KR100591499B1 (de)
CN (1)	CN1333074C (de)
AT (1)	ATE287959T1 (de)
CA (1)	CA2209889C (de)
DE (1)	DE69732327T2 (de)
DK (1)	DK0826773T3 (de)
TW (1)	TW581813B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP6724285B2 (ja) *	2014-11-12	2020-07-15	株式会社エーピーアイコーポレーション	シス−５−ヒドロキシ−ｌ−ピペコリン酸の製造方法
CN106086102B (zh) *	2015-04-29	2020-10-27	中国科学院微生物研究所	一种生产反式-4-羟基-l-脯氨酸的工程菌及其构建方法与应用
CN105483069B (zh) *	2015-12-09	2019-01-18	浙江绿创生物科技有限公司	一株生产反式-4-羟基-l-脯氨酸的重组菌株及其构建与应用
CN105543303A (zh) *	2016-01-19	2016-05-04	江南大学	一种通过敲除其他代谢途径进而提高反式-4-羟脯氨酸产量的生物合成方法
CN107304430B (zh) *	2016-04-19	2020-10-27	中国科学院微生物研究所	用于制备反式-4-羟基-l-脯氨酸的dna分子和方法
CN108220259B (zh) *	2016-12-22	2021-05-07	清华大学	L-脯氨酸4-羟化酶
CN107674863B (zh) *	2017-08-04	2019-03-05	中国科学院天津工业生物技术研究所	一种生产反式-4-羟基-l-脯氨酸的方法
CN107674864B (zh) *	2017-08-17	2019-02-22	中国科学院天津工业生物技术研究所	一种生产反式-4-羟基-l-脯氨酸的方法
CN107805621A (zh) *	2017-10-27	2018-03-16	中国科学院成都生物研究所	一种利用大肠杆菌合成反式‑4‑羟基‑l‑脯氨酸的方法
WO2022161914A1 (en) *	2021-01-26	2022-08-04	Basf Se	High temperature fermentation process and microorganisms
CN114231549B (zh) *	2021-11-25	2023-10-03	河北远大九孚生物科技有限公司	一种用于生产l-羟脯氨酸的重组表达载体、工程菌株和方法
CN116334015A (zh) *	2022-12-29	2023-06-27	河北科技大学	一种用于重组胶原修饰的脯氨酸羟化酶筛选方法及应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS60141284A (ja) *	1983-12-28	1985-07-26	Tanabe Seiyaku Co Ltd	Ｌ―プロリンの製法
CN1036584C (zh) *	1991-01-17	1997-12-03	中国科学院广州化学研究所	L-脯氨酸的纯化方法
EP0555475B1 (de) *	1991-08-26	1997-05-14	Kyowa Hakko Kogyo Co., Ltd.	Verfahren zur herstellung von 4-hydroxy-l-prolin
KR100356926B1 (ko) *	1993-09-07	2003-01-10	교와 핫꼬 고교 가부시끼가이샤	트랜스-4-히드록시-l-프롤린의제조법

1996
- 1996-09-03 JP JP23272496A patent/JP3739143B2/ja not_active Expired - Lifetime
1997
- 1997-09-01 KR KR1019970045362A patent/KR100591499B1/ko not_active Expired - Lifetime
- 1997-09-02 CN CNB971179298A patent/CN1333074C/zh not_active Expired - Lifetime
- 1997-09-03 TW TW086112674A patent/TW581813B/zh not_active IP Right Cessation
- 1997-09-03 DE DE69732327T patent/DE69732327T2/de not_active Expired - Lifetime
- 1997-09-03 CA CA002209889A patent/CA2209889C/en not_active Expired - Lifetime
- 1997-09-03 EP EP97115289A patent/EP0826773B1/de not_active Expired - Lifetime
- 1997-09-03 AT AT97115289T patent/ATE287959T1/de not_active IP Right Cessation
- 1997-09-03 DK DK97115289T patent/DK0826773T3/da active
2005
- 2005-12-07 KR KR1020050118504A patent/KR100591500B1/ko not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CN1178245A (zh)	1998-04-08
DK0826773T3 (da)	2005-04-25
CA2209889C (en)	2006-07-04
KR19980024241A (ko)	1998-07-06
DE69732327D1 (de)	2005-03-03
EP0826773A3 (de)	1999-08-18
CN1333074C (zh)	2007-08-22
TW581813B (en)	2004-04-01
JP3739143B2 (ja)	2006-01-25
EP0826773A2 (de)	1998-03-04
EP0826773B1 (de)	2005-01-26
DE69732327T2 (de)	2005-10-06
CA2209889A1 (en)	1998-03-03
KR100591499B1 (ko)	2006-12-07
KR100591500B1 (ko)	2006-06-20
JPH1075788A (ja)	1998-03-24

Legal Events

Date

Code

Title

Description

2005-10-15

UEP

Publication of translation of european patent specification

Ref document number: 0826773

Country of ref document: EP

2009-06-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE210729T1 (de)	2001-12-15	Verfahren zur herstellung von trans-4-hydroxy-l- prolin
ATE287959T1 (de)	2005-02-15	Verfahren zur herstellung von trans-4-hydroxy-l- prolin
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EP0321266A3 (en)	1990-03-21	Method for producing the foki restriction endonuclease and methylase
ATE196166T1 (de)	2000-09-15	Enzymatisches hydroxylierungsverfahren zur herstellung von hmg-coa-reduktaseinhibitoren und intermediate hiervon
MX9803762A (es)	1998-09-30	Produccion microbiana mejorada de indigo.
CA2058934A1 (en)	1990-12-14	Processes for the recovery of microbially produced chymosin
CA2253977A1 (en)	1997-12-04	Process for the preparation of amino alcohols and derivatives thereof
ATE164628T1 (de)	1998-04-15	L-proline-3-hydroxylase und verfahren zur herstellung von cis-3-hydroxy-l-prolin
EP0321269A3 (en)	1990-03-21	Method for producing the hinpi restriction endonuclease and methylase
ATE290084T1 (de)	2005-03-15	Verfahren zur herstellung von beta lactam antibiotika durch mikroorganismen mit erhoehter ligaseaktivitaet
CA2131776A1 (en)	1995-10-06	Process for producing cis-3-hydroxy-l-proline
Ozaki et al.	2001	Process for producing trans-4-hydroxy-l-proline
CA2131775A1 (en)	1995-06-28	Process for producing trans-4-hydroxy-l-proline
ATE118816T1 (de)	1995-03-15	Verfahren zur herstellung von acci- restriktionsendonuklease und -methylase.
DE58907274D1 (de)	1994-04-28	VERFAHREN ZUR STEIGERUNG VON ENZYM-AKTIVITÄTEN UND DER SYNTHESELEISTUNG VON MIKROORGANISMEN UND HöHEREN PFLANZEN.
ATE95568T1 (de)	1993-10-15	Mikrobiologisches verfahren zur herstellung von uk-61.689 und mikroorganismen zur verwendung darin.
EP0146929A3 (de)	1987-06-03	Mikroorganismus des Genus serratia ein hybrides Plasmid enthaltend und Verfahren zur Herstellung desselbes
DK0806479T3 (da)	2003-10-06	Produktion af biotin ved fermentering
DE59208669D1 (de)	1997-08-14	Verfahren zur Herstellung von MA
DE68908253D1 (de)	1993-09-16	Verfahren zur herstellung von itaconsaeure.
AU2564888A (en)	1989-05-18	Novel urease and method of producing the same