ATE196166T1 - Enzymatisches hydroxylierungsverfahren zur herstellung von hmg-coa-reduktaseinhibitoren und intermediate hiervon - Google Patents

Enzymatisches hydroxylierungsverfahren zur herstellung von hmg-coa-reduktaseinhibitoren und intermediate hiervon

Info

Publication number: ATE196166T1
Authority: AT; Austria
Prior art keywords: coa reductase; reductase inhibitors; hydroxylation process; hmg; enzymatic hydroxylation
Prior art date: 1993-10-22

Application number

AT94116409T

Other languages

English (en)

Inventor

Brian L Davis

Paul M Cino

Laszlo Szarka

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-10-22

Filing date

1994-10-18

Publication date

2000-09-15

1994-10-18 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2000-09-15 Application granted granted Critical

2000-09-15 Publication of ATE196166T1 publication Critical patent/ATE196166T1/de

Links

229940121710 HMGCoA reductase inhibitor Drugs 0.000 title abstract 3
230000033444 hydroxylation Effects 0.000 title abstract 3
238000005805 hydroxylation reaction Methods 0.000 title abstract 3
239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 3
229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 title abstract 3
230000002255 enzymatic effect Effects 0.000 title abstract 2
102000004190 Enzymes Human genes 0.000 abstract 2
108090000790 Enzymes Proteins 0.000 abstract 2
244000005700 microbiome Species 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/872—Nocardia
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT94116409T 1993-10-22 1994-10-18 Enzymatisches hydroxylierungsverfahren zur herstellung von hmg-coa-reduktaseinhibitoren und intermediate hiervon ATE196166T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/141,316 US6043064A (en)	1993-10-22	1993-10-22	Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof

Publications (1)

Publication Number	Publication Date
ATE196166T1 true ATE196166T1 (de)	2000-09-15

Family

ID=22495167

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94116409T ATE196166T1 (de)	1993-10-22	1994-10-18	Enzymatisches hydroxylierungsverfahren zur herstellung von hmg-coa-reduktaseinhibitoren und intermediate hiervon

Country Status (19)

Country	Link
US (1)	US6043064A (de)
EP (1)	EP0649907B1 (de)
JP (1)	JP3683606B2 (de)
KR (1)	KR100342627B1 (de)
CN (1)	CN1085250C (de)
AT (1)	ATE196166T1 (de)
AU (1)	AU679113B2 (de)
CA (1)	CA2134025A1 (de)
CY (1)	CY2216B1 (de)
DE (1)	DE69425801T2 (de)
DK (1)	DK0649907T3 (de)
ES (1)	ES2150459T3 (de)
FI (1)	FI113279B (de)
GR (1)	GR3034835T3 (de)
HU (1)	HU217104B (de)
IL (1)	IL111084A (de)
PT (1)	PT649907E (de)
SG (1)	SG47504A1 (de)
TW (1)	TW438888B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1999007872A1 (en)	1997-08-07	1999-02-18	Kyowa Hakko Kogyo Co., Ltd.	PROCESS FOR THE PREPARATION OF HMG-CoA REDUCTASE INHIBITORS
WO1999010499A1 (en) *	1997-08-22	1999-03-04	Dsm N.V.	Statin production by fermentation
SI9800144A (sl)	1998-05-21	1999-12-31	LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d.	Nov biotehnološki postopek pridobivanja 3-hidroksi-ML-236B derivatov poznanih kot M-4 in M-4'
KR100633867B1 (ko)	1999-01-20	2006-10-16	교와 핫꼬 고교 가부시끼가이샤	히드록시메틸글루타릴 코에이 환원효소 저해제의 제조방법
CZ20012728A3 (cs)	1999-01-29	2002-02-13	Kyowa Hakko Kogyo Co., Ltd.	Způsob výroby inhibitorů HMG-CoA reduktasy
HUP9902352A1 (hu) *	1999-07-12	2000-09-28	Gyógyszerkutató Intézet Kft.	Eljárás pravasztatin mikrobiológiai előállítására
JP2003093045A (ja) *	2001-09-26	2003-04-02	Godo Shusei Co Ltd	有用変換微生物
IL161079A0 (en) *	2001-09-27	2004-08-31	Biocon Ltd	A strain of streptomyces flavidovirens and process for the manufacture of pravastatin utilizing the same
EP1452602A1 (de) *	2003-02-25	2004-09-01	Antibiotic Co.,	Fermentatives Verfahren zur Herstellung von Pravastatin
TWI252253B (en) *	2004-01-09	2006-04-01	Chinese Petroleum Corp	A novel Pseudonocardia sp RMRC PAH4 and a process for bioconverting compactin into pravastatin using the same
CN101351551A (zh)	2005-11-29	2009-01-21	协和发酵工业株式会社	新型蛋白质和编码该蛋白质的dna
WO2007137816A1 (en) *	2006-05-30	2007-12-06	Dsm Ip Assets B.V.	Process for the preparation of epoxide intermediates for pharmaceutical compounds such as statins
EP1953233A1 (de) *	2007-02-02	2008-08-06	LEK Pharmaceuticals d.d.	Fermentationsverfahren zur Herstellung von Pravastatin
US20200115705A1 (en)	2017-06-06	2020-04-16	Zymergen Inc.	A high-throughput (htp) genomic engineering platform for improving saccharopolyspora spinosa

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5612114B2 (de) *	1974-06-07	1981-03-18
US4206206A (en) *	1977-03-24	1980-06-03	Kowa Company, Ltd.	Antibiotics of the KA-6606 series and pharmaceutical compositions thereof
US4444784A (en) *	1980-08-05	1984-04-24	Merck & Co., Inc.	Antihypercholesterolemic compounds
DK149080C (da) *	1980-06-06	1986-07-28	Sankyo Co	Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
US4450171A (en) *	1980-08-05	1984-05-22	Merck & Co., Inc.	Antihypercholesterolemic compounds
EP0069442B1 (de) *	1981-06-06	1985-02-20	Pfizer Limited	Fungizide Mittel, Verfahren zu deren Herstellung, und diese enthaltende pharmazeutische Zusammenstellungen
JPS5889191A (ja) *	1981-11-20	1983-05-27	Sankyo Co Ltd	３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法
JPS60176595A (ja) *	1984-02-21	1985-09-10	Akira Endo	生理活性物質ｍｌ−２３６ａ及びモナコリンｊの製造法
PT85109A (en) *	1986-06-23	1987-07-01	Merck & Co Inc	Process for the preparation of hydroxy-tetrahydropyranone derivatives or corresponding ring opened dihydroxy acids which are hmg-coa reductase inhibitors
US4857547A (en) *	1988-01-07	1989-08-15	Merck & Co., Inc.	Novel HMG-CoA reductase inhibitors
EP0337548A3 (de) *	1988-04-15	1991-08-14	Merck & Co. Inc.	Inhibitoren von HMG-COA-Reduktase, hergestellt durch Nocardia SP.(MA6455)(ATCC 53695)
JPH02245191A (ja) *	1989-02-01	1990-09-28	Merck & Co Inc	６―α―ヒドロキシメチルロバスタチン誘導体の製造方法
EP0408806A1 (de) *	1989-07-19	1991-01-23	Merck & Co. Inc.	Antihypercholesterolemische Mittel
MY106564A (en) *	1990-07-06	1995-06-30	Squibb & Sons Inc	Sulfur-substituted mevinic acid derivatives.
CA2053000C (en) *	1990-10-15	1995-08-29	Michael J. Conder	Biosynthetic production of 6(r)-[2-(8(s)-hydroxy-2(s), 6(r)-dimethyl-1,2,6,7,8,8a(r)-hexahydronaphthyl)-ethyl]-4 (r)-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-one triol acid by enzymatic hydrolysis of lovastatin acid using an enzyme derived from__lonostachys compactiuscula
IL108432A (en) *	1993-01-29	1997-09-30	Sankyo Co	DERIVATIVES OF 3, 5-DIHYDROXY-7- £1, 2, 6, 7, 8, 8a-HEXAHYDRO-2- METHYL-8- (SUBSTITUTED ALKANOYLOXY)-1-NAPHTHYL\| HEPTANOIC ACID AND THEIR LACTONES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

1993
- 1993-10-22 US US08/141,316 patent/US6043064A/en not_active Expired - Fee Related
1994
- 1994-09-29 IL IL111084A patent/IL111084A/en not_active IP Right Cessation
- 1994-10-01 TW TW083109094A patent/TW438888B/zh not_active IP Right Cessation
- 1994-10-18 PT PT94116409T patent/PT649907E/pt unknown
- 1994-10-18 SG SG1996002486A patent/SG47504A1/en unknown
- 1994-10-18 DE DE69425801T patent/DE69425801T2/de not_active Expired - Fee Related
- 1994-10-18 EP EP94116409A patent/EP0649907B1/de not_active Expired - Lifetime
- 1994-10-18 DK DK94116409T patent/DK0649907T3/da active
- 1994-10-18 ES ES94116409T patent/ES2150459T3/es not_active Expired - Lifetime
- 1994-10-18 AT AT94116409T patent/ATE196166T1/de not_active IP Right Cessation
- 1994-10-20 FI FI944926A patent/FI113279B/fi not_active IP Right Cessation
- 1994-10-21 CA CA002134025A patent/CA2134025A1/en not_active Abandoned
- 1994-10-21 AU AU75972/94A patent/AU679113B2/en not_active Ceased
- 1994-10-21 HU HU9403061A patent/HU217104B/hu not_active IP Right Cessation
- 1994-10-21 KR KR1019940026933A patent/KR100342627B1/ko not_active Expired - Fee Related
- 1994-10-21 JP JP25654894A patent/JP3683606B2/ja not_active Expired - Fee Related
- 1994-10-22 CN CN94117167A patent/CN1085250C/zh not_active Expired - Fee Related
2000
- 2000-11-13 GR GR20000402523T patent/GR3034835T3/el not_active IP Right Cessation
- 2000-11-28 CY CY0000057A patent/CY2216B1/xx unknown

Also Published As

Publication number	Publication date
CN1106067A (zh)	1995-08-02
CA2134025A1 (en)	1995-04-23
EP0649907A1 (de)	1995-04-26
DK0649907T3 (da)	2000-10-09
HUT69959A (en)	1995-09-28
KR100342627B1 (ko)	2002-11-18
AU679113B2 (en)	1997-06-19
HK1014740A1 (en)	1999-09-30
DE69425801D1 (de)	2000-10-12
IL111084A (en)	1998-01-04
AU7597294A (en)	1995-05-11
US6043064A (en)	2000-03-28
HU217104B (hu)	1999-11-29
DE69425801T2 (de)	2001-05-03
HU9403061D0 (en)	1994-12-28
JPH07184670A (ja)	1995-07-25
IL111084A0 (en)	1994-11-28
FI113279B (fi)	2004-03-31
CY2216B1 (en)	2003-04-18
FI944926A0 (fi)	1994-10-20
EP0649907B1 (de)	2000-09-06
ES2150459T3 (es)	2000-12-01
TW438888B (en)	2001-06-07
FI944926L (fi)	1995-04-23
GR3034835T3 (en)	2001-02-28
CN1085250C (zh)	2002-05-22
PT649907E (pt)	2000-12-29
KR950011616A (ko)	1995-05-15
JP3683606B2 (ja)	2005-08-17
SG47504A1 (en)	1998-04-17

Legal Events

Date	Code	Title	Description
2001-03-15	UEP	Publication of translation of european patent specification
2008-07-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE196166T1 (de)	2000-09-15	Enzymatisches hydroxylierungsverfahren zur herstellung von hmg-coa-reduktaseinhibitoren und intermediate hiervon
DE69721292D1 (de)	2003-05-28	Enzymatisches verfahren zur herstellung von ascorbinsäure,2-keto-l-gulonsäure und 2-keto-l-gulonsäure-estern
ATE199709T1 (de)	2001-03-15	Verfahren zur herstellung von (+)compactin und (+)mevinolin derivaten mit beta-hydroxy-delta- lactonresten
ATE210729T1 (de)	2001-12-15	Verfahren zur herstellung von trans-4-hydroxy-l- prolin
DE3582737D1 (de)	1991-06-13	Verfahren zur herstellung von 6-hydroxynikotinsaeure.
ATE287959T1 (de)	2005-02-15	Verfahren zur herstellung von trans-4-hydroxy-l- prolin
ATE197963T1 (de)	2000-12-15	Stereoselektive mikrobielle oder enzymatische reduktion von 3,5-dioxoestern zu 3,5- dihydroxyestern
EP0896057A3 (de)	2000-06-28	D-Aminoacylase
ATE127525T1 (de)	1995-09-15	Mikrobielles verfahren zur herstellung von 6- hydroxypicolinsäure.
DE69920943D1 (de)	2004-11-11	Verfahren zur herstellung von optisch aktiven 3-hydroxy-pyrrolidinderivaten durch enzymatische hydroxylierung
AU2818392A (en)	1993-01-14	Method for enhancing enzyme activities and the synthetic performance of organisms
DE58907667D1 (de)	1994-06-23	Gen und Genprodukt zur Herstellung von beta-lactamverbindungen.
DE59807569D1 (de)	2003-04-24	Verfahren zur herstellung von amiden
DE69407575D1 (de)	1998-02-05	Esterase und ihre verwendung in bioumwandlung
ATE164628T1 (de)	1998-04-15	L-proline-3-hydroxylase und verfahren zur herstellung von cis-3-hydroxy-l-prolin
EP0909757A3 (de)	1999-04-28	Verfahren zur Herstellung optisch aktiver Pentatetraole
ATE345394T1 (de)	2006-12-15	Verfahren zur enzymatischen umsetzung von verbindungen mit mindestens einer nitrilfunktion und/oder mindestens einer amidfunktion
DE59509637D1 (de)	2001-10-31	Verfahren sowie Wirkstoff zur Verhinderung von mikrobiellem Wachstum an Oberflächen sowie Masse zur Oberflächenbeschichtung oder -Veredelung
CA2131776A1 (en)	1995-10-06	Process for producing cis-3-hydroxy-l-proline
DE69432304D1 (de)	2003-04-24	Clavulansäure-dehydrogenase, herstellung und verwendung für die herstellung von clavulansäure