ATE211471T1 - Acridonderivate als antineoplastische-und antiretrovirale mittel - Google Patents

Acridonderivate als antineoplastische-und antiretrovirale mittel

Info

Publication number: ATE211471T1
Authority: AT; Austria
Prior art keywords: independently; compounds; antineoplastic; antiretroviral agents; treatment
Prior art date: 1996-04-12

Application number

AT97922508T

Other languages

English (en)

Inventor

Christopher J Michejda

W Marek Cholody

William G Rice

James A Turpin

Original Assignee

Us Gov Health & Human Serv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-12

Filing date

1997-04-09

Publication date

2002-01-15

1997-04-09 Application filed by Us Gov Health & Human Serv filed Critical Us Gov Health & Human Serv

2002-01-15 Application granted granted Critical

2002-01-15 Publication of ATE211471T1 publication Critical patent/ATE211471T1/de

Links

FZEYVTFCMJSGMP-UHFFFAOYSA-N acridone Chemical class C1=CC=C2C(=O)C3=CC=CC=C3NC2=C1 FZEYVTFCMJSGMP-UHFFFAOYSA-N 0.000 title abstract 2
229940034982 antineoplastic agent Drugs 0.000 title abstract 2
239000002246 antineoplastic agent Substances 0.000 title abstract 2
230000000118 anti-neoplastic effect Effects 0.000 title 1
229940124522 antiretrovirals Drugs 0.000 title 1
239000003903 antiretrovirus agent Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
GDALETGZDYOOGB-UHFFFAOYSA-N Acridone Natural products C1=C(O)C=C2N(C)C3=CC=CC=C3C(=O)C2=C1O GDALETGZDYOOGB-UHFFFAOYSA-N 0.000 abstract 1
241000725303 Human immunodeficiency virus Species 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
239000003443 antiviral agent Substances 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000001188 haloalkyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
230000003612 virological effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Virology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Steroid Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT97922508T 1996-04-12 1997-04-09 Acridonderivate als antineoplastische-und antiretrovirale mittel ATE211471T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US1532696P	1996-04-12	1996-04-12
US3505097P	1997-01-22	1997-01-22
PCT/US1997/007070 WO1997038999A1 (en)	1996-04-12	1997-04-09	Acridone-derived compounds useful as antineoplastic and antiretroviral agents

Publications (1)

Publication Number	Publication Date
ATE211471T1 true ATE211471T1 (de)	2002-01-15

Family

ID=26687242

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97922508T ATE211471T1 (de)	1996-04-12	1997-04-09	Acridonderivate als antineoplastische-und antiretrovirale mittel

Country Status (10)

Country	Link
US (2)	US6187775B1 (de)
EP (1)	EP0892801B1 (de)
JP (1)	JP4121151B2 (de)
AT (1)	ATE211471T1 (de)
AU (1)	AU725629B2 (de)
DE (1)	DE69709857T2 (de)
DK (1)	DK0892801T3 (de)
ES (1)	ES2171260T3 (de)
PT (1)	PT892801E (de)
WO (1)	WO1997038999A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1293525B1 (it) *	1997-08-01	1999-03-01	Uni Degli Studi Camerino	Bis-acridincarbossiammidi aventi attivita' antitumorale
AU2001240054B2 (en) *	2000-03-07	2005-08-11	The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	1,8-Naphthalimide Imidazo[4,5,1-de]acridones with Anti-Tumor Activity
US7144843B2 (en) *	2001-01-31	2006-12-05	Meiji Seika Kaisha, Ltd.	Pest controllers
US6670071B2 (en) *	2002-01-15	2003-12-30	Quallion Llc	Electric storage battery construction and method of manufacture
SK2662004A3 (sk)	2002-11-20	2005-06-02	Japan Tobacco, Inc.	Zlúčenina s obsahom 4-oxochinolínu a jej použitie ako inhibítora integráz
RU2275361C3 (ru) *	2002-11-20	2021-10-01	Джапан Тобакко Инк.	Соединение 4-оксохинолина и его применение в качестве ингибитора вич интегразы
US8512144B2 (en) *	2003-10-20	2013-08-20	Tipping Point Group, Llc	Method and apparatus for providing secondary gaming machine functionality
US7531554B2 (en)	2004-05-20	2009-05-12	Japan Tobacco Inc.	4-oxoquinoline compound and use thereof as HIV integrase inhibitor
MY134672A (en)	2004-05-20	2007-12-31	Japan Tobacco Inc	Stable crystal of 4-oxoquinoline compound
EP1761537B1 (de) *	2004-06-30	2011-08-03	Council of Scientific and Industrial Research	Über die piperazineinheit gebundene pyrrolo[2,1-c][1,4]benzodiazepin-napthalimid-konjugate und verfahren zu deren herstellung
US8377586B2 (en) *	2005-10-05	2013-02-19	California Institute Of Technology	Fluoride ion electrochemical cell
US7829578B1 (en)	2005-12-12	2010-11-09	Oregon Health & Science University	Aromatic ketones and uses thereof
WO2007092436A2 (en) *	2006-02-08	2007-08-16	Xanthus Pharmaceuticals, Inc.	Compounds for treating inflammatory disorders, demyelinating disorders and cancers
ES2531190T3 (es)	2006-03-06	2015-03-11	Japan Tobacco Inc	Método para producir un compuesto de 4-oxoquinolina
WO2007136858A2 (en)	2006-05-19	2007-11-29	H. Lee Moffitt Cancer Center & Research Institute	Small molecule inhibitors of stat3 with anti-tumor activity
WO2008016661A2 (en) *	2006-08-02	2008-02-07	Xanthus Pharmaceuticals, Inc.	Morpholino compounds for treating inflammatory and demyelinating diseases and cancers
EP2086521A2 (de) *	2006-11-07	2009-08-12	Government of the United States of America, Represented by the Secretary, Department of Health and Human Services	Aus transmembranpeptiden zusammengesetzte selbstanordnende nanopartikel und ihre anwendung zur spezifischen verabreichung von anti-krebs-wirkstoffen in einen tumor
US8592447B2 (en)	2006-11-13	2013-11-26	Oregon Health & Science University	Acridone compounds
US8598354B2 (en)	2008-12-05	2013-12-03	University Of South Florida	Compounds having antiparasitic or anti-infectious activity
PL3070078T3 (pl) *	2015-03-20	2018-02-28	Politechnika Gdańska	Niesymetryczne bisakrydyny o działaniu przeciwnowotworowym i ich zastosowania

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9104548D0 (en) *	1991-03-05	1991-04-17	Cholody Wienlaw M	Antineoplastic modified imidazoacridines
US5508289A (en) *	1994-03-14	1996-04-16	The United States America As Represented By The Department Of Health And Human Services	Bis-acridone chemotherapeutic derivatives

1997
- 1997-04-09 AT AT97922508T patent/ATE211471T1/de active
- 1997-04-09 JP JP53745697A patent/JP4121151B2/ja not_active Expired - Fee Related
- 1997-04-09 AU AU28157/97A patent/AU725629B2/en not_active Ceased
- 1997-04-09 DK DK97922508T patent/DK0892801T3/da active
- 1997-04-09 EP EP97922508A patent/EP0892801B1/de not_active Expired - Lifetime
- 1997-04-09 WO PCT/US1997/007070 patent/WO1997038999A1/en not_active Ceased
- 1997-04-09 PT PT97922508T patent/PT892801E/pt unknown
- 1997-04-09 ES ES97922508T patent/ES2171260T3/es not_active Expired - Lifetime
- 1997-04-09 US US09/155,141 patent/US6187775B1/en not_active Expired - Lifetime
- 1997-04-09 DE DE69709857T patent/DE69709857T2/de not_active Expired - Lifetime
2001
- 2001-01-15 US US09/760,047 patent/US6541483B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP2000508662A (ja)	2000-07-11
PT892801E (pt)	2002-06-28
AU725629B2 (en)	2000-10-19
US6541483B2 (en)	2003-04-01
US6187775B1 (en)	2001-02-13
US20010009914A1 (en)	2001-07-26
DE69709857D1 (de)	2002-02-28
EP0892801B1 (de)	2002-01-02
ES2171260T3 (es)	2002-09-01
AU2815797A (en)	1997-11-07
DE69709857T2 (de)	2002-08-29
JP4121151B2 (ja)	2008-07-23
WO1997038999A1 (en)	1997-10-23
EP0892801A1 (de)	1999-01-27
DK0892801T3 (da)	2002-04-22

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Legal Events

Date	Code	Title	Description
2002-06-15	UEP	Publication of translation of european patent specification