ATE211471T1 - Acridonderivate als antineoplastische-und antiretrovirale mittel - Google Patents

Acridonderivate als antineoplastische-und antiretrovirale mittel

Info

Publication number: ATE211471T1
Authority: AT; Austria
Prior art keywords: independently; compounds; antineoplastic; antiretroviral agents; treatment
Prior art date: 1996-04-12

Application number

AT97922508T

Other languages

English (en)

Inventor

Christopher J Michejda

W Marek Cholody

William G Rice

James A Turpin

Original Assignee

Us Gov Health & Human Serv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-12

Filing date

1997-04-09

Publication date

2002-01-15

1997-04-09 Application filed by Us Gov Health & Human Serv filed Critical Us Gov Health & Human Serv

2002-01-15 Application granted granted Critical

2002-01-15 Publication of ATE211471T1 publication Critical patent/ATE211471T1/de

Links

FZEYVTFCMJSGMP-UHFFFAOYSA-N acridone Chemical class C1=CC=C2C(=O)C3=CC=CC=C3NC2=C1 FZEYVTFCMJSGMP-UHFFFAOYSA-N 0.000 title abstract 2
229940034982 antineoplastic agent Drugs 0.000 title abstract 2
239000002246 antineoplastic agent Substances 0.000 title abstract 2
230000000118 anti-neoplastic effect Effects 0.000 title 1
229940124522 antiretrovirals Drugs 0.000 title 1
239000003903 antiretrovirus agent Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
GDALETGZDYOOGB-UHFFFAOYSA-N Acridone Natural products C1=C(O)C=C2N(C)C3=CC=CC=C3C(=O)C2=C1O GDALETGZDYOOGB-UHFFFAOYSA-N 0.000 abstract 1
241000725303 Human immunodeficiency virus Species 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
239000003443 antiviral agent Substances 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000001188 haloalkyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
230000003612 virological effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
AIDS & HIV (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Steroid Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Other In-Based Heterocyclic Compounds (AREA)

AT97922508T 1996-04-12 1997-04-09 Acridonderivate als antineoplastische-und antiretrovirale mittel ATE211471T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US1532696P	1996-04-12	1996-04-12
US3505097P	1997-01-22	1997-01-22
PCT/US1997/007070 WO1997038999A1 (en)	1996-04-12	1997-04-09	Acridone-derived compounds useful as antineoplastic and antiretroviral agents

Publications (1)

Publication Number	Publication Date
ATE211471T1 true ATE211471T1 (de)	2002-01-15

Family

ID=26687242

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97922508T ATE211471T1 (de)	1996-04-12	1997-04-09	Acridonderivate als antineoplastische-und antiretrovirale mittel

Country Status (10)

Country	Link
US (2)	US6187775B1 (de)
EP (1)	EP0892801B1 (de)
JP (1)	JP4121151B2 (de)
AT (1)	ATE211471T1 (de)
AU (1)	AU725629B2 (de)
DE (1)	DE69709857T2 (de)
DK (1)	DK0892801T3 (de)
ES (1)	ES2171260T3 (de)
PT (1)	PT892801E (de)
WO (1)	WO1997038999A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1293525B1 (it) *	1997-08-01	1999-03-01	Uni Degli Studi Camerino	Bis-acridincarbossiammidi aventi attivita' antitumorale
AU2001240054B2 (en) *	2000-03-07	2005-08-11	The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	1,8-Naphthalimide Imidazo[4,5,1-de]acridones with Anti-Tumor Activity
ATE556075T1 (de) *	2001-01-31	2012-05-15	Meiji Seika Pharma Co Ltd	Triazoquinolone-derivate als pestizide
US6670071B2 (en) *	2002-01-15	2003-12-30	Quallion Llc	Electric storage battery construction and method of manufacture
RU2275361C3 (ru) *	2002-11-20	2021-10-01	Джапан Тобакко Инк.	Соединение 4-оксохинолина и его применение в качестве ингибитора вич интегразы
US7176220B2 (en)	2002-11-20	2007-02-13	Japan Tobacco Inc.	4-oxoquinoline compound and use thereof as pharmaceutical agent
US8512144B2 (en) *	2003-10-20	2013-08-20	Tipping Point Group, Llc	Method and apparatus for providing secondary gaming machine functionality
US7531554B2 (en)	2004-05-20	2009-05-12	Japan Tobacco Inc.	4-oxoquinoline compound and use thereof as HIV integrase inhibitor
MY134672A (en)	2004-05-20	2007-12-31	Japan Tobacco Inc	Stable crystal of 4-oxoquinoline compound
EP1761537B1 (de) *	2004-06-30	2011-08-03	Council of Scientific and Industrial Research	Über die piperazineinheit gebundene pyrrolo[2,1-c][1,4]benzodiazepin-napthalimid-konjugate und verfahren zu deren herstellung
US8377586B2 (en) *	2005-10-05	2013-02-19	California Institute Of Technology	Fluoride ion electrochemical cell
US7829578B1 (en)	2005-12-12	2010-11-09	Oregon Health & Science University	Aromatic ketones and uses thereof
WO2007092436A2 (en) *	2006-02-08	2007-08-16	Xanthus Pharmaceuticals, Inc.	Compounds for treating inflammatory disorders, demyelinating disorders and cancers
JP4669040B2 (ja)	2006-03-06	2011-04-13	日本たばこ産業株式会社	４−オキソキノリン化合物の製造方法
WO2007136858A2 (en)	2006-05-19	2007-11-29	H. Lee Moffitt Cancer Center & Research Institute	Small molecule inhibitors of stat3 with anti-tumor activity
WO2008016661A2 (en) *	2006-08-02	2008-02-07	Xanthus Pharmaceuticals, Inc.	Morpholino compounds for treating inflammatory and demyelinating diseases and cancers
AU2007316416A1 (en) *	2006-11-07	2008-05-15	Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services	Self-assembling nanoparticles composed of transmembrane peptides and their application for specific intra-tumor delivery of anti-cancer drugs
US8592447B2 (en)	2006-11-13	2013-11-26	Oregon Health & Science University	Acridone compounds
US8598354B2 (en)	2008-12-05	2013-12-03	University Of South Florida	Compounds having antiparasitic or anti-infectious activity
EP3070078B1 (de) *	2015-03-20	2017-10-04	Politechnika Gdanska	Unsymmetrische bisacridine und ihre verwendung zur behandlung von tumoren

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9104548D0 (en) *	1991-03-05	1991-04-17	Cholody Wienlaw M	Antineoplastic modified imidazoacridines
US5508289A (en) *	1994-03-14	1996-04-16	The United States America As Represented By The Department Of Health And Human Services	Bis-acridone chemotherapeutic derivatives

1997
- 1997-04-09 AT AT97922508T patent/ATE211471T1/de active
- 1997-04-09 PT PT97922508T patent/PT892801E/pt unknown
- 1997-04-09 AU AU28157/97A patent/AU725629B2/en not_active Ceased
- 1997-04-09 ES ES97922508T patent/ES2171260T3/es not_active Expired - Lifetime
- 1997-04-09 US US09/155,141 patent/US6187775B1/en not_active Expired - Lifetime
- 1997-04-09 EP EP97922508A patent/EP0892801B1/de not_active Expired - Lifetime
- 1997-04-09 DE DE69709857T patent/DE69709857T2/de not_active Expired - Lifetime
- 1997-04-09 WO PCT/US1997/007070 patent/WO1997038999A1/en not_active Ceased
- 1997-04-09 JP JP53745697A patent/JP4121151B2/ja not_active Expired - Fee Related
- 1997-04-09 DK DK97922508T patent/DK0892801T3/da active
2001
- 2001-01-15 US US09/760,047 patent/US6541483B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0892801A1 (de)	1999-01-27
JP2000508662A (ja)	2000-07-11
ES2171260T3 (es)	2002-09-01
AU2815797A (en)	1997-11-07
AU725629B2 (en)	2000-10-19
US6187775B1 (en)	2001-02-13
DK0892801T3 (da)	2002-04-22
US6541483B2 (en)	2003-04-01
DE69709857T2 (de)	2002-08-29
US20010009914A1 (en)	2001-07-26
EP0892801B1 (de)	2002-01-02
JP4121151B2 (ja)	2008-07-23
DE69709857D1 (de)	2002-02-28
WO1997038999A1 (en)	1997-10-23
PT892801E (pt)	2002-06-28

Legal Events

Date	Code	Title	Description
2002-06-15	UEP	Publication of translation of european patent specification

Publication	Publication Date	Title
ATE211471T1 (de)	2002-01-15	Acridonderivate als antineoplastische-und antiretrovirale mittel
PE10399A1 (es)	1999-02-10	Derivados de aminoacidos
BR9815166A (pt)	2000-10-10	"método de inibição da replicação de vìrus, composto, método de inibição da replicação de citomegalovìrus, composto antiviral, utilização de um composto, composição farmacêutica, composição farmacêutica inibidora da replicação de vìrus e de citomegalovìrus e composição farmacêutica antiviral"
ATE245641T1 (de)	2003-08-15	Antivirale pyrimidinderivate
TR200002761T2 (tr)	2001-01-22	HIV enfeksiyonlarının tedavisi için üç-ikameli 1,3,5-triazin türevleri.
ES2086376T3 (es)	1996-07-01	Nucleosidos pirimidinicos antivirales.
ATE219366T1 (de)	2002-07-15	Verwendung von 5-fluoro-2'-deoxy-3'-thiacytidin zur behandlung von hepatitis b
ATE231149T1 (de)	2003-02-15	(1,8)-naphthyridinderivate derivate mit antiviraler wirkung
BR0110023A (pt)	2003-12-30	Derivados de nucleosìdeo 3'-ou-2' substituìdos para tratamento de infecções por vìrus da hepatite
DK0758327T3 (da)	2003-07-28	Pyranonforbindelser, der er nyttige til behandling af retrovirale infektioner
DE60101223D1 (de)	2003-12-18	Antivirale pyrimidin nucleoside derivate
ATE161267T1 (de)	1998-01-15	Antivirales 4'-thio-pyrimidin-nukleosid
DE69005164D1 (de)	1994-01-27	Acryloylsubstituierte Pyrrol-Derivate.
EP1399163A4 (de)	2005-08-31	Verbindungen, verfahren und zusammensetzungen für die behandlung von infektionen mit dem rinderdiarrhö-virus (bvdv) und dem hepatitis-c-virus (hcv)
WO1999058526A8 (en)	2001-03-08	Novel 2,5-pyridinedicarboxylic acid derivatives
ATE124050T1 (de)	1995-07-15	Chirale 2-(phosphonomethoxy)propyl-guanine als antivirale agentien.
CA2250863A1 (en)	1997-10-23	Acridone-derived compounds useful as antineoplastic and antiretroviral agents
DK0906909T3 (da)	2002-04-29	Hydroxy- og polyhydroxyderivater af coumarin, deres fremstilling og antivirale virkning
ATE187716T1 (de)	2000-01-15	Acridonderivate von diinterkalatoren als chemotherapeutische wirkstoffe
DE69519895D1 (de)	2001-02-22	Pyrimidinderivate und pharmazeutische Zusammensetzungen
TR200101319T2 (tr)	2001-10-22	2,4-Disübstitüe triazin türevleri.
ATE273012T1 (de)	2004-08-15	Kombinationen von lamivudin und entecavir für behandlung der hepatitis b virus infektion
PY0101564A (es)	2001-12-03	Triazine containing anionic compounds useful as antiviral agents
DE69904025D1 (de)	2003-01-02	Kondensierte Pyrimidinderivate und diese enthaltende pharmazeutische Zubereitungen
CA2525550A1 (en)	1997-10-23	Acridone-derived compounds useful as antiretroviral agents