ES2171260T3 - Compuestos derivados de acridona utiles como agentes antineoplasicos y antirretroviricos. - Google Patents

Compuestos derivados de acridona utiles como agentes antineoplasicos y antirretroviricos.

Info

Publication number
ES2171260T3
ES2171260T3 ES97922508T ES97922508T ES2171260T3 ES 2171260 T3 ES2171260 T3 ES 2171260T3 ES 97922508 T ES97922508 T ES 97922508T ES 97922508 T ES97922508 T ES 97922508T ES 2171260 T3 ES2171260 T3 ES 2171260T3
Authority
ES
Spain
Prior art keywords
useful
agents
acridona
independently
compounds derived
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97922508T
Other languages
English (en)
Inventor
Christopher J Michejda
Marek W Cholody
William G Rice
James A Turpin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
United States Department of Health and Human Services
Original Assignee
United States Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by United States Department of Health and Human Services filed Critical United States Department of Health and Human Services
Application granted granted Critical
Publication of ES2171260T3 publication Critical patent/ES2171260T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A VARIOS COMPUESTOS NUEVOS DERIVADOS DE LA ACRIDONA, DE FORMULA (I) O (II). ESTOS COMPUESTOS SON POTENTES AGENTES ANTI - VIRALES, UTILES EN EL TRATAMIENTO DE ENFERMEDADES VIRALES, TALES COMO EL VIRUS DE LA INMUNODEFICIENCIA HUMANA (VIH). ADEMAS, ESTOS COMPUESTOS SON AGENTES ANTI NEOPLASICOS, UTILES EN EL TRATAMIENTO DE DIVERSAS FORMAS DE CANCER. EN LAS MENCIONADAS FORMULAS (I) O (II) R 1 Y R 2 SON INDEPENDIENTEMENTE - H, - OH, AMINO, ALQUILAMINO, DIALQUILAMINO, ALCOXI, ALQUILO, HALOALQUILO O HALOGENO; N ES 2 A 6, X Y X'' SON INDEPENDIENTEMENTE - N O - NO 2 Y E Y'' SON INDEPENDIENTEMENTE N, - CH, O - H; Y EL DOBLE GUION REPRESENTA UN DOBLE ENLACE O LA INEXISTENCIA DE ENLACE.
ES97922508T 1996-04-12 1997-04-09 Compuestos derivados de acridona utiles como agentes antineoplasicos y antirretroviricos. Expired - Lifetime ES2171260T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1532696P 1996-04-12 1996-04-12
US3505097P 1997-01-22 1997-01-22

Publications (1)

Publication Number Publication Date
ES2171260T3 true ES2171260T3 (es) 2002-09-01

Family

ID=26687242

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97922508T Expired - Lifetime ES2171260T3 (es) 1996-04-12 1997-04-09 Compuestos derivados de acridona utiles como agentes antineoplasicos y antirretroviricos.

Country Status (10)

Country Link
US (2) US6187775B1 (es)
EP (1) EP0892801B1 (es)
JP (1) JP4121151B2 (es)
AT (1) ATE211471T1 (es)
AU (1) AU725629B2 (es)
DE (1) DE69709857T2 (es)
DK (1) DK0892801T3 (es)
ES (1) ES2171260T3 (es)
PT (1) PT892801E (es)
WO (1) WO1997038999A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1293525B1 (it) * 1997-08-01 1999-03-01 Uni Degli Studi Camerino Bis-acridincarbossiammidi aventi attivita' antitumorale
AU2001240054B2 (en) * 2000-03-07 2005-08-11 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services 1,8-Naphthalimide Imidazo[4,5,1-de]acridones with Anti-Tumor Activity
EP1364951B1 (en) * 2001-01-31 2012-05-02 Meiji Seika Pharma Co., Ltd. Triazoquinolone derivatives as pest controllers
US6670071B2 (en) * 2002-01-15 2003-12-30 Quallion Llc Electric storage battery construction and method of manufacture
RU2275361C3 (ru) * 2002-11-20 2021-10-01 Джапан Тобакко Инк. Соединение 4-оксохинолина и его применение в качестве ингибитора вич интегразы
US7176220B2 (en) * 2002-11-20 2007-02-13 Japan Tobacco Inc. 4-oxoquinoline compound and use thereof as pharmaceutical agent
US8512144B2 (en) * 2003-10-20 2013-08-20 Tipping Point Group, Llc Method and apparatus for providing secondary gaming machine functionality
US7531554B2 (en) 2004-05-20 2009-05-12 Japan Tobacco Inc. 4-oxoquinoline compound and use thereof as HIV integrase inhibitor
MY134672A (en) 2004-05-20 2007-12-31 Japan Tobacco Inc Stable crystal of 4-oxoquinoline compound
WO2006003670A1 (en) * 2004-06-30 2006-01-12 Council Of Scientific And Industrial Research Pyrrolo[2,1-c][1,4]benzodiazepine-napthalimide conjugates linked through piperazine moiety and process for preparation thereof
US8377586B2 (en) * 2005-10-05 2013-02-19 California Institute Of Technology Fluoride ion electrochemical cell
US7829578B1 (en) 2005-12-12 2010-11-09 Oregon Health & Science University Aromatic ketones and uses thereof
WO2007092436A2 (en) * 2006-02-08 2007-08-16 Xanthus Pharmaceuticals, Inc. Compounds for treating inflammatory disorders, demyelinating disorders and cancers
JP4669040B2 (ja) 2006-03-06 2011-04-13 日本たばこ産業株式会社 ４−オキソキノリン化合物の製造方法
WO2007136858A2 (en) 2006-05-19 2007-11-29 H. Lee Moffitt Cancer Center & Research Institute Small molecule inhibitors of stat3 with anti-tumor activity
WO2008016661A2 (en) * 2006-08-02 2008-02-07 Xanthus Pharmaceuticals, Inc. Morpholino compounds for treating inflammatory and demyelinating diseases and cancers
CN101610759A (zh) * 2006-11-07 2009-12-23 美国政府卫生与公共服务部 由跨膜肽组成的自组装纳米颗粒及其用于特异性肿瘤内递送抗癌药物的应用
WO2008064011A1 (en) 2006-11-13 2008-05-29 The Government Of The U.S. Of America As Represented By The Department Of Veterans Affairs Acridone compounds
US8598354B2 (en) 2008-12-05 2013-12-03 University Of South Florida Compounds having antiparasitic or anti-infectious activity
PL3070078T3 (pl) * 2015-03-20 2018-02-28 Politechnika Gdańska Niesymetryczne bisakrydyny o działaniu przeciwnowotworowym i ich zastosowania

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9104548D0 (en) * 1991-03-05 1991-04-17 Cholody Wienlaw M Antineoplastic modified imidazoacridines
US5508289A (en) * 1994-03-14 1996-04-16 The United States America As Represented By The Department Of Health And Human Services Bis-acridone chemotherapeutic derivatives

Also Published As

Publication number Publication date
JP4121151B2 (ja) 2008-07-23
PT892801E (pt) 2002-06-28
ATE211471T1 (de) 2002-01-15
EP0892801A1 (en) 1999-01-27
WO1997038999A1 (en) 1997-10-23
US6541483B2 (en) 2003-04-01
AU2815797A (en) 1997-11-07
US6187775B1 (en) 2001-02-13
JP2000508662A (ja) 2000-07-11
DE69709857T2 (de) 2002-08-29
US20010009914A1 (en) 2001-07-26
EP0892801B1 (en) 2002-01-02
DK0892801T3 (da) 2002-04-22
AU725629B2 (en) 2000-10-19
DE69709857D1 (de) 2002-02-28

Similar Documents

Publication Publication Date Title
MX9403380A (es) Inhibidores de proteasa de vih utiles para el tratamiento de sida.
SV1995000048A (es) Compuestos ariltios
EA199901031A1 (ru) Производные бензимидазола
CY1108578T1 (el) Φαρμακευτικες συνθεσεις (κιτ) περιλαμβανοντας ενωσεις διϋδροπυριδινονης και εναν ανοσορυθμιστικο (ή εναν αντιφλεγμονωδη) παραγοντα και οι χρησεις αυτων
PT892801E (pt) Compostos derivados de acridona uteis como agentes antineoplasicos e antiretrovirais
MX2024011695A (es) Compuestos de carbamoilpiridona triciclicos en puente y usos de estos
ES2149267T3 (es) Carbonilos ciclicos substituidos y derivados de los mismos utiles como inhibidores de la proteasa retroviral.
CY1106207T1 (el) Αντιιικα παραγωγα νουκλεοζιτων
GT200000014A (es) Derivados de quinolin - 2 - ona sustituidos con heteroarilo utiles como agentes anticancerigenos.
FI20001231A7 (fi) 2-Deoksi-2,3-didehydro-N-asetyylineuramiinihapon johdannaisia ja niiden analogeja ja niiden käyttö antiviraalisina aineina
TR200002761T2 (tr) HIV enfeksiyonlarının tedavisi için üç-ikameli 1,3,5-triazin türevleri.
DK1124842T3 (da) Betulinsyrederivater anvendelige til behandling af neuroektodermale tumorer
CY1111567T1 (el) Ενδιαμεσα διβενζο (b,f) αζεπινης
ES2165269A1 (es) Derivados de alfa-cetoamidas.
PA8471001A1 (es) Mesilato de n-(3-etinilfenilamino)-6,7-bis(2-metoxietoxi)-4-quinazolinamina anhidro y monohidratado
NO20024486D0 (no) Forbedret behandling av neovaskularisering
MX9308005A (es) Compuestos inhibidores de la proteasa del virus de la inmunodeficiencia humana, procedimiento para su preparacion y formulacion farmaceutica que los contiene.
ATE227569T1 (de) Robustaflavon und dessen derivate als antivirales mittel
CY1106444T1 (el) 17b-νιτρο-11β-αρυλοστepοειδη και παραγωγα αυτων ως ορμονικοι αγωνιστες ή ανταγωνιστες
DK1169057T3 (da) Anti-HIV-1-vaccine, der omfatter det hele eller en del af HIV-1-Tat-proteinet
ES2103577T3 (es) Compuestos antiviricos de naftoquinona, composiciones que los contienen y utilizaciones de estos compuestos.
DE69534361D1 (de) Therapeutische Quassinoid-Zubereitungen mit antineoplastischer, antiviraler und herbistatischer Wirkung
MX9700414A (es) Agentes antivirales de difluoroestatona.
DE69110528D1 (de) Chirale 2-(Phosphonomethoxy)propyl-Guanine als antivirale Agentien.
ES2101778T3 (es) Procedimiento para la obtencion de amino-benzodioxoles y -benzodioxanos y nuevos productos intermedios.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 892801

Country of ref document: ES