DK0892801T3 - Acridon-afledte forbindelser, der er anvendelige som antineoplastiske og antiretrovirale midler - Google Patents

Acridon-afledte forbindelser, der er anvendelige som antineoplastiske og antiretrovirale midler

Info

Publication number: DK0892801T3
Authority: DK; Denmark
Prior art keywords: acridone; antineoplastic; independently; derived compounds; compounds useful
Prior art date: 1996-04-12

Application number

DK97922508T

Other languages

Danish (da)

English (en)

Inventor

Christopher J Michejda

Marek W Cholody

William G Rice

James A Turpin

Original Assignee

Us Gov Health & Human Serv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-12

Filing date

1997-04-09

Publication date

2002-04-22

1997-04-09 Application filed by Us Gov Health & Human Serv filed Critical Us Gov Health & Human Serv

2002-04-22 Application granted granted Critical

2002-04-22 Publication of DK0892801T3 publication Critical patent/DK0892801T3/da

Links

150000001875 compounds Chemical class 0.000 title abstract 4
GDALETGZDYOOGB-UHFFFAOYSA-N Acridone Natural products C1=C(O)C=C2N(C)C3=CC=CC=C3C(=O)C2=C1O GDALETGZDYOOGB-UHFFFAOYSA-N 0.000 title abstract 2
FZEYVTFCMJSGMP-UHFFFAOYSA-N acridone Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3NC2=C1 FZEYVTFCMJSGMP-UHFFFAOYSA-N 0.000 title abstract 2
229940034982 antineoplastic agent Drugs 0.000 title abstract 2
239000002246 antineoplastic agent Substances 0.000 title abstract 2
230000000118 anti-neoplastic effect Effects 0.000 title 1
229940124522 antiretrovirals Drugs 0.000 title 1
239000003903 antiretrovirus agent Substances 0.000 title 1
241000725303 Human immunodeficiency virus Species 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
239000003443 antiviral agent Substances 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000001188 haloalkyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
230000003612 virological effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
AIDS & HIV (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Steroid Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK97922508T 1996-04-12 1997-04-09 Acridon-afledte forbindelser, der er anvendelige som antineoplastiske og antiretrovirale midler DK0892801T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US1532696P	1996-04-12	1996-04-12
US3505097P	1997-01-22	1997-01-22
PCT/US1997/007070 WO1997038999A1 (en)	1996-04-12	1997-04-09	Acridone-derived compounds useful as antineoplastic and antiretroviral agents

Publications (1)

Publication Number	Publication Date
DK0892801T3 true DK0892801T3 (da)	2002-04-22

Family

ID=26687242

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97922508T DK0892801T3 (da)	1996-04-12	1997-04-09	Acridon-afledte forbindelser, der er anvendelige som antineoplastiske og antiretrovirale midler

Country Status (10)

Country	Link
US (2)	US6187775B1 (de)
EP (1)	EP0892801B1 (de)
JP (1)	JP4121151B2 (de)
AT (1)	ATE211471T1 (de)
AU (1)	AU725629B2 (de)
DE (1)	DE69709857T2 (de)
DK (1)	DK0892801T3 (de)
ES (1)	ES2171260T3 (de)
PT (1)	PT892801E (de)
WO (1)	WO1997038999A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1293525B1 (it) *	1997-08-01	1999-03-01	Uni Degli Studi Camerino	Bis-acridincarbossiammidi aventi attivita' antitumorale
DE60100855T2 (de) *	2000-03-07	2004-07-15	The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	1,8-naphthalimid imidazo[4,5,1-de]acridone mit antitumorwirkung
EP1364951B1 (de) *	2001-01-31	2012-05-02	Meiji Seika Pharma Co., Ltd.	Triazoquinolone-Derivate als Pestizide
US6670071B2 (en) *	2002-01-15	2003-12-30	Quallion Llc	Electric storage battery construction and method of manufacture
RU2275361C3 (ru) *	2002-11-20	2021-10-01	Джапан Тобакко Инк.	Соединение 4-оксохинолина и его применение в качестве ингибитора вич интегразы
EP2161258A3 (de)	2002-11-20	2010-04-07	Japan Tabacco Inc.	4-Oxochinloin-Verbindung und Verwendung davon als HIV-Integrasehemmer
US8512144B2 (en) *	2003-10-20	2013-08-20	Tipping Point Group, Llc	Method and apparatus for providing secondary gaming machine functionality
MY134672A (en)	2004-05-20	2007-12-31	Japan Tobacco Inc	Stable crystal of 4-oxoquinoline compound
WO2005113509A1 (en)	2004-05-20	2005-12-01	Japan Tobacco Inc.	Novel 4-oxoquinoline compound and use thereof as hiv integrase inhibitor
JP4638485B2 (ja) *	2004-06-30	2011-02-23	カウンシルオブサイエンティフィクアンドインダストリアルリサーチ	ピペラジン部分により結合したピロロ［２，１−ｃ］［１，４］ベンゾジアゼピン−ナフタルイミド結合体及びそれを調製するための方法
US8377586B2 (en) *	2005-10-05	2013-02-19	California Institute Of Technology	Fluoride ion electrochemical cell
US7829578B1 (en)	2005-12-12	2010-11-09	Oregon Health & Science University	Aromatic ketones and uses thereof
WO2007092436A2 (en) *	2006-02-08	2007-08-16	Xanthus Pharmaceuticals, Inc.	Compounds for treating inflammatory disorders, demyelinating disorders and cancers
RS54047B1 (sr)	2006-03-06	2015-10-30	Japan Tobacco Inc.	Postupak za dobijanje jedinjenja 4-oksohinolina
US7960434B2 (en)	2006-05-19	2011-06-14	University Of South Florida	Small molecule inhibitors of STAT3 with anti-tumor activity
WO2008016661A2 (en) *	2006-08-02	2008-02-07	Xanthus Pharmaceuticals, Inc.	Morpholino compounds for treating inflammatory and demyelinating diseases and cancers
EP2086521A2 (de) *	2006-11-07	2009-08-12	Government of the United States of America, Represented by the Secretary, Department of Health and Human Services	Aus transmembranpeptiden zusammengesetzte selbstanordnende nanopartikel und ihre anwendung zur spezifischen verabreichung von anti-krebs-wirkstoffen in einen tumor
WO2008064011A1 (en)	2006-11-13	2008-05-29	The Government Of The U.S. Of America As Represented By The Department Of Veterans Affairs	Acridone compounds
US8598354B2 (en)	2008-12-05	2013-12-03	University Of South Florida	Compounds having antiparasitic or anti-infectious activity
PL3070078T3 (pl) *	2015-03-20	2018-02-28	Politechnika Gdańska	Niesymetryczne bisakrydyny o działaniu przeciwnowotworowym i ich zastosowania

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9104548D0 (en) *	1991-03-05	1991-04-17	Cholody Wienlaw M	Antineoplastic modified imidazoacridines
US5508289A (en) *	1994-03-14	1996-04-16	The United States America As Represented By The Department Of Health And Human Services	Bis-acridone chemotherapeutic derivatives

1997
- 1997-04-09 JP JP53745697A patent/JP4121151B2/ja not_active Expired - Fee Related
- 1997-04-09 ES ES97922508T patent/ES2171260T3/es not_active Expired - Lifetime
- 1997-04-09 PT PT97922508T patent/PT892801E/pt unknown
- 1997-04-09 AT AT97922508T patent/ATE211471T1/de active
- 1997-04-09 DE DE69709857T patent/DE69709857T2/de not_active Expired - Lifetime
- 1997-04-09 WO PCT/US1997/007070 patent/WO1997038999A1/en not_active Ceased
- 1997-04-09 US US09/155,141 patent/US6187775B1/en not_active Expired - Lifetime
- 1997-04-09 DK DK97922508T patent/DK0892801T3/da active
- 1997-04-09 EP EP97922508A patent/EP0892801B1/de not_active Expired - Lifetime
- 1997-04-09 AU AU28157/97A patent/AU725629B2/en not_active Ceased
2001
- 2001-01-15 US US09/760,047 patent/US6541483B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0892801A1 (de)	1999-01-27
AU2815797A (en)	1997-11-07
DE69709857T2 (de)	2002-08-29
US6187775B1 (en)	2001-02-13
US6541483B2 (en)	2003-04-01
PT892801E (pt)	2002-06-28
DE69709857D1 (de)	2002-02-28
AU725629B2 (en)	2000-10-19
JP4121151B2 (ja)	2008-07-23
WO1997038999A1 (en)	1997-10-23
ATE211471T1 (de)	2002-01-15
ES2171260T3 (es)	2002-09-01
JP2000508662A (ja)	2000-07-11
US20010009914A1 (en)	2001-07-26
EP0892801B1 (de)	2002-01-02

Publication	Publication Date	Title
DK0892801T3 (da)	2002-04-22	Acridon-afledte forbindelser, der er anvendelige som antineoplastiske og antiretrovirale midler
BR9815166A (pt)	2000-10-10	"método de inibição da replicação de vìrus, composto, método de inibição da replicação de citomegalovìrus, composto antiviral, utilização de um composto, composição farmacêutica, composição farmacêutica inibidora da replicação de vìrus e de citomegalovìrus e composição farmacêutica antiviral"
PE10399A1 (es)	1999-02-10	Derivados de aminoacidos
ES2086376T3 (es)	1996-07-01	Nucleosidos pirimidinicos antivirales.
ATE245641T1 (de)	2003-08-15	Antivirale pyrimidinderivate
NO178930C (no)	1996-07-03	Analogifremgangsmåte ved fremstilling av antivirale pyrimidinnukleosider
DE60101223D1 (de)	2003-12-18	Antivirale pyrimidin nucleoside derivate
IS6939A (is)	2003-09-04	Pýrasól afleiður til meðhöndlunar á HIV-smiti
ES2149267T3 (es)	2000-11-01	Carbonilos ciclicos substituidos y derivados de los mismos utiles como inhibidores de la proteasa retroviral.
DE69131317D1 (de)	1999-07-15	HIV-Proteaseinhibitoren
DK0758327T3 (da)	2003-07-28	Pyranonforbindelser, der er nyttige til behandling af retrovirale infektioner
DE69232649D1 (de)	2002-07-25	Verwendung von 5-fluoro-2'-deoxy-3'-thiacytidin zur behandlung von hepatitis b
DK0896533T3 (da)	2004-01-26	Pentafluorbenzensulfonamider og analoger
SE8900192D0 (sv)	1989-01-19	Dideoxididehydrokarbocykliska nukleosider
FI905758A0 (fi)	1990-11-21	Menetelmä anti-tuumoriaineina käyttökelpoisten akryloyylisubstituoitujen pyrrolijohdannaisten valmistamiseksi
ES2108969T3 (es)	1998-01-01	Utilizacion de analogos de didesoxinucleosidos en el tratamiento de infecciones virales.
PT915894E (pt)	2003-10-31	Analogos de nucleotidos
BR9912142A (pt)	2001-10-30	6-benzil-4-oxipirimidinas substituìdas, processopara sua preparação e composições contendo-as
AU643987B2 (en)	1993-12-02	Chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents
CA2250863A1 (en)	1997-10-23	Acridone-derived compounds useful as antineoplastic and antiretroviral agents
DE69519895D1 (de)	2001-02-22	Pyrimidinderivate und pharmazeutische Zusammensetzungen
TR200002318T2 (tr)	2000-11-21	Nükleositler
CA2525550A1 (en)	1997-10-23	Acridone-derived compounds useful as antiretroviral agents
GB2340490A (en)	2000-02-23	Diphenylacetic acid derivatives and their use as antiviral agents
DK0742791T3 (da)	2001-04-02	Makrocykliske difluorstatonderivater, der er nyttige som antivirale midler