ATE211762T1 - Antisense-oligonukleotide zur behandlung des immunsuppressiven effektes des transformierenden wachstumsfaktor-beta1(tgf-beta1) - Google Patents

Antisense-oligonukleotide zur behandlung des immunsuppressiven effektes des transformierenden wachstumsfaktor-beta1(tgf-beta1)

Info

Publication number: ATE211762T1
Authority: AT; Austria
Prior art keywords: beta1; tgf; growth factor; transforming growth; treating
Prior art date: 1993-04-30

Application number

AT94916170T

Other languages

English (en)

Inventor

Georg-Ferdinan Schlingensiepen

Wolfgang Brysch

Karl-Hermann Schlingensiepen

Reimar Schlingensiepen

Ulrich Bogdahn

Original Assignee

Biognostik Ges

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-04-30

Filing date

1994-04-29

Publication date

2002-01-15

1994-04-29 Application filed by Biognostik Ges filed Critical Biognostik Ges

2002-01-15 Application granted granted Critical

2002-01-15 Publication of ATE211762T1 publication Critical patent/ATE211762T1/de

Links

108020000948 Antisense Oligonucleotides Proteins 0.000 title abstract 2
239000000074 antisense oligonucleotide Substances 0.000 title abstract 2
238000012230 antisense oligonucleotides Methods 0.000 title abstract 2
102000046299 Transforming Growth Factor beta1 Human genes 0.000 title 1
101800002279 Transforming growth factor beta-1 Proteins 0.000 title 1
230000001506 immunosuppresive effect Effects 0.000 title 1
229940099456 transforming growth factor beta 1 Drugs 0.000 title 1
150000007523 nucleic acids Chemical group 0.000 abstract 3
102000004887 Transforming Growth Factor beta Human genes 0.000 abstract 2
108090001012 Transforming Growth Factor beta Proteins 0.000 abstract 2
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 2
108020004707 nucleic acids Proteins 0.000 abstract 1
102000039446 nucleic acids Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
Endocrinology (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Biochemistry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)

AT94916170T 1993-04-30 1994-04-29 Antisense-oligonukleotide zur behandlung des immunsuppressiven effektes des transformierenden wachstumsfaktor-beta1(tgf-beta1) ATE211762T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP93107089		1993-04-30
EP93107849		1993-05-13
PCT/EP1994/001362 WO1994025588A2 (en)	1993-04-30	1994-04-29	ANTISENSE-OLIGONUCLEOTIDES FOR THE TREATMENT OF IMMUNOSUPPRESSIVE EFFECTS OF TRANSFORMING GROWTH FACTOR-β (TGF-β)

Publications (1)

Publication Number	Publication Date
ATE211762T1 true ATE211762T1 (de)	2002-01-15

Family

ID=26133181

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT99125278T ATE235549T1 (de)	1993-04-30	1994-04-29	Antisense oligonukleotide zur behandlung von immunsuppressiven wirkungen von tgf-beta2
AT94916170T ATE211762T1 (de)	1993-04-30	1994-04-29	Antisense-oligonukleotide zur behandlung des immunsuppressiven effektes des transformierenden wachstumsfaktor-beta1(tgf-beta1)

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT99125278T ATE235549T1 (de)	1993-04-30	1994-04-29	Antisense oligonukleotide zur behandlung von immunsuppressiven wirkungen von tgf-beta2

Country Status (6)

Country	Link
US (3)	US6455689B1 (de)
JP (2)	JP3555952B2 (de)
AT (2)	ATE235549T1 (de)
AU (1)	AU6794594A (de)
DE (2)	DE69429617T2 (de)
WO (1)	WO1994025588A2 (de)

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WO1998046588A2 (en)	1997-04-11	1998-10-22	Neorx Corporation	Compounds and therapies for the prevention of vascular and non-vascular pathologies
DE69919869T2 (de) *	1998-06-10	2005-09-29	Biognostik Gesellschaft für Biomolekulare Diagnostik mbH	Stimulierung des immunsystems
FR2790955B1 (fr)	1999-03-19	2003-01-17	Assist Publ Hopitaux De Paris	Utilisation d'oligonucleotides stabilises comme principe actif antitumoral
US6436909B1 (en) *	1999-09-17	2002-08-20	Isis Pharmaceuticals, Inc.	Antisense inhibition of transforming growth factor-β expression
EP1133988A1 (de)	2000-03-11	2001-09-19	Biognostik Gesellschaft für biomolekulare Diagnostik mbH	Mischung enthaldend einen Inhibitor oder Suppressor von einen Gens und eine Moleküle bindende des Expressionprodukt des Gens
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CA2388049A1 (en)	2002-05-30	2003-11-30	Immunotech S.A.	Immunostimulatory oligonucleotides and uses thereof
EP1565201B1 (de) *	2002-11-18	2018-10-31	Vicuron Pharmaceuticals, Inc.	Methoden zur verabreichung von dalbavancin zur behandung bakterieller infektionen
CN1756773A (zh) *	2003-03-03	2006-04-05	斯蒂潘公司	降低天然橡胶胶乳制品的变应原性蛋白质含量的方法
ITRM20030149A1 (it)	2003-04-02	2004-10-03	Giuliani Spa	Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico
US7399853B2 (en) *	2003-04-28	2008-07-15	Isis Pharmaceuticals	Modulation of glucagon receptor expression
US7750142B2 (en) *	2003-04-28	2010-07-06	Isis Pharmaceuticals, Inc.	Modulation of glucagon receptor expression
AU2004257367A1 (en) *	2003-07-16	2005-01-27	Resverlogix, Inc.	Compounds and methods for downregulating the effects of TGF-beta
WO2005059133A2 (en) *	2003-12-19	2005-06-30	Antisense Pharma Gmbh	Combination therapy associating a tgf-breta antagonist with a chemiotherapeutic agent
EP2248895B8 (de) *	2003-12-19	2016-09-21	Autotelic LLC	Kombinations-therapie die ein TGF-beta Antagonisten mit einem Chemotherapeutikum assoziiert
CA2551524A1 (en) *	2003-12-24	2005-07-21	Scios, Inc.	Treatment of malignant gliomas with tgf-beta inhibitors
EP1568383A3 (de) *	2004-02-27	2005-11-16	Antisense Pharma GmbH	Verwendung eines Oligonukleotide oder seiner aktiven Ableitung für die Zubereitung einer pharmazeutische Zusammensetzung zur Hemmung der Metastasenbildung in Krebsbehandlung
US20070155685A1 (en) *	2004-02-27	2007-07-05	Karl-Hermann Schlingensiepen	Pharmaceutical composition
CN1961003B (zh)	2004-03-31	2013-03-27	健泰科生物技术公司	人源化抗TGF-β抗体
DE102004025881A1 (de) *	2004-05-19	2006-01-05	Beiersdorf Ag	Oligoribonukleotide zur Beeinflussung des Haarwachstums
MX2007007184A (es) *	2005-05-05	2008-01-14	Antisense Pharma Gmbh	Uso de bajas dosis de oligonucleotidos antisentido para tgf-beta, vegf, interleucina-10, c-jun, c-fos o genes e2 de prostaglandina en el tratamiento de tumores.
EP2096170B1 (de) *	2005-09-19	2011-08-10	Isis Pharmaceuticals, Inc.	Modulation der Glucagonrezeptorexpression
EP2862867A3 (de)	2005-10-25	2015-08-05	The Johns Hopkins University	Verfahren und Zusammensetzungen zur Behandlung des Marfan-Syndroms und assoziierter Erkrankungen
EP2230252A1 (de)	2006-03-13	2010-09-22	The Johns Hopkins University	Erhöhung der endothelialen Thromboresistenz
CN101553254A (zh)	2006-10-03	2009-10-07	建新公司	TGF-β拮抗物治疗具有罹患支气管肺发育不良风险的婴儿的用途
US8822425B2 (en) *	2008-11-14	2014-09-02	Antisense Pharma Gmbh	Dosage of oligonucleotides suitable for the treatment of tumors
EP2524038A4 (de) *	2010-01-12	2013-11-20	Isis Pharmaceuticals Inc	Modulation der transformierung einer wachstumsfaktor-beta-1-expression
EP3117709B1 (de)	2010-03-12	2018-08-01	Genzyme Corporation	Kombinationstherapie zur behandlung von brustkrebs
JP2013531981A (ja)	2010-06-11	2013-08-15	アンチセンス・ファーマ・ゲーエムベーハー	選択的オリゴヌクレオチド修飾の方法
US8956868B2 (en)	2010-12-27	2015-02-17	Lsip, Llc	Induced pluripotent stem cells produced with a connexin inhibitor and a TGF-β signaling inhibitor
WO2013014262A1 (en)	2011-07-27	2013-01-31	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods for diagnosing and treating myhre syndrome
EP2758533B1 (de)	2011-09-20	2018-04-11	Ionis Pharmaceuticals, Inc.	Antisense-modulation der gcgr-expression
US9468612B2 (en)	2011-10-26	2016-10-18	Seattle Children's Hospital	Cysteamine in the treatment of fibrotic disease
US20150044178A1 (en)	2011-12-28	2015-02-12	Kyoto Prefectural Public University Corporation	Normalization of culture of corneal endothelial cells
ME03512B (de)	2012-02-06	2020-04-20	Inhibrx Inc	Cd47-antikörper und verfahren zur verwendung davon
PT2978846T (pt)	2013-03-27	2020-04-21	Isarna Therapeutics Gmbh	Oligonucleótido de tgf-beta modificado para utilização num método de prevenção e/ou tratamento de uma doença oftálmica
CN105308182B (zh) *	2013-03-27	2018-09-25	伊萨纳治疗有限公司	修饰的TGF-β2寡核苷酸
CN109234274B (zh)	2013-03-27	2021-09-21	伊萨纳治疗有限公司	修饰的TGF-β寡核苷酸
CA2927898C (en)	2013-10-31	2021-11-16	Kyoto Prefectural Public University Corporation	Therapeutic drug for diseases related to endoplasmic reticulum cell death in corneal endothelium
WO2016187312A1 (en)	2015-05-18	2016-11-24	The Arizona Board Of Regents On Behalf Of The University Of Arizona	Methods and compositions for treating an alphavirus infection
WO2017138924A1 (en)	2016-02-09	2017-08-17	Autotelic Llc	Compositions and methods for treating pancreatic cancer
US9758786B2 (en)	2016-02-09	2017-09-12	Autotelic, Llc	Compositions and methods for treating pancreatic cancer
WO2022060208A1 (ko)	2020-09-21	2022-03-24	오토텔릭바이오 주식회사	안티센스 올리고뉴클레오타이드
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1994
- 1994-04-29 DE DE69429617T patent/DE69429617T2/de not_active Expired - Lifetime
- 1994-04-29 AT AT99125278T patent/ATE235549T1/de active
- 1994-04-29 AT AT94916170T patent/ATE211762T1/de active
- 1994-04-29 US US08/535,249 patent/US6455689B1/en not_active Expired - Lifetime
- 1994-04-29 AU AU67945/94A patent/AU6794594A/en not_active Abandoned
- 1994-04-29 WO PCT/EP1994/001362 patent/WO1994025588A2/en not_active Ceased
- 1994-04-29 JP JP52389894A patent/JP3555952B2/ja not_active Expired - Lifetime
- 1994-04-29 DE DE69432375T patent/DE69432375T2/de not_active Expired - Lifetime
2002
- 2002-05-16 US US10/146,058 patent/US20030040499A1/en not_active Abandoned
2003
- 2003-06-30 JP JP2003188524A patent/JP3600831B2/ja not_active Expired - Lifetime
2006
- 2006-12-29 US US11/647,586 patent/US7667027B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69432375T2 (de)	2004-02-12
US6455689B1 (en)	2002-09-24
WO1994025588A2 (en)	1994-11-10
JP3555952B2 (ja)	2004-08-18
JP2004024264A (ja)	2004-01-29
JPH08509370A (ja)	1996-10-08
AU6794594A (en)	1994-11-21
DE69432375D1 (de)	2003-04-30
US7667027B2 (en)	2010-02-23
ATE235549T1 (de)	2003-04-15
DE69429617T2 (de)	2002-08-22
US20080214483A1 (en)	2008-09-04
WO1994025588A3 (en)	1994-12-22
DE69429617D1 (de)	2002-02-14
US20030040499A1 (en)	2003-02-27
JP3600831B2 (ja)	2004-12-15

Legal Events

Date	Code	Title	Description
2002-06-15	UEP	Publication of translation of european patent specification

Publication	Publication Date	Title
ATE235549T1 (de)	2003-04-15	Antisense oligonukleotide zur behandlung von immunsuppressiven wirkungen von tgf-beta2
AU670843B2 (en)	1996-08-01	Methods for sequencing synthetic oligonucleotides containing non-phosphodiester internucleotide linkages
EP1762619A3 (de)	2007-05-09	Multi-tumor abweichende wachstumsgene
CA2048450A1 (en)	1992-02-24	Antisense oligonucleotide antibiotics complementary to the macromolecular synthesis operon, methods of treating bacterial infections and methods for identification of bacteria
CA2200371A1 (en)	1997-09-19	Human npik gene
NO983716D0 (no)	1998-08-13	Metoksyetoksy oligonukleotider for modulering av protein-kinase C ekspresjon
EP0702694A4 (de)	2000-10-04	$i(PSEUDOMONAS SYRINGAE) pv. $i(SYRINGAE hrpY)-GEN
DE69840748D1 (de)	2009-05-28	Verfahren zur zubereitung von antisense oligonukleotiden
EP1008649A3 (de)	2000-07-12	Antisense Oligonukleotide zur Behandlung von Immunosuppressive Wirkungen von TGF-beta2
CY1106978T1 (el)	2012-09-26	Ενζυμα φωσφοδιεστερασης
DK2256205T3 (da)	2013-07-08	Porphorymonas gingivalis-polypeptider og -polynukleotider
ATE137806T1 (de)	1996-05-15	Verfahren zur identifizierung von bakterien
ATE387493T1 (de)	2008-03-15	Gene, die für proteine mit transglykolysierungsaktivität kodieren.
PL317046A1 (en)	1997-03-03	Endotransglycosidase to tomato xyloglucane
ATE348158T1 (de)	2007-01-15	Neuartiges collectin
EP0824150A3 (de)	1998-07-08	Pflanzenpromotor und seine Verwendung
CA2156728A1 (en)	1994-09-01	Plant virus resistance conferring polyribozyme and resistant plants producing same
DE59611131D1 (de)	2004-12-09	Acarbose-Biosynthesegene aus Actinoplanes sp., Verfahren zu ihrer Isolierung sowie ihrer Verwendung
DK1038010T3 (da)	2006-05-29	Formiattransportörer i grampositive mikroorganisme
ES2109373T3 (es)	1998-01-16	Nueva proteina inhibidora de trombina a partir de garrapatas.
CA2203801A1 (en)	1996-05-09	Nucleotide sequences mediating male fertility and method of using same
TH52857A (th)	2002-09-04	แบคทีเรียของสกุล Bacillus และโปรตีนสำหรับฆ่าแมลง
CA2247087A1 (en)	1998-07-09	Flower organ-specific gene and its promoter sequence
IL126756A0 (en)	1999-08-17	Nucleotide sequences derived from the Grb3-3 gene capable of inhibiting the expression of GRB2 or GRB3-3 proteins and their uses