ATE212018T1 - Thiazole oder imidazole derivate als maillard reaktion inhibitoren - Google Patents
Thiazole oder imidazole derivate als maillard reaktion inhibitorenInfo
- Publication number
- ATE212018T1 ATE212018T1 AT94907081T AT94907081T ATE212018T1 AT E212018 T1 ATE212018 T1 AT E212018T1 AT 94907081 T AT94907081 T AT 94907081T AT 94907081 T AT94907081 T AT 94907081T AT E212018 T1 ATE212018 T1 AT E212018T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- maillard reaction
- thiazole
- imidazole derivatives
- reaction inhibitors
- Prior art date
Links
- RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical class C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 title 1
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title 1
- 239000002683 reaction inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/50—Nitrogen atoms bound to hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/54—Nitrogen and either oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3772093 | 1993-02-26 | ||
| JP23024393 | 1993-09-16 | ||
| PCT/JP1994/000260 WO1994019335A1 (en) | 1993-02-26 | 1994-02-21 | Thiazole or imidazole derivatives as maillard reaction inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE212018T1 true ATE212018T1 (de) | 2002-02-15 |
Family
ID=26376862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94907081T ATE212018T1 (de) | 1993-02-26 | 1994-02-21 | Thiazole oder imidazole derivate als maillard reaktion inhibitoren |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5677322A (de) |
| EP (1) | EP0638075B1 (de) |
| JP (2) | JP2821661B2 (de) |
| KR (2) | KR100250701B1 (de) |
| CN (2) | CN1037842C (de) |
| AT (1) | ATE212018T1 (de) |
| AU (1) | AU669427B2 (de) |
| CA (1) | CA2134347C (de) |
| DE (1) | DE69429641T2 (de) |
| DK (1) | DK0638075T3 (de) |
| ES (1) | ES2168294T3 (de) |
| PT (1) | PT638075E (de) |
| TW (1) | TW338041B (de) |
| WO (1) | WO1994019335A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6197806B1 (en) | 1995-12-20 | 2001-03-06 | Nippon Zoki Pharmaceutical Co., Ltd. | Eliminating agent for activated oxygen and free radicals |
| AU3117497A (en) | 1996-05-21 | 1997-12-09 | Pharmacia & Upjohn Company | Aminoguanidine carboxylate lactams for the treatment of non-insulin-dependent diabetes mellitus |
| WO1998043649A2 (en) * | 1997-03-28 | 1998-10-08 | Otsuka Pharmaceutical Co., Ltd. | Age production inhibitory composition comprising a maillard reaction inhibitor and vitamin b¿6? |
| CA2339879C (en) | 1998-08-24 | 2011-11-15 | Toshio Miyata | Carbonyl-stress improving agent and peritoneal dialysate |
| AU754989B2 (en) | 1998-11-16 | 2002-11-28 | Nippon Zoki Pharmaceutical Co., Ltd. | A therapeutic agent for intractable vasculitis |
| US6265571B1 (en) | 1999-07-12 | 2001-07-24 | Magellan Laboratories, Inc. | Purification process for anti-parasitic fermentation product |
| DE10052590A1 (de) * | 2000-10-24 | 2002-05-02 | Haarmann & Reimer Gmbh | Verwendung von 2-Hydrazino-1,3-thiazolen als Antioxidantien |
| JP4711523B2 (ja) | 2001-02-13 | 2011-06-29 | 日本臓器製薬株式会社 | 低アルブミン血症改善剤 |
| RU2270192C2 (ru) * | 2001-04-19 | 2006-02-20 | Эйсай Ко., Лтд. | Производные 2-иминопирролидина |
| AU2002322280A1 (en) | 2001-06-21 | 2003-01-21 | Millennium Pharmaceuticals, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer |
| ITRM20020016A1 (it) * | 2002-01-15 | 2003-07-15 | Sigma Tau Ind Farmaceuti | Derivati di acidi fenil(alchil)carbossilici e derivati fenilalchileterociclici dionici, loro uso come medicamenti ad attivita' ipoglicemizza |
| EP1602646A4 (de) | 2003-02-19 | 2010-07-28 | Eisai R&D Man Co Ltd | Verfahren zur herstellung von zyklischen benzamidinderivaten |
| US20050059790A1 (en) * | 2003-09-16 | 2005-03-17 | Roesler Richard R. | Process for preparing aspartates |
| BRPI0416752B8 (pt) | 2003-11-21 | 2021-05-25 | Actelion Pharmaceuticals Ltd | composição farmacêutica, uso de um ou mais compostos, e, compostos |
| USRE43833E1 (en) | 2003-11-21 | 2012-11-27 | Actelion Pharmaceuticals Ltd. | Thiazolidin-4-one derivatives |
| WO2005073180A1 (ja) * | 2003-12-25 | 2005-08-11 | Kureha Corporation | ヒドロキサム酸誘導体、及び該誘導体を含むａｇｅ生成阻害剤 |
| US8912340B2 (en) | 2006-11-23 | 2014-12-16 | Actelion Pharmaceuticals Ltd. | Process for the preparation of 2-imino-thiazolidin-4-one derivatives |
| DK2094676T3 (da) * | 2006-11-23 | 2013-06-10 | Actelion Pharmaceuticals Ltd | Ny fremgangsmåde til fremstillingen af 2-iminothiazolidin-4-on-derivater |
| HUE050733T2 (hu) | 2012-08-17 | 2021-01-28 | Actelion Pharmaceuticals Ltd | Eljárás (2Z,5Z)-5-(3-klór-4-((R)-2,3-dihidroxipropoxi)benzilidén)-2-(pro-pilimino)-3-(O-tolil)tiazolidin-4-on elõállítására és ezen eljárásban alkalmazott köztitermék |
| GB201405991D0 (en) * | 2014-04-03 | 2014-05-21 | Cambridge Entpr Ltd | Novel compounds |
| CN107459496B (zh) * | 2016-06-03 | 2022-07-19 | 华东理工大学 | 噻唑类衍生物在治疗病毒感染中的应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2528844A1 (fr) * | 1982-06-18 | 1983-12-23 | Chauvin Blache Lab | Nouvelles thiazolyl-2 hydrazones, leur procede de preparation et leur application en therapeutique |
| US5258381A (en) * | 1984-03-19 | 1993-11-02 | The Rockefeller University | 2-substituted-2-imidazolines |
| EP0325936A3 (de) * | 1988-01-16 | 1990-01-17 | Ono Pharmaceutical Co., Ltd. | Aminoguanidin-Derivate und für die Maillardreaktion inhibitorische Substanzen, die sie als aktive Inhaltsstoffe enthalten |
| TW221689B (de) * | 1991-08-27 | 1994-03-11 | Otsuka Pharma Co Ltd |
-
1994
- 1994-02-21 AT AT94907081T patent/ATE212018T1/de not_active IP Right Cessation
- 1994-02-21 US US08/325,233 patent/US5677322A/en not_active Expired - Fee Related
- 1994-02-21 ES ES94907081T patent/ES2168294T3/es not_active Expired - Lifetime
- 1994-02-21 DE DE69429641T patent/DE69429641T2/de not_active Expired - Fee Related
- 1994-02-21 AU AU60458/94A patent/AU669427B2/en not_active Ceased
- 1994-02-21 CA CA002134347A patent/CA2134347C/en not_active Expired - Fee Related
- 1994-02-21 WO PCT/JP1994/000260 patent/WO1994019335A1/en not_active Ceased
- 1994-02-21 DK DK94907081T patent/DK0638075T3/da active
- 1994-02-21 EP EP94907081A patent/EP0638075B1/de not_active Expired - Lifetime
- 1994-02-21 CN CN94190159A patent/CN1037842C/zh not_active Expired - Fee Related
- 1994-02-21 PT PT94907081T patent/PT638075E/pt unknown
- 1994-02-21 KR KR1019940703805A patent/KR100250701B1/ko not_active Expired - Fee Related
- 1994-02-25 JP JP6027096A patent/JP2821661B2/ja not_active Expired - Fee Related
- 1994-02-26 TW TW083101658A patent/TW338041B/zh active
- 1994-10-26 KR KR1019997007806A patent/KR100257180B1/ko not_active Expired - Fee Related
-
1997
- 1997-06-06 CN CN97105550A patent/CN1067992C/zh not_active Expired - Fee Related
- 1997-12-10 JP JP9340305A patent/JPH10167965A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| TW338041B (en) | 1998-08-11 |
| CA2134347C (en) | 2003-04-29 |
| EP0638075B1 (de) | 2002-01-16 |
| ES2168294T3 (es) | 2002-06-16 |
| JP2821661B2 (ja) | 1998-11-05 |
| CN1184105A (zh) | 1998-06-10 |
| AU6045894A (en) | 1994-09-14 |
| PT638075E (pt) | 2002-06-28 |
| KR100250701B1 (ko) | 2000-07-01 |
| WO1994019335A1 (en) | 1994-09-01 |
| CN1067992C (zh) | 2001-07-04 |
| EP0638075A1 (de) | 1995-02-15 |
| US5677322A (en) | 1997-10-14 |
| CN1106982A (zh) | 1995-08-16 |
| CN1037842C (zh) | 1998-03-25 |
| KR950701328A (ko) | 1995-03-23 |
| CA2134347A1 (en) | 1994-08-27 |
| JPH10167965A (ja) | 1998-06-23 |
| DK0638075T3 (da) | 2002-02-18 |
| AU669427B2 (en) | 1996-06-06 |
| DE69429641T2 (de) | 2002-08-29 |
| KR100257180B1 (ko) | 2000-05-15 |
| JPH07133264A (ja) | 1995-05-23 |
| DE69429641D1 (en) | 2002-02-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0638075T3 (da) | Thiazol- eller imidazolderivater som Maillard-reaktionsinhibitorer | |
| NO943475L (no) | Forbindelse for å regulere fethet i hud | |
| DE69614847D1 (de) | Spirocyclische und bicyclische diazinyl- und carbazinyloxazolidinone | |
| GB0225475D0 (en) | Therapeutic agents | |
| DE60037892D1 (de) | Nitroimidazolpräparationen zur äusseren anwendung zur behandlung von atopischer dermatitis | |
| PL306590A1 (en) | Substituted heterocyclic carboxylamides, method obtaining them and their application as therapeutic agents | |
| GB0318447D0 (en) | Therapeutic agents | |
| HRP990167B1 (en) | Sulphinic acid derivatives, method for producing them, and their use | |
| ES2132415T3 (es) | Nuevos derivados de 5-pirrolil-2-piridilmetilsulfinilbencimidazol. | |
| NZ332762A (en) | Isobutylgaba and its derivatives for the treatment of pain | |
| EP0641204A4 (de) | 17-ether und thioether von 4-aza-steroiden. | |
| GB0223038D0 (en) | Therapeutic compounds | |
| NZ515567A (en) | Method for treating chronic pain using MEK inhibitors | |
| BR0206514A (pt) | Composto, método de tratamento de um ser humano ou animal que sofre de enxaqueca, uso do composto, composição farmacêutica, e, processo para preparar um composto | |
| AU2002356991A1 (en) | Amino acid derivatives useful for the treatment of alzheimer's disease | |
| EP0774462A4 (de) | Heterocyclische verbindungen | |
| ATE180669T1 (de) | Verwendung von pregnanderivaten zur behandlung von tumoren | |
| AU3853697A (en) | N-benzenesulphonyl-l-proline derivatives as bradykinin b2 agonists | |
| CY2225B1 (en) | Organic compounds | |
| NO971743D0 (no) | Farmasöytisk sammensetning for profylakse og behandling av type I allergiske sykdommer | |
| HUT71513A (en) | 2-substituted-(3-chlorophenyl)-3,6-diazahexanoic acid derivatives for producing alkil-trazodone derivatives and process for producing them | |
| NO20003481L (no) | FremgangsmÕte for behandling av COPD | |
| DE69623767D1 (de) | Verwendung von pyrrolidinderivaten zur behandlung des alkoholismus | |
| HUP9801925A1 (hu) | Nátrium/hidrogén-csere inhibítorok alkalmazása protozoák által okozott betegségek kezelésére alkalmas gyógyszerkészítmények előállítására | |
| PT99280A (pt) | Processo de preparacao de derivados do indolo e de composicoes farmaceuticas |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0638075 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |