ATE212030T1 - Elektrolumineszente verbindungen und zwischenprodukte zur herstellung - Google Patents

Elektrolumineszente verbindungen und zwischenprodukte zur herstellung

Info

Publication number
ATE212030T1
ATE212030T1 AT94120516T AT94120516T ATE212030T1 AT E212030 T1 ATE212030 T1 AT E212030T1 AT 94120516 T AT94120516 T AT 94120516T AT 94120516 T AT94120516 T AT 94120516T AT E212030 T1 ATE212030 T1 AT E212030T1
Authority
AT
Austria
Prior art keywords
production
intermediate products
electroluminescent compounds
analyte
different
Prior art date
Application number
AT94120516T
Other languages
English (en)
Inventor
Richard J Massey
Michael J Powell
Paul A Mied
Mohindar S Poonian
Peter Feng
Leopoldo Della Ciana
Walter J Dressick
Original Assignee
Igen Int Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Igen Int Inc filed Critical Igen Int Inc
Application granted granted Critical
Publication of ATE212030T1 publication Critical patent/ATE212030T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/76—Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/002—Osmium compounds
    • C07F15/0026—Osmium compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0046—Ruthenium compounds
    • C07F15/0053—Ruthenium compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/30—Electrochemically active labels

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Reproductive Health (AREA)
  • Toxicology (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Luminescent Compositions (AREA)
  • Steroid Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT94120516T 1986-04-30 1987-04-30 Elektrolumineszente verbindungen und zwischenprodukte zur herstellung ATE212030T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85835486A 1986-04-30 1986-04-30

Publications (1)

Publication Number Publication Date
ATE212030T1 true ATE212030T1 (de) 2002-02-15

Family

ID=25328109

Family Applications (2)

Application Number Title Priority Date Filing Date
AT94120516T ATE212030T1 (de) 1986-04-30 1987-04-30 Elektrolumineszente verbindungen und zwischenprodukte zur herstellung
AT87904151T ATE127923T1 (de) 1986-04-30 1987-04-30 Elektrochemilumineszenz-testverfahren.

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT87904151T ATE127923T1 (de) 1986-04-30 1987-04-30 Elektrochemilumineszenz-testverfahren.

Country Status (12)

Country Link
EP (3) EP0265519B1 (de)
JP (6) JPH0737464B2 (de)
KR (1) KR960016340B1 (de)
AT (2) ATE212030T1 (de)
AU (2) AU644150B2 (de)
CA (1) CA1339465C (de)
DE (2) DE3751516T2 (de)
DK (1) DK173025B1 (de)
FI (1) FI102017B1 (de)
IL (1) IL82411A0 (de)
NO (1) NO176071C (de)
WO (1) WO1987006706A1 (de)

Families Citing this family (140)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6165729A (en) * 1986-04-30 2000-12-26 Hyperion Catalysis International, Inc. Electrochemiluminescent reaction utilizing amine-derived reductant
US5770459A (en) * 1986-04-30 1998-06-23 Igen International, Inc. Methods and apparatus for improved luminescence assays using particle concentration, electrochemical generation of chemiluminescence detection
US6881536B1 (en) * 1986-04-30 2005-04-19 Bioveris Corporation Particle based electrochemiluminescent assays
US6271041B1 (en) * 1986-04-30 2001-08-07 Igen International, Inc. Electrochemiluminescent reaction utilizing amine-derived reductant
US6451225B1 (en) 1986-04-30 2002-09-17 Igen International, Inc. Electrochemiluminescent reaction utilizing amine-derived reductant
US5635347A (en) * 1986-04-30 1997-06-03 Igen, Inc. Rapid assays for amplification products
US6881589B1 (en) 1987-04-30 2005-04-19 Bioveris Corporation Electrochemiluminescent localizable complexes for assay compositions
US5935779A (en) * 1988-11-03 1999-08-10 Igen International Inc. Methods for improved particle electrochemiluminescence assay
US6702986B1 (en) 1988-04-29 2004-03-09 Igen International, Inc. Electrochemiluminescent reaction utilizing amine-derived reductant
JPH076913B2 (ja) * 1988-11-03 1995-01-30 イゲン，インコーポレーテッド アミン誘導還元剤を利用する電気化学発光反応
US5746974A (en) * 1988-11-03 1998-05-05 Igen International, Inc. Apparatus for improved luminescence assays using particle concentration, electrochemical generation of chemiluminescence and chemiluminescence detection
US5962218A (en) * 1988-11-03 1999-10-05 Igen International Inc. Methods and apparatus for improved luminescence assays
US5705402A (en) * 1988-11-03 1998-01-06 Igen International, Inc. Method and apparatus for magnetic microparticulate based luminescence assay including plurality of magnets
DE68928994T2 (de) * 1988-11-03 1999-12-16 Igen International, Inc. Elektrochemilumineszente testverfahren
JPH0363571A (ja) * 1989-08-02 1991-03-19 Chisso Corp 大腸菌群の検査キット
IL100867A (en) * 1991-02-06 1995-12-08 Igen Inc Method and apparatus for improved luminescence assays
ZA92803B (en) 1991-02-06 1992-11-25 Igen Inc Method and apparatus for magnetic microparticulate based luminescene asay including plurality of magnets
IL100866A (en) * 1991-02-06 1995-10-31 Igen Inc Method and apparatus for magnetic microparticulate based luminescence assay including plurality of magnets
KR100212178B1 (ko) * 1991-07-10 1999-08-02 리차드 제이 마세이 입자농도 및 화학발광 검출을 이용한 개선된 발광 검정 장치 및 방법
DE69231124T2 (de) * 1991-11-15 2001-02-15 Igen International, Inc. Schnelle bestimmungsverfahren für amplifikationsprodukte
ZA929351B (en) * 1991-12-11 1993-06-04 Igen Inc Electrochemiluminescent label for DNA assays.
FR2699170B1 (fr) * 1992-12-15 1995-07-28 Asulab Sa Complexes d'un métal de transition à ligands 2,2'-bipyridine substitués par au moins un radical ammonium alkyle, leur procédé de fabrication et leur application comme médiateur redox.
US5541113A (en) * 1993-09-22 1996-07-30 Beckman Instruments, Inc. Method for detecting an analyte using an electrochemical luminescent transition metal label
DE59507438D1 (de) * 1994-07-25 2000-01-20 Roche Diagnostics Gmbh Hydrophile metallkomplexe
NZ306051A (en) 1995-03-10 1999-11-29 Meso Scale Technologies Llc Testing using electrochemiluminescence
US6319670B1 (en) 1995-05-09 2001-11-20 Meso Scale Technology Llp Methods and apparatus for improved luminescence assays using microparticles
ES2285713T3 (es) 1995-06-07 2007-11-16 Bioveris Corporation Enzimoinmunoanalisis electroquimioluminiscente.
JP3574457B2 (ja) * 1995-09-12 2004-10-06 エーザイ株式会社 電気化学発光検出方法と装置
US7192450B2 (en) 2003-05-21 2007-03-20 Dexcom, Inc. Porous membranes for use with implantable devices
US6862465B2 (en) 1997-03-04 2005-03-01 Dexcom, Inc. Device and method for determining analyte levels
US6001067A (en) 1997-03-04 1999-12-14 Shults; Mark C. Device and method for determining analyte levels
US8527026B2 (en) 1997-03-04 2013-09-03 Dexcom, Inc. Device and method for determining analyte levels
US6613583B1 (en) 1997-06-27 2003-09-02 Igen International, Inc. Electrochemiluminescent label based on multimetallic assemblies
DE19803528A1 (de) * 1998-01-30 1999-08-05 Roche Diagnostics Gmbh Verfahren zur Analyse einer Probe mittels eines Elektrochemolumineszenz-Bindungsreaktion-Tests
DE19811582A1 (de) * 1998-03-17 1999-09-23 Roche Diagnostics Gmbh Stabilisierung und Verstärkung von Elektrochemilumineszenz-Signalen
DE19828441A1 (de) * 1998-06-25 1999-12-30 Roche Diagnostics Gmbh Verwendung derivatisierter Reagenzien in Chemilumineszenz- und Elektrochemilumineszenz-Nachweisverfahren
US6214552B1 (en) 1998-09-17 2001-04-10 Igen International, Inc. Assays for measuring nucleic acid damaging activities
US6312896B1 (en) 1998-09-17 2001-11-06 Igen Inaternational, Inc. Assays for measuring nucleic acid binding proteins and enzyme activities
US7041807B1 (en) 1999-06-23 2006-05-09 Caprion Pharmaceuticals, Inc. Antibodies to a YYX epitope of a mammalian prion protein
JP2004534226A (ja) 2001-06-29 2004-11-11 メソ スケイル テクノロジーズ，エルエルシー 発光試験測定用のアッセイプレート、リーダシステム及び方法
US20030032874A1 (en) 2001-07-27 2003-02-13 Dexcom, Inc. Sensor head for use with implantable devices
US8815577B2 (en) 2001-07-30 2014-08-26 Meso Scale Technologies, Llc Assay electrode having immobilized lipid/protein layers, methods of making the same and methods of using the same for luminescence test measurements
CA2460114C (en) 2001-09-10 2012-11-06 Meso Scale Technologies, Llc Assay buffer, compositions containing the same, and methods of using the same
US9282925B2 (en) 2002-02-12 2016-03-15 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US8010174B2 (en) 2003-08-22 2011-08-30 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US10022078B2 (en) 2004-07-13 2018-07-17 Dexcom, Inc. Analyte sensor
US8260393B2 (en) 2003-07-25 2012-09-04 Dexcom, Inc. Systems and methods for replacing signal data artifacts in a glucose sensor data stream
US7482116B2 (en) 2002-06-07 2009-01-27 Dna Genotek Inc. Compositions and methods for obtaining nucleic acids from sputum
US20040072236A1 (en) 2002-09-27 2004-04-15 Neil Cashman PrPSc -interacting molecules and uses thereof
US8423113B2 (en) 2003-07-25 2013-04-16 Dexcom, Inc. Systems and methods for processing sensor data
US8369919B2 (en) 2003-08-01 2013-02-05 Dexcom, Inc. Systems and methods for processing sensor data
US6931327B2 (en) 2003-08-01 2005-08-16 Dexcom, Inc. System and methods for processing analyte sensor data
US8160669B2 (en) 2003-08-01 2012-04-17 Dexcom, Inc. Transcutaneous analyte sensor
US8275437B2 (en) 2003-08-01 2012-09-25 Dexcom, Inc. Transcutaneous analyte sensor
US20080119703A1 (en) 2006-10-04 2008-05-22 Mark Brister Analyte sensor
US7591801B2 (en) 2004-02-26 2009-09-22 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
US20190357827A1 (en) 2003-08-01 2019-11-28 Dexcom, Inc. Analyte sensor
US7933639B2 (en) 2003-08-01 2011-04-26 Dexcom, Inc. System and methods for processing analyte sensor data
US20100168543A1 (en) 2003-08-01 2010-07-01 Dexcom, Inc. System and methods for processing analyte sensor data
US7774145B2 (en) 2003-08-01 2010-08-10 Dexcom, Inc. Transcutaneous analyte sensor
US8761856B2 (en) 2003-08-01 2014-06-24 Dexcom, Inc. System and methods for processing analyte sensor data
US8233959B2 (en) 2003-08-22 2012-07-31 Dexcom, Inc. Systems and methods for processing analyte sensor data
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US20140121989A1 (en) 2003-08-22 2014-05-01 Dexcom, Inc. Systems and methods for processing analyte sensor data
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
US8615282B2 (en) 2004-07-13 2013-12-24 Dexcom, Inc. Analyte sensor
WO2005051170A2 (en) 2003-11-19 2005-06-09 Dexcom, Inc. Integrated receiver for continuous analyte sensor
US8364231B2 (en) 2006-10-04 2013-01-29 Dexcom, Inc. Analyte sensor
US8423114B2 (en) 2006-10-04 2013-04-16 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
DE602004029092D1 (de) 2003-12-05 2010-10-21 Dexcom Inc Kalibrationsmethoden für einen kontinuierlich arbeitenden analytsensor
US11633133B2 (en) 2003-12-05 2023-04-25 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
EP2316331B1 (de) 2003-12-09 2016-06-29 Dexcom, Inc. Signalverarbeitung in einem durchgehenden Analytsensor
US8808228B2 (en) 2004-02-26 2014-08-19 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
ITTO20040372A1 (it) 2004-06-01 2004-09-01 Giuseppe Caputo Composti luminescenti aventi un braccio di legame funzionalizzato.
EP1787124A2 (de) 2004-06-23 2007-05-23 The University Of Texas System Verfahren und zusammensetzungen zur detektion von biologischen molekülen mithilfe eines zwei-partikel-komplexes
US7946984B2 (en) 2004-07-13 2011-05-24 Dexcom, Inc. Transcutaneous analyte sensor
US8452368B2 (en) 2004-07-13 2013-05-28 Dexcom, Inc. Transcutaneous analyte sensor
WO2006038686A1 (ja) * 2004-10-07 2006-04-13 Matsushita Electric Industrial Co., Ltd. 遺伝子検出方法、及び遺伝子検出装置
KR101311815B1 (ko) 2005-06-03 2013-10-22 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 단일 패러데이 전극에서의 전기발생 화학발광 및 전기화학
EP1950566A4 (de) * 2005-11-10 2008-11-26 Univ Toyama Nat Univ Corp Verfahren zur bewertung von bindungseigenschaften von biosubstanzen und biosubstanz bindenden substanzen
US8562558B2 (en) 2007-06-08 2013-10-22 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
EP4159114B1 (de) 2007-10-09 2024-04-10 DexCom, Inc. Integriertes insulin-abgabesystem mit kontinuierlichem glucosesensor
JP5576288B2 (ja) * 2007-11-21 2014-08-20 バイオ−ラッド ラボラトリーズ，インコーポレイティド タンパク質染色のための光ルミネセンス性金属複合体
EP2252196A4 (de) 2008-02-21 2013-05-15 Dexcom Inc Systeme und verfahren zur verarbeitung, übertragung und anzeige von sensordaten
PL2271938T3 (pl) 2008-04-11 2014-07-31 Univ Texas Sposób i urządzenie do wzmacniania elektrogenerowanej chemiluminescencji nanocząsteczek
AU2009244904B2 (en) * 2008-05-08 2014-04-17 Board Of Regents Of The University Of Texas System Luminescent nanostructured materials for use in electrogenerated chemiluminescence
AU2014203680B2 (en) * 2008-05-08 2015-03-05 Board Of Regents Of The University Of Texas System Luminescent nanostructured materials for use in electrogenerated chemiluminescence
US8264347B2 (en) 2008-06-24 2012-09-11 Trelleborg Sealing Solutions Us, Inc. Seal system in situ lifetime measurement
FR2939895B1 (fr) * 2008-12-15 2011-01-14 Commissariat Energie Atomique Procede de detection non intrusive d'element chimique
EP4374790A3 (de) 2009-04-30 2024-07-31 DexCom, Inc. Mit kontinuierlichen sensordaten aus mehreren analysezeiträumen assoziierte leistungsberichte
US20140038834A1 (en) 2010-07-07 2014-02-06 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg Novel biomarkers for detecting neuronal loss
ES2644816T3 (es) * 2011-02-09 2017-11-30 Hoffmann-La Roche Ag Nuevos complejos basados en iridio para ECL
US20120265036A1 (en) 2011-04-15 2012-10-18 Dexcom, Inc. Advanced analyte sensor calibration and error detection
US9442046B2 (en) 2011-06-19 2016-09-13 Abogen, Inc. Device for sample collection
EP2729809B1 (de) * 2011-07-07 2018-10-17 DuPont Nutrition Biosciences ApS Assay
US9081001B2 (en) 2012-05-15 2015-07-14 Wellstat Diagnostics, Llc Diagnostic systems and instruments
US9213043B2 (en) 2012-05-15 2015-12-15 Wellstat Diagnostics, Llc Clinical diagnostic system including instrument and cartridge
US9625465B2 (en) 2012-05-15 2017-04-18 Defined Diagnostics, Llc Clinical diagnostic systems
CA2879093C (en) 2012-08-02 2020-10-20 F. Hoffmann-La Roche Ag Bis-iridium-complexes for manufacturing of ecl-labels
BR112015023108A8 (pt) 2013-03-13 2018-01-23 Geneweave Biosciences Inc sistema de acondicionamento de célula bacteriana, método para acondicionamento de uma molécula de ácido nucléico repórter, composição, método para detectar uma presença ou uma ausência de uma célula bacteriana em uma amostra, vetor, método para detectar um transcrito alvo em uma célula, método para detectar a presença de uma célula bacteriana em uma amostra e kit.
US9481903B2 (en) 2013-03-13 2016-11-01 Roche Molecular Systems, Inc. Systems and methods for detection of cells using engineered transduction particles
US9540675B2 (en) 2013-10-29 2017-01-10 GeneWeave Biosciences, Inc. Reagent cartridge and methods for detection of cells
WO2015154189A1 (en) 2014-04-10 2015-10-15 Dna Genotek Inc. Method and system for microbial lysis using periodates
WO2016091755A1 (en) 2014-12-08 2016-06-16 F. Hoffmann-La Roche Ag Method for measurement of vitamin d
KR102601323B1 (ko) 2015-08-20 2023-11-10 에프. 호프만-라 로슈 아게 페길화 분석물-특이적 결합제를 사용하는 입자-기반 면역어세이
US10351893B2 (en) 2015-10-05 2019-07-16 GeneWeave Biosciences, Inc. Reagent cartridge for detection of cells
BR112018017336A2 (pt) 2016-03-07 2018-12-26 Hoffmann La Roche método in vitro para detectar um anticorpo para p53 (anticorpo anti-p53) em uma amostra e polipeptídeo de fusão
ES2974284T3 (es) 2016-03-11 2024-06-26 Roche Diagnostics Gmbh Aminas de cadena ramificada en la detección de electroquimioluminiscencia
JP7068323B2 (ja) 2017-02-02 2022-05-16 エフ．ホフマン－ラ ロシュ アーゲー 少なくとも２種のペグ化された分析物特異的結合剤を使用する免疫アッセイ
US11077444B2 (en) 2017-05-23 2021-08-03 Roche Molecular Systems, Inc. Packaging for a molecular diagnostic cartridge
US11331022B2 (en) 2017-10-24 2022-05-17 Dexcom, Inc. Pre-connected analyte sensors
CN111246797B (zh) 2017-10-24 2025-09-09 德克斯康公司 预连接分析物传感器
EP3781600A1 (de) 2018-04-18 2021-02-24 F. Hoffmann-La Roche AG Neuartige anti-thymidinkinase-antikörper
WO2019215273A1 (en) 2018-05-09 2019-11-14 F. Hoffmann-La Roche Ag Devices and methods for determining particle concentration in a sample
WO2019223691A1 (zh) * 2018-05-21 2019-11-28 博阳生物科技（上海）有限公司 一种化学发光分析测定方法及使用该方法的系统、试剂盒
ES2983797T3 (es) 2018-08-31 2024-10-24 Hoffmann La Roche Timidina cinasa (TK-1) en índices pronóstico para LDLBG
EP4004551A1 (de) 2019-07-22 2022-06-01 F. Hoffmann-La Roche AG Substanz p als blutbiomarker zur nichtinvasiven diagnose von endometriose
JP2022542056A (ja) 2019-07-22 2022-09-29 エフ．ホフマン－ラ ロシュ アーゲー 子宮内膜症の非侵襲的診断のための血液バイオマーカーとしてのｓ１００ａ６
JP7315781B2 (ja) 2019-07-22 2023-07-26 エフ． ホフマン－ラ ロシュ アーゲー 子宮内膜症の非侵襲的診断のための血液バイオマーカーとしてのｓ１００ａ１２
JP7421631B2 (ja) 2019-07-22 2024-01-24 エフ． ホフマン－ラ ロシュ アーゲー 子宮内膜症の非侵襲的診断のための血液バイオマーカーとしてのｓ１００ａ８
KR20220016210A (ko) 2019-07-22 2022-02-08 에프. 호프만-라 로슈 아게 자궁내막증의 비-침습적 진단용 혈액 생물표지자로써 s100a9
BR112022009371A2 (pt) 2019-11-15 2022-08-09 Hoffmann La Roche Métodos para determinar a quantidade ou concentração de um ou mais analitos antibióticos, tubos de amostragem, usos de um reagente de derivatização nucleofílica e analito antibiótico
KR20230065272A (ko) 2020-08-21 2023-05-11 메소 스케일 테크놀러지즈, 엘엘시 정의된 계면 전위를 갖는 보조 전극을 구비한 전기화학 셀 및 이를 사용하는 방법
WO2022090455A1 (en) 2020-11-02 2022-05-05 F. Hoffmann-La Roche Ag Sars-cov-2 nucleocapsid antibodies
WO2022207628A1 (en) 2021-03-30 2022-10-06 F. Hoffmann-La Roche Ag Scf as blood biomarker for the non-invasive diagnosis of endometriosis
CN117099001A (zh) 2021-04-01 2023-11-21 豪夫迈·罗氏有限公司 Psp94作为血液生物标志物用于子宫内膜异位症的非侵入性诊断
EP4341700A1 (de) 2021-05-17 2024-03-27 F. Hoffmann-La Roche AG Sfrp4 als blutbiomarker zur nichtinvasiven diagnose von adenomyose
AU2022325891B2 (en) 2021-08-13 2026-03-26 Meso Scale Technologies, Llc. Electrochemical cell devices and methods of manufacturing
US20250042976A1 (en) 2021-10-26 2025-02-06 Roche Diagnostics Operations, Inc. Monoclonal antibodies specific for sars-cov-2 rbd
JP2025501000A (ja) 2022-01-04 2025-01-15 メソ スケール テクノロジーズ エルエルシー 電気化学セルデバイスおよびその製造方法
WO2023131594A1 (en) 2022-01-05 2023-07-13 F. Hoffmann-La Roche Ag Derivatization of compounds in patient samples for therapeutic drug monitoring (tdm)
WO2023247752A1 (en) 2022-06-23 2023-12-28 F. Hoffmann-La Roche Ag Method for diagnosing endometriosis and for classifying the stage of endometriosis
JP2025524025A (ja) 2022-07-22 2025-07-25 エフ． ホフマン－ラ ロシュ アーゲー 多嚢胞性卵巣症候群の診断のための（血液）バイオマーカーとしてのロイコトリエンａ４ヒドロラーゼ（ｌｔａ４ｈ）
EP4558826A1 (de) 2022-07-22 2025-05-28 F. Hoffmann-La Roche AG Fibroblastenwachstumsfaktor-bindendes protein 1 (fgfbp1) als (blut) biomarker zur diagnose des polyzystischen ovarialsyndroms
EP4558825A1 (de) 2022-07-22 2025-05-28 F. Hoffmann-La Roche AG Meteorin-ähnliches protein (metrnl) als (blut) biomarker zur diagnose des polyzystischen ovarialsyndroms
IL322791A (en) 2023-02-15 2025-10-01 Meso Scale Technologies Llc Electrochemical cell devices and methods for their manufacture
CN116832862B (zh) * 2023-05-23 2024-06-25 杭州师范大学 一种超薄金-锰纳米复合材料、制备方法及其在检测领域中的应用
EP4747637A1 (de) 2023-07-20 2026-05-27 F. Hoffmann-La Roche AG Screening-verfahren für antikörperzusammensetzungen
JP2026526931A (ja) 2023-07-28 2026-08-10 エフ ホフマン－ラ ロッシュ アクチェン ゲゼルシャフト 子宮内膜症のバイオマーカーとしての血清ＥｐｈＡ１
WO2026120128A1 (en) 2024-12-05 2026-06-11 Roche Diagnostics Gmbh Serum transcriptional regulator erg as biomarker for endometriosis

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL49685A (en) * 1976-05-31 1978-10-31 Technion Res & Dev Foundation Specific binding assay method for determining the concentration of materials and reagent means therefor
US4233144A (en) * 1979-04-16 1980-11-11 Technicon Instruments Corporation Electrode for voltammetric immunoassay
US4280815A (en) * 1979-06-18 1981-07-28 Technicon Instruments Corporation Electrochemiluminescent immunoassay and apparatus therefor
WO1981001883A1 (en) * 1979-12-19 1981-07-09 Electro Nucleonics Chemical luminescence amplification substrate system for immunochemistry
US4293310A (en) * 1980-03-14 1981-10-06 University Of Pittsburgh Photoelectrochemical immunoassay
EP0063810B1 (de) * 1981-04-29 1986-03-05 Ciba-Geigy Ag Prüfmittel und Ausrüstung für immunologische Analysen
US4514508A (en) * 1982-07-06 1985-04-30 Biond Inc. Assaying for a multiplicity of antigens or antibodies with a detection compound
GB2135773B (en) * 1983-01-31 1985-12-04 Boots Celltech Diagnostics Enzyme inhibitor labelled immunoassay
EP0139373A1 (de) * 1983-08-26 1985-05-02 The Regents Of The University Of California System für vielfache Immunoassays
IL75464A (en) * 1984-06-12 1990-08-31 Orgenics Ltd Method and apparatus for multi-analyte assay
CA1340372C (en) * 1984-07-09 1999-02-02 John D. Clements Production of e. coli lt-b enterotoxin subunit
DK365785A (da) * 1984-09-17 1986-03-18 Hoffmann La Roche Metalcomplexer
US4617265A (en) * 1984-09-19 1986-10-14 Board Of Regents, University Of Texas System Colony blot assay for enterotoxigenic bacteria
US5238808A (en) * 1984-10-31 1993-08-24 Igen, Inc. Luminescent metal chelate labels and means for detection
US5120662A (en) * 1989-05-09 1992-06-09 Abbott Laboratories Multilayer solid phase immunoassay support and method of use
EP0533753A1 (de) 1990-06-14 1993-03-31 Washington University Hydrolyse von rns

Also Published As

Publication number Publication date
JPH07309836A (ja) 1995-11-28
JPH07267972A (ja) 1995-10-17
FI102017B (fi) 1998-09-30
JP3509812B2 (ja) 2004-03-22
JP3349279B2 (ja) 2002-11-20
AU605158B2 (en) 1991-01-10
DE3752345T2 (de) 2002-08-22
JPH0737464B2 (ja) 1995-04-26
KR880701379A (ko) 1988-07-26
EP0658564A1 (de) 1995-06-21
HK1007442A1 (en) 1999-04-09
NO875476D0 (no) 1987-12-29
JPH01500146A (ja) 1989-01-19
HK1013653A1 (en) 1999-09-03
CA1339465C (en) 1997-09-16
EP0647849A2 (de) 1995-04-12
AU7433891A (en) 1991-08-08
JP2648474B2 (ja) 1997-08-27
WO1987006706A1 (en) 1987-11-05
JP2003128689A (ja) 2003-05-08
DE3751516T2 (de) 1996-02-15
AU685071B2 (en) 1998-01-15
IL82411A0 (en) 1987-11-30
EP0265519A4 (de) 1990-05-14
JPH09118688A (ja) 1997-05-06
EP0265519A1 (de) 1988-05-04
EP0265519B1 (de) 1995-09-13
JP3476679B2 (ja) 2003-12-10
DK16293A (da) 1993-02-12
DK16293D0 (da) 1993-02-12
DE3751516D1 (de) 1995-10-19
AU7581687A (en) 1987-11-24
FI875732A7 (fi) 1987-12-28
FI102017B1 (fi) 1998-09-30
FI875732A0 (fi) 1987-12-28
NO875476L (no) 1988-02-23
DK173025B1 (da) 1999-11-15
DE3752345D1 (de) 2002-02-21
AU5754094A (en) 1994-05-12
JPH11101800A (ja) 1999-04-13
EP0658564B1 (de) 2002-01-16
NO176071B (no) 1994-10-17
EP0647849A3 (de) 1996-05-15
AU644150B2 (en) 1993-12-02
JP2674957B2 (ja) 1997-11-12
KR960016340B1 (ko) 1996-12-09
NO176071C (no) 1995-01-25
ATE127923T1 (de) 1995-09-15

Similar Documents

Publication Publication Date Title
DE3752345D1 (de) Elektrolumineszente Verbindungen und Zwischenprodukte zur Herstellung
DE69023934D1 (de) Substanz PF 1022, Verfahren zu ihrer Herstellung und diese Substanz enthaltende anthelmintische Zusammensetzung.
DK0567635T3 (da) Hurtige assays for amplifikationsprodukter
DE69031534D1 (de) Verfahren zur Herstellung von optisch aktiven Zyklobutannukleosiden
DE69132276D1 (de) Verfahren zur herstellung von nukleotiden
PT88536A (pt) Procede de preparation de nouveaux steroiedes comportant un cycle spirannique a 3,4 ou 6 chainons en position 17
ATE43834T1 (de) Antimikrobiell wirksame substanzen, ihre herstellung und ihre verwendung.
ATE246696T1 (de) Verfahren zur herstellung von linkern zwischen markierungsgruppen und bio-organischen molekülen auf der basis von platin für die markierung von bio-organischen molekülen zur entdeckung interessanter biologischer substanzen
ATE77380T1 (de) Zwischenprodukte fuer die produktion von podophyllotoxin und verwandte verbindungen und verfahren zu deren herstellung und deren verwendung.
ATE51617T1 (de) Verfahren zur herstellung von 4-phenyl-pyrrolderivaten.
ATE89285T1 (de) Oberflaechenaktive verbindungen und verfahren zu deren herstellung.
ATE85363T1 (de) Verfahren und reagenz zur bestimmung von alphaamylase.
ATE199559T1 (de) N- und o-substituierte aminophenolderivate, zwischenprodukte zu deren herstellung, deren verwendung als hydrolasesubstrate, ein entsprechendes bestimmungsverfahren und hierfür geeignetes diagnostisches mittel
DE69724141D1 (de) Verbindungen verwendbar zur perhaloalkylierung, reagenz für ihrer durchführung und verfahren zu ihrer herstellung
ES2097733T3 (es) Derivados de la manobiosa.
ATE114637T1 (de) Verfahren zur herstellung von antikonvulsanten cyclischen aminosäureverbindungen.
DE69014152D1 (de) Verfahren zur Herstellung von Tigogenin-beta-Cellobioside.
DE3883911D1 (de) Verfahren zur Herstellung von Orotsäure durch Fermentierung.
ATE456T1 (de) Selektiv geschuetzte 4,6-d i-o-(aminoglykosyl)-1,3-diamino-cyclitole, verfahren zu deren herstellung und deren verwendung als zwischenprodukte.
JPS6419063A (en) Novel heterocyclic compound and use thereof
ATE88701T1 (de) Zwischenprodukte und deren verwendung fuer die synthese von organischen verbindungen.
DE3766089D1 (de) Verfahren zur herstellung von 2,2-dimethyl-3-formylcyclopropancarbonsaeure-pentafluorphenylmethylester, und seine verwendung bei der herstellung von pestiziden produkten.
ATE33384T1 (de) Verfahren zur herstellung eines 1,5-geschuetzten 1,5,10-triazadecans, zwischenprodukte hierfuer und deren herstellung.
ATE65780T1 (de) Verfahren zur herstellung von heterozyklen durch palladium-zyklische komplexe.
ATE66453T1 (de) Herstellung von zwischenverbindungen fuer leukotrien-antagonisten.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
EELA Cancelled due to lapse of time