ATE212065T1 - Nukleinsäuremoleküle mit der fähigkeit zur unterscheidung von prpc und prpsc-prionprotein- isoformen und verfahren zu deren herstellung - Google Patents

Nukleinsäuremoleküle mit der fähigkeit zur unterscheidung von prpc und prpsc-prionprotein- isoformen und verfahren zu deren herstellung

Info

Publication number
ATE212065T1
ATE212065T1 AT96937257T AT96937257T ATE212065T1 AT E212065 T1 ATE212065 T1 AT E212065T1 AT 96937257 T AT96937257 T AT 96937257T AT 96937257 T AT96937257 T AT 96937257T AT E212065 T1 ATE212065 T1 AT E212065T1
Authority
AT
Austria
Prior art keywords
nucleic acid
acid molecules
prpc
methods
distincting
Prior art date
Application number
AT96937257T
Other languages
English (en)
Inventor
Ernst-Ludwig Winnacker
Stefan Weiss
Michael Famulok
Original Assignee
Winnacker Ernst Ludwig Prof
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Winnacker Ernst Ludwig Prof filed Critical Winnacker Ernst Ludwig Prof
Application granted granted Critical
Publication of ATE212065T1 publication Critical patent/ATE212065T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811Selection methods for production or design of target specific oligonucleotides or binding molecules
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/16Aptamers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT96937257T 1995-10-26 1996-10-25 Nukleinsäuremoleküle mit der fähigkeit zur unterscheidung von prpc und prpsc-prionprotein- isoformen und verfahren zu deren herstellung ATE212065T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP95116890 1995-10-26
PCT/EP1996/004671 WO1997015685A1 (en) 1995-10-26 1996-10-25 NUCLEIC ACID MOLECULES CAPABLE OF DISTINGUISHING THE ISOFORMS PrPc AND PrPSc OF PRION PROTEINS AND PROCESSES FOR THEIR PRODUCTION

Publications (1)

Publication Number Publication Date
ATE212065T1 true ATE212065T1 (de) 2002-02-15

Family

ID=8219750

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96937257T ATE212065T1 (de) 1995-10-26 1996-10-25 Nukleinsäuremoleküle mit der fähigkeit zur unterscheidung von prpc und prpsc-prionprotein- isoformen und verfahren zu deren herstellung

Country Status (8)

Country Link
US (2) US6426409B1 (de)
EP (1) EP0862653B1 (de)
JP (1) JPH11514874A (de)
AT (1) ATE212065T1 (de)
DE (1) DE69618614T2 (de)
DK (1) DK0862653T3 (de)
ES (1) ES2171231T3 (de)
WO (1) WO1997015685A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59805338D1 (de) 1997-09-19 2002-10-02 Evotec Ag Verfahren zur messung der assoziation von teilstrukturen pathologischer proteinablagerungen
DE19916417A1 (de) * 1999-04-01 2000-10-19 Schering Ag Amyloidspezifisches Aptamer
DE19925073C2 (de) * 1999-06-01 2001-07-19 Stefan Weiss Nucleinsäuremoleküle mit spezifischer Erkennung von nativem PrP·S··c·, Herstellung und Verwendung
FR2808278A1 (fr) * 2000-04-28 2001-11-02 Inst Nat Sante Rech Med Proteines a prions et leurs utilisations
GB0012054D0 (en) * 2000-05-18 2000-07-12 Isis Innovation Ligands
EP1409720A4 (de) * 2000-10-27 2005-09-07 Res Dev Foundation In-vitro-selektion von signalaptameren
US20050261486A1 (en) * 2001-05-31 2005-11-24 Q-Rna Compositions and methods for binding agglomeration proteins
US20040005543A1 (en) * 2002-01-18 2004-01-08 Abraham Grossman Compositions and methods for binding agglomeration proteins
WO2002097049A2 (en) * 2001-05-31 2002-12-05 Q-Rna Compositions and methods for binding agglomeration proteins
US20040096880A1 (en) * 2001-08-07 2004-05-20 Kmiec Eric B. Compositions and methods for the treatment of diseases exhibiting protein misassembly and aggregation
US20040086924A1 (en) * 2001-10-26 2004-05-06 Research Development Foundation In vitro selection of signaling aptamers
EP1497459A4 (de) * 2002-04-15 2005-09-07 Q Rna Inc Vorrichtung und verfahren zur konzentration von prionprotein-isoformen
JP2006502709A (ja) * 2002-08-15 2006-01-26 キュー−アールエヌエイ,インク. タンパク質の凝集のために要求される因子を識別するために使用される組成物および方法
US20050196382A1 (en) * 2002-09-13 2005-09-08 Replicor, Inc. Antiviral oligonucleotides targeting viral families
AU2003267785C1 (en) * 2002-09-13 2009-12-24 Replicor, Inc. Non-sequence complementary antiviral oligonucleotides
US7399603B2 (en) * 2002-12-19 2008-07-15 Ortho-Clinical Diagnostics, Inc. Antibodies for discrimination of prions
AU2004200467A1 (en) * 2003-02-10 2004-08-26 Ortho-Clinical Diagnostics, Inc. Antibodies for discrimination of prions
AU2004271807A1 (en) * 2003-09-11 2005-03-24 Replicor, Inc. Oligonucleotides targeting prion diseases
US20070123480A1 (en) * 2003-09-11 2007-05-31 Replicor Inc. Oligonucleotides targeting prion diseases

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4917998A (en) * 1986-05-06 1990-04-17 Epitope, Inc. Method of detecting AIDS virus infection
US5567588A (en) * 1990-06-11 1996-10-22 University Research Corporation Systematic evolution of ligands by exponential enrichment: Solution SELEX
US5270163A (en) * 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
US5582981A (en) * 1991-08-14 1996-12-10 Gilead Sciences, Inc. Method for identifying an oligonucleotide aptamer specific for a target
US5573905A (en) * 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries

Also Published As

Publication number Publication date
WO1997015685A1 (en) 1997-05-01
DE69618614D1 (de) 2002-02-21
EP0862653A1 (de) 1998-09-09
ES2171231T3 (es) 2002-09-01
DK0862653T3 (da) 2002-03-11
US20030119019A1 (en) 2003-06-26
US6426409B1 (en) 2002-07-30
DE69618614T2 (de) 2002-09-12
JPH11514874A (ja) 1999-12-21
EP0862653B1 (de) 2002-01-16

Similar Documents

Publication Publication Date Title
ATE212065T1 (de) Nukleinsäuremoleküle mit der fähigkeit zur unterscheidung von prpc und prpsc-prionprotein- isoformen und verfahren zu deren herstellung
DE69942451D1 (de) Methode zum schnellen identifizieren von kleinen organischen liganden
ATE328006T1 (de) Neues protein und verfahren zu dessen herstellung
DE69739105D1 (de) Survivin, ein protein das zelluläre apoptosis hemmt, und dessen modulation
ATE348164T1 (de) Neuroprotektive eigenschaften von gdf-15, ein mitglied der tgf-beta superfamilie
DE69020143D1 (de) Verfahren zur verwendung und herstellung von peptiden.
DE50012831D1 (de) Verfahren zur verbindung von molekularen substanzen
ATE135371T1 (de) Mit akuter pankreatitis assoziiertes protein, mittel zur diagnose von akuter pankreatitis
ATE278785T1 (de) Neues verfahren zur gewinnung und reinigung von fusionsproteinen
ATE368688T1 (de) Peptide, deren herstellung und verwendung zur bindung von immunglobulinen
ATE90944T1 (de) Fuer ein hirudinaehnliches protein kodierende dns- sequenz und verfahren zur herstellung eines solchen proteins.
DE69831500D1 (de) Humane checkpointkinase, hcds1, zusammensetzungen und verfahren
DE60023860D1 (de) Verfahren zur herstellung von rekombinanten peptiden
DE69535901D1 (de) Proteinkinase npk-110
DK0948604T3 (da) Screeningsmetoder for forbindelser som binder til PYK2-polypeptidet
DE602004030041D1 (de) Verfahren und zusammensetzungen zur identifikation von rna-bindenden proteinen
AUPP627498A0 (en) Novel peptides - i
DE59004279D1 (de) Verfahren zur C-terminalen Modifizierung von Proteinen.
DE69734890D1 (de) Rdgb-proteine
ATE269905T1 (de) Verfahren zur herstellung von proteinen in wirtszellen unter verwendung von chaperoninen
WO2003012103A3 (fr) Acides nucleiques codant de nouvelles proteines a boite f, leurs utilisations en diagnostic et en therapie
DE69521281D1 (de) Verfahren zur Herstellung von menschlichem oder humanem Matrilysin mittels rekombinanter DNA.
DE59404414D1 (de) Verfahren zur Abtrennung von L-Leucin und L-Isoleucin aus wässrigen Lösungen
DE60308176D1 (de) Vorrichtung von peptid- oder proteindarstellung, verfahren zu deren herstellung und deren verwendung
DE60040485D1 (de) Molekulardisplay auf multimeren proteingerüsten, die von der e2 komponente der alpha-ketosäure-dehydrogenase stammen

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee