ATE212615T1 - Verfahren zur herstellung von (1s,2r)-1-amino-2- indanol-(r,r)-tartrate methanol solvat - Google Patents

Verfahren zur herstellung von (1s,2r)-1-amino-2- indanol-(r,r)-tartrate methanol solvat

Info

Publication number: ATE212615T1
Authority: AT; Austria
Prior art keywords: indanol; amino; tartrate; methanol; solvent
Prior art date: 1997-06-13

Application number

AT98201879T

Other languages

English (en)

Inventor

Patrick Robert Hof

Original Assignee

Dsm Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-06-13

Filing date

1998-06-05

Publication date

2002-02-15

1998-06-05 Application filed by Dsm Nv filed Critical Dsm Nv

2002-02-15 Application granted granted Critical

2002-02-15 Publication of ATE212615T1 publication Critical patent/ATE212615T1/de

Links

KIXKKIZBNLLSOJ-BGAVDPONSA-N (1s,2r)-1-amino-2,3-dihydro-1h-inden-2-ol;(2r,3r)-2,3-dihydroxybutanedioic acid;methanol Chemical compound OC.OC(=O)[C@H](O)[C@@H](O)C(O)=O.C1=CC=C2[C@H](N)[C@H](O)CC2=C1 KIXKKIZBNLLSOJ-BGAVDPONSA-N 0.000 title abstract 5
239000012453 solvate Substances 0.000 title abstract 5
238000004519 manufacturing process Methods 0.000 title 1
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 9
239000002904 solvent Substances 0.000 abstract 4
239000013078 crystal Substances 0.000 abstract 2
238000011084 recovery Methods 0.000 abstract 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
LOPKSXMQWBYUOI-DTWKUNHWSA-N (1r,2s)-1-amino-2,3-dihydro-1h-inden-2-ol Chemical compound C1=CC=C2[C@@H](N)[C@@H](O)CC2=C1 LOPKSXMQWBYUOI-DTWKUNHWSA-N 0.000 abstract 1
YUOMEKXYCXVZRL-YFQRKTQFSA-N (1r,2s)-1-amino-2,3-dihydro-1h-inden-2-ol;(2r,3r)-2,3-dihydroxybutanedioic acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.C1=CC=C2[C@@H](N)[C@@H](O)CC2=C1 YUOMEKXYCXVZRL-YFQRKTQFSA-N 0.000 abstract 1
LOPKSXMQWBYUOI-BDAKNGLRSA-N (1s,2r)-1-amino-2,3-dihydro-1h-inden-2-ol Chemical compound C1=CC=C2[C@H](N)[C@H](O)CC2=C1 LOPKSXMQWBYUOI-BDAKNGLRSA-N 0.000 abstract 1
YUOMEKXYCXVZRL-MHDNXTQBSA-N (1s,2r)-1-amino-2,3-dihydro-1h-inden-2-ol;(2r,3r)-2,3-dihydroxybutanedioic acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.C1=CC=C2[C@H](N)[C@H](O)CC2=C1 YUOMEKXYCXVZRL-MHDNXTQBSA-N 0.000 abstract 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
208000030507 AIDS Diseases 0.000 abstract 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
229960001936 indinavir Drugs 0.000 abstract 1
CBVCZFGXHXORBI-PXQQMZJSSA-N indinavir Chemical compound C([C@H](N(CC1)C[C@@H](O)C[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H]2C3=CC=CC=C3C[C@H]2O)C(=O)NC(C)(C)C)N1CC1=CC=CN=C1 CBVCZFGXHXORBI-PXQQMZJSSA-N 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000002245 particle Substances 0.000 abstract 1
239000000376 reactant Substances 0.000 abstract 1
239000011541 reaction mixture Substances 0.000 abstract 1
229960001367 tartaric acid Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers

Landscapes

Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT98201879T 1997-06-13 1998-06-05 Verfahren zur herstellung von (1s,2r)-1-amino-2- indanol-(r,r)-tartrate methanol solvat ATE212615T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
NL1006305A NL1006305C2 (nl)	1997-06-13	1997-06-13	Werkwijze voor de bereiding van (1S,2R)-1-amino-2-indanol-(R,R)-tartraat methanol solvaat.

Publications (1)

Publication Number	Publication Date
ATE212615T1 true ATE212615T1 (de)	2002-02-15

Family

ID=19765156

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98201879T ATE212615T1 (de)	1997-06-13	1998-06-05	Verfahren zur herstellung von (1s,2r)-1-amino-2- indanol-(r,r)-tartrate methanol solvat

Country Status (9)

Country	Link
US (1)	US6586634B1 (de)
EP (1)	EP0890571B1 (de)
JP (1)	JPH1180099A (de)
CN (1)	CN1203224A (de)
AT (1)	ATE212615T1 (de)
CA (1)	CA2240305A1 (de)
DE (1)	DE69803636T2 (de)
IL (1)	IL124840A0 (de)
NL (1)	NL1006305C2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4889501B2 (ja) *	2004-10-20	2012-03-07	田辺三菱製薬株式会社	フェニルエタノールアミン化合物の製造方法及びその中間体
WO2014034957A1 (ja) *	2012-08-31	2014-03-06	住友化学株式会社	（ｒ）－１，１，３－トリメチル－４－アミノインダンの製造方法
CN105061228A (zh) *	2015-08-26	2015-11-18	吴玲	一种制备r-6-羟基-1-氨基茚满的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4136605A1 (de)	1991-11-07	1993-05-13	Philips Patentverwaltung	Verstaerker
US5449830A (en) *	1994-03-11	1995-09-12	Marck & Co., Inc.	Regiospecific processes to make CIS-1-Amino-2-Alkanol from Diol or Halohydrin
US5420353A (en) *	1994-03-11	1995-05-30	Merck & Co., Inc.	Regiospecific process to make cis-1-amino-2-alkanol from epoxide
US5618937A (en) *	1995-03-15	1997-04-08	Merck & Co., Inc.	Process to make HIV protease inhibitor from (2S)-4-picolyl-2-piperazine-t-butylcarboxamide
US5612484A (en) *	1995-05-18	1997-03-18	Merck & Co., Inc.	Process for making HIV protease inhibitors
US5605819A (en) *	1995-05-19	1997-02-25	Merck & Co., Inc.	Quantitative conversion of indene to (1S,2R) indene oxide and (1S,2R)-indandiol by combination of haloperoxidase bioconversion and chemical steps

1997
- 1997-06-13 NL NL1006305A patent/NL1006305C2/nl not_active IP Right Cessation
1998
- 1998-06-05 AT AT98201879T patent/ATE212615T1/de not_active IP Right Cessation
- 1998-06-05 EP EP98201879A patent/EP0890571B1/de not_active Expired - Lifetime
- 1998-06-05 DE DE69803636T patent/DE69803636T2/de not_active Expired - Fee Related
- 1998-06-10 IL IL12484098A patent/IL124840A0/xx unknown
- 1998-06-11 JP JP10199421A patent/JPH1180099A/ja active Pending
- 1998-06-11 CA CA002240305A patent/CA2240305A1/en not_active Abandoned
- 1998-06-12 US US09/095,932 patent/US6586634B1/en not_active Expired - Fee Related
- 1998-06-12 CN CN98102925A patent/CN1203224A/zh active Pending

Also Published As

Publication number	Publication date
EP0890571B1 (de)	2002-01-30
EP0890571A1 (de)	1999-01-13
NL1006305C2 (nl)	1998-12-15
DE69803636T2 (de)	2002-09-05
JPH1180099A (ja)	1999-03-23
DE69803636D1 (de)	2002-03-14
CA2240305A1 (en)	1998-12-13
CN1203224A (zh)	1998-12-30
IL124840A0 (en)	1999-01-26
US6586634B1 (en)	2003-07-01

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Legal Events

Date	Code	Title	Description
2002-05-15	UEP	Publication of translation of european patent specification
2006-03-15	REN	Ceased due to non-payment of the annual fee