ATE213252T1 - Verfahren zur herstellung eines inter-alpha- trypsin inhibitor konzentrats mit therapeutischer anwendung und so erhaltenes konzentrat - Google Patents

Verfahren zur herstellung eines inter-alpha- trypsin inhibitor konzentrats mit therapeutischer anwendung und so erhaltenes konzentrat

Info

Publication number: ATE213252T1
Authority: AT; Austria
Prior art keywords: concentrate; pct; alpha; therapeutic use; inter
Prior art date: 1993-10-18

Application number

AT94931070T

Other languages

English (en)

Inventor

Catherine Michalski

Jacques Mizon

Original Assignee

Aetsrn

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-10-18

Filing date

1994-10-17

Publication date

2002-02-15

1994-10-17 Application filed by Aetsrn filed Critical Aetsrn

2002-02-15 Application granted granted Critical

2002-02-15 Publication of ATE213252T1 publication Critical patent/ATE213252T1/de

Links

239000012141 concentrate Substances 0.000 title abstract 3
230000001225 therapeutic effect Effects 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
108010093564 inter-alpha-inhibitor Proteins 0.000 abstract 3
238000000034 method Methods 0.000 abstract 2
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
238000001042 affinity chromatography Methods 0.000 abstract 1
238000005571 anion exchange chromatography Methods 0.000 abstract 1
229960002897 heparin Drugs 0.000 abstract 1
229920000669 heparin Polymers 0.000 abstract 1
230000002779 inactivation Effects 0.000 abstract 1
230000003612 virological effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biophysics (AREA)
Epidemiology (AREA)
Zoology (AREA)
Biochemistry (AREA)
Immunology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT94931070T 1993-10-18 1994-10-17 Verfahren zur herstellung eines inter-alpha- trypsin inhibitor konzentrats mit therapeutischer anwendung und so erhaltenes konzentrat ATE213252T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9312346A FR2711371B1 (fr)	1993-10-18	1993-10-18	Procédé de préparation d'un concentré d'inter-alpha-trypsine inhibiteur à usage thérapeutique et concentré obtenu.
PCT/FR1994/001197 WO1995011260A1 (fr)	1993-10-18	1994-10-17	Procede de preparation d'un concentre d'inter-alpha-trypsine inhibiteur a usage therapeutique et concentre obtenu

Publications (1)

Publication Number	Publication Date
ATE213252T1 true ATE213252T1 (de)	2002-02-15

Family

ID=9451908

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94931070T ATE213252T1 (de)	1993-10-18	1994-10-17	Verfahren zur herstellung eines inter-alpha- trypsin inhibitor konzentrats mit therapeutischer anwendung und so erhaltenes konzentrat

Country Status (12)

Country	Link
US (1)	US5777081A (de)
EP (1)	EP0724600B1 (de)
JP (1)	JP3650937B2 (de)
AT (1)	ATE213252T1 (de)
AU (1)	AU7996294A (de)
CA (1)	CA2174231C (de)
DE (1)	DE69429868T2 (de)
DK (1)	DK0724600T3 (de)
ES (1)	ES2173927T3 (de)
FR (1)	FR2711371B1 (de)
PT (1)	PT724600E (de)
WO (1)	WO1995011260A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3626982B2 (ja) *	1997-08-29	2005-03-09	アークレイ株式会社	タンパク質分解酵素阻害物質の測定方法およびそれに用いる測定キット
US6596705B1 (en)	1998-02-09	2003-07-22	The Regents Of The University Of California	Inhibition of L-selectin and P-selection mediated binding using heparin
US6660482B1 (en)	2000-02-28	2003-12-09	Rhode Island Hospital	Inter-alpha-trypsin inhibitor as a marker for sepsis
JP2004511492A (ja) *	2000-10-13	2004-04-15	オクタファルマ　アクチェン　ゲゼルシャフト	ビクニンを含む血漿画分、その調製方法、およびその使用
EP1542704A1 (de) *	2002-04-18	2005-06-22	Stephen H. Embury	VERFAHREN UND ZUSAMMENSETZUNG ZUR PRûVENTION VON SCHMERZEN BEI SICHELZELL-PATIENTEN
US7932365B2 (en) *	2003-11-08	2011-04-26	Pro Thera Biologics, Llc	Preparation and composition of inter-alpha inhibitor proteins from human plasma for therapeutic use
PT2291654T (pt)	2008-05-28	2018-06-15	Prothera Biologics Inc	Preparação e composição de proteínas inibidoras de interalfa do sangue
US8772462B2 (en)	2010-05-26	2014-07-08	Baxter International Inc.	Removal of serine proteases by treatment with finely divided silicon dioxide
AU2010202125B1 (en)	2010-05-26	2010-09-02	Takeda Pharmaceutical Company Limited	A method to produce an immunoglobulin preparation with improved yield
CN103119058A (zh)	2010-07-23	2013-05-22	巴克斯特国际公司	由血浆生产间-α-抑制蛋白(IAIP)
US9572872B2 (en)	2012-09-09	2017-02-21	Prothera Biologics, Inc.	Treatment of disease using inter-alpha inhibitor proteins
CN103880951B (zh) *	2014-03-31	2016-03-30	南昌市万华生化制品有限公司	一种通过乌司他丁亲和层析介质制备纯品乌司他丁的方法
EP3362464B1 (de) *	2015-10-15	2021-04-28	Plasma Technologies LLC	Verfahren zur extraktion von proteinen aus blutplasma
CA3036553A1 (en)	2016-09-13	2018-03-22	Prothera Biologics, Inc.	Methods for treating pulmonary disease using inter-alpha inhibitor proteins
KR102587810B1 (ko)	2017-04-25	2023-10-11	프로테라 바이오로직스, 인크.	인터-알파 억제제 단백질을 정량화하는 방법
CN109776674B (zh) *	2019-02-19	2020-01-17	广东天普生化医药股份有限公司	纯化的乌司他丁及其制备方法和含有该乌司他丁的药物组合物
US11725043B2 (en)	2020-03-05	2023-08-15	DiaMedica USA Inc.	Ulinastatin polypeptides

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1434199A (fr) *	1964-01-10	1966-04-08	Behringwerke Ag	Procédé d'isolement d'inhibiteurs de la plasmine et de la trypsine à partir de liquides organiques d'origine humaine ou animale
US4119774A (en) *	1976-03-05	1978-10-10	Ab Kabi	Heparin purification method
AT368883B (de) *	1980-07-22	1982-11-25	Immuno Ag	Verfahren zur herstellung einer neuen blutgerinnungsfoerdernden praeparation auf basis von humanproteinen
US4760130A (en) *	1984-12-06	1988-07-26	Synergen Biologicals, Inc.	Serine protease inhibitors and methods for isolation of same
US4629567A (en) *	1986-03-07	1986-12-16	Smithkline-Rit	Alpha-1-antiprotease purification
ES2045167T5 (es) *	1987-10-23	1996-07-01	Centre Regional De Transfusion	Preparacion de concentrado de factor ix humano de elevada pureza y de otras proteinas plasmaticas.
US5445958A (en) *	1987-12-22	1995-08-29	National Blood Authority	Process for purifying blood clotting factors

1993
- 1993-10-18 FR FR9312346A patent/FR2711371B1/fr not_active Expired - Lifetime
1994
- 1994-10-17 US US08/632,460 patent/US5777081A/en not_active Expired - Lifetime
- 1994-10-17 EP EP94931070A patent/EP0724600B1/de not_active Expired - Lifetime
- 1994-10-17 WO PCT/FR1994/001197 patent/WO1995011260A1/fr not_active Ceased
- 1994-10-17 ES ES94931070T patent/ES2173927T3/es not_active Expired - Lifetime
- 1994-10-17 DE DE69429868T patent/DE69429868T2/de not_active Expired - Lifetime
- 1994-10-17 AT AT94931070T patent/ATE213252T1/de not_active IP Right Cessation
- 1994-10-17 DK DK94931070T patent/DK0724600T3/da active
- 1994-10-17 AU AU79962/94A patent/AU7996294A/en not_active Abandoned
- 1994-10-17 JP JP51140495A patent/JP3650937B2/ja not_active Expired - Fee Related
- 1994-10-17 CA CA002174231A patent/CA2174231C/fr not_active Expired - Fee Related
- 1994-10-17 PT PT94931070T patent/PT724600E/pt unknown

Also Published As

Publication number	Publication date
JP3650937B2 (ja)	2005-05-25
DE69429868D1 (de)	2002-03-21
US5777081A (en)	1998-07-07
EP0724600B1 (de)	2002-02-13
PT724600E (pt)	2002-07-31
JPH09503775A (ja)	1997-04-15
WO1995011260A1 (fr)	1995-04-27
DE69429868T2 (de)	2002-09-19
AU7996294A (en)	1995-05-08
FR2711371B1 (fr)	1995-12-29
ES2173927T3 (es)	2002-11-01
CA2174231A1 (fr)	1995-04-27
FR2711371A1 (fr)	1995-04-28
CA2174231C (fr)	2004-06-01
EP0724600A1 (de)	1996-08-07
DK0724600T3 (da)	2002-05-27

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Legal Events

Date	Code	Title	Description
2002-08-15	UEP	Publication of translation of european patent specification
2011-07-15	REN	Ceased due to non-payment of the annual fee