ES2045167T5 - Preparacion de concentrado de factor ix humano de elevada pureza y de otras proteinas plasmaticas. - Google Patents

Preparacion de concentrado de factor ix humano de elevada pureza y de otras proteinas plasmaticas.

Info

Publication number
ES2045167T5
ES2045167T5 ES88402643T ES88402643T ES2045167T5 ES 2045167 T5 ES2045167 T5 ES 2045167T5 ES 88402643 T ES88402643 T ES 88402643T ES 88402643 T ES88402643 T ES 88402643T ES 2045167 T5 ES2045167 T5 ES 2045167T5
Authority
ES
Spain
Prior art keywords
concentrate
preparation
high purity
human factor
plasma proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88402643T
Other languages
English (en)
Other versions
ES2045167T3 (es
Inventor
Thierry Burnouf
Catherine Michalski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre Regional de Transfusion Sanguine
Original Assignee
Centre Regional de Transfusion Sanguine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26226280&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2045167(T5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from FR8714665A external-priority patent/FR2622108B1/fr
Priority claimed from FR8806923A external-priority patent/FR2631830B1/fr
Application filed by Centre Regional de Transfusion Sanguine filed Critical Centre Regional de Transfusion Sanguine
Application granted granted Critical
Publication of ES2045167T3 publication Critical patent/ES2045167T3/es
Publication of ES2045167T5 publication Critical patent/ES2045167T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

EL INVENTO ES UN PROCESO DE PREPARACION DE FACTOR IX CONCENTRADO Y DE ELEVADA PUREZA. EL CONCENTRADO SE OBTIENE POR TRATAMIENTO CROMATOGRAFICO DE UNA FRACCION DE PLASMA PREPURIFICADO, ASOCIANDO PRINCIPALMENTE LA CROMATOGRAFIA DE CAMBIO DE ANIONES Y LA CROMATOGRAFIA SOBRE HEPARINA INMOVILIZADA. ESTE CONCENTRADO ES UTILIZABLE PARA EL TRATAMIENTO DE LA HEMOFILIA B. EL PROCESO DE PREPARACION PERMITE IGUALMENTE OBTENER UNOS CONCENTRADOS DE ALFA - ANTITRIPSINA, DE PROTEINAS C Y S DE FACTORES II, VII Y X APROPIADOS PARA SU UTILIZACION TERAPEUTICAS. EL PROCESO PERMITE A SU VEZ RECUPERAR LA ALBUMINA LAS INMUNOGLOBULINAS Y LA ANTITROMBINA III.
ES88402643T 1987-10-23 1988-10-20 Preparacion de concentrado de factor ix humano de elevada pureza y de otras proteinas plasmaticas. Expired - Lifetime ES2045167T5 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8714665A FR2622108B1 (fr) 1987-10-23 1987-10-23 Preparation de concentres de proconvertine (facteur vii), de facteur antihemophilique b (facteur ix) et d'autres proteines plasmatiques, et leur utilisation therapeutique
FR8806923A FR2631830B1 (fr) 1988-05-25 1988-05-25 Concentre de facteur ix de haute purete, sa preparation et son utilisation en therapeutique

Publications (2)

Publication Number Publication Date
ES2045167T3 ES2045167T3 (es) 1994-01-16
ES2045167T5 true ES2045167T5 (es) 1996-07-01

Family

ID=26226280

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88402643T Expired - Lifetime ES2045167T5 (es) 1987-10-23 1988-10-20 Preparacion de concentrado de factor ix humano de elevada pureza y de otras proteinas plasmaticas.

Country Status (8)

Country Link
US (1) US5457181A (es)
EP (1) EP0317376B2 (es)
JP (1) JP2768957B2 (es)
DE (1) DE3877529T2 (es)
DK (1) DK173859B1 (es)
ES (1) ES2045167T5 (es)
GR (2) GR3006910T3 (es)
NO (1) NO179997C (es)

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DE3914869C1 (es) * 1989-05-05 1990-08-09 Biotest Pharma Gmbh, 6072 Dreieich, De
IE73210B1 (en) * 1990-01-24 1997-05-07 Warner Lambert Co Process for the production of thrombin and high purity thrombin preparation thereby obtained
ES2131504T3 (es) * 1990-02-20 1999-08-01 Baxter Int Trombina humana purificada viricamente segura.
AT402261B (de) * 1991-01-25 1997-03-25 Immuno Ag Komplex enthaltend den gerinnungsfaktor ix
JP3418621B2 (ja) 1991-03-01 2003-06-23 アヴェンティス ベーリング エルエルシー Ｉｘ因子の調製
FR2711371B1 (fr) * 1993-10-18 1995-12-29 Aetsrn Procédé de préparation d'un concentré d'inter-alpha-trypsine inhibiteur à usage thérapeutique et concentré obtenu.
DE4342132C1 (de) * 1993-12-10 1994-11-03 Octapharma Ag Verfahren zur Herstellung virusinaktivierte Vitamin K abhängige Plasmakomponenten sowie Protein C und Protein S enthaltender Mittel durch Membran-Chromatographie
DE4406515C1 (de) * 1994-02-28 1995-10-19 Immuno Ag Verfahren zur Isolierung und Reinigung Vitamin K-abhängiger Proteine
US6372716B1 (en) 1994-04-26 2002-04-16 Genetics Institute, Inc. Formulations for factor IX
DE4435520A1 (de) * 1994-10-04 1996-04-11 Immuno Ag Verfahren zur Trennung von rekombinantem pro-Faktor IX von rekombinantem Faktor IX
DE19504852C2 (de) * 1995-02-15 2003-01-23 Octapharma Ag Lachen Verfahren zur Reinigung Vitamin K-abhängiger Gerinnungsfaktoren durch Affinitäts-Chromatographie
DE19506633A1 (de) * 1995-02-25 1996-08-29 Octapharma Ag Verfahren zur Herstellung von Faktor IX aus biologischen Quellen
US5714583A (en) * 1995-06-07 1998-02-03 Genetics Institute, Inc. Factor IX purification methods
US5770700A (en) * 1996-01-25 1998-06-23 Genetics Institute, Inc. Liquid factor IX formulations
ES2127695B1 (es) * 1997-02-14 2000-03-16 Grifols Grupo Sa Procedimiento para la reduccion del contenido de factor plaquetar 4 en proteinas plasmaticas que poseen afinidad a heparina.
AT407484B (de) * 1997-11-12 2001-03-26 Bio Prod & Bio Eng Ag Arzneimittel zur förderung der wundheilung
JP2005530683A (ja) 2001-12-21 2005-10-13 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 第ｖｉｉ因子ポリペプチドの液体組成物
US20040009918A1 (en) * 2002-05-03 2004-01-15 Hanne Nedergaard Stabilised solid compositions of modified factor VII
CN101912601B (zh) 2002-06-21 2012-08-29 诺和诺德医疗保健公司 因子vii多肽的稳定化固体组合物
SE0203551D0 (sv) * 2002-12-02 2002-12-02 Biovitrum Ab Prothrombin purification
US20040106779A1 (en) * 2002-12-03 2004-06-03 Bigler Douglas E. Modified factor IX preparation
AT501088A2 (de) * 2002-12-18 2006-06-15 Bio Prod & Bio Eng Ag Stabile therapeutische proteine
US7897734B2 (en) * 2003-03-26 2011-03-01 Novo Nordisk Healthcare Ag Method for the production of proteins
KR20060015574A (ko) * 2003-05-23 2006-02-17 노보 노르디스크 헬스 케어 악티엔게젤샤프트 용액 중 단백질 안정화
JP5306597B2 (ja) * 2003-07-01 2013-10-02 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 第ｖｉｉ因子ポリペプチドの液体水性薬学的組成物
EP1656158B1 (en) 2003-08-14 2016-03-09 Novo Nordisk Health Care AG Liquid, aqueous pharmaceutical composition of factor vii polypeptides
JP4855074B2 (ja) * 2003-09-30 2012-01-18 一般財団法人化学及血清療法研究所 高純度血液凝固ｉｘ因子調製物およびその精製方法
EP2311437A1 (en) * 2003-12-19 2011-04-20 Novo Nordisk Health Care AG Stabilised compositions of factor VII polypeptides
WO2005094873A1 (en) * 2004-03-19 2005-10-13 Baxter International Inc. Factor ixa for the treatment of bleeding disorders
KR100667860B1 (ko) 2005-10-18 2007-01-11 주식회사 녹십자 고순도 사람 혈액응고 제9인자의 정제 방법
TW200821026A (en) * 2006-09-08 2008-05-16 Wyeth Corp Arginine wash in protein purification using affinity chromatography
US8399632B2 (en) * 2007-02-28 2013-03-19 Baxter International Inc. Method for the purification of recombinant blood coagulation factor IX enriched in sulfated and/or phosphorylated molecules
ES2595059T3 (es) 2007-03-20 2016-12-27 Csl Behring Gmbh Métodos para la producción a escala industrial de preparados terapéuticos del Factor H del complemento a partir de plasma humano
RU2649363C2 (ru) * 2010-11-16 2018-04-02 Октафарма Аг СПОСОБЫ СНИЖЕНИЯ И/ИЛИ УДАЛЕНИЯ FXI и FXIa ИЗ РАСТВОРОВ, СОДЕРЖАЩИХ УКАЗАННЫЕ ФАКТОРЫ СВЕРТЫВАНИЯ
EP2652491B1 (en) 2010-12-15 2017-11-29 Baxalta GmbH Eluate collection using conductivity gradient
PL2748179T3 (pl) 2011-10-14 2022-04-11 Takeda Pharmaceutical Company Limited Oczyszczanie białka metodą anionowej chromatografii jonowymiennej
US20140206844A1 (en) 2013-01-18 2014-07-24 Prothera Biologics Methods for isolating blood products from an inter-alpha inhibitor protein-depleted blood product material
US9663553B2 (en) 2014-01-29 2017-05-30 Hemarus Therapeutics Limited Integrated process for the production of therapeutics (human albumin, immunoglobulins, clotting factor VIII and clotting factor IX) from human plasma
GB201506113D0 (en) 2015-04-10 2015-05-27 Ge Healthcare Bio Sciences Ab Method for chromatography
GB201506117D0 (en) * 2015-04-10 2015-05-27 Ge Healthcare Bio Sciences Ab Method for chromatography
CN110339209B (zh) * 2019-07-18 2023-06-06 上海泰坦科技股份有限公司 一种去甲状腺结合蛋白的小牛血清的制备方法

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DE2459291C3 (de) * 1974-12-14 1981-06-04 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur Herstellung eines antihämophiles Globulin A enthaltenden Konzentrats neben einem Prothrombin- Komplex und einer Lösung von lagerstabilen Serumproteinen
US4374763A (en) * 1979-09-17 1983-02-22 Morishita Pharmaceutical Co., Ltd. Method for producing gamma-globulin for use in intravenous administration and method for producing a pharmaceutical preparation thereof
US4440679A (en) * 1980-03-05 1984-04-03 Cutter Laboratories, Inc. Pasteurized therapeutically active protein compositions
ATE15489T1 (de) * 1980-05-27 1985-09-15 Miles Lab Die blutkoagulation aktivierendes produkt und verfahren zu dessen herstellung.
AT368883B (de) * 1980-07-22 1982-11-25 Immuno Ag Verfahren zur herstellung einer neuen blutgerinnungsfoerdernden praeparation auf basis von humanproteinen
US4447416A (en) * 1982-04-28 1984-05-08 American National Red Cross Plasma protein concentrates of reduced thrombogenicity and their use in clinical replacement therapy
US4397841A (en) * 1982-06-28 1983-08-09 Monsanto Company Production of blood coagulation factor VIII:C
US4540573A (en) * 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
DE3336631A1 (de) * 1983-10-08 1985-04-18 Behringwerke Ag, 3550 Marburg Verfahren zur pasteurisierung von plasma oder von konzentraten der blutgerinnungsfaktoren ii, vii, ix und x
US4777043A (en) * 1985-12-17 1988-10-11 Genentech, Inc. Stabilized human tissue plasminogen activator compositions
EP0229026B1 (en) * 1986-01-06 1995-11-22 Blood Systems Inc, an Arizona not-for-profit corporation Therapeutic blood product, means and methods of preparing same

Also Published As

Publication number Publication date
EP0317376B1 (fr) 1993-01-13
NO179997C (no) 1997-01-29
DK173859B1 (da) 2001-12-31
EP0317376A1 (fr) 1989-05-24
NO884688D0 (no) 1988-10-21
NO179997B (no) 1996-10-21
EP0317376B2 (fr) 1996-04-03
NO884688L (no) 1989-04-24
JPH01207239A (ja) 1989-08-21
DE3877529D1 (de) 1993-02-25
US5457181A (en) 1995-10-10
JP2768957B2 (ja) 1998-06-25
ES2045167T3 (es) 1994-01-16
DK587788D0 (da) 1988-10-21
GR3006910T3 (en) 1993-06-30
DE3877529T2 (de) 1996-11-07
DK587788A (da) 1989-04-24
GR3019900T3 (en) 1996-08-31

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