DK0724600T3 - Fremgangsmåde til fremstilling af et koncentrat af inter-alfa-trypsininhibitor til terapeutisk anvendelse og det fremstillede koncentrat - Google Patents
Fremgangsmåde til fremstilling af et koncentrat af inter-alfa-trypsininhibitor til terapeutisk anvendelse og det fremstillede koncentratInfo
- Publication number
- DK0724600T3 DK0724600T3 DK94931070T DK94931070T DK0724600T3 DK 0724600 T3 DK0724600 T3 DK 0724600T3 DK 94931070 T DK94931070 T DK 94931070T DK 94931070 T DK94931070 T DK 94931070T DK 0724600 T3 DK0724600 T3 DK 0724600T3
- Authority
- DK
- Denmark
- Prior art keywords
- concentrate
- pct
- alpha
- inter
- therapeutic use
- Prior art date
Links
- 108010093564 inter-alpha-inhibitor Proteins 0.000 title abstract 4
- 239000012141 concentrate Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
- 238000001042 affinity chromatography Methods 0.000 abstract 1
- 238000005571 anion exchange chromatography Methods 0.000 abstract 1
- 229960002897 heparin Drugs 0.000 abstract 1
- 229920000669 heparin Polymers 0.000 abstract 1
- 230000002779 inactivation Effects 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9312346A FR2711371B1 (fr) | 1993-10-18 | 1993-10-18 | Procédé de préparation d'un concentré d'inter-alpha-trypsine inhibiteur à usage thérapeutique et concentré obtenu. |
| PCT/FR1994/001197 WO1995011260A1 (fr) | 1993-10-18 | 1994-10-17 | Procede de preparation d'un concentre d'inter-alpha-trypsine inhibiteur a usage therapeutique et concentre obtenu |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0724600T3 true DK0724600T3 (da) | 2002-05-27 |
Family
ID=9451908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94931070T DK0724600T3 (da) | 1993-10-18 | 1994-10-17 | Fremgangsmåde til fremstilling af et koncentrat af inter-alfa-trypsininhibitor til terapeutisk anvendelse og det fremstillede koncentrat |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5777081A (da) |
| EP (1) | EP0724600B1 (da) |
| JP (1) | JP3650937B2 (da) |
| AT (1) | ATE213252T1 (da) |
| AU (1) | AU7996294A (da) |
| CA (1) | CA2174231C (da) |
| DE (1) | DE69429868T2 (da) |
| DK (1) | DK0724600T3 (da) |
| ES (1) | ES2173927T3 (da) |
| FR (1) | FR2711371B1 (da) |
| PT (1) | PT724600E (da) |
| WO (1) | WO1995011260A1 (da) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3626982B2 (ja) * | 1997-08-29 | 2005-03-09 | アークレイ株式会社 | タンパク質分解酵素阻害物質の測定方法およびそれに用いる測定キット |
| US6596705B1 (en) | 1998-02-09 | 2003-07-22 | The Regents Of The University Of California | Inhibition of L-selectin and P-selection mediated binding using heparin |
| US6660482B1 (en) | 2000-02-28 | 2003-12-09 | Rhode Island Hospital | Inter-alpha-trypsin inhibitor as a marker for sepsis |
| EP1326893A2 (de) * | 2000-10-13 | 2003-07-16 | Octapharma AG | Bikunin enthaltende plasmafraktion, verfahren zu ihrer herstellung und ihrer verwendung |
| EP1542704A1 (en) * | 2002-04-18 | 2005-06-22 | Stephen H. Embury | Method and composition for preventing pain in sickle cell patients |
| EP3087991A1 (en) * | 2003-11-08 | 2016-11-02 | Prothera Biologics | Composition of inter-alpha inhibitor proteins from human plasma for therapeutic use |
| CN106928346B (zh) * | 2008-05-28 | 2021-09-07 | 普罗瑟拉生物公司 | 来自血液的间-α抑制物蛋白的制备和组合物 |
| AU2010202125B1 (en) | 2010-05-26 | 2010-09-02 | Takeda Pharmaceutical Company Limited | A method to produce an immunoglobulin preparation with improved yield |
| WO2011150284A2 (en) | 2010-05-26 | 2011-12-01 | Baxter International Inc. | Removal of serine proteases by treatment with finely divided silicon dioxide |
| SG187599A1 (en) | 2010-07-23 | 2013-03-28 | Baxter Int | Manufacture of inter -alpha - inhibitor proteins (iaip) from plasma |
| WO2014039987A2 (en) | 2012-09-09 | 2014-03-13 | Prothera Biologics, Inc. | Treatment of disease using inter-alpha inhibitor proteins |
| CN103880951B (zh) * | 2014-03-31 | 2016-03-30 | 南昌市万华生化制品有限公司 | 一种通过乌司他丁亲和层析介质制备纯品乌司他丁的方法 |
| WO2017066683A1 (en) * | 2015-10-15 | 2017-04-20 | Plasma Technologies, Llc | Methods for extracting proteins from blood plasma |
| WO2018053029A1 (en) | 2016-09-13 | 2018-03-22 | Prothera Biologics, Inc. | Methods for treating pulmonary disease using inter-alpha inhibitor proteins |
| BR112019022358A2 (pt) | 2017-04-25 | 2020-05-19 | Prothera Biologics, Inc. | métodos para quantificar proteínas inibidoras inter-alfa |
| CN109776674B (zh) * | 2019-02-19 | 2020-01-17 | 广东天普生化医药股份有限公司 | 纯化的乌司他丁及其制备方法和含有该乌司他丁的药物组合物 |
| CA3174478A1 (en) | 2020-03-05 | 2021-09-10 | DiaMedica USA Inc. | Ulinastatin polypeptides |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1434199A (fr) * | 1964-01-10 | 1966-04-08 | Behringwerke Ag | Procédé d'isolement d'inhibiteurs de la plasmine et de la trypsine à partir de liquides organiques d'origine humaine ou animale |
| US4119774A (en) * | 1976-03-05 | 1978-10-10 | Ab Kabi | Heparin purification method |
| AT368883B (de) * | 1980-07-22 | 1982-11-25 | Immuno Ag | Verfahren zur herstellung einer neuen blutgerinnungsfoerdernden praeparation auf basis von humanproteinen |
| US4760130A (en) * | 1984-12-06 | 1988-07-26 | Synergen Biologicals, Inc. | Serine protease inhibitors and methods for isolation of same |
| US4629567A (en) * | 1986-03-07 | 1986-12-16 | Smithkline-Rit | Alpha-1-antiprotease purification |
| DE3877529T2 (de) * | 1987-10-23 | 1996-11-07 | Centre Regional De Transfusion | Herstellung von hoch-gereingtem menschlichen Faktor IX sowie anderem Plasmaproteinkonzentrat und dessen therapeutische Verwendung. |
| US5445958A (en) * | 1987-12-22 | 1995-08-29 | National Blood Authority | Process for purifying blood clotting factors |
-
1993
- 1993-10-18 FR FR9312346A patent/FR2711371B1/fr not_active Expired - Lifetime
-
1994
- 1994-10-17 EP EP94931070A patent/EP0724600B1/fr not_active Expired - Lifetime
- 1994-10-17 ES ES94931070T patent/ES2173927T3/es not_active Expired - Lifetime
- 1994-10-17 CA CA002174231A patent/CA2174231C/fr not_active Expired - Fee Related
- 1994-10-17 JP JP51140495A patent/JP3650937B2/ja not_active Expired - Fee Related
- 1994-10-17 WO PCT/FR1994/001197 patent/WO1995011260A1/fr not_active Ceased
- 1994-10-17 DK DK94931070T patent/DK0724600T3/da active
- 1994-10-17 PT PT94931070T patent/PT724600E/pt unknown
- 1994-10-17 DE DE69429868T patent/DE69429868T2/de not_active Expired - Lifetime
- 1994-10-17 AT AT94931070T patent/ATE213252T1/de not_active IP Right Cessation
- 1994-10-17 US US08/632,460 patent/US5777081A/en not_active Expired - Lifetime
- 1994-10-17 AU AU79962/94A patent/AU7996294A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE69429868T2 (de) | 2002-09-19 |
| FR2711371A1 (fr) | 1995-04-28 |
| ATE213252T1 (de) | 2002-02-15 |
| AU7996294A (en) | 1995-05-08 |
| CA2174231A1 (fr) | 1995-04-27 |
| EP0724600B1 (fr) | 2002-02-13 |
| WO1995011260A1 (fr) | 1995-04-27 |
| US5777081A (en) | 1998-07-07 |
| ES2173927T3 (es) | 2002-11-01 |
| EP0724600A1 (fr) | 1996-08-07 |
| FR2711371B1 (fr) | 1995-12-29 |
| JP3650937B2 (ja) | 2005-05-25 |
| CA2174231C (fr) | 2004-06-01 |
| JPH09503775A (ja) | 1997-04-15 |
| DE69429868D1 (de) | 2002-03-21 |
| PT724600E (pt) | 2002-07-31 |
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