ATE214100T1 - Herstellung von rekombinanten proteinen in einem rinderadenovirus-expressionsvektorsystem - Google Patents
Herstellung von rekombinanten proteinen in einem rinderadenovirus-expressionsvektorsystemInfo
- Publication number
- ATE214100T1 ATE214100T1 AT95902725T AT95902725T ATE214100T1 AT E214100 T1 ATE214100 T1 AT E214100T1 AT 95902725 T AT95902725 T AT 95902725T AT 95902725 T AT95902725 T AT 95902725T AT E214100 T1 ATE214100 T1 AT E214100T1
- Authority
- AT
- Austria
- Prior art keywords
- bovine adenovirus
- production
- expression vector
- recombinant proteins
- vector system
- Prior art date
Links
- 241000283690 Bos taurus Species 0.000 title abstract 3
- 241000701161 unidentified adenovirus Species 0.000 title abstract 3
- 239000013604 expression vector Substances 0.000 title abstract 2
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 title 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 title 1
- 239000012634 fragment Substances 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 101150029662 E1 gene Proteins 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
- 229940031626 subunit vaccine Drugs 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10351—Methods of production or purification of viral material
- C12N2710/10352—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/164,292 US5820868A (en) | 1993-12-09 | 1993-12-09 | Recombinant protein production in bovine adenovirus expression vector system |
| PCT/CA1994/000678 WO1995016048A2 (en) | 1993-12-09 | 1994-12-09 | Recombinant protein production in bovine adenovirus expression vector system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE214100T1 true ATE214100T1 (de) | 2002-03-15 |
Family
ID=22593842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95902725T ATE214100T1 (de) | 1993-12-09 | 1994-12-09 | Herstellung von rekombinanten proteinen in einem rinderadenovirus-expressionsvektorsystem |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US5820868A (de) |
| EP (1) | EP0736100B1 (de) |
| AT (1) | ATE214100T1 (de) |
| AU (1) | AU1189195A (de) |
| DE (1) | DE69430071T2 (de) |
| WO (1) | WO1995016048A2 (de) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5820868A (en) | 1993-12-09 | 1998-10-13 | Veterinary Infectious Disease Organization | Recombinant protein production in bovine adenovirus expression vector system |
| AU6261696A (en) | 1995-06-05 | 1996-12-24 | Trustees Of The University Of Pennsylvania, The | A replication-defective adenovirus human type 5 recombinant as a vaccine carrier |
| AUPN477695A0 (en) * | 1995-08-14 | 1995-09-07 | Commonwealth Scientific And Industrial Research Organisation | Gene therapy |
| US20020193580A1 (en) * | 1995-12-15 | 2002-12-19 | Mitchell Lloyd G. | Methods and compositions for use in spliceosome mediated RNA trans-splicing |
| US20060088938A1 (en) * | 1995-12-15 | 2006-04-27 | Mitchell Lloyd G | Methods and compositions for use in spliceosome mediated RNA trans-splicing in plants |
| US20030027250A1 (en) * | 1995-12-15 | 2003-02-06 | Mitchell Lloyd G. | Methods and compositions for use in spliceosome mediated RNA trans-splicing |
| FR2748753B1 (fr) * | 1996-05-20 | 1998-08-14 | Transgene Sa | Nouveaux vecteurs adenoviraux pour la therapie genique |
| JP2002512501A (ja) * | 1996-07-03 | 2002-04-23 | メリアル インコーポレイテッド | 外来性dnaを含む組換えイヌアデノウィルス(cav) |
| WO1998010087A1 (en) * | 1996-09-06 | 1998-03-12 | Trustees Of The University Of Pennsylvania | Chimpanzee adenovirus vectors |
| US6420629B1 (en) * | 1996-09-09 | 2002-07-16 | B.C. Research Inc. | Process of increasing plant growth and yield and modifying cellulose production in plants |
| FR2761689B1 (fr) | 1997-04-02 | 1999-06-25 | Transgene Sa | Fibre adenovirale modifiee et adenovirus cibles |
| JP4812914B2 (ja) * | 1997-06-23 | 2011-11-09 | ユニバーシティ オブ サスカチュワン | ウシアデノウイルスタイプ3ゲノム |
| US6348450B1 (en) * | 1997-08-13 | 2002-02-19 | The Uab Research Foundation | Noninvasive genetic immunization, expression products therefrom and uses thereof |
| US6716823B1 (en) | 1997-08-13 | 2004-04-06 | The Uab Research Foundation | Noninvasive genetic immunization, expression products therefrom, and uses thereof |
| US20030045492A1 (en) * | 1997-08-13 | 2003-03-06 | Tang De-Chu C. | Vaccination by topical application of recombinant vectors |
| US20030125278A1 (en) * | 1997-08-13 | 2003-07-03 | Tang De-Chu C. | Immunization of animals by topical applications of a salmonella-based vector |
| US6706693B1 (en) | 1997-08-13 | 2004-03-16 | The Uab Research Foundation | Vaccination by topical application of genetic vectors |
| US7135191B2 (en) * | 1997-09-04 | 2006-11-14 | Zsolt Istvan Hertelendy | Urogenital or anorectal transmucosal vaccine delivery system |
| WO2000026395A2 (en) * | 1998-11-02 | 2000-05-11 | University Of Saskatchewan | Bovine cells expressing adenovirus essential functions for propagation of recombinant adenoviral vectors |
| US6303362B1 (en) * | 1998-11-19 | 2001-10-16 | The Board Of Trustees Of The Leland Stanford Junior University | Adenoviral vector and methods for making and using the same |
| CA2365911A1 (en) * | 1999-04-09 | 2000-10-19 | Schering-Plough Ltd. | Recombinant and mutant adenoviruses derived of bovine adenovirus type 1 |
| US6451319B1 (en) * | 1999-04-09 | 2002-09-17 | Schering-Plough Veterinary Corporation | Recombinant and mutant adenoviruses |
| US20040009936A1 (en) * | 1999-05-03 | 2004-01-15 | Tang De-Chu C. | Vaccine and drug delivery by topical application of vectors and vector extracts |
| EP1198579A1 (de) * | 1999-08-06 | 2002-04-24 | DeveloGen Aktiengesellschaft für entwicklungsbiologische Forschung | Nicht-humaner adenoviraler vektor für den gentransfer, seine anwendung und seine herstellung |
| ATE284898T1 (de) * | 1999-08-25 | 2005-01-15 | Merck & Co Inc | Synthetische papillomavirus gene, welche für expression in menschlichen zellen optimiert sind |
| CA2410665C (en) * | 2000-05-31 | 2017-11-07 | University Of Saskatchewan | Modified bovine adenovirus having altered tropism |
| US20040126774A1 (en) * | 2001-01-08 | 2004-07-01 | Mitchell Lioyd G. | Correction of factor VIII genetic defects using spliceosome mediated RNA trans splicing |
| EP1427816A4 (de) | 2001-09-18 | 2004-12-01 | Clontech Lab Inc | Auf stellenspezifischer rekombinase beruhendes verfahren zur herstellung von adenovirusvektoren |
| US7399753B2 (en) * | 2002-02-25 | 2008-07-15 | Virxsys Corporation | Trans-splicing mediated photodynamic therapy |
| US7094399B2 (en) * | 2002-05-08 | 2006-08-22 | Intronn, Inc. | Use of spliceosome mediated RNA trans-splicing to confer cell selective replication to adenoviruses |
| AU2003255967A1 (en) * | 2002-07-19 | 2004-02-09 | University Of Saskatchewan | Pav regions for encapsidation and e1 transcriptioonal control |
| EP1579004B1 (de) * | 2002-10-23 | 2010-06-16 | VIRxSYS Corporation | Screening-verfahren zur identifizierung wirksamer prä-trans-spleissmoleküle |
| US7264818B2 (en) * | 2003-06-10 | 2007-09-04 | University Of Saskatchewan | BAV packaging regions and E1 transcriptional control regions |
| EP1631582A2 (de) * | 2003-06-10 | 2006-03-08 | University of Saskatchewan | Chimäre adenoviruscapsidproteine |
| KR101203817B1 (ko) * | 2003-10-02 | 2012-11-23 | 크루셀 홀란드 비.브이. | 재조합 아데노바이러스를 위한 포장 세포 |
| WO2005067506A2 (en) * | 2004-01-06 | 2005-07-28 | Cedars-Sinai Medical Center | Method for monitoring and generating high capacity gutless adenoviral vector |
| WO2005070948A1 (en) * | 2004-01-23 | 2005-08-04 | Intronn, Inc. | Correction of alpha-1-antitrypsin genetic defects using spliceosome mediated rna trans splicing |
| AU2005207053A1 (en) * | 2004-01-23 | 2005-08-04 | Virxsys Corporation | Expression of ApoA-1 and variants thereof using spliceosome mediated RNA trans-splicing |
| US7968334B2 (en) * | 2004-01-23 | 2011-06-28 | Virxsys Corporation | Expression of apoAI and variants thereof using spliceosome mediated RNA trans-splicing |
| US7342107B2 (en) * | 2004-05-27 | 2008-03-11 | Centocor, Inc. | Cynomolgus prostate specific antigen |
| AU2005329405A1 (en) * | 2004-06-15 | 2006-09-28 | Centocor, Inc. | Method for screening agents against human prostate disease |
| US20060094110A1 (en) * | 2004-07-30 | 2006-05-04 | Mcgarrity Gerard J | Use of spliceosome mediated RNA trans-splicing for immunotherapy |
| US20060134658A1 (en) * | 2004-08-09 | 2006-06-22 | Garcia-Blanco Mariano A | Use of RNA trans-splicing for generation of interfering RNA molecules |
| DE102004047492B4 (de) * | 2004-09-23 | 2006-07-20 | Jost-Werke Gmbh & Co. Kg | Verfahren zum Übertragen von elektrischer, pneumatischer oder hydraulischer Energie sowie ein Energieübertragungssystem |
| US7871795B2 (en) | 2004-10-08 | 2011-01-18 | Virxsys Corporation | Targeted trans-splicing of highly abundant transcripts for in vivo production of recombinant proteins |
| AU2005326784B2 (en) * | 2004-10-08 | 2012-03-15 | Virxsys Corporation | Use of RNA trans-splicing for antibody gene transfer and antibody polypeptide production |
| US7524510B2 (en) * | 2005-02-23 | 2009-04-28 | The Uab Research Foundation | Alkyl-glycoside enhanced vaccination |
| KR20080052509A (ko) * | 2005-04-11 | 2008-06-11 | 더 거버먼트 오브 더 유나이티드 스테이츠 오브 아메리카, 애즈 레프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비시즈, 센터스 포 디지즈 컨트롤 앤드 프리벤션 | 유행성 독감 바이러스에 대한 백신 |
| US20150284729A1 (en) * | 2012-11-15 | 2015-10-08 | National University Of Singapore | Univariant Extrinsic Initiator Control System for Microbes and an In Vitro Assembly of Large Recombinant DNA Molecules From Multiple Components |
| CN109715204B (zh) | 2016-09-20 | 2023-08-22 | 勃林格殷格翰动物保健有限公司 | 新的ehv插入位点orf70 |
| AU2017332677B2 (en) | 2016-09-20 | 2024-01-11 | Boehringer Ingelheim Vetmedica Gmbh | Canine adenovirus vectors |
| DK3516064T3 (da) | 2016-09-20 | 2025-07-14 | Boehringer Ingelheim Vetmedica Gmbh | Nye promotorer |
| AR109538A1 (es) | 2016-09-20 | 2018-12-19 | Boehringer Ingelheim Vetmedica Gmbh | Vacuna contra la gripe porcina |
| US10525127B2 (en) * | 2018-03-31 | 2020-01-07 | Femtomab | P14.7 protein and uses thereof as vaccine adjuvant |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB185573A (en) | 1921-07-12 | 1922-09-14 | Richard Saleck | Apparatus for measuring off and cutting strings in bundles |
| US3962424A (en) * | 1974-01-31 | 1976-06-08 | Recherche Et Industrie Therapeutiques (R.I.T.) | Live brovine adenovirus vaccines, preparation thereof and method of vaccination using them |
| US4510245A (en) * | 1982-11-18 | 1985-04-09 | Chiron Corporation | Adenovirus promoter system |
| ZA858044B (en) * | 1984-11-01 | 1987-05-27 | American Home Prod | Oral vaccines |
| FR2573436B1 (fr) * | 1984-11-20 | 1989-02-17 | Pasteur Institut | Adn recombinant comportant une sequence nucleotidique codant pour un polypeptide determine sous le controle d'un promoteur d'adenovirus, vecteurs contenant cet adn recombinant, cellules eucaryotes transformees par cet adn recombinant, produits d'excretion de ces cellules transformees et leurs applications, notamment a la constitution de vaccins |
| EP0221955A4 (de) * | 1985-05-01 | 1988-12-22 | Genetics Inst | Hochstufige verstärkung und expression von exogener dns. |
| CA1319101C (en) | 1986-09-03 | 1993-06-15 | Marta Iris Sabara | Rotavirus nucleocapsid protein with or without binding peptides as immunologic carriers for macromolecules |
| US5024939A (en) * | 1987-07-09 | 1991-06-18 | Genentech, Inc. | Transient expression system for producing recombinant protein |
| US5151267A (en) | 1988-07-15 | 1992-09-29 | University Of Saskatchewan | Bovine herpesvirus type 1 polypeptides and vaccines |
| FR2642797B1 (fr) * | 1989-01-10 | 1991-05-17 | Secmair | Dispositif d'asservissement de la pression d'appui au sol d'un rouleau equipant une tete de coupe, notamment de fauchage |
| FR2642767B1 (fr) | 1989-01-19 | 1993-10-01 | Transgene Sa | Vecteurs d'expression de proteines heterologues dans les cellules eucaryotes, lignees cellulaires obtenues et procede pour leur preparation |
| ATE140154T1 (de) * | 1989-03-24 | 1996-07-15 | Wistar Inst | Rekombinanter cytomegalovirus-impfstoff |
| GB9001766D0 (en) * | 1990-01-25 | 1990-03-28 | Univ Court Of The University O | Vaccines |
| FR2657880A1 (fr) * | 1990-02-02 | 1991-08-09 | Fondation Nale Transfusion San | Production de proteines recombinantes a partir de cellules lymphoblastouides humaines et d'heteromyelomes. |
| US5543328A (en) | 1993-08-13 | 1996-08-06 | Genetic Therapy, Inc. | Adenoviruses having modified fiber proteins |
| US5820868A (en) | 1993-12-09 | 1998-10-13 | Veterinary Infectious Disease Organization | Recombinant protein production in bovine adenovirus expression vector system |
| US5846782A (en) | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
| AU4857496A (en) | 1995-01-17 | 1996-08-07 | Environmental Projects, Inc. | Method for purification of saline minerals |
| US5770442A (en) | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
| US5871727A (en) | 1995-12-08 | 1999-02-16 | Uab Research Foundation | Targeted adenovirus vectors |
| JP4812914B2 (ja) | 1997-06-23 | 2011-11-09 | ユニバーシティ オブ サスカチュワン | ウシアデノウイルスタイプ3ゲノム |
| US5922576A (en) | 1998-02-27 | 1999-07-13 | The John Hopkins University | Simplified system for generating recombinant adenoviruses |
| CA2410665C (en) | 2000-05-31 | 2017-11-07 | University Of Saskatchewan | Modified bovine adenovirus having altered tropism |
| EP1301615A2 (de) | 2000-07-14 | 2003-04-16 | University of Saskatchewan | Introneneinhaltende adenovirale vektoren |
| US20030143200A1 (en) | 2001-09-24 | 2003-07-31 | Tikoo Suresh K. | Porcine adenovirus E1 region |
| US7569217B2 (en) | 2001-09-24 | 2009-08-04 | University Of Saskatchewan | Porcine adenovirus E1 and E4 regions |
-
1993
- 1993-12-09 US US08/164,292 patent/US5820868A/en not_active Expired - Lifetime
-
1994
- 1994-12-09 EP EP95902725A patent/EP0736100B1/de not_active Expired - Lifetime
- 1994-12-09 WO PCT/CA1994/000678 patent/WO1995016048A2/en not_active Ceased
- 1994-12-09 AT AT95902725T patent/ATE214100T1/de not_active IP Right Cessation
- 1994-12-09 AU AU11891/95A patent/AU1189195A/en not_active Abandoned
- 1994-12-09 DE DE69430071T patent/DE69430071T2/de not_active Expired - Lifetime
-
1997
- 1997-03-13 US US08/815,927 patent/US6086890A/en not_active Expired - Lifetime
- 1997-04-25 US US08/845,623 patent/US6001591A/en not_active Expired - Lifetime
-
1999
- 1999-11-05 US US09/435,242 patent/US6379944B1/en not_active Expired - Lifetime
-
2002
- 2002-01-14 US US10/046,938 patent/US7025967B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69430071T2 (de) | 2002-11-28 |
| US7025967B2 (en) | 2006-04-11 |
| WO1995016048A3 (en) | 1995-09-28 |
| EP0736100B1 (de) | 2002-03-06 |
| EP0736100A1 (de) | 1996-10-09 |
| AU1189195A (en) | 1995-06-27 |
| US6086890A (en) | 2000-07-11 |
| DE69430071D1 (de) | 2002-04-11 |
| US6379944B1 (en) | 2002-04-30 |
| US20020192185A1 (en) | 2002-12-19 |
| WO1995016048A2 (en) | 1995-06-15 |
| US5820868A (en) | 1998-10-13 |
| US6001591A (en) | 1999-12-14 |
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