ATE284954T1 - Hyaluronan synthase gen und seine verwendung - Google Patents

Hyaluronan synthase gen und seine verwendung

Info

Publication number: ATE284954T1
Authority: AT; Austria
Prior art keywords: nucleic acid; hyaluronan synthase; synthase gene; hyaluronan; synthase
Prior art date: 1997-10-31

Application number

AT98957450T

Other languages

English (en)

Inventor

Paul H Weigel

Kshama Kumari

Paul Deangelis

Original Assignee

Univ Oklahoma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-31

Filing date

1998-10-30

Publication date

2005-01-15

1998-10-30 Application filed by Univ Oklahoma filed Critical Univ Oklahoma

2005-01-15 Application granted granted Critical

2005-01-15 Publication of ATE284954T1 publication Critical patent/ATE284954T1/de

Links

108090000320 Hyaluronan Synthases Proteins 0.000 title abstract 6
102000003918 Hyaluronan Synthases Human genes 0.000 abstract 5
229920002674 hyaluronan Polymers 0.000 abstract 3
150000007523 nucleic acids Chemical group 0.000 abstract 3
KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract 2
229960003160 hyaluronic acid Drugs 0.000 abstract 2
108020004707 nucleic acids Proteins 0.000 abstract 2
102000039446 nucleic acids Human genes 0.000 abstract 2
241000701248 Chlorella virus Species 0.000 abstract 1
108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 abstract 1
229940099552 hyaluronan Drugs 0.000 abstract 1
229920001184 polypeptide Polymers 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/832—Bacillus
- Y10S435/836—Bacillus licheniformis
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/832—Bacillus
- Y10S435/839—Bacillus subtilis
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/848—Escherichia

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Medicinal Chemistry (AREA)
General Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Materials Engineering (AREA)
Polymers & Plastics (AREA)
Immunology (AREA)
Mycology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

AT98957450T 1997-10-31 1998-10-30 Hyaluronan synthase gen und seine verwendung ATE284954T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US6443597P	1997-10-31	1997-10-31
US17885198A	1998-10-26	1998-10-26
PCT/US1998/023153 WO1999023227A2 (en)	1997-10-31	1998-10-30	Hyaluronan synthase gene and uses thereof

Publications (1)

Publication Number	Publication Date
ATE284954T1 true ATE284954T1 (de)	2005-01-15

Family

ID=26744517

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98957450T ATE284954T1 (de)	1997-10-31	1998-10-30	Hyaluronan synthase gen und seine verwendung

Country Status (13)

Country	Link
US (10)	US6833264B1 (de)
EP (2)	EP1025211B1 (de)
JP (1)	JP4731013B2 (de)
KR (1)	KR20010031682A (de)
CN (1)	CN1322121C (de)
AT (1)	ATE284954T1 (de)
AU (2)	AU762036B2 (de)
BR (1)	BR9814834B1 (de)
CA (1)	CA2307842C (de)
DE (1)	DE69828193T2 (de)
DK (1)	DK1025211T3 (de)
ES (1)	ES2235378T3 (de)
WO (1)	WO1999023227A2 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7091008B1 (en)	1994-07-01	2006-08-15	The Board Of Regents Of The University Of Oklahoma	Hyaluronan synthase genes and expression thereof in Bacillus hosts
CN1322121C (zh) *	1997-10-31	2007-06-20	俄克拉何马大学董事会	透明质酸合酶基因及其应用
US7060469B2 (en) *	1998-04-02	2006-06-13	The Board Of Regents Of The University Of Oklahoma	Polymer grafting by polysaccharide synthases
EP1832662B1 (de) *	1998-04-02	2011-03-09	The Board Of Regents Of The University Of Oklahoma	Chondroitin-Synthase kodierendes DNA der Pasteurella multocida und Verwendungsverfahren
US7534589B2 (en) *	1999-11-10	2009-05-19	The Board Of Regents Of The University Of Oklahoma	Polymer grafting by polysaccharide synthases
US20070020737A1 (en) *	2001-12-03	2007-01-25	Pummill Philip E	Hyaluronan synthases and methods of making and using same
AU2008200910C1 (en) *	2001-12-21	2012-11-22	Novozymes A/S	Methods for producing hyaluronan in a recombinant host cell
AU2002366711C1 (en)	2001-12-21	2009-01-22	Novozymes A/S	Methods for producing hyaluronan in a recombinant host cell
US9733625B2 (en) *	2006-03-20	2017-08-15	General Electric Company	Trip optimization system and method for a train
JP4402588B2 (ja) *	2002-06-20	2010-01-20	ノボザイムスバイオファーマデーコーアクティーゼルスカブ	２価の塩を使用する凝集法
US7547819B2 (en)	2003-07-31	2009-06-16	Toyo Boseki Kabushiki Kaisha	Plant producing hyaluronic acid
WO2006032538A1 (en)	2004-09-23	2006-03-30	Bayer Cropscience Gmbh	Methods and means for producing hyaluronan
EP1640457A1 (de) *	2004-09-23	2006-03-29	Bayer CropScience GmbH	Verfahren und Mittel zur Herstellung von Hyaluronan
CN101123942A (zh) *	2005-01-03	2008-02-13	诺维信生物聚合物公司	具有保湿和抗皱纹性质的透明质酸级分
JP2006204260A (ja) *	2005-01-31	2006-08-10	Toyobo Co Ltd	ヒアルロン酸合成酵素及びその遺伝子
CA2620210A1 (en) *	2005-08-25	2007-03-01	Toyo Boseki Kabushiki Kaisha	Plant producing hyaluronic acid
JP2009509557A (ja) *	2005-10-05	2009-03-12	バイエル・クロップサイエンス・アーゲー	改善されたヒアルロン酸産生方法および手段
BRPI0616844A2 (pt) *	2005-10-05	2011-07-05	Bayer Cropscience Ag	célula de planta geneticamente modificada, uso da mesma, planta, processo para produção da mesma, material de reprodução de plantas, partes de plantas colhìveis, processo para produção de hialuronano, composição, bem como seu processo de produção
US10428341B2 (en) *	2005-10-05	2019-10-01	Basf Se	Transgenic potato plants with increased hyaluronan production
EP1772052A1 (de) *	2005-10-05	2007-04-11	Bayer CropScience GmbH	Verbesserte Verfahren und Mittel zur Herstellung von Hyaluronan
JP2007174957A (ja) *	2005-12-27	2007-07-12	Toyobo Co Ltd	ヒアルロン酸生産酵母
CN101501075B (zh)	2006-08-04	2013-07-10	诺维信生物制药丹麦公司	支化透明质酸和制造方法
CN108192909A (zh) *	2007-03-29	2018-06-22	未来基因以色列有限公司	包含可溶性细胞壁多糖的转基因植物
WO2009026635A1 (en) *	2007-08-31	2009-03-05	The University Of Queensland	Production of hyaluronic acid
CN101878230B (zh)	2007-12-19	2012-11-21	赢创高施米特有限公司	乳液中的交联透明质酸
KR20140034853A (ko)	2011-05-30	2014-03-20	노보자임스 바이오파마 디케이 에이/에스	고분자량 히알루론산의 분무 건조
CA2847328A1 (en)	2011-09-02	2013-03-07	Novozymes Biopharma Dk A/S	Oral formulations containing hyaluronic acid for sustained drug release
WO2014100837A1 (en)	2012-12-17	2014-06-26	Bui The Duy	Computer aided implantation of body implants
ES2968068T3 (es) *	2013-03-15	2024-05-07	Prime Merger Sub Llc	Preparaciones derivadas de materiales placentarios y métodos para fabricarlas y utilizarlas
US12551509B2 (en)	2015-11-18	2026-02-17	Lucina Patent Holdco, Llc	Acellular regenerative products and methods of their manufacture
KR102135044B1 (ko) *	2018-12-10	2020-07-17	대화제약 주식회사	히알루론산 합성효소 변이 단백질 및 이를 이용한 히알루론산 생산 방법
RU2719140C1 (ru)	2019-07-26	2020-04-17	Общество с ограниченной ответственностью "ЦЕНТР ТРАНСФЕРА БИОТЕХНОЛОГИЙ ОКА-Биотех"	Бактерия рода bacillus, продуцирующая гиалуроновую кислоту, и способ получения гиалуроновой кислоты с использованием указанной бактерии
WO2025012149A1 (en)	2023-07-07	2025-01-16	Nupep As	Consensus peptides in hya
EP4487863A1 (de)	2023-07-07	2025-01-08	NuPep AS	Konsensuspeptide in hya zur verwendung bei der behandlung degenerierter gelenke
EP4487834A1 (de)	2023-07-07	2025-01-08	NuPep AS	Konsensuspeptide in hya
CN119020314A (zh) *	2024-09-30	2024-11-26	海南省深海技术创新中心	一种透明质酸合成酶及其应用

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH624011A5 (de)	1977-08-05	1981-07-15	Battelle Memorial Institute
US4235871A (en)	1978-02-24	1980-11-25	Papahadjopoulos Demetrios P	Method of encapsulating biologically active materials in lipid vesicles
ZA811368B (en)	1980-03-24	1982-04-28	Genentech Inc	Bacterial polypedtide expression employing tryptophan promoter-operator
EP0038776B1 (de)	1980-04-17	1983-09-21	Ciba-Geigy Ag	Phenylharnstoffe
US4517295A (en)	1983-02-18	1985-05-14	Diagnostic, Inc.	Hyaluronic acid from bacterial culture
CA1167797A (en)	1983-06-30	1984-05-22	Herbert E. Gladish	Air conveyor components
JPS6060177A (ja)	1983-09-12	1985-04-06	Hiroyuki Yugawa	冷却用寒剤
US4511478A (en)	1983-11-10	1985-04-16	Genetic Systems Corporation	Polymerizable compounds and methods for preparing synthetic polymers that integrally contain polypeptides
AU565354B2 (en)	1983-11-14	1987-09-10	Bio-Mimetics Inc.	Bioadhesive compositions and methods of treatment therewith
US4983392A (en)	1983-11-14	1991-01-08	Bio-Mimetics, Inc.	Bioadhesive compositions and methods of treatment therewith
NO161573C (no)	1983-11-25	1989-08-30	Miles Inc	Fremgangsmaate til fremstilling av hyaluronsyre.
US4708861A (en)	1984-02-15	1987-11-24	The Liposome Company, Inc.	Liposome-gel compositions
JPS60251898A (ja)	1984-05-25	1985-12-12	Shiseido Co Ltd	醗酵法によるヒアルロン酸の製造方法
DE3531612A1 (de)	1984-09-04	1986-03-27	Chisso Corp., Osaka	Verfahren zur herstellung von hyaluronsaeure
JPS6163294A (ja) *	1984-09-05	1986-04-01	Chisso Corp	発酵法によるヒアルロン酸の製造法
US5171689A (en)	1984-11-08	1992-12-15	Matsushita Electric Industrial Co., Ltd.	Solid state bio-sensor
US4784990A (en) *	1985-01-18	1988-11-15	Bio-Technology General Corporation	High molecular weight sodium hyaluronate
US4780414A (en)	1985-01-18	1988-10-25	Bio-Technology General Corp.	Method of producing high molecular weight sodium hyallronate by fermentation of streptococcus
IT1208514B (it)	1985-03-19	1989-07-10	Eniricerche Spa	Vettori plasmidici ad espressione in escherichia coli e/o bacillussubtilis.
JPS61267189A (ja)	1985-05-22	1986-11-26	株式会社東芝	結束装置付入金集計機
JPS6232893A (ja)	1985-08-01	1987-02-12	Kyowa Hakko Kogyo Co Ltd	ヒアルロン酸の製造法
US5023175A (en)	1986-05-01	1991-06-11	Kabushiki Kaisha Yakult Honsha	Novel production process of hyaluronic acid and bacterium strain therefor
JPS6394988A (ja)	1986-10-08	1988-04-26	Meiji Seika Kaisha Ltd	ヒアルロン酸の製造法
JPH072117B2 (ja)	1986-10-09	1995-01-18	三菱レイヨン株式会社	ヒアルロン酸の製造法
EP0265578A1 (de)	1986-10-30	1988-05-04	Jan-Olof Eriksson	Zusammensetzung eines nicht abschleifenden Polier- und Reinigungsmittels und Verfahren zu ihrer Herstellung
US4822867A (en)	1987-02-02	1989-04-18	Semih Erhan	Protein polymer grafts
JPH02193818A (ja)	1989-01-23	1990-07-31	Okura Yusoki Co Ltd	パレット荷積み装置
US5015577A (en) *	1989-08-29	1991-05-14	Board Of Regents, The University Of Texas System	DNA encoding hyaluronate synthase
FR2652736A1 (fr)	1989-10-06	1991-04-12	Neftel Frederic	Dispositif implantable d'evaluation du taux de glucose.
JP2986519B2 (ja)	1990-07-24	1999-12-06	生化学工業株式会社	燐脂質結合グリコサミノグリカン
JPH04124854A (ja)	1990-09-17	1992-04-24	Nikko Kyodo Co Ltd	半導体装置の製造方法
CA2061703C (en) *	1992-02-20	2002-07-02	Rudolf E. Falk	Formulations containing hyaluronic acid
JPH04134854A (ja)	1990-09-26	1992-05-08	Shimadzu Corp	Ｉｃチップ間配線方法
JPH04158798A (ja)	1990-10-19	1992-06-01	Tdk Corp	酵素活性の測定方法
JPH0630605B2 (ja)	1990-10-23	1994-04-27	チッソ株式会社	ヒアルロン酸ナトリウム水溶液の製造法
IT1250421B (it)	1991-05-30	1995-04-07	Recordati Chem Pharm	Composizione farmaceutica a rilascio controllato con proprieta' bio-adesive.
US5217743A (en)	1992-02-07	1993-06-08	Paradigm Biotechnologies Partnership	Biomaterials of enhanced biocompatibility
US5621089A (en)	1992-05-27	1997-04-15	Novo Nordisk Biotech, Inc.	Nucleic acid constructs for the production of a Bacillus alkaline protease
IT1260153B (it) *	1992-06-19	1996-03-28	Michael O'regan	Individuazione di un frammento di dna codificante l'enzima acido ialuronico sintetasi (has) e della sua sequenza nucleotidica
DE69530914T2 (de)	1994-02-17	2004-03-11	New York Blood Center, Inc.	Biologische bioadhäsive präparate, die fibrinkleber und liposomen enthalten, verfahren für ihre herstellung und verwendung
IT1268954B1 (it)	1994-03-11	1997-03-18	Fidia Advanced Biopolymers Srl	Processo per la preparazione di acido ialuronico mediante sintesienzimatica e relative composizioni farmaceutiche
US5473034A (en)	1994-03-18	1995-12-05	Hyogo Prefectural Government	Method for producing protein-synthetic polymer conjugate and said conjugate produced thereby
EP0804582A1 (de)	1994-05-16	1997-11-05	The Uab Research Foundation	$i(STREPTOCOCCUS PNEUMONIAE) KAPSULÄRE POLYSACCHARIDGENEN UND FLANKIERENDE REGIONEN
SE9401806D0 (sv)	1994-05-26	1994-05-26	Pharmacia Ab	Method and means for the production of hyaluronic acid
US6951743B2 (en) *	1997-10-31	2005-10-04	University Of Oklahoma Board Of Regents	Hyaluronan synthase genes and expression thereof in bacillus hosts
US6455304B1 (en) *	1994-07-01	2002-09-24	The Board Of Regents Of The University Of Oklahoma	Hyaluronate synthase gene and uses thereof
US7091008B1 (en) *	1994-07-01	2006-08-15	The Board Of Regents Of The University Of Oklahoma	Hyaluronan synthase genes and expression thereof in Bacillus hosts
JPH0838336A (ja)	1994-08-01	1996-02-13	Matsushita Electric Ind Co Ltd	電気カーペット用カバー
CN1161060A (zh) *	1994-09-12	1997-10-01	M·G·伯杰龙	用于微生物学实验室日常诊断中迅速检测和鉴别临床样品中普通细菌病原体和抗生素抗性基因之特异性和通用性探针及扩增引物
US5831057A (en) *	1995-10-05	1998-11-03	Cold Spring Harbor Laboratory	Associative learning and the linotte gene
JP3420586B2 (ja)	1995-11-28	2003-06-23	ジェンベク、インコーポレイティッド	細胞への遣伝子導入のためのベクターおよび方法
WO1997020061A1 (en) *	1995-11-30	1997-06-05	The Scripps Research Institute	Synthesis of hyaluronic acid
SE9504304D0 (sv)	1995-11-30	1995-11-30	Sandvik Ab	Coated milling insert
US6423514B1 (en)	1996-04-22	2002-07-23	Millennium Pharmaceuticals, Inc.	Mammalian hyaluronan synthases, nucleic acids and uses thereof
US5610241A (en)	1996-05-07	1997-03-11	Cornell Research Foundation, Inc.	Reactive graft polymer with biodegradable polymer backbone and method for preparing reactive biodegradable polymers
US6492150B1 (en) *	1996-07-03	2002-12-10	Clear Colutions Biotech, Inc.	Gene encoding hyaluronan synthase
US6602693B1 (en) *	1996-07-03	2003-08-05	Clear Solutions Biotech, Inc.	Gene encoding hyaluronan synthase
CN1322121C (zh)	1997-10-31	2007-06-20	俄克拉何马大学董事会	透明质酸合酶基因及其应用
CN101113436B (zh)	1997-10-31	2013-02-06	俄克拉何马大学董事会	透明质酸合酶基因及其应用
US20060188966A1 (en)	1998-04-02	2006-08-24	Deangelis Paul L	Natural, chimeric and hybrid glycosaminoglycan polymers and methods of making and using same
US6987023B2 (en)	1998-04-02	2006-01-17	The Board Of Regents Of The University Of Oklahoma	DNA encoding hyaluronan synthase from Pasteurella multocida and methods of use
US20080108110A1 (en)	1998-04-02	2008-05-08	Deangelis Paul L	Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US7060469B2 (en)	1998-04-02	2006-06-13	The Board Of Regents Of The University Of Oklahoma	Polymer grafting by polysaccharide synthases
US7223571B2 (en)	1998-04-02	2007-05-29	The Board Of Regents Of The Universtiy Of Oklahoma	Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US7094581B2 (en) *	1998-10-26	2006-08-22	The Board Of Regents Of The University Of Oklahoma	Hyaluronan synthases and methods of making and using same
US20060105431A1 (en)	1998-11-11	2006-05-18	Deangelis Paul L	Polymer grafting by polysaccharide synthases using artificial sugar acceptors
DE69940353D1 (en)	1998-11-11	2009-03-12	Univ Oklahoma	Polymerpfropfung mittels polysaccharide-synthase
US7534589B2 (en)	1999-11-10	2009-05-19	The Board Of Regents Of The University Of Oklahoma	Polymer grafting by polysaccharide synthases
AU2002366711C1 (en)	2001-12-21	2009-01-22	Novozymes A/S	Methods for producing hyaluronan in a recombinant host cell
CA2572154A1 (en)	2004-06-30	2006-03-30	Paul L. Deangelis	Methods of selectively treating diseases with specific glycosaminoglycan polymers

1998
- 1998-10-30 CN CNB988127733A patent/CN1322121C/zh not_active Expired - Lifetime
- 1998-10-30 ES ES98957450T patent/ES2235378T3/es not_active Expired - Lifetime
- 1998-10-30 JP JP2000519083A patent/JP4731013B2/ja not_active Expired - Lifetime
- 1998-10-30 BR BRPI9814834-6A patent/BR9814834B1/pt not_active IP Right Cessation
- 1998-10-30 WO PCT/US1998/023153 patent/WO1999023227A2/en not_active Ceased
- 1998-10-30 AT AT98957450T patent/ATE284954T1/de active
- 1998-10-30 DK DK98957450T patent/DK1025211T3/da active
- 1998-10-30 AU AU13706/99A patent/AU762036B2/en not_active Expired
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- 1998-10-30 KR KR1020007004743A patent/KR20010031682A/ko not_active Ceased
- 1998-10-30 EP EP04029227A patent/EP1522579A3/de not_active Withdrawn
- 1998-10-30 CA CA2307842A patent/CA2307842C/en not_active Expired - Lifetime
- 1998-10-30 DE DE69828193T patent/DE69828193T2/de not_active Expired - Lifetime
1999
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2001
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2003
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2005
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Also Published As

Publication number	Publication date
JP2001521741A (ja)	2001-11-13
CN1322121C (zh)	2007-06-20
CN1283224A (zh)	2001-02-07
JP4731013B2 (ja)	2011-07-20
WO1999023227A9 (en)	2000-07-13
CA2307842C (en)	2010-10-19
US7153677B2 (en)	2006-12-26
US20070087416A1 (en)	2007-04-19
EP1025211A2 (de)	2000-08-09
AU762036B2 (en)	2003-06-19
BR9814834B1 (pt)	2011-08-23
US20060216794A1 (en)	2006-09-28
US20060216793A1 (en)	2006-09-28
CA2307842A1 (en)	1999-05-14
EP1522579A3 (de)	2007-11-07
US7504246B2 (en)	2009-03-17
KR20010031682A (ko)	2001-04-16
US20050202540A1 (en)	2005-09-15
US20060018924A1 (en)	2006-01-26
US7109011B2 (en)	2006-09-19
US7141409B2 (en)	2006-11-28
US20060216808A1 (en)	2006-09-28
DE69828193D1 (de)	2005-01-20
US7060466B2 (en)	2006-06-13
AU2003248204A1 (en)	2003-10-30
US20030082780A1 (en)	2003-05-01
EP1522579A2 (de)	2005-04-13
DK1025211T3 (da)	2005-04-04
US20030073221A1 (en)	2003-04-17
ES2235378T3 (es)	2005-07-01
AU1370699A (en)	1999-05-24
US20060013829A1 (en)	2006-01-19
WO1999023227A3 (en)	1999-08-19
EP1025211B1 (de)	2004-12-15
DE69828193T2 (de)	2005-12-01
US7087413B2 (en)	2006-08-08
WO1999023227A2 (en)	1999-05-14
BR9814834A (pt)	2001-07-17
US7166450B2 (en)	2007-01-23
US6833264B1 (en)	2004-12-21
US7115405B2 (en)	2006-10-03
US6991921B2 (en)	2006-01-31

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