ATE214287T1 - Verwendung von relaxin zur herstellung eines arzneimittels für die behandlung kardiovaskulären krankeiten. - Google Patents

Verwendung von relaxin zur herstellung eines arzneimittels für die behandlung kardiovaskulären krankeiten.

Info

Publication number
ATE214287T1
ATE214287T1 AT92918862T AT92918862T ATE214287T1 AT E214287 T1 ATE214287 T1 AT E214287T1 AT 92918862 T AT92918862 T AT 92918862T AT 92918862 T AT92918862 T AT 92918862T AT E214287 T1 ATE214287 T1 AT E214287T1
Authority
AT
Austria
Prior art keywords
relaxin
treatment
production
cardiovascular diseases
medicinal product
Prior art date
Application number
AT92918862T
Other languages
English (en)
Inventor
Michael Cronin
Phyllis L Osheroff
G Roger Thomas
David G Ward
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/747,080 external-priority patent/US5166191A/en
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE214287T1 publication Critical patent/ATE214287T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/64—Relaxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2221—Relaxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT92918862T 1991-08-19 1992-08-18 Verwendung von relaxin zur herstellung eines arzneimittels für die behandlung kardiovaskulären krankeiten. ATE214287T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/747,080 US5166191A (en) 1991-08-19 1991-08-19 Use of relaxin in cardiovascular therapy
US07/902,637 US5478807A (en) 1991-08-19 1992-06-23 Use of relaxin in the treatment of bradycardia
PCT/US1992/006927 WO1993003755A2 (en) 1991-08-19 1992-08-18 Use of relaxin in cardiovascular therapy and in the treatment of neurodegenerative diseases

Publications (1)

Publication Number Publication Date
ATE214287T1 true ATE214287T1 (de) 2002-03-15

Family

ID=27114692

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92918862T ATE214287T1 (de) 1991-08-19 1992-08-18 Verwendung von relaxin zur herstellung eines arzneimittels für die behandlung kardiovaskulären krankeiten.

Country Status (11)

Country Link
US (1) US5478807A (de)
EP (1) EP0600010B1 (de)
JP (1) JP3747058B2 (de)
AT (1) ATE214287T1 (de)
AU (1) AU662923B2 (de)
CA (1) CA2114250C (de)
DE (1) DE69232485T2 (de)
DK (1) DK0600010T3 (de)
ES (1) ES2173868T3 (de)
NZ (1) NZ243970A (de)
WO (1) WO1993003755A2 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995003822A2 (en) * 1993-07-27 1995-02-09 Mario Bigazzi Use of relaxin as therapeutic or preventing agent
US7069634B1 (en) 1995-04-28 2006-07-04 Medtronic, Inc. Method for manufacturing a catheter
US5911997A (en) * 1995-06-07 1999-06-15 Connetics Corporation Relaxin-like factor and methods and uses thereof
US5811395A (en) 1995-06-07 1998-09-22 Medical University Of South Carolina Relaxin analogs and derivatives methods and uses thereof
CA2229479C (en) 1995-08-15 2010-03-30 Connective Therapeutics, Inc. Method of promoting angiogenesis
US5612051A (en) * 1995-11-17 1997-03-18 Yue; Samuel K. Method of treating involuntary muscle dysfunction with relaxin hormone
US7189222B2 (en) 1996-04-30 2007-03-13 Medtronic, Inc. Therapeutic method of treatment of alzheimer's disease
US5846220A (en) 1996-04-30 1998-12-08 Medtronic, Inc. Therapeutic method for treatment of Alzheimer's disease
US6627746B1 (en) 1998-04-17 2003-09-30 Exelixis, Inc. Nucleic acids and proteins of C. elegans insulin-like genes and uses thereof
US6251863B1 (en) * 1998-09-08 2001-06-26 Samuel K. Yue Method of preventing and treating symptoms of aging and neurodegenerative dysfunctions with relaxin
US6266554B1 (en) 1999-02-12 2001-07-24 Cardiac Pacemakers, Inc. System and method for classifying cardiac complexes
US6308095B1 (en) 1999-02-12 2001-10-23 Cardiac Pacemakers, Inc. System and method for arrhythmia discrimination
US6312388B1 (en) * 1999-03-12 2001-11-06 Cardiac Pacemakers, Inc. Method and system for verifying the integrity of normal sinus rhythm templates
US6223078B1 (en) 1999-03-12 2001-04-24 Cardiac Pacemakers, Inc. Discrimination of supraventricular tachycardia and ventricular tachycardia events
US6449503B1 (en) * 1999-07-14 2002-09-10 Cardiac Pacemakers, Inc. Classification of supraventricular and ventricular cardiac rhythms using cross channel timing algorithm
US6684100B1 (en) 2000-10-31 2004-01-27 Cardiac Pacemakers, Inc. Curvature based method for selecting features from an electrophysiologic signals for purpose of complex identification and classification
DE10155843A1 (de) * 2000-11-16 2003-01-30 Immundiagnostik Ag Verfahren zur Prognose und Diagnose von Herzinsuffizienz
US20040006205A1 (en) * 2001-04-03 2004-01-08 Li Li Therapeutic polypeptides, nucleic acids encoding same, and methods of use
US6526313B2 (en) 2001-06-05 2003-02-25 Cardiac Pacemakers, Inc. System and method for classifying cardiac depolarization complexes with multi-dimensional correlation
AUPR814401A0 (en) 2001-10-08 2001-11-01 Howard Florey Institute Of Experimental Physiology And Medicine Human 3 relaxin
US6950702B2 (en) 2002-07-15 2005-09-27 Cardiac Pacemakers, Inc. Use of curvature based features for beat detection
US7792571B2 (en) 2003-06-27 2010-09-07 Cardiac Pacemakers, Inc. Tachyarrhythmia detection and discrimination based on curvature parameters
US7878978B2 (en) * 2004-03-18 2011-02-01 University Of Pittsburgh- Of The Commonwealth System Of Higher Education Use of relaxin to increase arterial compliance
AU2005223694B2 (en) * 2004-03-19 2011-04-28 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Use of relaxin to increase arterial compliance
US7430446B2 (en) 2005-01-20 2008-09-30 Cardiac Pacemakers, Inc. Methods and apparatuses for cardiac arrhythmia classification using morphology stability
EP1880728A4 (de) * 2005-04-26 2010-03-31 Eisai R&D Man Co Ltd Peptid mit wirkung gegen angstzustände und screening-verfahren dafür
US20060264367A1 (en) * 2005-05-21 2006-11-23 Howard Florey Institute Prevention of fibrosis following cardiac injury
US9314210B2 (en) 2005-06-13 2016-04-19 Cardiac Pacemakers, Inc. Method and apparatus for rate-dependent morphology-based cardiac arrhythmia classification
EP1989144A4 (de) 2006-02-02 2014-01-29 Innovative Bio Therapies Extrakorporale zellbasierte therapeutische vorrichtung und freisetzungssystem
JP5651586B2 (ja) 2008-05-16 2015-01-14 コーセラ，インコーポレーテッド 急性心不全に伴う呼吸困難のリラキシンによる治療
WO2010071692A2 (en) 2008-06-18 2010-06-24 Innovative Biotherapies, Inc. Methods for enhanced propagation of cells
US9653006B2 (en) 2008-09-17 2017-05-16 Avery Dennison Corporation Activatable adhesive, labels, and related methods
RU2552497C2 (ru) 2009-09-17 2015-06-10 Авери Деннисон Корпорейшн Способные активироваться адгезивы, этикетки и соответствующие способы
KR102533456B1 (ko) 2016-05-18 2023-05-17 모더나티엑스, 인크. 릴랙신을 인코딩하는 폴리뉴클레오타이드
JP2025528469A (ja) 2022-08-31 2025-08-28 リラクセラ ファルマツォイティッシュ ゲゼルシャフト エムベーハー ウント コー． カーゲー 免疫抑制薬及び処置方法
WO2025056188A1 (en) 2023-09-15 2025-03-20 Relaxera Pharmazeutische Gmbh & Co. Kg Relaxin medication

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4656249A (en) * 1982-06-10 1987-04-07 Howard Florey Institute Of Experimental Physiology And Medicine Peptides with relaxin activity
AU562962B2 (en) * 1982-08-12 1987-06-25 Howard Florey Institute Of Experimental Physiology And Medicine Molecular cloning and characterisation of the gene sequence coding for human relaxin
EP0101309B1 (de) * 1982-08-12 1991-01-16 Howard Florey Institute Of Experimental Physiology And Medicine Molekulare Klonierung und Charakterisierung der das menschliche Relaxin kodierenden Gen-Sequenz
DE3236264A1 (de) * 1982-09-30 1984-04-05 Serono Pharmazeutische Präparate GmbH, 7800 Freiburg Verfahren zur gewinnung von relaxin
DE3236267A1 (de) * 1982-09-30 1984-04-05 Serono Pharmazeutische Präparate GmbH, 7800 Freiburg Verfahren zur herstellung von relaxin und verfahren zur hochreinigung von relaxin
IL70414A (en) * 1982-12-13 1991-06-10 Florey Howard Inst Polypeptide having human h2-relaxin activity,double-stranded dna fragments coding therefor,vectors containing the dna fragments and methods for preparing the polypeptide,dna fragments and vectors
AU562713B2 (en) * 1982-12-13 1987-06-18 Howard Florey Institute Of Experimental Physiology And Medicine Cloning for human relaxin
US5023321A (en) * 1982-12-13 1991-06-11 Howard Florey Institute Of Experimental Physiology & Medicine Molecular cloning and characterization of a further gene sequence coding for human relaxin
US4835251A (en) * 1986-06-23 1989-05-30 Genetech, Inc. Method of chain combination
AU626840B2 (en) * 1988-02-26 1992-08-13 Genentech Inc. Human relaxin formulation
CA2051375C (en) * 1989-05-04 2000-09-12 Dennis J. Henner Process and compositions for the isolation of human relaxin
US5166191A (en) * 1991-08-19 1992-11-24 Genentech, Inc. Use of relaxin in cardiovascular therapy

Also Published As

Publication number Publication date
JPH06510045A (ja) 1994-11-10
ES2173868T3 (es) 2002-11-01
DK0600010T3 (da) 2002-07-01
AU662923B2 (en) 1995-09-21
JP3747058B2 (ja) 2006-02-22
WO1993003755A2 (en) 1993-03-04
EP0600010B1 (de) 2002-03-13
US5478807A (en) 1995-12-26
AU2518692A (en) 1993-03-16
NZ243970A (en) 1997-06-24
DE69232485T2 (de) 2002-11-21
DE69232485D1 (de) 2002-04-18
CA2114250C (en) 2007-10-16
WO1993003755A3 (en) 1993-04-01
CA2114250A1 (en) 1993-03-04
EP0600010A1 (de) 1994-06-08

Similar Documents

Publication Publication Date Title
ATE214287T1 (de) Verwendung von relaxin zur herstellung eines arzneimittels für die behandlung kardiovaskulären krankeiten.
ATE332702T1 (de) Verwendung von glu-trp dipeptiden zur herstellung eines arzneimittels zur behandlung von verschiedenen gefässneubildung-assozierten erkrankungen
MXPA03003960A (es) Combinaciones de farmacos (v.gr., clorpromazina y pentamidina) para el tratamiento de desordenes neoplasticos.
DE69434431D1 (de) Methoden zur behandlung von muskelerkrankungen und muskelstörungen
DE3484055D1 (de) Verwendung von ubidecarenon zur herstellung eines medikaments zur behandlung von durch radiotherapie hervorgerufenen geschwueren.
DE59205846D1 (de) Azaheterocyclylmethyl-chromane als Wirkstoffe zur Behandlung von Erkrankungen des Zentralnervensystems
DE3585607D1 (de) Verwendung von paroxetine zur herstellung eines arzneimittel zur behandlung von obesitaet.
DE69713620D1 (de) Verwendung von arachidonsäure und/oder docohexaensäure zur herstellung eines arzneimittels zur behandlung von dyspraxia
ATE192923T1 (de) Verwendung von boswelliasäure zur behandlung von hirntumoren
EP0319962A3 (de) Piperidinyl-Methanol-Derivate zur Behandlung von Angstzuständen
HU9201799D0 (en) New 2-amino-5-ciano-1,4-dihydropiridine-derivatives, process for their use and their use as medicaments
EE9700231A (et) Aminotetraliini derivaat kardiovaskulaarsete haiguste raviks
ATE235237T1 (de) Sertralin zur behandlung von post-myocard-infarkt-patienten
DE3380923D1 (de) Pharmazeutische zusammensetzungen zur behandlung von stoerungen, bedingt durch humanendrogen.
DE3578374D1 (de) Verwendung von chinolonen fuer die herstellung eines arzneimittels zur behandlung von herzerkrankungen.
ATE234613T1 (de) Verwendung von comt inhibitoren zur herstellung eines arzneimittels zur vorbeugung von diabetischen vaskulären funktionsstörungen
DE69701258D1 (de) Verwendung von benzonaphtalene-derivaten zur herstellung eines arzneimittels zur behandlung von krankheiten des nervensystems
ATE222762T1 (de) 4-hydroxycoumarin-3-carboxamide für die behandlung von nicht-insulin-abhängigen diabetes mellitus
ATE239492T1 (de) Verwendung von einem bpi protein zur herstellung eines medikamentes zur behandlung von chronischen herzerkrankungen
ATE207353T1 (de) Verwendung von benzydamin zur behandlung von krankheitszuständen, die durch tnf verursacht werden
DE60123105D1 (de) Verfahren zur Herstellung von 4'-O-substituierten 4'-Demethyl-1 desoxypodophyllotoxinderivaten und geometrischen Isomeren davon ,und Antikrebspräparat, das diese enthält
DE69905489D1 (de) Protein c zur behandlung von sichelzellanämie und thalassämie
ATE320263T1 (de) Verwendung von menschliche protein c zur herstellung eines arzneimittels zur behandlung von heparininduzierter thrombozytopenie
ATE263565T1 (de) Verwendung von 8,9-dehydroestron zur herstellung eines arzneimittels zur behandlung von durch freie radikale verursachte krankheiten
ATE186640T1 (de) Verwendung von efaroxan und dessen derivaten zur herstellung eines arzneimittels zur behandlung neurogenerativer erkrankungen

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0600010

Country of ref document: EP