ATE332702T1 - Verwendung von glu-trp dipeptiden zur herstellung eines arzneimittels zur behandlung von verschiedenen gefässneubildung-assozierten erkrankungen - Google Patents

Verwendung von glu-trp dipeptiden zur herstellung eines arzneimittels zur behandlung von verschiedenen gefässneubildung-assozierten erkrankungen

Info

Publication number
ATE332702T1
ATE332702T1 AT96934021T AT96934021T ATE332702T1 AT E332702 T1 ATE332702 T1 AT E332702T1 AT 96934021 T AT96934021 T AT 96934021T AT 96934021 T AT96934021 T AT 96934021T AT E332702 T1 ATE332702 T1 AT E332702T1
Authority
AT
Austria
Prior art keywords
glu
treatment
production
associated diseases
medicinal product
Prior art date
Application number
AT96934021T
Other languages
English (en)
Inventor
Lawrence R Green
John W Blasecki
Original Assignee
Cytran Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytran Ltd filed Critical Cytran Ltd
Application granted granted Critical
Publication of ATE332702T1 publication Critical patent/ATE332702T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
AT96934021T 1995-10-03 1996-10-02 Verwendung von glu-trp dipeptiden zur herstellung eines arzneimittels zur behandlung von verschiedenen gefässneubildung-assozierten erkrankungen ATE332702T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53870195A 1995-10-03 1995-10-03
US08/614,764 US5902790A (en) 1995-10-03 1996-03-13 Pharmaceutical angiostatic dipeptide compositions and method of use thereof

Publications (1)

Publication Number Publication Date
ATE332702T1 true ATE332702T1 (de) 2006-08-15

Family

ID=27065900

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96934021T ATE332702T1 (de) 1995-10-03 1996-10-02 Verwendung von glu-trp dipeptiden zur herstellung eines arzneimittels zur behandlung von verschiedenen gefässneubildung-assozierten erkrankungen

Country Status (23)

Country Link
US (4) US5902790A (de)
EP (1) EP0869808B1 (de)
JP (2) JP3679129B2 (de)
KR (1) KR100483779B1 (de)
CN (1) CN1128636C (de)
AT (1) ATE332702T1 (de)
AU (1) AU714846B2 (de)
BR (1) BR9610838A (de)
CA (1) CA2233457C (de)
CZ (1) CZ298345B6 (de)
DE (1) DE69636343T2 (de)
DK (1) DK0869808T3 (de)
EA (1) EA001146B1 (de)
ES (1) ES2268710T3 (de)
HU (1) HUP9902105A3 (de)
IL (1) IL123889A0 (de)
MX (1) MX9802564A (de)
NO (1) NO326298B1 (de)
NZ (1) NZ319907A (de)
PL (1) PL186123B1 (de)
SK (1) SK283677B6 (de)
TR (1) TR199800653T1 (de)
WO (1) WO1997012625A1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5902790A (en) * 1995-10-03 1999-05-11 Cytran, Inc. Pharmaceutical angiostatic dipeptide compositions and method of use thereof
US6060452A (en) * 1996-03-13 2000-05-09 Cytran, Inc. Analogs of L-Glu-L-Trp having pharmacological activity
AU3467099A (en) * 1998-04-03 1999-10-25 Cytran Ltd. Methods for production of therapeutic cytokines
AU2001279313B2 (en) 2000-08-04 2007-03-01 Ampio Pharmaceuticals, Inc. Method of using diketopiperazines and composition containing them
JP2004520330A (ja) * 2001-01-02 2004-07-08 インスティテュート ヒューア メディツィンテクノロギー マグデブルク ゲーエムベーハー イーエムテーエム 動脈硬化症の治療と予防的治療、ゲル−クームズ分類ｉ型のアレルギー反応の治療と予防、ならびに、毛包性および表皮性の過角化症とケラチノサイトの促進された増殖を伴う皮膚病の治療と予防のための、酵素阻害因子およびその薬剤化合物の併用
DE10100052A1 (de) * 2001-01-02 2002-07-11 Inst Medizintechnologie Magdeb Kombinierte Verwendung von Enzyminhibitoren und pharmazeutischen Zubereitungen daraus zur Therapie und Prophylaxe der Atheriosklerose
US20030087830A1 (en) * 2001-06-12 2003-05-08 Eric Dupont Low molecular weight components of cartilage, complexes of metals with amino acids, DI-peptides and analogs thereof; processes for preparation and therapeutic uses thereof
RU2213571C2 (ru) * 2001-11-30 2003-10-10 Филиппова Ольга Всеволодовна Антигипоксическое средство
ATE520981T1 (de) 2002-10-02 2011-09-15 Dmi Biosciences Inc Diagnose und überwachung von krankheiten
CA3050734A1 (en) 2003-05-15 2004-12-02 Ampio Pharmaceuticals, Inc. Treatment of t-cell mediated diseases
WO2005016326A2 (en) * 2003-07-11 2005-02-24 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Analogs of thalidomide as potential angiogenesis inhibitors
WO2005028436A2 (en) 2003-09-17 2005-03-31 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Thalidomide analogs as tnf-alpha modulators
US8952895B2 (en) 2011-06-03 2015-02-10 Apple Inc. Motion-based device operations
US20080233053A1 (en) * 2005-02-07 2008-09-25 Pharmalight Inc. Method and Device for Ophthalmic Administration of Active Pharmaceutical Ingredients
CA2569204A1 (en) 2006-11-28 2008-05-28 Apotex Technologies Inc. Crystalline d-isoglutamyl-d-tryptophan and the mono ammonium salt of d-isoglutamyl-d-tryptophan
CA2571645A1 (en) * 2006-12-19 2008-06-19 Apotex Technologies Inc. Pharmaceutically acceptable salts of thymodepressin and processes for their manufacture
EP2120986A4 (de) * 2007-02-13 2010-04-07 Sciclone Pharmaceuticals Inc Verfahren zur behandlung oder prävention von gewebeverschleiss, -verletzungen oder -schäden aufgrund von erkrankungen der schleimhaut
CA2579119C (en) * 2007-02-16 2013-03-05 Apotex Technologies Inc. Crystalline forms of the mono-sodium salt of d-isoglutamyl-d-tryptophan
CN101842009A (zh) * 2007-08-23 2010-09-22 赛生制药有限公司 肺癌的治疗
WO2009146320A1 (en) 2008-05-27 2009-12-03 Dmi Life Sciences, Inc. Therapeutic methods and compounds
DE102008032828A1 (de) * 2008-07-02 2010-01-07 Technische Universität Dresden Tryptophanhaltige Peptide aus alpha-Lactalbumin mit blutdrucksenkender und vasoprotektiver Wirkung für biofunktionelle Lebensmittel
US8507496B2 (en) 2010-09-07 2013-08-13 Dmi Acquisition Corp. Treatment of diseases
EA027343B1 (ru) 2011-10-10 2017-07-31 Ампио Фармасьютикалз, Инк. Имплантируемые устройства медицинского назначения с повышенной иммунной толерантностью и способы изготовления и имплантирования
EP2766029B1 (de) 2011-10-10 2020-03-25 Ampio Pharmaceuticals, Inc. Behandlung degenerativer gelenkerkrankungen
CA2846394A1 (en) 2011-10-28 2013-05-02 Ampio Pharmaceuticals, Inc. Treatment of rhinitis
US8927725B2 (en) 2011-12-02 2015-01-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Thio compounds
CN102631464B (zh) * 2012-05-18 2013-07-31 崔新明 一种治疗婴幼儿血管瘤的中药膏剂及其制备方法
BR112015020469A2 (pt) 2013-03-15 2020-01-28 Ampio Pharmaceuticals Inc Usos de da-dkp, composição e método para fornecimento de células-tronco a umindivíduo
AU2015305611B2 (en) 2014-08-18 2020-04-23 Ampio Pharmaceuticals, Inc. Treatment of joint conditions
US9750785B2 (en) 2015-01-30 2017-09-05 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9687526B2 (en) 2015-01-30 2017-06-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9744239B2 (en) 2015-01-30 2017-08-29 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9925233B2 (en) 2015-01-30 2018-03-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9744209B2 (en) 2015-01-30 2017-08-29 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9937223B2 (en) 2015-01-30 2018-04-10 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US11389512B2 (en) 2015-06-22 2022-07-19 Ampio Pharmaceuticals, Inc. Use of low molecular weight fractions of human serum albumin in treating diseases
WO2019043649A2 (en) * 2017-08-31 2019-03-07 Singapore Health Services Pte Ltd ANGIO -3 FOR THE TREATMENT OF RETINAL ANGIOGENIC DISEASES
CN116874557B (zh) * 2023-08-01 2024-12-20 首都医科大学 2-Trp-AA-四氢咔啉-3-羧酸类化合物及其PAF抑制剂的应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH611878A5 (de) * 1974-07-04 1979-06-29 Takeda Chemical Industries Ltd
US4191753A (en) * 1978-11-06 1980-03-04 University Of Miami Anti-hypertensive peptide analogs
AU616236B2 (en) * 1987-12-30 1991-10-24 Cytran Ltd. Pharmaceutical preparation for treating immunodeficiency conditions
US5728680A (en) * 1987-12-30 1998-03-17 Cytoven J.V. Methods for normalizing numbers of lymphocytes
GR1000608B (el) * 1988-07-21 1992-08-31 Erba Carlo Spa Μεθοδος για την παρασκευη ανταγωνιστων bombesin.
SU1642398A1 (ru) * 1988-12-21 1991-04-15 Ростовский медицинский институт Способ лечени синуитов у детей
US5902790A (en) * 1995-10-03 1999-05-11 Cytran, Inc. Pharmaceutical angiostatic dipeptide compositions and method of use thereof
US5770576A (en) * 1989-08-30 1998-06-23 Cytran, Inc. Pharmaceutical dipeptide compositions and methods of use thereof: systemic toxicity
RU1827255C (ru) * 1990-10-22 1993-07-15 Киевский государственный институт усовершенствования врачей Способ лечени туберкулеза легких
JP3068656B2 (ja) * 1991-03-07 2000-07-24 アピ株式会社 新規なペプチド及びアンジオテンシン変換酵素阻害ペプチド並びにそれらを含有する経口摂食組成物
CA2107460A1 (en) * 1991-04-01 1992-10-02 Vladimir K. Khavinson Pharmaceutical dipeptide compositions and methods of use thereof
RU2014063C1 (ru) * 1991-04-23 1994-06-15 Сочинский научно-исследовательский институт курортологии и физиотерапии Способ лечения подострых воспалительных заболеваний гениталий
WO1993008815A1 (en) * 1991-10-28 1993-05-13 Cytoven Pharmaceutical dipeptide compositions and methods of use thereof
WO1995003067A1 (en) * 1993-07-21 1995-02-02 Khavinson Vladimir Khatskelevi Pharmaceutical with immunomodulating activity
DE69435301D1 (de) * 1993-09-24 2010-08-26 Univ Southern California Verwendung von Angiotensin-II-Analogen zur Gewebewiederherstellung

Also Published As

Publication number Publication date
DE69636343T2 (de) 2007-07-19
PL326149A1 (en) 1998-08-31
EP0869808B1 (de) 2006-07-12
CA2233457C (en) 2004-08-03
CZ91398A3 (cs) 1998-11-11
US6911431B1 (en) 2005-06-28
ES2268710T3 (es) 2007-03-16
EA199800357A1 (ru) 1998-10-29
SK42398A3 (en) 1998-10-07
US5902790A (en) 1999-05-11
US6096713A (en) 2000-08-01
PL186123B1 (pl) 2003-10-31
HUP9902105A2 (hu) 1999-09-28
KR19990063958A (ko) 1999-07-26
HUP9902105A3 (en) 2001-02-28
DE69636343D1 (de) 2006-08-24
JP3679129B2 (ja) 2005-08-03
US20060094665A1 (en) 2006-05-04
NO981436L (no) 1998-05-19
NO981436D0 (no) 1998-03-30
WO1997012625A1 (en) 1997-04-10
CN1198673A (zh) 1998-11-11
NZ319907A (en) 2000-09-29
AU714846B2 (en) 2000-01-13
JP2005194287A (ja) 2005-07-21
BR9610838A (pt) 1999-12-21
CZ298345B6 (cs) 2007-09-05
KR100483779B1 (ko) 2007-03-02
TR199800653T1 (xx) 1998-06-22
DK0869808T3 (da) 2006-11-13
MX9802564A (es) 1998-11-30
SK283677B6 (sk) 2003-11-04
JPH11504943A (ja) 1999-05-11
EA001146B1 (ru) 2000-10-30
CN1128636C (zh) 2003-11-26
IL123889A0 (en) 1998-10-30
EP0869808A1 (de) 1998-10-14
NO326298B1 (no) 2008-11-03
AU7254096A (en) 1997-04-28
CA2233457A1 (en) 1997-04-10

Similar Documents

Publication Publication Date Title
DE69636343D1 (de) Verwendung von glu-trp dipeptiden zur herstellung eines arzneimittels zur behandlung von verschiedenen gefässneubildung-assozierten erkrankungen
DE69713526D1 (de) Lösliche prodrugs von paclitaxel
DE69636085D1 (de) Verwendung von gamma-Linolensäure oder Dihomogammalinolensäure zur Herstellung eines Medikaments zur Behandlung von Huntington's Chorea
ATE205086T1 (de) Verwendung von dem chelatbildner clioquinol zur herstellung eines arzneimittelszur behandlung von alzheimerschen krankheit
DE3876877D1 (de) Verwendung von indolon-derivaten zur herstellung von arzneimitteln zur behandlung des parkinsonismus.
ATE185268T1 (de) Fortschrittliches arzneistoffabgabesystem und verfahren zur behandlung von psychiatrischen, neurologischen und anderen erkrankungen mit carbamazepin
DE3684190D1 (de) Verwendung von tetrahydrobiopterinen zur herstellung eines medikaments zur behandlung von kinderautismus.
ATE205389T1 (de) Verwendung von lokalanaesthetika zur herstellung eines arzneimittels zur behandlung von bronchialasthma
ATE152910T1 (de) Verwendung von taxol zur herstellung eines arzneimittels zur behandlung von krebs
ATE214287T1 (de) Verwendung von relaxin zur herstellung eines arzneimittels für die behandlung kardiovaskulären krankeiten.
ATE353645T1 (de) Verwendung von 2-oxo-1-pyrrolidin-derivaten zur herstellung eines arzneimittels zur behandlung von dyskinesia
DE69515038D1 (de) Verwendung von raloxifen und dessen analogen zur herstellung eines medikaments zur behandlung viraler erkrankungen
DE59508961D1 (de) Verwendung von weihrauch zur behandlung der alzheimer-krankheit
ATE194497T1 (de) Monoklonale antikoerper gegen lfa-1 zur herstellung eines arzneimittels zur vorbeugung der transplantatabstossung von organen
ATE206914T1 (de) Verwendung von ursolsäure zur herstellung eines arzneimittels zur unterdrückung von metastasen
DE69130679D1 (de) Die herstellung von zusammensetzungen zur behandlung von krankheiten der zellproliferation
DE3686520D1 (de) Verwendung von einigen alkanoyl-l-carnitinen zur herstellung eines arzneimittels zur therapeutischen behandlung von ideopathischem oder induziertem parkinsonismus.
ATE194076T1 (de) Verwendung von n,s-diacetylcystein-ethylester (dacee) zur herstellung eines medikaments zur behandlung viraler erkrankungen
ATE192650T1 (de) Verwendung von efaroxan und dessen derivaten zur herstellung eines arzneimittels zur behandlung parkinsonscher krankheit
DE68905657D1 (de) Verwendung von arginin-aspartat zur herstellung eines arzneimittels zur behandlung gewisser gedaechtnisstoerungen.
DE69701258D1 (de) Verwendung von benzonaphtalene-derivaten zur herstellung eines arzneimittels zur behandlung von krankheiten des nervensystems
ATE239492T1 (de) Verwendung von einem bpi protein zur herstellung eines medikamentes zur behandlung von chronischen herzerkrankungen
DE3578374D1 (de) Verwendung von chinolonen fuer die herstellung eines arzneimittels zur behandlung von herzerkrankungen.
ATE186640T1 (de) Verwendung von efaroxan und dessen derivaten zur herstellung eines arzneimittels zur behandlung neurogenerativer erkrankungen
ATE263565T1 (de) Verwendung von 8,9-dehydroestron zur herstellung eines arzneimittels zur behandlung von durch freie radikale verursachte krankheiten

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties