ATE214396T1 - Kombinatorische bibliotheken aus markierten biochemischen verbindungen und verfahren zu ihrer herstellung - Google Patents

Kombinatorische bibliotheken aus markierten biochemischen verbindungen und verfahren zu ihrer herstellung

Info

Publication number
ATE214396T1
ATE214396T1 AT96919473T AT96919473T ATE214396T1 AT E214396 T1 ATE214396 T1 AT E214396T1 AT 96919473 T AT96919473 T AT 96919473T AT 96919473 T AT96919473 T AT 96919473T AT E214396 T1 ATE214396 T1 AT E214396T1
Authority
AT
Austria
Prior art keywords
labeled
methods
labeled biochemical
biochemical compounds
combinatorial libraries
Prior art date
Application number
AT96919473T
Other languages
English (en)
Inventor
Jonathan M Brown
F C Thomas Allnutt
Hao Chen
Richard Radmer
Original Assignee
Martek Biosciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Martek Biosciences Corp filed Critical Martek Biosciences Corp
Application granted granted Critical
Publication of ATE214396T1 publication Critical patent/ATE214396T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047Simultaneous synthesis of different peptide species; Peptide libraries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Indole Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT96919473T 1995-06-21 1996-06-13 Kombinatorische bibliotheken aus markierten biochemischen verbindungen und verfahren zu ihrer herstellung ATE214396T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49330095A 1995-06-21 1995-06-21
PCT/US1996/010526 WO1997000887A1 (en) 1995-06-21 1996-06-13 Combinatorial libraries of labeled biochemical compounds and methods for producing same

Publications (1)

Publication Number Publication Date
ATE214396T1 true ATE214396T1 (de) 2002-03-15

Family

ID=23959668

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96919473T ATE214396T1 (de) 1995-06-21 1996-06-13 Kombinatorische bibliotheken aus markierten biochemischen verbindungen und verfahren zu ihrer herstellung

Country Status (11)

Country Link
US (1) US5741713A (de)
EP (1) EP0839152B1 (de)
JP (1) JPH11509086A (de)
AT (1) ATE214396T1 (de)
AU (1) AU6180696A (de)
CA (1) CA2225313A1 (de)
DE (1) DE69619825T2 (de)
DK (1) DK0839152T3 (de)
ES (1) ES2174075T3 (de)
PT (1) PT839152E (de)
WO (1) WO1997000887A1 (de)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999055825A1 (en) * 1998-04-30 1999-11-04 Mirus Corporation A process of making a compound by forming a polymer from a template drug
WO2001044828A1 (en) * 1999-12-17 2001-06-21 Maxygen, Inc. Methods for parallel detection of compositions having desired characteristics by means of mri spectroscopy
EP1326892A2 (de) 2000-10-12 2003-07-16 University of Rochester Zusammensetzungen die die proliferation von krebszellen hemmen
US7367155B2 (en) 2000-12-20 2008-05-06 Monsanto Technology Llc Apparatus and methods for analyzing and improving agricultural products
WO2003065997A2 (en) 2002-02-06 2003-08-14 Vicor Technologies, Inc. Anti-infarction molecules
AU2003253580A1 (en) * 2002-02-26 2003-11-17 University Of Minnesota Variants of nedd4l associated with hypertension and viral budding
AU2003260261A1 (en) 2002-04-04 2003-10-20 Monsanto Technology Llc Automated picking, weighing and sorting system for particulate matter
EP1575992A4 (de) 2002-08-05 2007-02-21 Univ Rochester Chimäre proteine aus proteintransduzierender domäne/deaminase, verwandte verbindungen und deren verwendungen
US20040214232A1 (en) * 2002-08-16 2004-10-28 Burke Martin D. Generation of skeletal diversity within a combinatorial library
JP2005538573A (ja) 2002-09-05 2005-12-15 ナノシス・インク. ナノ構造及びナノ複合材をベースとする組成物
BRPI0414708B1 (pt) 2003-09-23 2019-05-14 Monsanto Technology Llc Sistema e método para processamento de sementes.
CN101052295B (zh) 2004-08-26 2014-03-05 孟山都技术有限公司 种子自动检验
US7703238B2 (en) 2004-08-26 2010-04-27 Monsanto Technology Llc Methods of seed breeding using high throughput nondestructive seed sampling
US8076090B2 (en) 2005-04-05 2011-12-13 Corning Incorporated Label free biosensors and cells
CA2789262C (en) 2005-04-28 2016-10-04 Proteus Digital Health, Inc. Pharma-informatics system
AU2005332058B2 (en) 2005-05-19 2011-12-01 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, Centers For Disease Control And Prevention Functional epitopes of Streptococcus pneumoniae PsaA antigen and uses thereof
ES2626018T3 (es) 2005-06-07 2017-07-21 Dsm Nutritional Products Ag Microorganismos eucariotas para la producción de lípidos y antioxidantes
EP2392645A1 (de) 2005-10-14 2011-12-07 MUSC Foundation For Research Development Targeting von PAX2 zur Induktion der DEFB1-vermittelten Tumorimmunität und Krebstherapie
US8080534B2 (en) * 2005-10-14 2011-12-20 Phigenix, Inc Targeting PAX2 for the treatment of breast cancer
WO2007053570A2 (en) * 2005-10-31 2007-05-10 Janssen Pharmaceutica N.V. A polypeptide complex of trpm8 and calmodulin and its uses thereof
US7998669B2 (en) 2006-03-02 2011-08-16 Monsanto Technology Llc Automated contamination-free seed sampler and methods of sampling, testing and bulking seeds
US8028469B2 (en) 2006-03-02 2011-10-04 Monsanto Technology Llc Automated high-throughput seed sampler and methods of sampling, testing and bulking seeds
GB0605584D0 (en) * 2006-03-20 2006-04-26 Olink Ab Method for analyte detection using proximity probes
EP2035157B1 (de) 2006-06-28 2017-09-06 Monsanto Technology, LLC System zur sortierung kleiner objekte
CN101981201A (zh) * 2006-08-01 2011-02-23 加拿大海洋营养食品有限公司 产油微生物及改良这些微生物的方法
EP2560001B1 (de) 2006-09-21 2016-04-13 University of Rochester Zusammensetzungen und Verfahren für eine Proteinverlagerungstherapie für myotone Dystrophie
US8999317B2 (en) 2006-11-01 2015-04-07 University Of Rochester Methods and compositions related to the structure and function of APOBEC3G
US20100129358A1 (en) 2006-12-22 2010-05-27 University Of Utah Research Foundation Method of detecting ocular diseases and pathologic conditions and treatment of same
JP2010514839A (ja) 2007-01-03 2010-05-06 バーナム インスティテュート フォー メディカル リサーチ クロット結合化合物に関連する方法および組成物
WO2008098182A1 (en) 2007-02-08 2008-08-14 University Of Utah Research Foundation Methods and compositions related to inhibition of viral entry
WO2008150903A1 (en) 2007-05-31 2008-12-11 Monsanto Technology Llc Seed sorter
US8961412B2 (en) 2007-09-25 2015-02-24 Proteus Digital Health, Inc. In-body device with virtual dipole signal amplification
WO2010019963A2 (en) * 2008-08-15 2010-02-18 Georgetown University Na channels, disease, and related assays and compositions
US20120070443A1 (en) 2008-12-02 2012-03-22 University Of Utah Research Foundation Pde1 as a target therapeutic in heart disease
PT2373988E (pt) 2008-12-05 2015-06-03 C2N Diagnostics Métodos para medir concentrações de biomoléculas
WO2010129288A2 (en) 2009-04-28 2010-11-11 Proteus Biomedical, Inc. Highly reliable ingestible event markers and methods for using the same
WO2011022502A1 (en) 2009-08-18 2011-02-24 Georgetown University Boronic acid compositions and methods related to cancer
JP2013507365A (ja) 2009-10-07 2013-03-04 サンフォード−バーナム メディカル リサーチ インスティテュート 血餅結合脂質化合物に関する方法および組成物
CA2784145A1 (en) 2009-12-18 2011-06-23 Sanford-Burnham Medical Research Institute Methods and compositions related to clot-binding compounds
GB201004292D0 (en) * 2010-03-15 2010-04-28 Olink Ab Assay for localised detection of analytes
GB201101621D0 (en) 2011-01-31 2011-03-16 Olink Ab Method and product
CA2868735C (en) 2011-03-28 2020-02-25 University Of Utah Research Foundation D-peptide conjugates comprising a membrane localizing potency-enhancing cargo molecule for inhibiting hiv entry
BR112014008862A2 (pt) 2011-10-14 2018-08-07 Genentech Inc anticorpo isolado que se liga à htra1, ácido nucleico isolado, célula hospedeira, imunoconjugado, formulação farmacêutica, métodos e usos
EP2786137A4 (de) * 2011-12-02 2015-06-17 C2N Diagnostics Verfahren zur messung von biomolekülkonzentrationen
GB201201547D0 (en) 2012-01-30 2012-03-14 Olink Ab Method and product
WO2014139979A1 (en) 2013-03-12 2014-09-18 Ventana Medical Systems, Inc. Quantum dot in situ hybridization
CA2901513C (en) 2013-03-12 2020-12-29 Ventana Medical Systems, Inc. Proximity assay for in situ detection of targets
DK2970926T3 (en) 2013-03-13 2018-04-16 Dsm Nutritional Products Ag GENMANIPULATION OF MICROorganisms
CN107003323B (zh) 2014-11-25 2019-06-04 文塔纳医疗系统公司 使用化学连接和半抗原转移的邻近测定法
GB201518655D0 (en) 2015-10-21 2015-12-02 Olink Ab Method for generating proximity probes
MY196448A (en) 2015-10-30 2023-04-12 Genentech Inc Anti-Htra1 Antibodies and Methods of use Thereof
US12025615B2 (en) 2017-09-15 2024-07-02 Arizona Board Of Regents On Behalf Of Arizona State University Methods of classifying response to immunotherapy for cancer
CN111819185A (zh) 2017-12-15 2020-10-23 旗舰创业创新第六有限责任公司 包含环状多核糖核苷酸的组合物及其用途
MA55082A (fr) 2019-03-01 2022-01-05 Flagship Pioneering Innovations Vi Llc Compositions, procédés, et kits pour l'administration de polyribonucléotides
WO2020198403A2 (en) 2019-03-25 2020-10-01 Flagship Pioneering Innovations Vi, Llc Compositions comprising modified circular polyribonucleotides and uses thereof
JP2022537154A (ja) 2019-06-14 2022-08-24 フラッグシップ パイオニアリング イノベーションズ シックス,エルエルシー 細胞治療のための環状rna
KR20220024647A (ko) 2019-06-19 2022-03-03 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 원형 폴리리보뉴클레오티드의 투여 방법
WO2021067550A1 (en) 2019-10-02 2021-04-08 Arizona Board Of Regents On Behalf Of Arizona State University Methods and compositions for identifying neoantigens for use in treating and preventing cancer
EP4096681A1 (de) 2020-01-29 2022-12-07 Flagship Pioneering Innovations VI, LLC Verabreichung von zusammensetzungen mit zirkulären polyribonukleotiden
WO2022005902A1 (en) 2020-06-30 2022-01-06 Monsanto Technology Llc Automated systems for use in sorting small objects, and related methods
EP4266991A4 (de) 2021-01-29 2025-01-01 The Regents of University of California Implantierbare bildgebungsvorrichtungen zur in-vivo-bildgebung

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0474790B1 (de) * 1989-06-14 1997-05-21 Martek Corporation Medien zur zellzucht und verfahren dazu
US5650489A (en) * 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
KR100310939B1 (ko) * 1992-10-01 2002-06-20 추후제출 태그로암호화한복합조합화학라이브러리

Also Published As

Publication number Publication date
PT839152E (pt) 2002-09-30
EP0839152B1 (de) 2002-03-13
DE69619825D1 (de) 2002-04-18
JPH11509086A (ja) 1999-08-17
CA2225313A1 (en) 1997-01-09
WO1997000887A1 (en) 1997-01-09
EP0839152A1 (de) 1998-05-06
DK0839152T3 (da) 2002-07-08
ES2174075T3 (es) 2002-11-01
US5741713A (en) 1998-04-21
AU6180696A (en) 1997-01-22
DE69619825T2 (de) 2002-10-10

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee