ATE214701T1 - 3-aryl pyrazolo(4,3-d)pyrimidin derivaten; corticotropin auslösefaktor- (crf1) spezifischen liganden - Google Patents

3-aryl pyrazolo(4,3-d)pyrimidin derivaten; corticotropin auslösefaktor- (crf1) spezifischen liganden

Info

Publication number: ATE214701T1
Authority: AT; Austria
Prior art keywords: crf1; corticotropin; pyrimidine derivatives; specific ligands; trigger factor
Prior art date: 1996-12-31

Application number

AT97954301T

Other languages

English (en)

Inventor

Jun Yuan

Original Assignee

Neurogen Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-31

Filing date

1997-12-23

Publication date

2002-04-15

1997-12-23 Application filed by Neurogen Corp filed Critical Neurogen Corp

2002-04-15 Application granted granted Critical

2002-04-15 Publication of ATE214701T1 publication Critical patent/ATE214701T1/de

Links

APXRHPDHORGIEB-UHFFFAOYSA-N 1H-pyrazolo[4,3-d]pyrimidine Chemical class N1=CN=C2C=NNC2=C1 APXRHPDHORGIEB-UHFFFAOYSA-N 0.000 title 1
102400000739 Corticotropin Human genes 0.000 title 1
101800000414 Corticotropin Proteins 0.000 title 1
101710154918 Trigger factor Proteins 0.000 title 1
IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 title 1
229960000258 corticotropin Drugs 0.000 title 1
239000003446 ligand Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
208000028173 post-traumatic stress disease Diseases 0.000 abstract 2
208000019901 Anxiety disease Diseases 0.000 abstract 1
108091005471 CRHR1 Proteins 0.000 abstract 1
206010019233 Headaches Diseases 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
238000003745 diagnosis Methods 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
231100000869 headache Toxicity 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
239000004031 partial agonist Substances 0.000 abstract 1
125000003226 pyrazolyl group Chemical group 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT97954301T 1996-12-31 1997-12-23 3-aryl pyrazolo(4,3-d)pyrimidin derivaten; corticotropin auslösefaktor- (crf1) spezifischen liganden ATE214701T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/775,404 US5723608A (en)	1996-12-31	1996-12-31	3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands
PCT/US1997/024172 WO1998029413A1 (en)	1996-12-31	1997-12-23	3-ARYL SUBSTITUTED PYRAZOLO[4,3-d]PYRIMIDINE DERIVATIVES; CORTICOTROPIN-RELEASING FACTOR RECEPTOR (CRF1) SPECIFIC LIGANDS

Publications (1)

Publication Number	Publication Date
ATE214701T1 true ATE214701T1 (de)	2002-04-15

Family

ID=25104303

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97954301T ATE214701T1 (de)	1996-12-31	1997-12-23	3-aryl pyrazolo(4,3-d)pyrimidin derivaten; corticotropin auslösefaktor- (crf1) spezifischen liganden

Country Status (15)

Country	Link
US (2)	US5723608A (de)
EP (1)	EP0960110B8 (de)
JP (1)	JP2001507705A (de)
KR (1)	KR20000069827A (de)
CN (1)	CN1100779C (de)
AT (1)	ATE214701T1 (de)
AU (1)	AU738324B2 (de)
BR (1)	BR9713808A (de)
CA (1)	CA2276610A1 (de)
DE (1)	DE69711241T2 (de)
ES (1)	ES2172830T3 (de)
IL (1)	IL130680A0 (de)
NO (1)	NO993240L (de)
NZ (1)	NZ336529A (de)
WO (1)	WO1998029413A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6313124B1 (en)	1997-07-23	2001-11-06	Dupont Pharmaceuticals Company	Tetrazine bicyclic compounds
US6124289A (en) *	1996-07-24	2000-09-26	Dupont Pharmaceuticals Co.	Azolo triazines and pyrimidines
US6191131B1 (en)	1997-07-23	2001-02-20	Dupont Pharmaceuticals Company	Azolo triazines and pyrimidines
US7094782B1 (en) *	1996-07-24	2006-08-22	Bristol-Myers Squibb Company	Azolo triazines and pyrimidines
US6060478A (en) *	1996-07-24	2000-05-09	Dupont Pharmaceuticals	Azolo triazines and pyrimidines
US5723608A (en) *	1996-12-31	1998-03-03	Neurogen Corporation	3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands
WO1999045007A1 (en) *	1998-03-06	1999-09-10	Janssen Pharmaceutica N.V.	Crf antagonistic pyrazolo[4,3-b]pyridines
DK1129096T3 (da)	1998-11-12	2003-09-15	Neurocrine Biosciences Inc	CRF-receptorantagonister og fremgangsmåder, der er relateret dertil
ES2180338T3 (es)	1998-11-12	2003-02-01	Neurocrine Biosciences Inc	Antagonistas del receptor de crf y metodos relacionados.
US6432989B1 (en)	1999-08-27	2002-08-13	Pfizer Inc	Use of CRF antagonists to treat circadian rhythm disorders
WO2002076987A1 (en)	2001-03-27	2002-10-03	Neurogen Corporation	(oxo-pyrazolo[1,5a]pyrimidin-2-yl)alkyl-carboxamides
ATE478872T1 (de) *	2002-03-28	2010-09-15	Ustav Ex Botan Av Cr V V I I O	Pyrazoloä4,3-düpyrimidine, verfahren zu ihrer herstellung und therapeutische anwendung
TW200400034A (en) *	2002-05-20	2004-01-01	Bristol Myers Squibb Co	Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors
US7268133B2 (en) *	2003-04-23	2007-09-11	Pfizer, Inc. Patent Department	Cannabinoid receptor ligands and uses thereof
EP1656379B1 (de) *	2003-08-15	2007-01-10	Merck & Co., Inc.	4-cycloalkylaminopyrazolopyrimidin als nmda/nr2b-antagonisten
WO2005019222A1 (en) *	2003-08-15	2005-03-03	Merck & Co., Inc.	4-cycloalkylaminopyrazolo pyrimidine nmda/nr2b antagonists
JPWO2006126718A1 (ja) *	2005-05-27	2008-12-25	田辺三菱製薬株式会社	ピラゾロピリミジン誘導体
US7932257B2 (en) *	2005-07-22	2011-04-26	Sunesis Pharmaceuticals, Inc.	Substituted pyrazolo[4,3-d]pyrimidines as aurora kinase inhibitors
EP2167094A2 (de) *	2007-06-13	2010-03-31	Research Development Foundation	Verfahren zur behandlung und prävention von tauopathien und amyloid-beta-amyloidose durch modulierung der crf-rezeptor-signalgebung
AU2012244550C1 (en) *	2011-04-21	2017-06-22	Origenis Gmbh	Pyrazolo [4, 3-d] pyrimidines useful as kinase inhibitors
BR112013026744B1 (pt)	2011-04-21	2022-05-17	Origenis Gmbh	Compostos heterocíclicos, seus usos e seus intermediários, e composição farmacêutica
US9637491B2 (en)	2012-10-19	2017-05-02	Origenis Gmbh	Pyrazolo[4,3-D]pyrimidines as kinase inhibitors
WO2014060113A1 (en)	2012-10-19	2014-04-24	Origenis Gmbh	Novel kinase inhibitors
CN111233719B (zh) *	2020-02-27	2021-08-20	泰兴先先化工有限公司	α-肟基苯乙酮衍生物的制备方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE210265C (de)	1907-09-09
GB1103061A (en) *	1963-05-16	1968-02-14	Anson Units Ltd	Shell mould sand blowing machines
US4495195A (en) *	1982-11-01	1985-01-22	Eli Lilly And Company	Xanthine oxidase inhibiting 3(5)-phenyl-substituted-5(3)-pyrazole-carboxylic acid derivatives, compositions, and methods of use
US4605642A (en) *	1984-02-23	1986-08-12	The Salk Institute For Biological Studies	CRF antagonists
US5063245A (en) *	1990-03-28	1991-11-05	Nova Pharmaceutical Corporation	Corticotropin-releasing factor antagonism compounds
US5712303A (en) *	1992-12-17	1998-01-27	Pfizer Inc.	Pyrazoles and pyrazolopyrimidines having CRF antagonistic activity
ES2128544T3 (es) *	1992-12-17	1999-05-16	Pfizer	Pirrolopirimidinas como antagonistas del crf.
TW336932B (en) *	1992-12-17	1998-07-21	Pfizer	Amino-substituted pyrazoles
TW444018B (en) *	1992-12-17	2001-07-01	Pfizer	Pyrazolopyrimidines
CA2150703C (en) *	1992-12-17	2002-01-08	Pfizer Limited	Substituted pyrazoles
TW574214B (en) *	1994-06-08	2004-02-01	Pfizer	Corticotropin releasing factor antagonists
US5646152A (en)	1994-06-15	1997-07-08	Pfizer Inc.	Methods of administering CRF antagonists
HRP950330A2 (en) *	1994-07-05	1997-10-31	Ciba Geigy Ag	New herbicides
US5644057A (en) *	1995-05-12	1997-07-01	Neurogen Corporation	Deazapurine derivatives; a new class of CRF1 specific ligands
JPH10506126A (ja) *	1995-05-12	1998-06-16	ニューロゲンコーポレイション	新規なデアザプリン誘導体；ｃｒｆ１特異性リガンドの新規なクラス
WO1997029109A1 (en)	1996-02-07	1997-08-14	Janssen Pharmaceutica N.V.	Pyrazolopyrimidines as crf receptor antagonists
US5723608A (en) *	1996-12-31	1998-03-03	Neurogen Corporation	3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands

1996
- 1996-12-31 US US08/775,404 patent/US5723608A/en not_active Expired - Fee Related
1997
- 1997-12-23 US US09/341,024 patent/US6211187B1/en not_active Expired - Fee Related
- 1997-12-23 JP JP53031298A patent/JP2001507705A/ja active Pending
- 1997-12-23 CA CA002276610A patent/CA2276610A1/en not_active Abandoned
- 1997-12-23 NZ NZ336529A patent/NZ336529A/xx unknown
- 1997-12-23 DE DE69711241T patent/DE69711241T2/de not_active Expired - Fee Related
- 1997-12-23 EP EP97954301A patent/EP0960110B8/de not_active Expired - Lifetime
- 1997-12-23 ES ES97954301T patent/ES2172830T3/es not_active Expired - Lifetime
- 1997-12-23 AU AU58110/98A patent/AU738324B2/en not_active Ceased
- 1997-12-23 WO PCT/US1997/024172 patent/WO1998029413A1/en not_active Ceased
- 1997-12-23 AT AT97954301T patent/ATE214701T1/de not_active IP Right Cessation
- 1997-12-23 CN CN97181857A patent/CN1100779C/zh not_active Expired - Fee Related
- 1997-12-23 IL IL13068097A patent/IL130680A0/xx unknown
- 1997-12-23 KR KR1019997005989A patent/KR20000069827A/ko not_active Ceased
- 1997-12-23 BR BR9713808-8A patent/BR9713808A/pt not_active Application Discontinuation
1999
- 1999-06-29 NO NO993240A patent/NO993240L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
JP2001507705A (ja)	2001-06-12
KR20000069827A (ko)	2000-11-25
EP0960110B1 (de)	2002-03-20
IL130680A0 (en)	2000-06-01
AU5811098A (en)	1998-07-31
AU738324B2 (en)	2001-09-13
EP0960110B8 (de)	2002-11-27
US5723608A (en)	1998-03-03
DE69711241T2 (de)	2002-12-12
WO1998029413A1 (en)	1998-07-09
NZ336529A (en)	2001-03-30
CN1100779C (zh)	2003-02-05
DE69711241D1 (de)	2002-04-25
CN1246860A (zh)	2000-03-08
BR9713808A (pt)	2000-01-25
US6211187B1 (en)	2001-04-03
EP0960110A1 (de)	1999-12-01
ES2172830T3 (es)	2002-10-01
CA2276610A1 (en)	1998-07-09
NO993240L (no)	1999-08-27
HK1025958A1 (en)	2000-12-01
NO993240D0 (no)	1999-06-29

Legal Events

Date	Code	Title	Description
2002-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69711241D1 (de)	2002-04-25	3-aryl pyrazolo[4,3-d]pyrimidin derivaten; corticotropin auslösefaktor- (crf1) spezifischen liganden
DE69329727D1 (de)	2001-01-11	Neue imidazol derivate, ihre herstellung und therapeutische verwendung
BG101806A (bg)	1998-04-30	Индолови производни като антагонисти на 5-нт рецептори
DE69611377D1 (de)	2001-02-01	1,2,4-triazolo[1,5-c]pyrimidin-heterocyclische analoge mit antagonistischer aktivität auf dem adenosine a2a rezeptor
BG101110A (bg)	1997-08-29	Заместени пиримидинови съединения и тяхното използване
BR9809451A (pt)	2000-06-20	Pirazóis substituìdos com 3(5)-heteroarila como inibidores de quinase p38.
EA200501253A1 (ru)	2006-02-24	Производные пиразоло[1,5-a][1,3,5]триазина в качестве лигандов каннабиноидных рецепторов
ES2158513T3 (es)	2001-09-01	Compuestos de n-((1,2,4)triazoloazinil)bencenosulfonamida y piridinsulfonamida, y su uso como herbicidas.
DK0675886T3 (da)	2000-09-18	Aminomethylensubstituerede ikke-aromatiske heterocykler og deres anvendelse som substance P-antagonister
ES2174836T3 (es)	2002-11-16	Heterrociclos nitrogenados triciclicos condesados como antagonistas de receptor de la sustancia p.
NO952398D0 (no)	1995-06-16	Pyrrolpyrimidiner som CRF antagonister
EA199900693A1 (ru)	2000-02-28	Атропизомеры 3-арил-4(3h)-хиназолинонов и их использование в качестве антагонистов амра-рецепторов
ATE187726T1 (de)	2000-01-15	A1 adenosin rezeptor agonisten und antagonisten
DE69718194D1 (de)	2003-02-06	Amidinophenyl-pyrrolidine, -pyrroline und -isoxazolidine und ihre derivate
ES2150039T3 (es)	2000-11-16	Benzonitrilos como 5-ht agonistas y antagonistas.
EA199700111A1 (ru)	1997-12-30	Трициклические бензазепиновые антагонисты вазопрессина
ATE418555T1 (de)	2009-01-15	A2a-adenosinrezeptorantagonisten
DE60231386D1 (de)	2009-04-16	Adenosin-a2a-rezeptor-antagonisten in kombination mit verbindungen mit neurotrophischer aktivität bei der behandlung von morbus parkinson
ES2098158T3 (es)	1997-04-16	Derivados de imidazo(1,2-a)pirazina-4-ona, utiles como antagonistas de los receptores ampa y nmda.
ES2154470T3 (es)	2001-04-01	Derivados de tetrahidroisoquinolina y su uso farmaceutico.
AU5614198A (en)	1998-07-15	Isoquinolinamine and phthalazinamine derivatives which interact with crf receptors
EA200200562A1 (ru)	2002-10-31	Антагонисты аденозиновых рецепторов и способы их получения и использования
ES2058191T3 (es)	1994-11-01	Acidos 2-fenil-4-quinolincarboxilicos substituidos.
BR0115121A (pt)	2003-09-30	Compostos n-((1,2,4)triazoloazinil)tiofenossulfonamida como herbicidas
DE69328964D1 (de)	2000-08-10	Arylindazoline und ihre anwendung als herbizide