NO993240L - 3-arylsubstituerte pyrazolo[4,3-d]pyrimidinderivater, samt kortikotropin-frigjöringsfaktor reseptor (CRF1) spesifikke ligander - Google Patents

3-arylsubstituerte pyrazolo[4,3-d]pyrimidinderivater, samt kortikotropin-frigjöringsfaktor reseptor (CRF1) spesifikke ligander

Info

Publication number: NO993240L
Authority: NO; Norway
Prior art keywords: well; crf1; corticotropin; aryl; factor receptor
Prior art date: 1996-12-31

Application number

NO993240A

Other languages

English (en)

Norwegian (no)

Other versions

NO993240D0 (no

Inventor

Jun Yuan

Original Assignee

Neurogen Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-31

Filing date

1999-06-29

Publication date

1999-08-27

1999-06-29 Application filed by Neurogen Corp filed Critical Neurogen Corp

1999-06-29 Publication of NO993240D0 publication Critical patent/NO993240D0/no

1999-08-27 Publication of NO993240L publication Critical patent/NO993240L/no

Links

108010056643 Corticotropin-Releasing Hormone Receptors Chemical class 0.000 title 2
102100038018 Corticotropin-releasing factor receptor 1 Human genes 0.000 title 2
APXRHPDHORGIEB-UHFFFAOYSA-N 1H-pyrazolo[4,3-d]pyrimidine Chemical class N1=CN=C2C=NNC2=C1 APXRHPDHORGIEB-UHFFFAOYSA-N 0.000 title 1
239000003446 ligand Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
208000028173 post-traumatic stress disease Diseases 0.000 abstract 2
208000019901 Anxiety disease Diseases 0.000 abstract 1
108091005471 CRHR1 Proteins 0.000 abstract 1
206010019233 Headaches Diseases 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
238000003745 diagnosis Methods 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
231100000869 headache Toxicity 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
239000004031 partial agonist Substances 0.000 abstract 1
125000003226 pyrazolyl group Chemical group 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO993240A 1996-12-31 1999-06-29 3-arylsubstituerte pyrazolo[4,3-d]pyrimidinderivater, samt kortikotropin-frigjöringsfaktor reseptor (CRF1) spesifikke ligander NO993240L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/775,404 US5723608A (en)	1996-12-31	1996-12-31	3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands
PCT/US1997/024172 WO1998029413A1 (en)	1996-12-31	1997-12-23	3-ARYL SUBSTITUTED PYRAZOLO[4,3-d]PYRIMIDINE DERIVATIVES; CORTICOTROPIN-RELEASING FACTOR RECEPTOR (CRF1) SPECIFIC LIGANDS

Publications (2)

Publication Number	Publication Date
NO993240D0 NO993240D0 (no)	1999-06-29
NO993240L true NO993240L (no)	1999-08-27

Family

ID=25104303

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO993240A NO993240L (no)	1996-12-31	1999-06-29	3-arylsubstituerte pyrazolo[4,3-d]pyrimidinderivater, samt kortikotropin-frigjöringsfaktor reseptor (CRF1) spesifikke ligander

Country Status (15)

Country	Link
US (2)	US5723608A (de)
EP (1)	EP0960110B8 (de)
JP (1)	JP2001507705A (de)
KR (1)	KR20000069827A (de)
CN (1)	CN1100779C (de)
AT (1)	ATE214701T1 (de)
AU (1)	AU738324B2 (de)
BR (1)	BR9713808A (de)
CA (1)	CA2276610A1 (de)
DE (1)	DE69711241T2 (de)
ES (1)	ES2172830T3 (de)
IL (1)	IL130680A0 (de)
NO (1)	NO993240L (de)
NZ (1)	NZ336529A (de)
WO (1)	WO1998029413A1 (de)

Families Citing this family (24)

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US6313124B1 (en)	1997-07-23	2001-11-06	Dupont Pharmaceuticals Company	Tetrazine bicyclic compounds
US6124289A (en) *	1996-07-24	2000-09-26	Dupont Pharmaceuticals Co.	Azolo triazines and pyrimidines
US6191131B1 (en)	1997-07-23	2001-02-20	Dupont Pharmaceuticals Company	Azolo triazines and pyrimidines
US7094782B1 (en) *	1996-07-24	2006-08-22	Bristol-Myers Squibb Company	Azolo triazines and pyrimidines
US6060478A (en) *	1996-07-24	2000-05-09	Dupont Pharmaceuticals	Azolo triazines and pyrimidines
US5723608A (en) *	1996-12-31	1998-03-03	Neurogen Corporation	3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands
WO1999045007A1 (en) *	1998-03-06	1999-09-10	Janssen Pharmaceutica N.V.	Crf antagonistic pyrazolo[4,3-b]pyridines
DK1129096T3 (da)	1998-11-12	2003-09-15	Neurocrine Biosciences Inc	CRF-receptorantagonister og fremgangsmåder, der er relateret dertil
ES2180338T3 (es)	1998-11-12	2003-02-01	Neurocrine Biosciences Inc	Antagonistas del receptor de crf y metodos relacionados.
US6432989B1 (en)	1999-08-27	2002-08-13	Pfizer Inc	Use of CRF antagonists to treat circadian rhythm disorders
WO2002076987A1 (en)	2001-03-27	2002-10-03	Neurogen Corporation	(oxo-pyrazolo[1,5a]pyrimidin-2-yl)alkyl-carboxamides
ATE478872T1 (de) *	2002-03-28	2010-09-15	Ustav Ex Botan Av Cr V V I I O	Pyrazoloä4,3-düpyrimidine, verfahren zu ihrer herstellung und therapeutische anwendung
TW200400034A (en) *	2002-05-20	2004-01-01	Bristol Myers Squibb Co	Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors
US7268133B2 (en) *	2003-04-23	2007-09-11	Pfizer, Inc. Patent Department	Cannabinoid receptor ligands and uses thereof
EP1656379B1 (de) *	2003-08-15	2007-01-10	Merck & Co., Inc.	4-cycloalkylaminopyrazolopyrimidin als nmda/nr2b-antagonisten
WO2005019222A1 (en) *	2003-08-15	2005-03-03	Merck & Co., Inc.	4-cycloalkylaminopyrazolo pyrimidine nmda/nr2b antagonists
JPWO2006126718A1 (ja) *	2005-05-27	2008-12-25	田辺三菱製薬株式会社	ピラゾロピリミジン誘導体
US7932257B2 (en) *	2005-07-22	2011-04-26	Sunesis Pharmaceuticals, Inc.	Substituted pyrazolo[4,3-d]pyrimidines as aurora kinase inhibitors
EP2167094A2 (de) *	2007-06-13	2010-03-31	Research Development Foundation	Verfahren zur behandlung und prävention von tauopathien und amyloid-beta-amyloidose durch modulierung der crf-rezeptor-signalgebung
AU2012244550C1 (en) *	2011-04-21	2017-06-22	Origenis Gmbh	Pyrazolo [4, 3-d] pyrimidines useful as kinase inhibitors
BR112013026744B1 (pt)	2011-04-21	2022-05-17	Origenis Gmbh	Compostos heterocíclicos, seus usos e seus intermediários, e composição farmacêutica
US9637491B2 (en)	2012-10-19	2017-05-02	Origenis Gmbh	Pyrazolo[4,3-D]pyrimidines as kinase inhibitors
WO2014060113A1 (en)	2012-10-19	2014-04-24	Origenis Gmbh	Novel kinase inhibitors
CN111233719B (zh) *	2020-02-27	2021-08-20	泰兴先先化工有限公司	α-肟基苯乙酮衍生物的制备方法

Family Cites Families (17)

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Publication number	Priority date	Publication date	Assignee	Title
DE210265C (de)	1907-09-09
GB1103061A (en) *	1963-05-16	1968-02-14	Anson Units Ltd	Shell mould sand blowing machines
US4495195A (en) *	1982-11-01	1985-01-22	Eli Lilly And Company	Xanthine oxidase inhibiting 3(5)-phenyl-substituted-5(3)-pyrazole-carboxylic acid derivatives, compositions, and methods of use
US4605642A (en) *	1984-02-23	1986-08-12	The Salk Institute For Biological Studies	CRF antagonists
US5063245A (en) *	1990-03-28	1991-11-05	Nova Pharmaceutical Corporation	Corticotropin-releasing factor antagonism compounds
US5712303A (en) *	1992-12-17	1998-01-27	Pfizer Inc.	Pyrazoles and pyrazolopyrimidines having CRF antagonistic activity
ES2128544T3 (es) *	1992-12-17	1999-05-16	Pfizer	Pirrolopirimidinas como antagonistas del crf.
TW336932B (en) *	1992-12-17	1998-07-21	Pfizer	Amino-substituted pyrazoles
TW444018B (en) *	1992-12-17	2001-07-01	Pfizer	Pyrazolopyrimidines
CA2150703C (en) *	1992-12-17	2002-01-08	Pfizer Limited	Substituted pyrazoles
TW574214B (en) *	1994-06-08	2004-02-01	Pfizer	Corticotropin releasing factor antagonists
US5646152A (en)	1994-06-15	1997-07-08	Pfizer Inc.	Methods of administering CRF antagonists
HRP950330A2 (en) *	1994-07-05	1997-10-31	Ciba Geigy Ag	New herbicides
US5644057A (en) *	1995-05-12	1997-07-01	Neurogen Corporation	Deazapurine derivatives; a new class of CRF1 specific ligands
JPH10506126A (ja) *	1995-05-12	1998-06-16	ニューロゲンコーポレイション	新規なデアザプリン誘導体；ｃｒｆ１特異性リガンドの新規なクラス
WO1997029109A1 (en)	1996-02-07	1997-08-14	Janssen Pharmaceutica N.V.	Pyrazolopyrimidines as crf receptor antagonists
US5723608A (en) *	1996-12-31	1998-03-03	Neurogen Corporation	3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands

1996
- 1996-12-31 US US08/775,404 patent/US5723608A/en not_active Expired - Fee Related
1997
- 1997-12-23 US US09/341,024 patent/US6211187B1/en not_active Expired - Fee Related
- 1997-12-23 JP JP53031298A patent/JP2001507705A/ja active Pending
- 1997-12-23 CA CA002276610A patent/CA2276610A1/en not_active Abandoned
- 1997-12-23 NZ NZ336529A patent/NZ336529A/xx unknown
- 1997-12-23 DE DE69711241T patent/DE69711241T2/de not_active Expired - Fee Related
- 1997-12-23 EP EP97954301A patent/EP0960110B8/de not_active Expired - Lifetime
- 1997-12-23 ES ES97954301T patent/ES2172830T3/es not_active Expired - Lifetime
- 1997-12-23 AU AU58110/98A patent/AU738324B2/en not_active Ceased
- 1997-12-23 WO PCT/US1997/024172 patent/WO1998029413A1/en not_active Ceased
- 1997-12-23 AT AT97954301T patent/ATE214701T1/de not_active IP Right Cessation
- 1997-12-23 CN CN97181857A patent/CN1100779C/zh not_active Expired - Fee Related
- 1997-12-23 IL IL13068097A patent/IL130680A0/xx unknown
- 1997-12-23 KR KR1019997005989A patent/KR20000069827A/ko not_active Ceased
- 1997-12-23 BR BR9713808-8A patent/BR9713808A/pt not_active Application Discontinuation
1999
- 1999-06-29 NO NO993240A patent/NO993240L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
JP2001507705A (ja)	2001-06-12
KR20000069827A (ko)	2000-11-25
EP0960110B1 (de)	2002-03-20
IL130680A0 (en)	2000-06-01
AU5811098A (en)	1998-07-31
ATE214701T1 (de)	2002-04-15
AU738324B2 (en)	2001-09-13
EP0960110B8 (de)	2002-11-27
US5723608A (en)	1998-03-03
DE69711241T2 (de)	2002-12-12
WO1998029413A1 (en)	1998-07-09
NZ336529A (en)	2001-03-30
CN1100779C (zh)	2003-02-05
DE69711241D1 (de)	2002-04-25
CN1246860A (zh)	2000-03-08
BR9713808A (pt)	2000-01-25
US6211187B1 (en)	2001-04-03
EP0960110A1 (de)	1999-12-01
ES2172830T3 (es)	2002-10-01
CA2276610A1 (en)	1998-07-09
HK1025958A1 (en)	2000-12-01
NO993240D0 (no)	1999-06-29

Legal Events

Date	Code	Title	Description
2002-09-16	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO993240D0 (no)	1999-06-29	3-arylsubstituerte pyrazolo[4,3-d]pyrimidinderivater, samt kortikotropinfrigj°ringsfaktor reseptor (CRF1) spesifikke ligander
BG101806A (bg)	1998-04-30	Индолови производни като антагонисти на 5-нт рецептори
DE69611377D1 (de)	2001-02-01	1,2,4-triazolo[1,5-c]pyrimidin-heterocyclische analoge mit antagonistischer aktivität auf dem adenosine a2a rezeptor
CA2175204A1 (en)	1995-05-11	Certain Fused Pyrrolecarboxanilides; a New Class of GABA Brain Receptor Ligands
ES2174836T3 (es)	2002-11-16	Heterrociclos nitrogenados triciclicos condesados como antagonistas de receptor de la sustancia p.
PT885210E (pt)	2002-09-30	Compostos triciclicos que possuem afinidade de ligacao para receptores de melatonina sua producao e utilizacao
BG101110A (bg)	1997-08-29	Заместени пиримидинови съединения и тяхното използване
NO20022238L (no)	2002-07-12	Polycykloalkyl-puriner som adenosinreseptor-antagonister
DE69329727D1 (de)	2001-01-11	Neue imidazol derivate, ihre herstellung und therapeutische verwendung
ATE32721T1 (de)	1988-03-15	Benzodiazepin-rezeptoren und ihre herstellung.
IE900456L (en)	1990-08-13	Improvements in and relating to organic compounds
ES2150039T3 (es)	2000-11-16	Benzonitrilos como 5-ht agonistas y antagonistas.
EA200000783A1 (ru)	2000-12-25	Производные триазолопиридазина в качестве лигандов для гамк рецепторов
CA2207784A1 (en)	1998-12-13	Certain pyrrolopyridine derivatives; novel crf1 specific ligands
ES2154470T3 (es)	2001-04-01	Derivados de tetrahidroisoquinolina y su uso farmaceutico.
BR0007864A (pt)	2001-11-06	Composto, e, uso de um composto
ES2098158T3 (es)	1997-04-16	Derivados de imidazo(1,2-a)pirazina-4-ona, utiles como antagonistas de los receptores ampa y nmda.
MX9305833A (es)	1994-06-30	Procedimiento para la preparacion de pirrolo[2,3-d]pirimidinas 5-sustituidas.
NO20022237L (no)	2002-07-12	Adenosinreseptor-antagonister samt fremgangsmåter ved fremstilling derav
AU5614198A (en)	1998-07-15	Isoquinolinamine and phthalazinamine derivatives which interact with crf receptors
ES2058191T3 (es)	1994-11-01	Acidos 2-fenil-4-quinolincarboxilicos substituidos.
BR0115121A (pt)	2003-09-30	Compostos n-((1,2,4)triazoloazinil)tiofenossulfonamida como herbicidas
TR199801659T2 (xx)	1998-12-21	Yeni triazolopurinler, haz�rlama y�ntemi, ila� olarak kullan�m�.
ES2093286T3 (es)	1996-12-16	Bencimidazoles, medicamentos que contienen estos compuestos y procedimiento para su preparacion.
MX9700305A (es)	1998-01-31	Nuevos derivados de deazapurina; una clase de ligandos especificos del crf1.