ATE215540T1 - Benzofuran-carboxamide und -sulfonamide - Google Patents

Benzofuran-carboxamide und -sulfonamide

Info

Publication number: ATE215540T1
Authority: AT; Austria
Prior art keywords: sulfonamides; benzofuran; benzofuran carboxamides; carboxamides; carboxides
Prior art date: 1995-12-05

Application number

AT96941138T

Other languages

English (en)

Inventor

Hazel Joan Dyke

Hannah Jayne Kendall

Christopher Lowe

John Gary Montana

Original Assignee

Darwin Discovery Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-05

Filing date

1996-12-05

Publication date

2002-04-15

1995-12-05 Priority claimed from GBGB9524832.4A external-priority patent/GB9524832D0/en

1996-05-20 Priority claimed from GBGB9610515.0A external-priority patent/GB9610515D0/en

1996-05-22 Priority claimed from GBGB9610712.3A external-priority patent/GB9610712D0/en

1996-12-05 Application filed by Darwin Discovery Ltd filed Critical Darwin Discovery Ltd

2002-04-15 Application granted granted Critical

2002-04-15 Publication of ATE215540T1 publication Critical patent/ATE215540T1/de

Links

IANQTJSKSUMEQM-UHFFFAOYSA-N benzofuran Natural products C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 title abstract 3
150000003456 sulfonamides Chemical class 0.000 title abstract 2
-1 BENZOFURAN CARBOXAMIDES Chemical class 0.000 title 1
229940124530 sulfonamide Drugs 0.000 title 1
206010061218 Inflammation Diseases 0.000 abstract 1
102000004861 Phosphoric Diester Hydrolases Human genes 0.000 abstract 1
108090001050 Phosphoric Diester Hydrolases Proteins 0.000 abstract 1
108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1
102000003390 tumor necrosis factor Human genes 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Furan Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT96941138T 1995-12-05 1996-12-05 Benzofuran-carboxamide und -sulfonamide ATE215540T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GBGB9524832.4A GB9524832D0 (en)	1995-12-05	1995-12-05	Novel compounds
GBGB9610515.0A GB9610515D0 (en)	1996-05-20	1996-05-20	Novel compounds
GBGB9610712.3A GB9610712D0 (en)	1995-12-05	1996-05-22	Novel compounds
PCT/GB1996/003012 WO1997020833A1 (en)	1995-12-05	1996-12-05	Benzofuran carboxamides and sulphonamides

Publications (1)

Publication Number	Publication Date
ATE215540T1 true ATE215540T1 (de)	2002-04-15

Family

ID=27268015

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96941138T ATE215540T1 (de)	1995-12-05	1996-12-05	Benzofuran-carboxamide und -sulfonamide

Country Status (16)

Country	Link
US (1)	US5773467A (de)
EP (1)	EP0873331B1 (de)
JP (1)	JP2000501411A (de)
KR (1)	KR19990071894A (de)
CN (1)	CN1100773C (de)
AT (1)	ATE215540T1 (de)
AU (1)	AU697976B2 (de)
BR (1)	BR9611897A (de)
CA (1)	CA2238376C (de)
CZ (1)	CZ292443B6 (de)
DE (1)	DE69620458T2 (de)
ES (1)	ES2172695T3 (de)
HU (1)	HUP9903797A3 (de)
NO (1)	NO982570L (de)
PL (1)	PL327181A1 (de)
WO (1)	WO1997020833A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ332340A (en) *	1996-05-20	2000-04-28	Darwin Discovery Ltd	4-(aryl or heteroaryl) substituted benzofurancarboxamide derivatives and medicaments
JP4309475B2 (ja) *	1996-08-19	2009-08-05	ニコメッドゲゼルシャフトミットベシュレンクテルハフツング	新規のベンゾフラン―４―カルボキサミド
JP3268236B2 (ja)	1997-07-22	2002-03-25	シャープ株式会社	電子写真感光体、及びビスヒドラゾン化合物およびその中間体、ならびにそれら化合物の製造方法
JP4219554B2 (ja) *	1997-10-01	2009-02-04	協和発酵キリン株式会社	ベンゾフラン誘導体
AU1983599A (en) *	1998-01-26	1999-08-09	Kyowa Hakko Kogyo Co. Ltd.	Oxygenic heterocyclic compounds
CA2317478A1 (en) *	1998-02-09	1999-08-12	Darwin Discovery Limited	Benzofuran-4-carboxamides and their therapeutic use
FR2778662B1 (fr) *	1998-05-12	2000-06-16	Adir	Nouveaux composes cycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
TW555759B (en) *	1998-06-08	2003-10-01	Darwin Discovery Ltd	Heterocyclic compounds and their therapeutic use
US6303789B1 (en) *	1998-06-10	2001-10-16	Byk Gulden Lomberg Chemische Fabrik Gmbh	Benzamides with tetrahydrofuranyloxy substitutents as phosphodiesterase 4 inhibitors
SK287231B6 (sk)	1999-08-21	2010-04-07	Nycomed Gmbh	Liečivo zahŕňajúce PDE inhibítor a agonistu beta2 adrenoreceptora
US7217722B2 (en)	2000-02-01	2007-05-15	Kirin Beer Kabushiki Kaisha	Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
GB0011802D0 (en) *	2000-05-16	2000-07-05	Smithkline Beecham	Method for enhancing cognitive function
AU2004226353A1 (en)	2003-04-01	2004-10-14	Laboratoires Serono Sa	Inhibitors of phosphodiesterases in infertility
FR2903106B1 (fr) *	2006-07-03	2010-07-30	Sanofi Aventis	Utilisations de 2-benzoyl-imidazopyridines en therapeutique
EP2196465A1 (de)	2008-12-15	2010-06-16	Almirall, S.A.	(3-oxo)pyridazin-4-ylurea-Derivate als PDE4 Hemmern
AR074760A1 (es) *	2008-12-18	2011-02-09	Metabolex Inc	Agonistas del receptor gpr120 y usos de los mismos en medicamentos para el tratamiento de diabetes y el sindrome metabolico.
EP2226323A1 (de)	2009-02-27	2010-09-08	Almirall, S.A.	Neuartige Tetrahydropyrazol[3,4-c]isochinolin-5-amin-Derivate
EP2380890A1 (de)	2010-04-23	2011-10-26	Almirall, S.A.	Neue 7,8-Dihydro-1,6-Naphthyridin-5(6H)-on-Derivate als PDE4 Inhibitoren
EP2394998A1 (de)	2010-05-31	2011-12-14	Almirall, S.A.	3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl Derivate als PDE4 Inhibitoren
KR101734868B1 (ko)	2010-07-22	2017-05-12	후소 야쿠힝 고교 가부시끼가이샤	벤조푸라논 화합물 및 그것을 포함하는 의약 조성물
EP3597186B1 (de)	2015-01-05	2021-12-08	The U.S.A. as represented by the Secretary, Department of Health and Human Services	Myc-g-quadruplex-stabilisierende kleine moleküle und deren verwendung
CN114149457B (zh) *	2021-11-03	2024-04-12	湖北民族大学	一种苯并[c][1,2]氧杂硼戊环-1(3H)-醇类合物及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS62155269A (ja) *	1984-12-29	1987-07-10	Kaken Pharmaceut Co Ltd	ベンゾフラン誘導体
EP0685475B1 (de) *	1994-05-31	1999-01-13	Bayer Ag	Aminobenzofuryl- und -thienylderivate
FI970246L (fi) *	1994-07-22	1997-01-21	Byk Gulden Lomberg Chem Fab	Dihydrobentsofuraanit
ES2258775T3 (es) *	1995-05-19	2006-09-01	Kyowa Hakko Kogyo Co., Ltd.	Compuestos heterociclicos que contienen oxigeno.
NZ332340A (en) *	1996-05-20	2000-04-28	Darwin Discovery Ltd	4-(aryl or heteroaryl) substituted benzofurancarboxamide derivatives and medicaments

1996
- 1996-12-05 CZ CZ19981714A patent/CZ292443B6/cs not_active IP Right Cessation
- 1996-12-05 ES ES96941138T patent/ES2172695T3/es not_active Expired - Lifetime
- 1996-12-05 CN CN96198844A patent/CN1100773C/zh not_active Expired - Fee Related
- 1996-12-05 BR BR9611897-0A patent/BR9611897A/pt active Search and Examination
- 1996-12-05 HU HU9903797A patent/HUP9903797A3/hu unknown
- 1996-12-05 JP JP9521090A patent/JP2000501411A/ja not_active Ceased
- 1996-12-05 DE DE69620458T patent/DE69620458T2/de not_active Expired - Fee Related
- 1996-12-05 PL PL96327181A patent/PL327181A1/xx unknown
- 1996-12-05 CA CA002238376A patent/CA2238376C/en not_active Expired - Fee Related
- 1996-12-05 US US08/761,102 patent/US5773467A/en not_active Expired - Fee Related
- 1996-12-05 KR KR1019980704179A patent/KR19990071894A/ko not_active Ceased
- 1996-12-05 AT AT96941138T patent/ATE215540T1/de not_active IP Right Cessation
- 1996-12-05 WO PCT/GB1996/003012 patent/WO1997020833A1/en not_active Ceased
- 1996-12-05 EP EP96941138A patent/EP0873331B1/de not_active Expired - Lifetime
- 1996-12-05 AU AU10386/97A patent/AU697976B2/en not_active Ceased
1998
- 1998-06-04 NO NO982570A patent/NO982570L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP0873331B1 (de)	2002-04-03
HUP9903797A2 (hu)	2001-04-28
CA2238376A1 (en)	1997-06-12
MX9804466A (es)	1998-12-31
CZ292443B6 (cs)	2003-09-17
AU1038697A (en)	1997-06-27
CA2238376C (en)	2006-08-15
CN1208411A (zh)	1999-02-17
JP2000501411A (ja)	2000-02-08
CZ171498A3 (cs)	1998-10-14
PL327181A1 (en)	1998-11-23
AU697976B2 (en)	1998-10-22
DE69620458T2 (de)	2002-10-02
BR9611897A (pt)	1999-12-28
NO982570D0 (no)	1998-06-04
EP0873331A1 (de)	1998-10-28
WO1997020833A1 (en)	1997-06-12
ES2172695T3 (es)	2002-10-01
NO982570L (no)	1998-08-04
US5773467A (en)	1998-06-30
CN1100773C (zh)	2003-02-05
HUP9903797A3 (en)	2001-08-28
KR19990071894A (ko)	1999-09-27
DE69620458D1 (de)	2002-05-08

Legal Events

Date	Code	Title	Description
2002-06-15	UEP	Publication of translation of european patent specification
2004-09-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE215540T1 (de)	2002-04-15	Benzofuran-carboxamide und -sulfonamide
DK0944643T3 (da)	2003-05-05	Oxyiminopregnancarbolactoner.
MY132705A (en)	2007-10-31	Novel compounds with analgesic effect
ATE227587T1 (de)	2002-11-15	Kombinierte verwendung von hyaluronsäure und therapeutischen wirkstoffen zur verbesserung des therapeutischen effekts
ATE251140T1 (de)	2003-10-15	N-(2 oxoacetyl oder sulphonyl)- pyrrolidine/piperidine-2-carbonsäurederivate mit verbesserter multi-drug resistenz aktivität
DE69720811D1 (de)	2003-05-15	L-Ribavirin und dessen Verwendung
TR200000755T2 (tr)	2000-09-21	Karşıt olma-karşı gelme bozukluğunun tedavisi.
KR960705815A (ko)	1996-11-08	신규한 피라진 카복스아미드 유도체, 이의 제조방법 및 약제에 있어서의 이의 용도(Novel pyrazine carboxamide derivatives, their production and their use in medicaments)
EP0664128A4 (de)	1997-12-17	Pharmazeutisches mittel zur hemmung der tumornekrosefaktorproduktion.
SE9802208D0 (sv)	1998-06-22	Novel compounds
DE69034070D1 (de)	2003-06-12	Racemisches Huperzin A
DK0637306T3 (da)	2001-07-30	4-Imidomethyl-1-[2'-phenyl-2'-oxoethyl]-piperidiner som serotonin-5HT2-antagonister, deres fremstilling og anvendelse til terapi
DK1242410T3 (da)	2004-11-29	Nye forbindelser
BG50159A3 (bg)	1992-05-15	Метод за получаване на производни на пиранобензоксадиазол
ES2068714T3 (es)	1995-04-16	Derivados de pirimidina para aumentar la actividad antitumoral.
SE9802209D0 (sv)	1998-06-22	Novel compounds
MX9202366A (es)	1992-11-01	Nuevas 2-amino-5-ciano-1,4-di hidro piridinas y procedimiento para su fabricacion.
AU2002223731A1 (en)	2002-05-15	Anti-inflammatory and healing medicine based on laminarin sulphate
RU96104062A (ru)	1998-05-27	Средство "витадерм" в комплексной терапии ожоговых ран
RU94024337A (ru)	1996-05-10	Антиметастатическое средство
BR0108187A (pt)	2005-04-05	Moléculas trade e usos relacionados com as mesmas
FI965171L (fi)	1996-12-20	Oksatsofosforiinien, esimerkiksi ifosfamidin, enantiomeerien käyttö kasvainten hoidossa sivuvaikutuksien vähentämiseksi
SE9802207D0 (sv)	1998-06-22	Novel compounds
EP1714661A3 (de)	2012-03-14	Verfahren zur Diagnose und Behandlung von hämostatischen Störungen durch Modulation der P-Selectin Aktivität
AU5870298A (en)	1998-08-07	1,4-dihydropyridin derivatives and their use in therapy