ATE215598T1 - Monoklonale antikörper, die flk-2-rezeptoren erkennen, und die isolierung primitiver hämatopoietischer stammzellpopulationen - Google Patents

Monoklonale antikörper, die flk-2-rezeptoren erkennen, und die isolierung primitiver hämatopoietischer stammzellpopulationen

Info

Publication number
ATE215598T1
ATE215598T1 AT94929168T AT94929168T ATE215598T1 AT E215598 T1 ATE215598 T1 AT E215598T1 AT 94929168 T AT94929168 T AT 94929168T AT 94929168 T AT94929168 T AT 94929168T AT E215598 T1 ATE215598 T1 AT E215598T1
Authority
AT
Austria
Prior art keywords
flk
hematopoietic stem
receptors
isolation
recognize
Prior art date
Application number
AT94929168T
Other languages
English (en)
Inventor
Neil I Goldstein
Ratchanee Songsakphisan
Caroline Rose
Original Assignee
Imclone Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imclone Systems Inc filed Critical Imclone Systems Inc
Application granted granted Critical
Publication of ATE215598T1 publication Critical patent/ATE215598T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT94929168T 1993-09-08 1994-09-07 Monoklonale antikörper, die flk-2-rezeptoren erkennen, und die isolierung primitiver hämatopoietischer stammzellpopulationen ATE215598T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11846893A 1993-09-08 1993-09-08
PCT/US1994/010194 WO1995007348A1 (en) 1993-09-08 1994-09-07 Monoclonal antibodies that recognize flk-2 receptors and the isolation of primitive hematopoietic stem cell populations

Publications (1)

Publication Number Publication Date
ATE215598T1 true ATE215598T1 (de) 2002-04-15

Family

ID=22378791

Family Applications (2)

Application Number Title Priority Date Filing Date
AT01122476T ATE336262T1 (de) 1993-09-08 1994-09-07 Monoklonale antikörper die flk-2 rezeptoren erkennen, und die isolierung primitiver hämatopoietischer stammzellpopulationen
AT94929168T ATE215598T1 (de) 1993-09-08 1994-09-07 Monoklonale antikörper, die flk-2-rezeptoren erkennen, und die isolierung primitiver hämatopoietischer stammzellpopulationen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT01122476T ATE336262T1 (de) 1993-09-08 1994-09-07 Monoklonale antikörper die flk-2 rezeptoren erkennen, und die isolierung primitiver hämatopoietischer stammzellpopulationen

Country Status (8)

Country Link
EP (3) EP1186301B1 (de)
JP (1) JPH09502352A (de)
AT (2) ATE336262T1 (de)
AU (1) AU7832394A (de)
CA (1) CA2171112A1 (de)
DE (2) DE69434828T2 (de)
ES (2) ES2174879T3 (de)
WO (1) WO1995007348A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5635388A (en) * 1994-04-04 1997-06-03 Genentech, Inc. Agonist antibodies against the flk2/flt3 receptor and uses thereof
US5911995A (en) * 1994-08-19 1999-06-15 Regents Of The University Of Minnesota EGF-genistein conjugates for the treatment of cancer
US5587459A (en) * 1994-08-19 1996-12-24 Regents Of The University Of Minnesota Immunoconjugates comprising tyrosine kinase inhibitors
DE19608769C1 (de) * 1996-03-07 1997-04-10 Univ Eberhard Karls Antikörper BV10A4H2
DE19727814C1 (de) * 1997-06-30 1998-10-01 Univ Eberhard Karls Anitkörper 4G8B4B12
US7361336B1 (en) 1997-09-18 2008-04-22 Ivan Bergstein Methods of cancer therapy targeted against a cancer stem line
AR071891A1 (es) 2008-05-30 2010-07-21 Imclone Llc Anticuerpos humanos anti-flt3 (receptor tirosina cinasa 3 tipo fms humano)
KR20230066647A (ko) 2016-06-17 2023-05-16 마젠타 테라퓨틱스 인코포레이티드 Cd117+ 세포의 고갈을 위한 조성물 및 방법
AU2019404098A1 (en) 2018-12-18 2021-05-27 Boehringer Ingelheim Io Canada Inc. FLT3 agonist antibodies and uses thereof
JP7679399B2 (ja) 2020-04-14 2025-05-19 レ ラボラトワール セルヴィエ 抗ｆｌｔ３抗体及び組成物
WO2026052513A1 (en) 2024-09-09 2026-03-12 Adcytherix Sas Antibody-drug conjugates comprising an flt3 binding antibody

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5130144B1 (en) * 1984-02-06 1995-08-15 Univ Johns Hopkins Human stem cells and monoclonal antibodies
US5061620A (en) * 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
US5185438A (en) * 1991-04-02 1993-02-09 The Trustees Of Princeton University Nucleic acids encoding hencatoporetic stem cell receptor flk-2
US6228609B1 (en) * 1992-07-09 2001-05-08 Systemix, Inc. Soluble Flk-2 sequence

Also Published As

Publication number Publication date
EP1186301B1 (de) 2006-08-16
AU7832394A (en) 1995-03-27
DE69430313T2 (de) 2002-08-08
ATE336262T1 (de) 2006-09-15
EP1186301A3 (de) 2002-05-15
ES2269266T3 (es) 2007-04-01
EP1734053A3 (de) 2009-04-22
ES2174879T3 (es) 2002-11-16
JPH09502352A (ja) 1997-03-11
EP0722489B1 (de) 2002-04-03
EP0722489A1 (de) 1996-07-24
EP0722489A4 (de) 1996-06-11
CA2171112A1 (en) 1995-03-16
DE69434828D1 (de) 2006-09-28
EP1186301A2 (de) 2002-03-13
EP1734053A2 (de) 2006-12-20
DE69430313D1 (de) 2002-05-08
WO1995007348A1 (en) 1995-03-16
DE69434828T2 (de) 2007-03-01

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Legal Events

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UEP Publication of translation of european patent specification
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