ES2110230T3 - Ensayo de rapamicina. - Google Patents

Ensayo de rapamicina.

Info

Publication number
ES2110230T3
ES2110230T3 ES94913093T ES94913093T ES2110230T3 ES 2110230 T3 ES2110230 T3 ES 2110230T3 ES 94913093 T ES94913093 T ES 94913093T ES 94913093 T ES94913093 T ES 94913093T ES 2110230 T3 ES2110230 T3 ES 2110230T3
Authority
ES
Spain
Prior art keywords
test
rapamicine
haptenes
rapamicin
rented
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94913093T
Other languages
English (en)
Inventor
Valerie Quesniaux
Richard Sedrani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10733650&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2110230(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ciba Geigy AG, Novartis AG filed Critical Ciba Geigy AG
Application granted granted Critical
Publication of ES2110230T3 publication Critical patent/ES2110230T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1292—Gram-positive bacteria from Actinomyces; from Streptomyces (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

SE PRESENTAN ANTICUERPOS MONOCLONALES PARA LA RAPAMICINA Y PARA DERIVADOS 40-O-ALQUILADOS DE RAPAMICINA, JUNTO CON NUEVOS HAPTENOS, CONJUGADOS INMUNOGENICOS, Y PROCESOS PARA FABRICARLOS Y EQUIPOS DE ENSAYO PARA USARLOS.
ES94913093T 1993-04-08 1994-03-30 Ensayo de rapamicina. Expired - Lifetime ES2110230T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939307491A GB9307491D0 (en) 1993-04-08 1993-04-08 Organic compounds

Publications (1)

Publication Number Publication Date
ES2110230T3 true ES2110230T3 (es) 1998-02-01

Family

ID=10733650

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94913093T Expired - Lifetime ES2110230T3 (es) 1993-04-08 1994-03-30 Ensayo de rapamicina.

Country Status (22)

Country Link
US (3) US8039599B1 (es)
EP (1) EP0693132B1 (es)
JP (4) JP3397325B2 (es)
KR (2) KR100347166B1 (es)
CN (1) CN1080312C (es)
AT (1) ATE161289T1 (es)
AU (1) AU677321B2 (es)
BR (1) BR9406210A (es)
CZ (1) CZ284431B6 (es)
DE (1) DE69407402T2 (es)
DK (1) DK0693132T3 (es)
ES (1) ES2110230T3 (es)
FI (1) FI110670B (es)
GB (1) GB9307491D0 (es)
GR (1) GR3025753T3 (es)
HU (1) HU221606B (es)
NO (1) NO320470B1 (es)
NZ (1) NZ265051A (es)
PL (1) PL185855B1 (es)
RU (1) RU2175672C2 (es)
SK (1) SK280048B6 (es)
WO (1) WO1994024304A1 (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9307491D0 (en) 1993-04-08 1993-06-02 Sandoz Ltd Organic compounds
USRE40596E1 (en) * 1993-04-08 2008-12-02 Novartis Ag Rapamycin assay
US7279561B1 (en) 1993-04-23 2007-10-09 Wyeth Anti-rapamycin monoclonal antibodies
DE69435044T2 (de) * 1993-04-23 2008-09-18 Wyeth Rapamycin - Konjugate und Antikörper
GB9318612D0 (en) * 1993-09-08 1993-10-27 Sandoz Ltd An assay
US5635406A (en) * 1995-06-07 1997-06-03 Abbott Laboratories Stabilized standards and calibrators containing rapamycin and tacrolimus bound to anti-rapamycin and anti-tacrolimus antibodies
CN1235608A (zh) * 1996-09-09 1999-11-17 美国家用产品公司 烷基化的雷帕霉素衍生物
US6709873B1 (en) 1997-04-09 2004-03-23 Isodiagnostika Inc. Method for production of antibodies to specific sites of rapamycin
JP2001518784A (ja) * 1997-04-09 2001-10-16 アイソテクニカ，インコーポレイテッド ラパマイシンの特異的部位に対する抗体の産生方法
DE19951684A1 (de) * 1999-10-27 2001-05-03 Aventis Pharma Gmbh Neuer immunologischer Assay zur Bestimmung von C-peptidhaltigen Kontaminanten in Proben von Humanisulin und dessen Derivaten
US7157561B2 (en) * 2001-07-13 2007-01-02 Roche Diagnostics Operations, Inc. Methods of inhibiting transmission of a costimulatory signal of lymphocytes
US7193065B2 (en) * 2001-07-13 2007-03-20 Roche Diagnostics Operations, Inc. Protease inhibitor conjugates and antibodies useful in immunoassay
US20040243224A1 (en) * 2003-04-03 2004-12-02 Medtronic Vascular, Inc. Methods and compositions for inhibiting narrowing in mammalian vascular pathways
US20050176080A1 (en) * 2004-02-10 2005-08-11 Vani Bodepudi Hapten, immunogens and derivatives of ascomycin useful for preparation of antibodies and immunoassays
EP1723179A1 (en) * 2004-03-05 2006-11-22 Astellas Pharma Inc. Anti fk778 antibodies and high sensitive immunoassay methods
ES2425167T3 (es) * 2004-03-10 2013-10-11 Seradyn, Inc. Inmunoensayos para everolimús
AU2005238432A1 (en) * 2004-04-14 2005-11-10 Wyeth Process for preparing rapamycin 42-esters and FK-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
MX2007001676A (es) * 2004-08-10 2007-04-12 Wyeth Corp Derivados de 42-ester de rapamicina con acido 2,2-bis(hidroximetil)propionico y metodos para hacer los mismos.
US8021849B2 (en) 2004-11-05 2011-09-20 Siemens Healthcare Diagnostics Inc. Methods and kits for the determination of sirolimus in a sample
RU2413538C2 (ru) 2005-03-21 2011-03-10 Сютакоат Аб Противомикробное средство, содержащее цистеиновое соединение, ковалентно связанное с субстратом, в частности, связыванием при помощи s-s мостика через спейсерную молекулу
US7189582B2 (en) * 2005-04-27 2007-03-13 Dade Behring Inc. Compositions and methods for detection of sirolimus
US20080081379A1 (en) * 2006-07-13 2008-04-03 Sigler Gerald F Homogeneous double receptor agglutination assay for immunosuppressant drugs
US7883855B2 (en) 2006-07-21 2011-02-08 Abbott Laboratories Immunosuppressant drug extraction reagent for immunoassays
FR2908658B1 (fr) * 2006-11-20 2011-11-11 Centre Nat Rech Scient Composition pour la prevention et/ou le traitement des maladies associees a la surexpression du tnf et/ou de l'il-12
US7914999B2 (en) 2006-12-29 2011-03-29 Abbott Laboratories Non-denaturing lysis reagent
CA2673296C (en) 2006-12-29 2012-10-16 Abbott Laboratories Improved assay for immunosuppressant drugs
CA2673314C (en) 2006-12-29 2014-03-11 Abbott Laboratories Non-denaturing lysis reagent for use with capture-in-solution immunoassay
WO2008082979A2 (en) 2006-12-29 2008-07-10 Abbott Laboratories Diagnostic test for the detection of a molecule or drug in whole blood
US20080287675A1 (en) * 2007-05-18 2008-11-20 Abbott Laboratories Cascade system
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
US20110097733A1 (en) 2009-10-27 2011-04-28 Michel Anciaux Process for the production of a hybridoma and antibody obtained therefrom, able to recognize more than one vitamin d metabolite
AU2011243294C1 (en) 2010-04-21 2015-12-03 Syntarga B.V. Novel conjugates of CC-1065 analogs and bifunctional linkers
BR112014032916A2 (pt) * 2012-06-28 2017-08-01 Pfizer anticorpos anti-fármacos e usos destes para o monitoramento de fármaco
HUE029672T2 (en) 2014-01-10 2017-03-28 Synthon Biopharmaceuticals Bv Duokarmicin-ADCs for use in the treatment of endometrial cancer
CN105899236B (zh) 2014-01-10 2019-07-26 斯索恩生物制药有限公司 表现出改进的体内抗肿瘤活性的倍癌霉素adc
WO2016046173A1 (en) * 2014-09-22 2016-03-31 Synthon Biopharmaceuticals B.V. Pan-reactive antibodies to duocarmycins
JP7319362B2 (ja) 2018-11-02 2023-08-01 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド マクロフィリン結合医薬アッセイに使用するための結合競合剤およびその使用方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5169773A (en) * 1984-10-04 1992-12-08 Sandoz Ltd. Monoclonal antibodies to cyclosporins
ATE92501T1 (de) 1984-10-04 1993-08-15 Sandoz Ag Monoklonale antikoerper gegen zyklosporine.
US4650803A (en) 1985-12-06 1987-03-17 University Of Kansas Prodrugs of rapamycin
DE3886265T2 (de) 1987-06-05 1994-04-28 Fujisawa Pharmaceutical Co Anti-FR-900506-Stoffe-Antikörper und höchstempfindliches Enzym-Immunoassay-Verfahren.
JPH02495A (ja) * 1987-12-25 1990-01-05 Tosoh Corp モノクローナル抗体、その製法及びそれを用いた測定法
CA2039541A1 (en) * 1990-04-05 1991-10-06 Ethel B. Jacobson Monoclonal antibodies to avermectins
EP0473961B1 (en) * 1990-08-15 1996-01-03 Abbott Laboratories Immunoassay reagents and method for determining cyclosporine
US5130307A (en) 1990-09-28 1992-07-14 American Home Products Corporation Aminoesters of rapamycin
PT98990A (pt) * 1990-09-19 1992-08-31 American Home Prod Processo para a preparacao de esteres de acidos carboxilicos de rapamicina
US5120842A (en) * 1991-04-01 1992-06-09 American Home Products Corporation Silyl ethers of rapamycin
US5100883A (en) 1991-04-08 1992-03-31 American Home Products Corporation Fluorinated esters of rapamycin
US5322772A (en) 1991-04-09 1994-06-21 Children's Research Institute Rapamycin assay
FI921595A7 (fi) * 1991-04-17 1992-10-18 American Home Prod Rapamysiinikarbamaatteja
US5118678A (en) 1991-04-17 1992-06-02 American Home Products Corporation Carbamates of rapamycin
US5194447A (en) 1992-02-18 1993-03-16 American Home Products Corporation Sulfonylcarbamates of rapamycin
US5118677A (en) 1991-05-20 1992-06-02 American Home Products Corporation Amide esters of rapamycin
US5514544A (en) * 1991-07-26 1996-05-07 Eli Lilly And Company Activator gene for macrolide biosynthesis
US5151413A (en) 1991-11-06 1992-09-29 American Home Products Corporation Rapamycin acetals as immunosuppressant and antifungal agents
US5177203A (en) 1992-03-05 1993-01-05 American Home Products Corporation Rapamycin 42-sulfonates and 42-(N-carboalkoxy) sulfamates useful as immunosuppressive agents
GB9221220D0 (en) 1992-10-09 1992-11-25 Sandoz Ag Organic componds
US5258389A (en) 1992-11-09 1993-11-02 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives
GB9307491D0 (en) 1993-04-08 1993-06-02 Sandoz Ltd Organic compounds
US5504091A (en) 1993-04-23 1996-04-02 American Home Products Corporation Biotin esters of rapamycin
WO1994025072A1 (en) 1993-04-23 1994-11-10 American Home Products Corporation Rapamycin conjugates and antibodies
DE69435044T2 (de) 1993-04-23 2008-09-18 Wyeth Rapamycin - Konjugate und Antikörper
US6187547B1 (en) * 1993-09-08 2001-02-13 Novartis Ag Assay kit

Also Published As

Publication number Publication date
SK280048B6 (sk) 1999-07-12
FI110670B (fi) 2003-03-14
CZ284431B6 (cs) 1998-11-11
HU9501975D0 (en) 1995-08-28
DE69407402T2 (de) 1998-06-04
WO1994024304A1 (en) 1994-10-27
FI954319A0 (fi) 1995-09-14
US20020002273A1 (en) 2002-01-03
JP2006249090A (ja) 2006-09-21
JP2003024065A (ja) 2003-01-28
CN1120854A (zh) 1996-04-17
JPH08508647A (ja) 1996-09-17
SK125795A3 (en) 1996-06-05
KR100404162B1 (ko) 2003-11-01
CN1080312C (zh) 2002-03-06
KR100347166B1 (ko) 2002-11-04
EP0693132B1 (en) 1997-12-17
AU6537794A (en) 1994-11-08
PL185855B1 (pl) 2003-08-29
JP2001302698A (ja) 2001-10-31
NO953975L (no) 1995-11-24
EP0693132A1 (en) 1996-01-24
KR960702003A (ko) 1996-03-28
DE69407402D1 (de) 1998-01-29
US20020022717A1 (en) 2002-02-21
AU677321B2 (en) 1997-04-17
JP4287619B2 (ja) 2009-07-01
US8039599B1 (en) 2011-10-18
PL310967A1 (en) 1996-01-22
US8039600B2 (en) 2011-10-18
JP3397325B2 (ja) 2003-04-14
RU2175672C2 (ru) 2001-11-10
HUT72835A (en) 1996-05-28
GB9307491D0 (en) 1993-06-02
DK0693132T3 (da) 1998-03-02
CZ258395A3 (en) 1996-01-17
US6635745B2 (en) 2003-10-21
HU221606B (hu) 2002-11-28
ATE161289T1 (de) 1998-01-15
BR9406210A (pt) 1996-02-06
FI954319L (fi) 1995-09-14
NO953975D0 (no) 1995-10-06
NO320470B1 (no) 2005-12-12
GR3025753T3 (en) 1998-03-31
NZ265051A (en) 1996-09-25

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