ES2075327T3 - Metodo para multiplicar linfocitos de sangre periferica humana in vitro que producen anticuerpos monoclonales especificos para un antigeno. - Google Patents

Metodo para multiplicar linfocitos de sangre periferica humana in vitro que producen anticuerpos monoclonales especificos para un antigeno.

Info

Publication number
ES2075327T3
ES2075327T3 ES91200912T ES91200912T ES2075327T3 ES 2075327 T3 ES2075327 T3 ES 2075327T3 ES 91200912 T ES91200912 T ES 91200912T ES 91200912 T ES91200912 T ES 91200912T ES 2075327 T3 ES2075327 T3 ES 2075327T3
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ES
Spain
Prior art keywords
peripheral blood
human peripheral
antigen
multiplying
monoclonal antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91200912T
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English (en)
Inventor
Goroff Diana Keenan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo Nobel NV
Original Assignee
Akzo Nobel NV
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Publication date
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Publication of ES2075327T3 publication Critical patent/ES2075327T3/es
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/40—Nucleotides, nucleosides or bases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

UN METODO PARA AMPLIAR LA PRODUCCION DE ANTICUERPOS MONOCLONALES HUMANOS DE ANTIGENO ESPECIFICOS IGG, IGA E IGM A PARTIR DE LINFOCITOS TRANSFORMADOS DE SANGRE PERIFERICA HUMANA, DE CELULAS T EMPOBRECIDAS, A TRAVES DEL USO DE UN SISTEMA ADYACENTE QUE CONSISTE EN 8-MERCAPTOGNANOSINA Y POR LO MENOS UNA DE LAS CITOQUINAS INTERLEUKIN-4 E INTERLEUKIN-6. TAMBIEN SE INCLUYE EN LA INVENCION EL SISTEMA ADYACENTE Y UN EQUIPO QUE INCLUYE EL SISTEMA.
ES91200912T 1990-04-26 1991-04-17 Metodo para multiplicar linfocitos de sangre periferica humana in vitro que producen anticuerpos monoclonales especificos para un antigeno. Expired - Lifetime ES2075327T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/514,775 US5229275A (en) 1990-04-26 1990-04-26 In-vitro method for producing antigen-specific human monoclonal antibodies

Publications (1)

Publication Number Publication Date
ES2075327T3 true ES2075327T3 (es) 1995-10-01

Family

ID=24048643

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91200912T Expired - Lifetime ES2075327T3 (es) 1990-04-26 1991-04-17 Metodo para multiplicar linfocitos de sangre periferica humana in vitro que producen anticuerpos monoclonales especificos para un antigeno.

Country Status (14)

Country Link
US (1) US5229275A (es)
EP (1) EP0454225B1 (es)
JP (1) JPH0686690A (es)
KR (1) KR0151408B1 (es)
AT (1) ATE123311T1 (es)
AU (1) AU647112B2 (es)
CA (1) CA2041213A1 (es)
DE (1) DE69110084T2 (es)
DK (1) DK0454225T3 (es)
ES (1) ES2075327T3 (es)
FI (1) FI97392C (es)
GR (1) GR3017162T3 (es)
IE (1) IE66523B1 (es)
ZA (1) ZA912998B (es)

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DE69110084T2 (de) 1995-10-19
ATE123311T1 (de) 1995-06-15
JPH0686690A (ja) 1994-03-29
KR0151408B1 (ko) 1998-08-17
EP0454225B1 (en) 1995-05-31
EP0454225A1 (en) 1991-10-30
IE66523B1 (en) 1996-01-10
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