ATE215601T1 - Rezeptoren der steroid/thyroid superfamilie von rezeptoren - Google Patents

Rezeptoren der steroid/thyroid superfamilie von rezeptoren

Info

Publication number
ATE215601T1
ATE215601T1 AT92919761T AT92919761T ATE215601T1 AT E215601 T1 ATE215601 T1 AT E215601T1 AT 92919761 T AT92919761 T AT 92919761T AT 92919761 T AT92919761 T AT 92919761T AT E215601 T1 ATE215601 T1 AT E215601T1
Authority
AT
Austria
Prior art keywords
receptors
steroid
thyroid superfamily
expression vectors
novel
Prior art date
Application number
AT92919761T
Other languages
English (en)
Inventor
Ronald M Evans
David J Mangelsdorf
Estelita S Ong
Anthony E Oro
Uwe K Borgmeyer
Vincent Giguere
Tso-Pang Yao
Original Assignee
Salk Inst For Biological Studi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salk Inst For Biological Studi filed Critical Salk Inst For Biological Studi
Application granted granted Critical
Publication of ATE215601T1 publication Critical patent/ATE215601T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT92919761T 1991-09-17 1992-09-08 Rezeptoren der steroid/thyroid superfamilie von rezeptoren ATE215601T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76106891A 1991-09-17 1991-09-17
PCT/US1992/007570 WO1993006215A1 (en) 1991-09-17 1992-09-08 Receptor of the thyroid/steroid hormone receptor superfamily

Publications (1)

Publication Number Publication Date
ATE215601T1 true ATE215601T1 (de) 2002-04-15

Family

ID=25061029

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92919761T ATE215601T1 (de) 1991-09-17 1992-09-08 Rezeptoren der steroid/thyroid superfamilie von rezeptoren

Country Status (8)

Country Link
US (3) US5571696A (de)
EP (1) EP0609240B1 (de)
JP (1) JP2002514881A (de)
AT (1) ATE215601T1 (de)
AU (1) AU2579692A (de)
CA (1) CA2115452A1 (de)
DE (1) DE69232537T2 (de)
WO (1) WO1993006215A1 (de)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0514488B1 (de) * 1990-02-09 2000-09-13 The Salk Institute For Biological Studies Retinoid-rezeptor-zusammensetzungen und verfahren
EP0609240B1 (de) * 1991-09-17 2002-04-03 The Salk Institute For Biological Studies Rezeptoren der steroid/thyroid superfamilie von rezeptoren
US5756448A (en) * 1992-02-26 1998-05-26 The General Hospital Corporation Constitute activator of retinoid (CAR) receptor polypeptides
EP0577932A3 (de) * 1992-05-08 1995-04-19 American Cyanamid Co Entwicklung von einem "Screening" für den Nachweis von androgenen Rezeptorenagonisten und Antagonisten.
ATE365209T1 (de) * 1992-05-14 2007-07-15 Baylor College Medicine Mutierte steroidhormonrezeptoren, methoden für ihre benutzung und molekularer schalter für gentherapie
JPH08504325A (ja) * 1992-10-30 1996-05-14 ザ ゼネラル ホスピタル コーポレーション 核のホルモン受容体と相互作用するポリペプチド及び関連する分子並びに方法
EP0743520A3 (de) * 1993-12-30 1999-11-10 The Salk Institute For Biological Studies Neue Verwendungen von Gal4-Rezeptor-Konstruktionen
EP0769023A4 (de) * 1994-06-24 1999-05-26 Human Genome Sciences Inc Epsilon retinsäure-rezeptor
WO1996000242A1 (en) * 1994-06-24 1996-01-04 Human Genome Sciences, Inc. Retinoic acid receptor epsilon
CA2194169A1 (en) * 1994-07-01 1996-01-18 Ronald M. Evans Mammalian peroxisome proliferator-activated receptors and uses thereof
GB9416536D0 (en) * 1994-08-16 1994-10-12 Karobio Ab Orphan receptor
WO1996021457A1 (en) * 1995-01-13 1996-07-18 The Salk Institute For Biological Studies Allosteric control of nuclear hormone receptors
US6005086A (en) * 1995-01-13 1999-12-21 The Salk Institute For Biological Studies Farnesoid activated receptor polypeptides, and nucleic acid encoding the same
US5958954A (en) * 1995-09-01 1999-09-28 Allergan Sales, Inc. Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
US6008204A (en) 1995-09-01 1999-12-28 Allergan Sales, Inc. Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
US6942980B1 (en) 1995-09-01 2005-09-13 Allergan, Inc. Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities
US5776699A (en) * 1995-09-01 1998-07-07 Allergan, Inc. Method of identifying negative hormone and/or antagonist activities
US5952345A (en) * 1995-09-01 1999-09-14 Allergan Sales, Inc. Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
US6218128B1 (en) 1997-09-12 2001-04-17 Allergan Sales, Inc. Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities
EP0859851A1 (de) 1995-10-10 1998-08-26 Novartis AG Juvenilhormon oder einer seiner agonisten als chemischer ligand für die kontrolle der pflanzengenexpression durch rezeptorvermittelte transaktivation
CA2200423C (en) * 1996-03-26 2006-12-19 Sietse Mosselman Novel estrogen receptor
US6246815B1 (en) 1996-08-12 2001-06-12 Toyota Jidosha Kabushiki Kaisha Grating element, light wavelength selection utilizing the same, and optical signal transmitting system
US6893830B1 (en) 1996-09-27 2005-05-17 The Board Of Regents Of The University Of Texas System Method of screening oxysterol activation of LXRα
US6037488A (en) 1997-04-19 2000-03-14 Allergan Sales, Inc. Trisubstituted phenyl derivatives having retinoid agonist, antagonist or inverse agonist type biological activity
SE9801148D0 (sv) * 1997-10-14 1998-03-31 Pharmacia & Upjohn Ab New receptors
US7118885B2 (en) 1997-10-14 2006-10-10 Pfizer Inc. Nucleic acid encoding vitamin D receptor related polypeptide
US6153148A (en) * 1998-06-15 2000-11-28 Becton, Dickinson And Company Centrifugal hematology disposable
WO2000015791A1 (en) * 1998-09-10 2000-03-23 Pioneer Hi-Bred International, Inc. Ecdysone receptors and methods for their use
EP1143953A3 (de) * 1998-11-20 2002-02-06 Genentech, Inc. Verfahren zur hemmung der angiogenese
US20020132223A1 (en) * 1999-03-26 2002-09-19 City Of Hope Methods for modulating activity of the FXR nuclear receptor
US6548739B2 (en) 1999-06-18 2003-04-15 City Of Hope Method for activating peroxisome proliferator activated receptor-γ
US6586189B2 (en) 1999-06-18 2003-07-01 City Of Hope Screening method for PPAR-γ ligands
CA2284103A1 (en) * 1999-09-30 2001-03-30 Edith Bonnelye Estrogen related receptor, err.alpha., a regulator of bone formation
US20040033600A1 (en) 2001-03-21 2004-02-19 Palli Subba Reddy Ecdysone receptor-based inducible gene expression system
CA2402439A1 (en) * 2000-03-24 2001-10-04 City Of Hope Methods of modulating drug clearance mechanisms by altering sxr activity
CA2417005A1 (en) 2000-07-20 2002-01-31 Bristol Myers Squibb Company Regulators of ppar.delta.(.beta.) and their use in the treatment of obesity and insulin resistance
US8105825B2 (en) * 2000-10-03 2012-01-31 Intrexon Corporation Multiple inducible gene regulation system
JP2004533212A (ja) 2000-10-24 2004-11-04 シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト 植物における遺伝子発現のコントロール
JP4328094B2 (ja) 2001-02-20 2009-09-09 イントレクソン・コーポレイション 新規置換突然変異体受容体および核受容体−ベースの誘導性遺伝子発現システムにおけるその使用
WO2002066614A2 (en) 2001-02-20 2002-08-29 Rheogene Holdings, Inc. Chimeric retinoid x receptors and their use in a novel ecdysone receptor-based inducible gene expression system
DK1534738T3 (da) 2001-02-20 2012-10-01 Intrexon Corp Nye substitutionsmutantreceptorer og anvendelse heraf i et inducérbart genekpressionssystem på basis af en nuklear receptor
US9493540B2 (en) 2001-02-20 2016-11-15 Intrexon Corporation Ecdysone receptor/invertebrate retinoid X receptor-based inducible gene expression system
AU2002305052A1 (en) 2001-03-13 2002-09-24 Corvas International, Inc. Nucleic acid molecules encoding a transmembrane serine protease 7, the encoded polypeptides and methods based thereon
US7172892B2 (en) 2001-03-22 2007-02-06 Dendreon Corporation Nucleic acid molecules encoding serine protease CVSP14, the encoded polypeptides and methods based thereon
EP1379637A4 (de) 2001-03-27 2005-04-06 Dendreon Corp Transmembran-serinprotease 9 codierende nukleinsäuremoleküle, die codierten polypeptide sowie darauf beruhende verfahren
US7112430B2 (en) 2001-05-14 2006-09-26 Dendreon Corporation Nucleic acid molecules encoding a transmembrane serine protease 10, the encoded polypeptides and methods based thereon
US20030134298A1 (en) * 2001-07-03 2003-07-17 Madison Edwin L. Nucleic acid molecules encoding a transmembrane serine protease 20, the encoded polypeptides and methods based thereon
US20030031627A1 (en) * 2001-07-31 2003-02-13 Mallinckrodt Inc. Internal image antibodies for optical imaging and therapy
WO2003030125A1 (de) * 2001-09-25 2003-04-10 Werner Keber Verfahren und einrichtung zum verhindern einer unzulässiggen flugannäherung von flugzeugen an zu schützende bodenobjekte
JP2005507247A (ja) * 2001-09-26 2005-03-17 レオジーン・ホールディングス,インコーポレーテッド コナジラミエクジソン受容体核酸、ポリペプチド、およびそれらの使用
EP1436394A4 (de) * 2001-09-26 2004-12-29 Rheo Gene Holdings Inc Zikaden-ecdyson-rezeptor-nukleinsäuren, -polypeptide und ihre verwendungen
US6924311B2 (en) * 2001-10-17 2005-08-02 X-Ceptor Therapeutics, Inc. Methods for affecting various diseases utilizing LXR compounds
AU2002357004A1 (en) * 2001-11-20 2003-06-10 Dendreon San Diego Llc Nucleic acid molecules encoding serine protease 17, the encoded polypeptides and methods based thereon
US7998986B2 (en) 2001-12-21 2011-08-16 Exelixis Patent Company Llc Modulators of LXR
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
US20030228607A1 (en) * 2002-04-15 2003-12-11 Wagner Brandee Lynn Screening method and modulators having an improved therapeutic profile
US20040001801A1 (en) * 2002-05-23 2004-01-01 Corvas International, Inc. Conjugates activated by cell surface proteases and therapeutic uses thereof
EP1371662A1 (de) * 2002-06-13 2003-12-17 LION Bioscience AG Neue zelluläre LXR-alpha Rezeptorvariante
WO2004024884A2 (en) 2002-09-16 2004-03-25 Exelixis, Inc. Syts as modifiers of the p21 pathway and methods of use
US7304161B2 (en) * 2003-02-10 2007-12-04 Intrexon Corporation Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
US7456315B2 (en) 2003-02-28 2008-11-25 Intrexon Corporation Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
GB0306185D0 (en) * 2003-03-19 2003-04-23 Astrazeneca Ab Molecules
US7935510B2 (en) 2004-04-30 2011-05-03 Intrexon Corporation Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
US8097431B2 (en) 2004-08-04 2012-01-17 University Of Utah Research Foundation Methods and compositions for detecting steroids
JP5237799B2 (ja) 2005-06-27 2013-07-17 エグゼリクシス パテント カンパニー エルエルシー ピラゾールベースのlxrモジュレーター
CA2761934C (en) 2009-05-28 2018-01-09 Exelixis Patent Company Llc Substituted 1-(biphenyl-4-yl)-2-benzyl-4-hydroxyalkyl-1h-imidazole compounds and their use as lxr modulators
AR088728A1 (es) 2011-03-25 2014-07-02 Bristol Myers Squibb Co Moduladores de lxr como prodroga de imidazol
RU2637946C2 (ru) 2013-03-15 2017-12-08 Интрексон Корпорейшн Борсодержащие диацилгидразины
EP3194359B1 (de) 2014-09-17 2020-04-08 Intrexon Corporation Borhaltige diacylhydrazinverbindungen
JP2020517259A (ja) 2017-04-19 2020-06-18 ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム 操作された抗原受容体を発現する免疫細胞
JP7273421B2 (ja) 2018-02-21 2023-05-15 ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム ナチュラルキラー細胞の活性化および拡大のための方法ならびにその使用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071773A (en) * 1986-10-24 1991-12-10 The Salk Institute For Biological Studies Hormone receptor-related bioassays
US4981784A (en) * 1987-12-02 1991-01-01 The Salk Institute For Biological Studies Retinoic acid receptor method
CA2003996A1 (en) * 1988-11-30 1990-05-31 Ronald M. Evans Model drosophila receptors
EP0514488B1 (de) * 1990-02-09 2000-09-13 The Salk Institute For Biological Studies Retinoid-rezeptor-zusammensetzungen und verfahren
ES2180529T3 (es) * 1990-02-26 2003-02-16 Univ Leland Stanford Junior Identificacion y expresion de secuencias de adn de un receptor de esteroides de insectos.
EP0609240B1 (de) * 1991-09-17 2002-04-03 The Salk Institute For Biological Studies Rezeptoren der steroid/thyroid superfamilie von rezeptoren

Also Published As

Publication number Publication date
DE69232537D1 (de) 2002-05-08
US5696233A (en) 1997-12-09
WO1993006215A1 (en) 1993-04-01
EP0609240A1 (de) 1994-08-10
CA2115452A1 (en) 1993-04-01
US5710004A (en) 1998-01-20
DE69232537T2 (de) 2002-10-24
EP0609240B1 (de) 2002-04-03
AU2579692A (en) 1993-04-27
JP2002514881A (ja) 2002-05-21
US5571696A (en) 1996-11-05

Similar Documents

Publication Publication Date Title
ATE215601T1 (de) Rezeptoren der steroid/thyroid superfamilie von rezeptoren
ES2193145T3 (es) Proteinas procoagulants quimericas.
EP0653940A4 (de) Glialmitogene faktoren, ihre herstellung und verwendung.
ATE286907T1 (de) Cytokinin-designiertes lerk-5
NO953901L (no) Rekombinante alfavirus-vektorer
BR9711123A (pt) Quimeras de leucotoxina-gnrh
BG46598A3 (bg) Метод за получаване на алфа-хетероциклично заместени толунитрили
BR0214350A (pt) Sequências de ácido nucleico e aminoácido de adenovìrus de sìmio, vetores contendo as mesmas e métodos de uso
DE69433552D1 (de) An den zelloberflächenrezeptor hek bindendes cytokin
DE69432787D1 (de) Klonierung von Enterokinase und Verfahren zu deren Verwendung
DE69433690D1 (de) Chimere proteine, welche borrelia polypeptide beinhalten, verwendungen dafür
ATE194168T1 (de) Varianten in den leltin domäne von selektin
DK0724637T3 (da) Kortikotropinfrigørende faktor2-receptorer
DE68917556D1 (de) Quinolyloxazol-2-one, nützlich als Proteinkinase-C-Inhibitoren.
WO1996001317A3 (en) Mammalian peroxisome proliferator-activated receptors and uses thereof
BR9407693A (pt) Sequência nucleotídica vetor composiçao farmacêutica utilizaçao do vetor e de um composto
SE9801148D0 (sv) New receptors
DK0643719T3 (da) Nukleinsyresekvenser, som koder for eller er komplementære til nukleinsyresekvenser, som koder for interleukin 9-receptor
DE69619808D1 (de) Chimäre msp und daf proteine mit einem telloberflächenlokalisierendem domän
AR022150A1 (es) Acidos nucleicos derivados de monocitos y composiciones y metodos relacionados
ATE215123T1 (de) Or-1, ein wais-rezeptor der nuklearen rezeptoren familie
DK447083A (da) Dna, som koder for humant interferon-gamma, rekombinant-dna indeholdende denne dna, mikroorganisme indeholdende rekombinant-dna'en og fremgangsmaade til fremstilling af humant interferon-gamma-polypeptid
DE59005647D1 (de) Verwendung von polyglykolethergemischen als antischaummittel.
DK192890D0 (da) 24r-scumnol, fremgangsmaade til fremstilling heraf samt anvendelse af samme
EP0659217A4 (de) KLONIERUNG UND EXPRESSION VON DEM -g(b)APP-C100 REZEPTOR.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties