ATE215601T1 - Rezeptoren der steroid/thyroid superfamilie von rezeptoren - Google Patents

Rezeptoren der steroid/thyroid superfamilie von rezeptoren

Info

Publication number
ATE215601T1
ATE215601T1 AT92919761T AT92919761T ATE215601T1 AT E215601 T1 ATE215601 T1 AT E215601T1 AT 92919761 T AT92919761 T AT 92919761T AT 92919761 T AT92919761 T AT 92919761T AT E215601 T1 ATE215601 T1 AT E215601T1
Authority
AT
Austria
Prior art keywords
receptors
steroid
thyroid superfamily
expression vectors
novel
Prior art date
Application number
AT92919761T
Other languages
English (en)
Inventor
Ronald M Evans
David J Mangelsdorf
Estelita S Ong
Anthony E Oro
Uwe K Borgmeyer
Vincent Giguere
Tso-Pang Yao
Original Assignee
Salk Inst For Biological Studi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salk Inst For Biological Studi filed Critical Salk Inst For Biological Studi
Application granted granted Critical
Publication of ATE215601T1 publication Critical patent/ATE215601T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT92919761T 1991-09-17 1992-09-08 Rezeptoren der steroid/thyroid superfamilie von rezeptoren ATE215601T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76106891A 1991-09-17 1991-09-17
PCT/US1992/007570 WO1993006215A1 (en) 1991-09-17 1992-09-08 Receptor of the thyroid/steroid hormone receptor superfamily

Publications (1)

Publication Number Publication Date
ATE215601T1 true ATE215601T1 (de) 2002-04-15

Family

ID=25061029

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92919761T ATE215601T1 (de) 1991-09-17 1992-09-08 Rezeptoren der steroid/thyroid superfamilie von rezeptoren

Country Status (8)

Country Link
US (3) US5571696A (de)
EP (1) EP0609240B1 (de)
JP (1) JP2002514881A (de)
AT (1) ATE215601T1 (de)
AU (1) AU2579692A (de)
CA (1) CA2115452A1 (de)
DE (1) DE69232537T2 (de)
WO (1) WO1993006215A1 (de)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2152920T3 (es) * 1990-02-09 2001-02-16 Salk Inst For Biological Studi Composiciones receptoras de retinoides y metodos.
CA2115452A1 (en) * 1991-09-17 1993-04-01 Ronald M. Evans Receptor of the thyroid/steroid hormone receptor superfamily
US5756448A (en) * 1992-02-26 1998-05-26 The General Hospital Corporation Constitute activator of retinoid (CAR) receptor polypeptides
EP0577932A3 (de) * 1992-05-08 1995-04-19 American Cyanamid Co Entwicklung von einem "Screening" für den Nachweis von androgenen Rezeptorenagonisten und Antagonisten.
EP0745121B1 (de) * 1992-05-14 2007-06-20 Baylor College Of Medicine Mutierte steroidhormonrezeptoren, methoden für ihre benutzung und molekularer schalter für gentherapie
EP0666926A4 (de) * 1992-10-30 1998-04-29 Gen Hospital Corp Mit hormonrezeptoren wechselwirkende polypeptide aus zellkernen und verwandte moleküle sowie verfahren.
EP0737314A4 (de) * 1993-12-30 1999-11-03 Salk Inst For Biological Studi Verwendungen für gal 4-rezeptor-konstrukte
WO1996000242A1 (en) * 1994-06-24 1996-01-04 Human Genome Sciences, Inc. Retinoic acid receptor epsilon
EP0769023A4 (de) * 1994-06-24 1999-05-26 Human Genome Sciences Inc Epsilon retinsäure-rezeptor
AU2952695A (en) * 1994-07-01 1996-01-25 Salk Institute For Biological Studies, The Mammalian peroxisome proliferator-activated receptors and uses thereof
GB9416536D0 (en) * 1994-08-16 1994-10-12 Karobio Ab Orphan receptor
AU4530496A (en) * 1995-01-13 1996-07-31 Salk Institute For Biological Studies, The Allosteric control of nuclear hormone receptors
US6005086A (en) * 1995-01-13 1999-12-21 The Salk Institute For Biological Studies Farnesoid activated receptor polypeptides, and nucleic acid encoding the same
US5952345A (en) * 1995-09-01 1999-09-14 Allergan Sales, Inc. Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
US5958954A (en) * 1995-09-01 1999-09-28 Allergan Sales, Inc. Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
US6218128B1 (en) 1997-09-12 2001-04-17 Allergan Sales, Inc. Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities
US6942980B1 (en) 1995-09-01 2005-09-13 Allergan, Inc. Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities
US6008204A (en) 1995-09-01 1999-12-28 Allergan Sales, Inc. Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
US5776699A (en) * 1995-09-01 1998-07-07 Allergan, Inc. Method of identifying negative hormone and/or antagonist activities
WO1997013864A1 (en) 1995-10-10 1997-04-17 Novartis Ag Juvenile hormone or one of its agonists as a chemical ligand to control gene expression in plants by receptor mediated transactivation
CA2200423C (en) 1996-03-26 2006-12-19 Sietse Mosselman Novel estrogen receptor
WO1998007064A1 (en) 1996-08-12 1998-02-19 Toyota Jidosha Kabushiki Kaisha Grating element, light wavelength selection utilizing the same, and optical signal transmitting system
US6893830B1 (en) 1996-09-27 2005-05-17 The Board Of Regents Of The University Of Texas System Method of screening oxysterol activation of LXRα
US6037488A (en) 1997-04-19 2000-03-14 Allergan Sales, Inc. Trisubstituted phenyl derivatives having retinoid agonist, antagonist or inverse agonist type biological activity
US7118885B2 (en) 1997-10-14 2006-10-10 Pfizer Inc. Nucleic acid encoding vitamin D receptor related polypeptide
SE9801148D0 (sv) * 1997-10-14 1998-03-31 Pharmacia & Upjohn Ab New receptors
US6153148A (en) * 1998-06-15 2000-11-28 Becton, Dickinson And Company Centrifugal hematology disposable
CA2336207C (en) 1998-09-10 2004-03-23 Pioneer Hi-Bred International, Inc. Ecdysone receptors and methods for their use
WO2000030628A2 (en) * 1998-11-20 2000-06-02 Genentech, Inc. Method of inhibiting angiogenesis
US20020132223A1 (en) * 1999-03-26 2002-09-19 City Of Hope Methods for modulating activity of the FXR nuclear receptor
US6548739B2 (en) 1999-06-18 2003-04-15 City Of Hope Method for activating peroxisome proliferator activated receptor-γ
US6586189B2 (en) 1999-06-18 2003-07-01 City Of Hope Screening method for PPAR-γ ligands
CA2284103A1 (en) * 1999-09-30 2001-03-30 Edith Bonnelye Estrogen related receptor, err.alpha., a regulator of bone formation
US20040033600A1 (en) 2001-03-21 2004-02-19 Palli Subba Reddy Ecdysone receptor-based inducible gene expression system
AU2001252944A1 (en) * 2000-03-24 2001-10-08 City Of Hope Methods of modulating drug clearance mechanisms by altering SXR activity
IL153543A0 (en) 2000-07-20 2003-07-06 Bristol Myers Squibb Co PHARMACEUTICAL COMPOSITIONS CONTAINING A COMPOUND WHICH INHIBITS OR MODULATES PPARdelta (beta) ACTIVITY
US8105825B2 (en) 2000-10-03 2012-01-31 Intrexon Corporation Multiple inducible gene regulation system
EP1356066A2 (de) 2000-10-24 2003-10-29 Syngenta Participations AG Kontrolle der pflanzengenexpression
EP1373470B1 (de) * 2001-02-20 2013-04-24 Intrexon Corporation Neue substitutionsmutantenrezeptoren und ihre verwendung in einem induzierbaren genexpressionssystem auf basis eines nukleären rezeptors
WO2002066614A2 (en) * 2001-02-20 2002-08-29 Rheogene Holdings, Inc. Chimeric retinoid x receptors and their use in a novel ecdysone receptor-based inducible gene expression system
EP1534738B1 (de) 2001-02-20 2012-06-20 Intrexon Corporation Neue substitutionsmutantenrezeptoren und ihre verwendung in einem induzierbaren genexpressionsystem auf grundlage eines nukleären rezeptors
JP4955904B2 (ja) 2001-02-20 2012-06-20 イントレキソン コーポレーション 新規エクジソン受容体／無脊椎動物レチノイドｘ受容体−ベースの誘導性遺伝子発現システム
WO2002072786A2 (en) 2001-03-13 2002-09-19 Corvas International, Inc. Nucleic acid molecules encoding a transmembrane serine protease 7, the encoded polypeptides and methods based thereon
AU2002254357A1 (en) 2001-03-22 2002-10-08 Dendreon Corporation Nucleic acid molecules encoding serine protease cvsp14, the encoded polypeptides and methods based thereon
CA2442089A1 (en) 2001-03-27 2002-10-03 Dendreon San Diego Llc Nucleic acid molecules encoding a transmembran serine protease 9, the encoded polypeptides and methods based thereon
US7112430B2 (en) 2001-05-14 2006-09-26 Dendreon Corporation Nucleic acid molecules encoding a transmembrane serine protease 10, the encoded polypeptides and methods based thereon
AU2002315525A1 (en) * 2001-07-03 2003-01-21 Dendreon San Diego Llc Nucleic acid molecules encoding a transmembrane serine protease 20, the encoded polypeptides and methods based thereon
US20030031627A1 (en) * 2001-07-31 2003-02-13 Mallinckrodt Inc. Internal image antibodies for optical imaging and therapy
DE10244149A1 (de) * 2001-09-25 2003-04-30 Werner Keber Verfahren und Einrichtung zum Verhindern einer unzulässigen Flugannäherung von Flugzeugen an zu schützende Bodenobjeke
US7919269B2 (en) * 2001-09-26 2011-04-05 Intrexon Corporation Whitefly ecdysone receptor nucleic acids, polypeptides, and uses thereof
MXPA04002810A (es) * 2001-09-26 2005-06-06 Rheogene Holdings Inc Acidos nucleicos receptores de ecdisona de saltarilla, polipeptidos, y sus usos.
US6924311B2 (en) * 2001-10-17 2005-08-02 X-Ceptor Therapeutics, Inc. Methods for affecting various diseases utilizing LXR compounds
AU2002357004A1 (en) * 2001-11-20 2003-06-10 Dendreon San Diego Llc Nucleic acid molecules encoding serine protease 17, the encoded polypeptides and methods based thereon
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
EP1465869B1 (de) 2001-12-21 2013-05-15 Exelixis Patent Company LLC Modulatoren von lxr
US20030228607A1 (en) * 2002-04-15 2003-12-11 Wagner Brandee Lynn Screening method and modulators having an improved therapeutic profile
US20040001801A1 (en) * 2002-05-23 2004-01-01 Corvas International, Inc. Conjugates activated by cell surface proteases and therapeutic uses thereof
EP1371662A1 (de) * 2002-06-13 2003-12-17 LION Bioscience AG Neue zelluläre LXR-alpha Rezeptorvariante
WO2004024880A2 (en) 2002-09-16 2004-03-25 Exelixis, Inc. AMPDs AS MODIFIERS OF THE p21 PATHWAY AND METHODS OF USE
US7304161B2 (en) * 2003-02-10 2007-12-04 Intrexon Corporation Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
US7456315B2 (en) 2003-02-28 2008-11-25 Intrexon Corporation Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
GB0306185D0 (en) * 2003-03-19 2003-04-23 Astrazeneca Ab Molecules
US7935510B2 (en) * 2004-04-30 2011-05-03 Intrexon Corporation Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
US8097431B2 (en) 2004-08-04 2012-01-17 University Of Utah Research Foundation Methods and compositions for detecting steroids
BRPI0612287A8 (pt) 2005-06-27 2019-01-22 Exelixis Inc composição para uso farmacêutico no tratamento de doenças através da medicina nuclear e métodos de uso e para modulação de atividade de receptor nuclear
KR101676704B1 (ko) 2009-05-28 2016-11-16 엑셀리시스 페이턴트 컴퍼니 엘엘씨 Ｌｘｒ 조절자
AR088728A1 (es) 2011-03-25 2014-07-02 Bristol Myers Squibb Co Moduladores de lxr como prodroga de imidazol
US9127024B2 (en) 2013-03-15 2015-09-08 Intrexon Corporation Boron-containing diacylhydrazines
AU2015317862A1 (en) 2014-09-17 2017-04-06 Intrexon Corporation Boron-containing diacylhydrazine compounds
EP3612210A4 (de) 2017-04-19 2021-01-27 Board Of Regents, The University Of Texas System Manipulierte antigenrezeptoren exprimierende immunzellen
US12473336B2 (en) 2018-02-21 2025-11-18 Board Of Regents, The University Of Texas System Methods for activation and expansion of natural killer cells and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071773A (en) * 1986-10-24 1991-12-10 The Salk Institute For Biological Studies Hormone receptor-related bioassays
US4981784A (en) * 1987-12-02 1991-01-01 The Salk Institute For Biological Studies Retinoic acid receptor method
CA2003996A1 (en) * 1988-11-30 1990-05-31 Ronald M. Evans Model drosophila receptors
ES2152920T3 (es) * 1990-02-09 2001-02-16 Salk Inst For Biological Studi Composiciones receptoras de retinoides y metodos.
AU7492291A (en) * 1990-02-26 1991-09-18 Board Of Trustees Of The Leland Stanford Junior University Identification and expression of insect steroid receptor dna sequences
CA2115452A1 (en) * 1991-09-17 1993-04-01 Ronald M. Evans Receptor of the thyroid/steroid hormone receptor superfamily

Also Published As

Publication number Publication date
US5696233A (en) 1997-12-09
US5571696A (en) 1996-11-05
DE69232537D1 (de) 2002-05-08
AU2579692A (en) 1993-04-27
DE69232537T2 (de) 2002-10-24
EP0609240B1 (de) 2002-04-03
EP0609240A1 (de) 1994-08-10
CA2115452A1 (en) 1993-04-01
WO1993006215A1 (en) 1993-04-01
JP2002514881A (ja) 2002-05-21
US5710004A (en) 1998-01-20

Similar Documents

Publication Publication Date Title
ATE215601T1 (de) Rezeptoren der steroid/thyroid superfamilie von rezeptoren
ES2193145T3 (es) Proteinas procoagulants quimericas.
EP0653940A4 (de) Glialmitogene faktoren, ihre herstellung und verwendung.
DE69533923D1 (de) Cytokinin-designiertes lerk-5
NO953901L (no) Rekombinante alfavirus-vektorer
BR9711123A (pt) Quimeras de leucotoxina-gnrh
BG46598A3 (bg) Метод за получаване на алфа-хетероциклично заместени толунитрили
BR0214350A (pt) Sequências de ácido nucleico e aminoácido de adenovìrus de sìmio, vetores contendo as mesmas e métodos de uso
DE69433552D1 (de) An den zelloberflächenrezeptor hek bindendes cytokin
ATE242330T1 (de) Klonierung von enterokinase und verfahren zu deren verwendung
DE69433690D1 (de) Chimere proteine, welche borrelia polypeptide beinhalten, verwendungen dafür
DE69328928D1 (de) Varianten in den leltin domäne von selektin
DK0724637T4 (da) Kortikotropinfrigørende faktor2-receptorer
DK0612218T3 (da) Hidtil ukendte coleoptera-aktive isolater fra Bacillus thuringiensis samt gener, der koder for coleoptera-aktive toksiner
SE9801148D0 (sv) New receptors
DK0643719T3 (da) Nukleinsyresekvenser, som koder for eller er komplementære til nukleinsyresekvenser, som koder for interleukin 9-receptor
DE68910676D1 (de) Verwendung von Creosot als antispastischer Wirkstoff.
DE69619808D1 (de) Chimäre msp und daf proteine mit einem telloberflächenlokalisierendem domän
ES8800353A1 (es) Procedimiento de clonacion de factor humano viii-r.
ATE215123T1 (de) Or-1, ein wais-rezeptor der nuklearen rezeptoren familie
DK447083A (da) Dna, som koder for humant interferon-gamma, rekombinant-dna indeholdende denne dna, mikroorganisme indeholdende rekombinant-dna'en og fremgangsmaade til fremstilling af humant interferon-gamma-polypeptid
DE59005647D1 (de) Verwendung von polyglykolethergemischen als antischaummittel.
DK0870015T3 (da) Xylanaser, gener, der koder for disse, samt anvendelser deraf
ES2059801T3 (es) Nuevas linfoquinas, secuencias de adn que codifican para estas linfoquinas, y composiciones farmaceuticas conteniendo estas linfoquinas.
DK192890D0 (da) 24r-scumnol, fremgangsmaade til fremstilling heraf samt anvendelse af samme

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties