ES2152920T3 - Composiciones receptoras de retinoides y metodos. - Google Patents

Composiciones receptoras de retinoides y metodos.

Info

Publication number
ES2152920T3
ES2152920T3 ES91905013T ES91905013T ES2152920T3 ES 2152920 T3 ES2152920 T3 ES 2152920T3 ES 91905013 T ES91905013 T ES 91905013T ES 91905013 T ES91905013 T ES 91905013T ES 2152920 T3 ES2152920 T3 ES 2152920T3
Authority
ES
Spain
Prior art keywords
receptors
novel
compounds
transformed
expression vectors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91905013T
Other languages
English (en)
Inventor
David John Mangelsdorf
Ronald Mark Evans
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Salk Institute for Biological Studies
Original Assignee
Salk Institute for Biological Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23898398&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2152920(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Salk Institute for Biological Studies filed Critical Salk Institute for Biological Studies
Application granted granted Critical
Publication of ES2152920T3 publication Critical patent/ES2152920T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/75—Vector systems having a special element relevant for transcription from invertebrates

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A NUEVOS POLIPEPTIDOS RECEPTORES, QUE, BAJO LA INTERACCION CON CIERTOS LIGANTES, O LA ACTIVACION POR MEDIO DE CIERTOS COMPUESTOS, MODULAN LA TRANSCRIPCION DE CIERTOS GENES MEDIANTE LA UNION PARA EL COGNADO DE ELEMENTOS DE RESPUESTA ASOCIADOS CON PROMOTORES DE TALES GENES. LOS NUEVOS RECEPTORES DE LA INVENCION MODULAN LA TRANSCRIPCION EN LA PRESENCIA DE COMPUESTOS DE RETINOIDE. LOS RECEPTORES DE LA PRESENTE INVENCION DIFIEREN SIGNIFICATIVAMENTE DE LOS RECEPTORES DE ACIDO RETINOIDE CONOCIDOS, EN SECUENCIA PRIMARIA DE PROTEINA Y EN RESPUESTA A LA EXPOSICION A VARIOS RETINOIDES. LA INVENCION PROPORCIONA ADNS QUE DECODIFICAN LOS NUEVOS RECEPTORES, VECTORES DE EXPRESION PARA LA EXPRESION DE LOS RECEPTORES, CELULAS TRANSFORMADAS CON TALES VECTORES DE EXPRESION, CELULAS COTRANSFORMADAS CON TALES VECTORES DE EXPRESION Y CON VECTORES INFORMADORES PARA CONTROLAR LA MODULACION DE LA TRANSCRIPCION POR LOS RECEPTORES, Y METODOS DE UTILIZAR TALES CELULAS COTRANSFORMADAS ENLA DEPURACION DE LOS COMPUESTOS QUE PUEDEN, DIRECTA O INDIRECTAMENTE, ACTIVAR LOS RECEPTORES. LA INVENCION TAMBIEN PROPORCIONA ENSAYOS DE ACIDO NUCLEICO PARA LA IDENTIFICACION DE LOS ADN QUE DECODIFICAN LOS RECEPTORES RETINOIDES ADICIONALES DE LA MISMA CLASE ASI COMO LOS NUEVOS RECEPTORES DESCRITOS EN EL MISMO.
ES91905013T 1990-02-09 1991-01-22 Composiciones receptoras de retinoides y metodos. Expired - Lifetime ES2152920T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US47807190A 1990-02-09 1990-02-09

Publications (1)

Publication Number Publication Date
ES2152920T3 true ES2152920T3 (es) 2001-02-16

Family

ID=23898398

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91905013T Expired - Lifetime ES2152920T3 (es) 1990-02-09 1991-01-22 Composiciones receptoras de retinoides y metodos.

Country Status (9)

Country Link
US (2) US5723329A (es)
EP (2) EP0999271A3 (es)
JP (1) JPH05504479A (es)
AT (1) ATE196310T1 (es)
AU (2) AU654270B2 (es)
CA (1) CA2075182C (es)
DE (1) DE69132411T2 (es)
ES (1) ES2152920T3 (es)
WO (1) WO1991012258A1 (es)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091518A (en) * 1989-11-16 1992-02-25 The Salk Institute For Biological Studies Beta retinoic acid response elements compositions and assays
ES2152920T3 (es) 1990-02-09 2001-02-16 Salk Inst For Biological Studi Composiciones receptoras de retinoides y metodos.
JPH11508121A (ja) * 1990-03-22 1999-07-21 ザ ソーク インスティテュート フォア バイオロジカル スタディーズ 昆虫レチノイドレセプター組成物および方法
CA2115452A1 (en) * 1991-09-17 1993-04-01 Ronald M. Evans Receptor of the thyroid/steroid hormone receptor superfamily
US7098310B1 (en) 1991-12-24 2006-08-29 Ligand Pharmaceuticals Heterodimers of retinoid X receptors (RXRS) and other steroid hormone receptors
US6989242B1 (en) 1992-02-26 2006-01-24 The General Hospital Coporation Car receptors and related molecules and methods
US5756448A (en) * 1992-02-26 1998-05-26 The General Hospital Corporation Constitute activator of retinoid (CAR) receptor polypeptides
GB9206874D0 (en) * 1992-03-30 1992-05-13 Connaught Lab Generation of improved inducible mammalian expression vectors
EP0769023A4 (en) * 1994-06-24 1999-05-26 Human Genome Sciences Inc EPSILON RETINIC ACID RECEPTOR
US5877018A (en) * 1994-10-20 1999-03-02 Connaught Laboratories Limited Synthetic eukaryotic promoters containing two inducible elements
CA2211142A1 (en) * 1995-01-23 1996-08-01 Ligand Pharmaceuticals Incorporated Human retinoid x receptor - gamma (hrxr-gamma)
US7115728B1 (en) 1995-01-30 2006-10-03 Ligand Pharmaceutical Incorporated Human peroxisome proliferator activated receptor γ
ATE293699T1 (de) * 1995-03-03 2005-05-15 Syngenta Participations Ag Kontrolle der pflanzengenexpression durch rezeptor-vermittelte transaktivation in gegenwart von einem chemischen ligand
WO1997013864A1 (en) 1995-10-10 1997-04-17 Novartis Ag Juvenile hormone or one of its agonists as a chemical ligand to control gene expression in plants by receptor mediated transactivation
US6893830B1 (en) 1996-09-27 2005-05-17 The Board Of Regents Of The University Of Texas System Method of screening oxysterol activation of LXRα
US6489451B1 (en) 1997-04-10 2002-12-03 Hefei-Siu-Fung Ustc Pharmaceutical Co., Ltd. Antithrombosis enzyme from the snake venom of agkistrodon acutus
WO1999005161A1 (en) 1997-07-25 1999-02-04 Ligand Pharmaceuticals Incorporated HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA (PPARη) GENE REGULATORY SEQUENCES AND USES THEREFOR
US6479653B1 (en) 1997-08-26 2002-11-12 Ariad Gene Therapeutics, Inc. Compositions and method for regulation of transcription
JP2003524368A (ja) * 1997-08-26 2003-08-19 アリアド ジーン セラピューティクス インコーポレイテッド ニ量化ドメイン、三量化ドメインまたは四量化ドメインおよび補足的非相同転写活性化ドメイン、転写抑制ドメイン、ｄｎａ結合ドメインまたはリガンド結合ドメインを含む融合蛋白
US7833529B1 (en) 1999-01-07 2010-11-16 Zymogenetics, Inc. Methods for inhibiting B lymphocyte proliferation with soluble ztnf4 receptor
US20040033600A1 (en) * 2001-03-21 2004-02-19 Palli Subba Reddy Ecdysone receptor-based inducible gene expression system
US8105825B2 (en) 2000-10-03 2012-01-31 Intrexon Corporation Multiple inducible gene regulation system
EP1356066A2 (en) 2000-10-24 2003-10-29 Syngenta Participations AG Control of gene expression in plants
EP1373470B1 (en) * 2001-02-20 2013-04-24 Intrexon Corporation Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
EP1534738B1 (en) 2001-02-20 2012-06-20 Intrexon Corporation Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
WO2002066614A2 (en) * 2001-02-20 2002-08-29 Rheogene Holdings, Inc. Chimeric retinoid x receptors and their use in a novel ecdysone receptor-based inducible gene expression system
JP4955904B2 (ja) 2001-02-20 2012-06-20 イントレキソン コーポレーション 新規エクジソン受容体／無脊椎動物レチノイドｘ受容体−ベースの誘導性遺伝子発現システム
DE10244149A1 (de) * 2001-09-25 2003-04-30 Werner Keber Verfahren und Einrichtung zum Verhindern einer unzulässigen Flugannäherung von Flugzeugen an zu schützende Bodenobjeke
US7919269B2 (en) * 2001-09-26 2011-04-05 Intrexon Corporation Whitefly ecdysone receptor nucleic acids, polypeptides, and uses thereof
MXPA04002810A (es) * 2001-09-26 2005-06-06 Rheogene Holdings Inc Acidos nucleicos receptores de ecdisona de saltarilla, polipeptidos, y sus usos.
US20030170724A1 (en) * 2002-03-08 2003-09-11 Anderson David C. Methods of identifying target polypeptides
EP1489094A4 (en) * 2002-03-25 2005-11-02 Fujisawa Pharmaceutical Co ISOFORM RXR ALPHA NUCLEAR RECEPTOR
US7304161B2 (en) * 2003-02-10 2007-12-04 Intrexon Corporation Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
US7456315B2 (en) 2003-02-28 2008-11-25 Intrexon Corporation Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US7935510B2 (en) * 2004-04-30 2011-05-03 Intrexon Corporation Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
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US9127024B2 (en) 2013-03-15 2015-09-08 Intrexon Corporation Boron-containing diacylhydrazines
AU2015317862A1 (en) 2014-09-17 2017-04-06 Intrexon Corporation Boron-containing diacylhydrazine compounds
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EP3612210A4 (en) 2017-04-19 2021-01-27 Board Of Regents, The University Of Texas System MANIPULATED ANTIGEN RECEPTORS EXPRESSING IMMUNE CELLS
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* Cited by examiner, † Cited by third party
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FR2603280B1 (fr) * 1986-08-29 1988-10-28 Cird Nouveau compose marque au tritium, sa preparation et son application notamment dans la determination de l'affinite des retinoides pour leur recepteur cellulaire
US4981784A (en) * 1987-12-02 1991-01-01 The Salk Institute For Biological Studies Retinoic acid receptor method
US5171671A (en) * 1987-12-02 1992-12-15 The Salk Institute For Biological Studies Retinoic acid receptor composition
US5274077A (en) * 1987-12-02 1993-12-28 The Salk Institute For Biological Studies Retinoic acid receptor composition
US5571692A (en) * 1987-12-02 1996-11-05 The Salk Institute For Biological Studies Retinoic acid receptor α, vectors and cells comprising the same DNA encoding
US5260432A (en) * 1989-06-22 1993-11-09 Sloan-Kettering Institute For Cancer Research Human gamma retinoic acid receptor DNA
US5403925A (en) * 1989-12-13 1995-04-04 The United States Of America As Represented By The Department Of Health And Human Services Nucleic acids encoding mammalian H-2RIIBP or RXR.sub.β and uses thereof
ES2152920T3 (es) 1990-02-09 2001-02-16 Salk Inst For Biological Studi Composiciones receptoras de retinoides y metodos.
CA2115452A1 (en) * 1991-09-17 1993-04-01 Ronald M. Evans Receptor of the thyroid/steroid hormone receptor superfamily
EP0577814A4 (en) * 1992-01-24 1997-08-20 Inst Nat Sante Rech Med Novel heterodimeric nuclear receptors proteins, genes encoding same, and usage thereof

Also Published As

Publication number Publication date
EP0999271A2 (en) 2000-05-10
AU654270B2 (en) 1994-11-03
ATE196310T1 (de) 2000-09-15
WO1991012258A1 (en) 1991-08-22
AU7338391A (en) 1991-09-03
CA2075182C (en) 2003-03-25
AU1155395A (en) 1995-05-25
EP0514488A4 (en) 1993-02-17
AU680575B2 (en) 1997-07-31
US7501487B1 (en) 2009-03-10
DE69132411T2 (de) 2001-06-07
EP0999271A3 (en) 2003-04-02
CA2075182A1 (en) 1991-08-10
EP0514488B1 (en) 2000-09-13
JPH05504479A (ja) 1993-07-15
EP0514488A1 (en) 1992-11-25
US5723329A (en) 1998-03-03
DE69132411D1 (de) 2000-10-19

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